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Clinical Research

Abstract 2735: Diagnosis of prostate cancer without tumor cells using differentially expressed genes in the tumor microenvironment

Zhenyu Jia, Yipeng Wang, Michael McClelland, Anne Sawyers, Huazhen Yao, Farahnaz Rahmatpanah, Xiao-Qin Xia, Qiang Xu, James Koziol, Philip Carpenter, Jessica Wang-Rodriquez, Anne Simoneau, Frank Meyskens, Manuel Sutton, Waldemar Lernhardt, Thomas Beach and Dan Mercola
Zhenyu Jia
1UC Irvine, Irvine, CA
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Yipeng Wang
1UC Irvine, Irvine, CA
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Michael McClelland
1UC Irvine, Irvine, CA
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Anne Sawyers
1UC Irvine, Irvine, CA
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Huazhen Yao
1UC Irvine, Irvine, CA
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Farahnaz Rahmatpanah
1UC Irvine, Irvine, CA
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Xiao-Qin Xia
2Vaccine Research Institute of San Diego, San Diego, CA
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Qiang Xu
3Althea Technologies Inc, San Diego, CA
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James Koziol
4The Scripps Research Institute, La Jolla, CA
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Philip Carpenter
1UC Irvine, Irvine, CA
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Jessica Wang-Rodriquez
5UC San Diego, San Diego, CA
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Anne Simoneau
1UC Irvine, Irvine, CA
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Frank Meyskens
1UC Irvine, Irvine, CA
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Manuel Sutton
1UC Irvine, Irvine, CA
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Waldemar Lernhardt
6Proveri Inc, San Diego, CA
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Thomas Beach
7The Sun Health Research Institute, Phoenix, CA.
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Dan Mercola
1UC Irvine, Irvine, CA
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DOI: 10.1158/1538-7445.AM10-2735 Published April 2010
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Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC

Abstract

Over one million prostate biopsies are performed in the U.S. every year. However, pathology examination is not definitive in a significant percentage of cases due to missing the tumor or equivocal structures. Given that the tissue near tumors will experience expression changes, biopsies could reveal the presence of a nearby tumor even if the biopsy contains no tumor. In order to identify reliable examples of such genes we compared gene expression profiles (Affymetrix U133plus2) from 15 volunteer biopsy specimens to 13 specimens containing largely tumor-adjacent stroma. More than a thousand significant expression changes were found and thereafter filtered to eliminate possible aging-related genes and genes also expressed at detectable levels in tumor cells. Classifiers were constructed based on 114 unique candidate genes (131 Affymetrix probe sets) and tested on 380 independent cases, including 255 tumor-bearing cases, 125 nontumor cases (normal biopsies, normal autopsies, remote stroma as well as pure tumor adjacent stroma). The classifier predicted the tumor status of patients with an average accuracy of 97.4% (sensitivity = 98.0% and specificity = 89.7%). These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for detecting “presence of tumor”.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2735.

  • ©2010 American Association for Cancer Research
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Cancer Research: 70 (8 Supplement)
April 2010
Volume 70, Issue 8 Supplement
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Abstract 2735: Diagnosis of prostate cancer without tumor cells using differentially expressed genes in the tumor microenvironment
Zhenyu Jia, Yipeng Wang, Michael McClelland, Anne Sawyers, Huazhen Yao, Farahnaz Rahmatpanah, Xiao-Qin Xia, Qiang Xu, James Koziol, Philip Carpenter, Jessica Wang-Rodriquez, Anne Simoneau, Frank Meyskens, Manuel Sutton, Waldemar Lernhardt, Thomas Beach and Dan Mercola
Cancer Res April 15 2010 (70) (8 Supplement) 2735; DOI: 10.1158/1538-7445.AM10-2735

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Abstract 2735: Diagnosis of prostate cancer without tumor cells using differentially expressed genes in the tumor microenvironment
Zhenyu Jia, Yipeng Wang, Michael McClelland, Anne Sawyers, Huazhen Yao, Farahnaz Rahmatpanah, Xiao-Qin Xia, Qiang Xu, James Koziol, Philip Carpenter, Jessica Wang-Rodriquez, Anne Simoneau, Frank Meyskens, Manuel Sutton, Waldemar Lernhardt, Thomas Beach and Dan Mercola
Cancer Res April 15 2010 (70) (8 Supplement) 2735; DOI: 10.1158/1538-7445.AM10-2735
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Cancer Research Online ISSN: 1538-7445
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