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Tumor Biology

Abstract 4310: Prospective isolation of clongenic mantle cell lymphoma initiating cells

Zheng Chen, Paul Ayala, Michael Wang, Luis Fayad, Ruth L. Katz, Jorge Romaguera, Nancy Caraway, Sattva S. Neelapu, Larry W. Kwak, Paul Simmons and McCarty Nami
Zheng Chen
1UT-HSC, Houston, TX
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Paul Ayala
1UT-HSC, Houston, TX
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Michael Wang
2MD Anderson Cancer Center, Houston, TX.
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Luis Fayad
2MD Anderson Cancer Center, Houston, TX.
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Ruth L. Katz
2MD Anderson Cancer Center, Houston, TX.
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Jorge Romaguera
2MD Anderson Cancer Center, Houston, TX.
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Nancy Caraway
2MD Anderson Cancer Center, Houston, TX.
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Sattva S. Neelapu
2MD Anderson Cancer Center, Houston, TX.
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Larry W. Kwak
2MD Anderson Cancer Center, Houston, TX.
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Paul Simmons
1UT-HSC, Houston, TX
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McCarty Nami
1UT-HSC, Houston, TX
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DOI: 10.1158/1538-7445.AM10-4310 Published April 2010
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Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC

Abstract

We have prospectively isolated and characterized clonogenic cells with self-renewal capacities from mantle cell lymphoma (MCL), a particularly deadly form of non-hodgkin's lymphoma (NHL). Self-renewal and tumorigenic activities were enriched in MCL cell fractions that lacked expression of the prototypic B cell surface marker, CD19. CD45+CD19- cells represented a relatively small fraction of the total MCL tumor cells, however, they recapitulated the heterogeneity of original patient tumors upon transplantation into immunodeficient mice. As few as 100 of these cells displayed self-renewal capacities in secondary and tertiary recipient mice by in vivo limiting dilution assays. Similar to leukemic stem cells, CD45+CD19- MCL cells also displayed a quiescent status as determined by dye efflux assays. In summary, this study is the first to isolate subpopulations of MCL cells that have self-renewal and tumorigenic capacities. Identification and characterization of MCL-ICs is an important first step toward understanding how self-renewal and tumorigenicity are regulated in MCL.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4310.

  • ©2010 American Association for Cancer Research
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Cancer Research: 70 (8 Supplement)
April 2010
Volume 70, Issue 8 Supplement
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Abstract 4310: Prospective isolation of clongenic mantle cell lymphoma initiating cells
Zheng Chen, Paul Ayala, Michael Wang, Luis Fayad, Ruth L. Katz, Jorge Romaguera, Nancy Caraway, Sattva S. Neelapu, Larry W. Kwak, Paul Simmons and McCarty Nami
Cancer Res April 15 2010 (70) (8 Supplement) 4310; DOI: 10.1158/1538-7445.AM10-4310

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Abstract 4310: Prospective isolation of clongenic mantle cell lymphoma initiating cells
Zheng Chen, Paul Ayala, Michael Wang, Luis Fayad, Ruth L. Katz, Jorge Romaguera, Nancy Caraway, Sattva S. Neelapu, Larry W. Kwak, Paul Simmons and McCarty Nami
Cancer Res April 15 2010 (70) (8 Supplement) 4310; DOI: 10.1158/1538-7445.AM10-4310
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Cancer Research Online ISSN: 1538-7445
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