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Table of Contents

Breaking Advances

Reviews

Priority Reports

  • Priority Reports
    Indirubins Decrease Glioma Invasion by Blocking Migratory Phenotypes in Both the Tumor and Stromal Endothelial Cell Compartments
    Shanté P. Williams, Michal O. Nowicki, Fang Liu, Rachael Press, Jakub Godlewski, Mahmoud Abdel-Rasoul, Balveen Kaur, Soledad A. Fernandez, E. Antonio Chiocca and Sean E. Lawler
    Cancer Res August 15 2011 71 (16) 5374-5380; DOI:10.1158/0008-5472.CAN-10-3026

    Preclinical studies validate a novel class of small molecule inhibitors of the enzyme GSK-3, which exert potent antitumor properties by blocking both tumor invasion and angiogenesis.

  • Priority Reports
    Imatinib Sensitivity in BCR-ABL1–Positive Chronic Myeloid Leukemia Cells Is Regulated by the Remaining Normal ABL1 Allele
    Anna Virgili, Mateusz Koptyra, Yashodhara Dasgupta, Eliza Glodkowska-Mrowka, Tomasz Stoklosa, Elisabeth P. Nacheva and Tomasz Skorski
    Cancer Res August 15 2011 71 (16) 5381-5386; DOI:10.1158/0008-5472.CAN-11-0068

    The lack of a complete cytogenetic response in chronic phase CML patients treated with the ABL kinase inhibitor imatinib can be explained by loss of the remaining normal ABL1 allele in CML cells.

  • Priority Reports
    TMPRSS2–ERG-Mediated Feed-Forward Regulation of Wild-Type ERG in Human Prostate Cancers
    Ram-Shankar Mani, Matthew K. Iyer, Qi Cao, J. Chad Brenner, Lei Wang, Aparna Ghosh, Xuhong Cao, Robert J. Lonigro, Scott A. Tomlins, Sooryanarayana Varambally and Arul M. Chinnaiyan
    Cancer Res August 15 2011 71 (16) 5387-5392; DOI:10.1158/0008-5472.CAN-11-0876

    This study identifies an important mechanism of ERG regulation in human prostate cancers, with implications for understanding prostate tumor progression.

  • Priority Reports
    IL-18 Induces PD-1–Dependent Immunosuppression in Cancer
    Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Mélanie Desbois, Nicolas Delahaye, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Nathalie Chaput and Laurence Zitvogel
    Cancer Res August 15 2011 71 (16) 5393-5399; DOI:10.1158/0008-5472.CAN-11-0993

    IL-18 suppresses the crucial role of natural killer cells (NK cells) in supporting tumor immunosurveillance, with implications for clinical strategies to reverse this mechanism of tumoral immune escape.

Integrated Systems and Technologies

  • Integrated Systems and Technologies | Free Article
    Comparing Signaling Networks between Normal and Transformed Hepatocytes Using Discrete Logical Models
    Julio Saez-Rodriguez, Leonidas G. Alexopoulos, MingSheng Zhang, Melody K. Morris, Douglas A. Lauffenburger and Peter K. Sorger
    Cancer Res August 15 2011 71 (16) 5400-5411; DOI:10.1158/0008-5472.CAN-10-4453

    Findings illustrate a novel approach to creating cell-specific computational models of signaling networks based on biochemical data, applying it in this study to define deregulated pathways in hepatocellular carcinoma.

Microenvironment and Immunology

  • Microenvironment and Immunology
    Profound Coordinated Alterations of Intratumoral NK Cell Phenotype and Function in Lung Carcinoma
    Sophia Platonova, Julien Cherfils-Vicini, Diane Damotte, Lucile Crozet, Vincent Vieillard, Pierre Validire, Pascale André, Marie-Caroline Dieu-Nosjean, Marco Alifano, Jean-François Régnard, Wolf-Herman Fridman, Catherine Sautès-Fridman and Isabelle Cremer
    Cancer Res August 15 2011 71 (16) 5412-5422; DOI:10.1158/0008-5472.CAN-10-4179

    The tissue microenvironment in human lung carcinomas suppresses the tumoricidal activity of natural killer cells, thereby contributing to immune escape and progression.

  • Microenvironment and Immunology
    Quantitative and Functional Alterations of Plasmacytoid Dendritic Cells Contribute to Immune Tolerance in Ovarian Cancer
    Sana Intidhar Labidi-Galy, Vanja Sisirak, Pierre Meeus, Michael Gobert, Isabelle Treilleux, Agathe Bajard, Jean-Damien Combes, Julien Faget, François Mithieux, Alexandre Cassignol, Olivier Tredan, Isabelle Durand, Christine Ménétrier-Caux, Christophe Caux, Jean-Yves Blay, Isabelle Ray-Coquard and Nathalie Bendriss-Vermare
    Cancer Res August 15 2011 71 (16) 5423-5434; DOI:10.1158/0008-5472.CAN-11-0367

    Findings define a critical cellular mechanism of immune escape in human ovarian cancers, offering new insights into the pathophysiology of this often fatal cancer.

  • Microenvironment and Immunology
    A Novel Tumor Antigen Derived from Enhanced Degradation of Bax Protein in Human Cancers
    Cláudia Trindade Nunes, Kelly L. Miners, Garry Dolton, Chris Pepper, Chris Fegan, Malcolm D. Mason and Stephen Man
    Cancer Res August 15 2011 71 (16) 5435-5444; DOI:10.1158/0008-5472.CAN-11-0393

    Study findings suggest that useful peptide antigens for cancer vaccination might be derived from proteins commonly expressed in normal cells but abnormally proteolyzed in cancer.

  • Microenvironment and Immunology
    Maximal T Cell–Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells
    Alicia González-Martín, Lucio Gómez, Joseph Lustgarten, Emilia Mira and Santos Mañes
    Cancer Res August 15 2011 71 (16) 5455-5466; DOI:10.1158/0008-5472.CAN-11-1687

    A chemokine receptor that is critical to organize leukocyte trafficking responses to infection is also found to be critical for T cell-mediated responses against tumors, suggesting mechanistic similarities in the way that the immune system interprets cancer cells and infectious pathogens.

  • Microenvironment and Immunology
    TLR4 Engagement during TLR3-Induced Proinflammatory Signaling in Dendritic Cells Promotes IL-10–Mediated Suppression of Antitumor Immunity
    Dusan Bogunovic, Olivier Manches, Emmanuelle Godefroy, Alice Yewdall, Anne Gallois, Andres M. Salazar, Isabelle Marie, David E. Levy and Nina Bhardwaj
    Cancer Res August 15 2011 71 (16) 5467-5476; DOI:10.1158/0008-5472.CAN-10-3988

    Findings suggest that the anti-tumor properties of a potent immune stimulatory Toll receptor ligand with therapeutic potential may be reduced or negated if the Toll receptor TLR4 is also activated, with implications for the design of immunotherapy trials.

Molecular and Cellular Pathobiology

Therapeutics, Targets, and Chemical Biology

  • Therapeutics, Targets, and Chemical Biology
    CXCL12/CXCR4 Blockade Induces Multimodal Antitumor Effects That Prolong Survival in an Immunocompetent Mouse Model of Ovarian Cancer
    Elda Righi, Satoshi Kashiwagi, Jianping Yuan, Michael Santosuosso, Pierre Leblanc, Rachel Ingraham, Benjamin Forbes, Beth Edelblute, Brian Collette, Deyin Xing, Magdalena Kowalski, Maria Cristina Mingari, Fabrizio Vianello, Michael Birrer, Sandra Orsulic, Glenn Dranoff and Mark C. Poznansky
    Cancer Res August 15 2011 71 (16) 5522-5534; DOI:10.1158/0008-5472.CAN-10-3143

    A druggable target implicated in promoting metastasis is found to coordinately promote immune escape, illustrating the important linkage between these two processes in ovarian cancer progression.

  • Therapeutics, Targets, and Chemical Biology
    Identification of the MEK1(F129L) Activating Mutation as a Potential Mechanism of Acquired Resistance to MEK Inhibition in Human Cancers Carrying the B-RafV600E Mutation
    Huisheng Wang, Sherif Daouti, Wen-hui Li, Yang Wen, Christine Rizzo, Brian Higgins, Kathryn Packman, Neal Rosen, John F. Boylan, David Heimbrook and Huifeng Niu
    Cancer Res August 15 2011 71 (16) 5535-5545; DOI:10.1158/0008-5472.CAN-10-4351

    Combined inhibition of Raf and MEK may offer a clinical strategy to bypass or overcome acquired resistance to MEK inhibitors that can arise as the result of a powerful activating mutation in MEK1.

  • Therapeutics, Targets, and Chemical Biology
    p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage
    Juhong Jiang, Eddy S. Yang, Guochun Jiang, Somaira Nowsheen, Hong Wang, Tong Wang, Yihan Wang, Dean Billheimer, A. Bapsi Chakravarthy, Melissa Brown, Bruce Haffty and Fen Xia
    Cancer Res August 15 2011 71 (16) 5546-5557; DOI:10.1158/0008-5472.CAN-10-3423

    This study suggests novel strategies to re-sensitize p53-deficient breast cancer cells to genotoxic chemotherapy by restoring nuclear shuttling which is dysfunctional in such cells.

Tumor and Stem Cell Biology

  • Tumor and Stem Cell Biology
    GPR56 Regulates VEGF Production and Angiogenesis during Melanoma Progression
    Liquan Yang, Guangchun Chen, Sonali Mohanty, Glynis Scott, Fabeha Fazal, Arshad Rahman, Shahinoor Begum, Richard O. Hynes and Lei Xu
    Cancer Res August 15 2011 71 (16) 5558-5568; DOI:10.1158/0008-5472.CAN-10-4543

    Findings identify a novel G protein-coupled receptor that regulates VEGF production, offering a new therapeutic target for angiogenesis inhibition.

  • Tumor and Stem Cell Biology
    YB-1 Bridges Neural Stem Cells and Brain Tumor–Initiating Cells via Its Roles in Differentiation and Cell Growth
    Abbas Fotovati, Samah Abu-Ali, Pei-Shan Wang, Loic P. Deleyrolle, Cathy Lee, Joanna Triscott, James Y. Chen, Sonia Franciosi, Yasuhiro Nakamura, Yasuo Sugita, Takeshi Uchiumi, Michihiko Kuwano, Blair R. Leavitt, Sheila K. Singh, Alexa Jury, Chris Jones, Hiroaki Wakimoto, Brent A. Reynolds, Catherine J. Pallen and Sandra E. Dunn
    Cancer Res August 15 2011 71 (16) 5569-5578; DOI:10.1158/0008-5472.CAN-10-2805

    A transcription factor required for embryonic brain development also contributes in later life to brain tumor development, due to its roles in normal and malignant neural stem cells.

  • Tumor and Stem Cell Biology
    Protein Arginine Methyltransferase 5 Accelerates Tumor Growth by Arginine Methylation of the Tumor Suppressor Programmed Cell Death 4
    Matthew A. Powers, Marta M. Fay, Rachel E. Factor, Alana L. Welm and Katharine S. Ullman
    Cancer Res August 15 2011 71 (16) 5579-5587; DOI:10.1158/0008-5472.CAN-11-0458

    This article reports a new regulatory node in cancer in which a protein methyltransferase works in conjunction with the tumor suppressor PDCD4 to cause accelerated tumor growth.

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Cancer Research: 71 (16)
August 2011
Volume 71, Issue 16

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