Abstract
Purpose: To evaluate the clinical characteristics, natural history and outcomes in patients with ≤1cm, node-negative triple negative breast cancer (TNBC).
Materials and Methods: After excluding patients who received neoadjuvant therapy, 1,022 TNBC patients who received definitive breast surgery from 1999 to 2006 were identified from an institutional database. Among these, 194 patients had node-negative tumors ≤1cm and comprise the study population. Clinical data was abstracted and survival outcomes were analyzed.
Results: Median follow-up time was 71 months (range 2–143). Median age at diagnosis was 55.5 years (range 27–84). T stage was T1mic in 16 (8.2%), T1a in 49 (25.3%), T1b in 129 (66.5%). The majority of tumors were poorly differentiated (N= 142, 73%), lacked lymphovascular invasion (N= 170, 87.6%) and were screening-detected (69%, N=134). Breast-conserving surgery (BCS) was employed in 129 (66.5%) and mastectomy in 65 (33.5%) patients. 113 (58%) patients received adjuvant chemotherapy and 123 (63%) received whole breast radiation. Patients who received chemotherapy tended to have more adverse clinical and disease features (younger age,T1b, poor tumor grade; all p<0.05). For the entire group, 5 year local recurrence-free survival was 96% and distant metastasis-free survival was 95%, with no difference in distant relapse rates between T1mic/T1a vs. T1b patients (94.5% vs 95.5%, p=0.81 )or by receipt of chemotherapy (95.9% vs 94.5%, p=0.63).
Conclusion: Excellent 5-year locoregional and distant control rates were achievable in patients with TNBC tumors ≤ 1.0 cm, 58% of whom received chemotherapy. These results identify a group of TNBC patients with favorable outcomes following early detection and multimodality treatment.
Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-14-13.
Volume 71, Issue 24 Supplement
