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Molecular and Cellular Biology

Abstract 4189: Excess c-Myc loads tissue-specific enhancers in tumor cells

Charles Lin, Peter B. Rahl, Jakob Loven, Michael H. Kagey, Christopher B. Burge and Richard A. Young
Charles Lin
1Massachusetts Institute of Technology, Cambridge, MA
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Peter B. Rahl
2Whitehead Institute for Biomedical Research, Cambridge, MA
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Jakob Loven
2Whitehead Institute for Biomedical Research, Cambridge, MA
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Michael H. Kagey
2Whitehead Institute for Biomedical Research, Cambridge, MA
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Christopher B. Burge
1Massachusetts Institute of Technology, Cambridge, MA
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Richard A. Young
2Whitehead Institute for Biomedical Research, Cambridge, MA
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DOI: 10.1158/1538-7445.AM2012-4189 Published April 2012
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Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL

Abstract

Excessive expression of c-Myc occurs frequently in human cancers, where high levels are associated with tumor aggression and poor clinical outcome. It is well established that the c-Myc protein forms a heterodimer with Max, binds to E-box sequences typically located near the core promoter elements of target genes involved in cellular proliferation, and alters expression of these genes. It is not yet clear, however, how altering the levels of c-Myc affects its activity across the genome to enhance the oncogenic state of cells. We show here that c-Myc occupies occupies enhancer elements only in tumor cells with elevated levels of c-Myc. The enhancers that are occupied are often tumor-specific and associated with the cell-of-origin of the tumor. These and additional results provide insights into a key mechanism by which c-Myc overexpression alters the transcriptional state of cancer cells to enforce their tumorigenic state and malignant potential.

Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4189. doi:1538-7445.AM2012-4189

  • ©2012 American Association for Cancer Research
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Cancer Research: 72 (8 Supplement)
April 2012
Volume 72, Issue 8 Supplement
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Abstract 4189: Excess c-Myc loads tissue-specific enhancers in tumor cells
Charles Lin, Peter B. Rahl, Jakob Loven, Michael H. Kagey, Christopher B. Burge and Richard A. Young
Cancer Res April 15 2012 (72) (8 Supplement) 4189; DOI: 10.1158/1538-7445.AM2012-4189

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Abstract 4189: Excess c-Myc loads tissue-specific enhancers in tumor cells
Charles Lin, Peter B. Rahl, Jakob Loven, Michael H. Kagey, Christopher B. Burge and Richard A. Young
Cancer Res April 15 2012 (72) (8 Supplement) 4189; DOI: 10.1158/1538-7445.AM2012-4189
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Cancer Research Online ISSN: 1538-7445
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