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Genetic and Functional Heterogeneity

Abstract B34: The impact of chromosome 17p loss on cancer

Yu Liu, Claudio Scuoppo and Scott Lowe
Yu Liu
1Memorial Sloan-Kettering Cancer Center, New York, NY,
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Claudio Scuoppo
2Columbia University, New York, NY.
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Scott Lowe
1Memorial Sloan-Kettering Cancer Center, New York, NY,
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DOI: 10.1158/1538-7445.FBCR13-B34 Published October 2013
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Abstract

Chromosome 17p deletions are associated with short survival and poor response to current chemotherapy treatment in non-Hodgkin's lymphomas. Although the prevailing view is that these deletions serve as a “second hit” event to inactivate p53, these deletions often hundreds of other genes. Using an in vivo RNAi screening approach for tumor suppressor genes, we identified and validated two additional tumor suppressors adjacent to p53 suggesting these deletions may do more than merely inactivate p53. To test this hypothesis, we constructed a new mouse model conditionally targeting a broad region of 17p and are intending to investigate whether and how genes co-deleted with well-known tumor suppressor p53 affect lymphoma development and chemotherapy responses. These results will elucidate the aggressive nature of tumors harboring 17p deletions and create the first mouse model that can be used to test strategies to overcome its deleterious effects.

Citation Format: Yu Liu, Claudio Scuoppo, Scott Lowe. The impact of chromosome 17p loss on cancer. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr B34.

  • ©2013 American Association for Cancer Research.
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Cancer Research: 73 (19 Supplement)
October 2013
Volume 73, Issue 19 Supplement
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Abstract B34: The impact of chromosome 17p loss on cancer
Yu Liu, Claudio Scuoppo and Scott Lowe
Cancer Res October 1 2013 (73) (19 Supplement) B34; DOI: 10.1158/1538-7445.FBCR13-B34

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Abstract B34: The impact of chromosome 17p loss on cancer
Yu Liu, Claudio Scuoppo and Scott Lowe
Cancer Res October 1 2013 (73) (19 Supplement) B34; DOI: 10.1158/1538-7445.FBCR13-B34
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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