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Poster Session Abstracts

Abstract P4-12-28: HER2-related biomarkers in HER2+ breast cancer patients in Asia Pacific

S-B Kim, J Tsang, T-Y Kim, YS Yap, G Cornelio, G Gong, S Paik, S Lee, T-Y Ng, S Park, H-S Oh, T Yau, SH Lee, JH Lim, Y-J Choi, EM Lee, K-H Park, I-G Do, E-M Yeoh and J Ro
S-B Kim
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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J Tsang
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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T-Y Kim
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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YS Yap
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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G Cornelio
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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G Gong
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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S Paik
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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S Lee
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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T-Y Ng
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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S Park
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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H-S Oh
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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T Yau
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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SH Lee
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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JH Lim
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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Y-J Choi
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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EM Lee
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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K-H Park
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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I-G Do
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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E-M Yeoh
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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J Ro
Asan Medical Center, Korea; Queen Mary Hospital, Hong Kong; Seoul National University Hospital, Korea; National Cancer Center, Singapore; San Juan De Dios Hospital, Philippines; Severance Biomedical Research Institute, Yonsei University College of Medicine, Korea; Dong-A University Medical Centre, Korea; Tuen Mun Hospital, Hong Kong; Seoul St. Mary's Hospital, Korea; GangNeung Asan Hospital, Korea; Yonsei University Medical Centre, Korea; Inha University Hospital, Korea; Pusan National University Hospital, Korea; Kosin University Gospel Hospital, Korea; Korea University Anam Hospital, Korea; Samsung Medical Center, Korea; GlaxoSmithKline Pte Ltd, Singapore; National Cancer Center, Korea
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DOI: 10.1158/0008-5472.SABCS13-P4-12-28 Published December 2013
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Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX

Abstract

Recent findings suggest that HER2-related molecular markers such as PTEN deletion or downregulation, PIK3CA mutation, truncated HER2 receptor (p95HER2), and tumor HER2 mRNA levels, have the potential to predict anti-HER2 treatment response. We evaluated the distribution of these biomarkers at the time of primary diagnosis and their relationship to responsiveness to lapatinib treatment in the metastatic setting in HER2+ breast cancer patients.

We conducted an observational study of female HER2+ breast cancer patients who were initiated on lapatinib treatment following recurrence or metastases in five Asia Pacific countries. Patients were enrolled between August 2010 and December 2012. Eligible patients had a tumor biopsy specimen available from their primary breast cancer diagnosis or before they started on any anti-HER2 treatment, had not been exposed to more than two lines of anti-HER2 treatment in the metastatic setting or other experimental anti-HER2 treatment, and had no other primary tumor. Biomarkers levels at primary diagnosis were measured; PTEN levels were assessed by immunohistochemistry and PIK3CA mutations were detected by a mass spectroscopy-based approach. The primary endpoint was progression-free survival (PFS) from the initiation of first lapatinib-based regimen given in metastatic setting to disease progression from that regimen or death from any cause. PFS analysis was conducted with a data cut-off date of 31 December 2012.

A total of 162 patients were included in this study and 96% have confirmed HER2+ breast cancer primary tumor. The mean age was 52±10 years and 97% had metastases at study entry, with bone being the most common site of metastasis (48%). About a quarter had PTEN protein loss (24%), 30% had PIK3CA mutation, and 7% had both at primary diagnosis. No significant association was observed between both biomarkers or between each biomarker and estrogen receptor status or HER2 status.

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Table 1. Relationship between PTEN and PIK3CA

Patients with altered PTEN expression, or PIK3CA mutation showed comparable PFS with lapatinib-based treatment as those with normal PTEN or PIK3CA expression at analysis cut-off date (median PFS 7.5 and 8.5 months respectively vs. 8.9 and 9.0 months respectively; p = 0.502 and p = 0.268 respectively). There remained no significant difference in PFS after having adjusted for significant confounders (HR 1.2 and 1.1 respectively; 95% CI 0.7–1.9 and 0.7–1.8 respectively; p = 0.481 and p = 0.730 respectively). The distribution of p95HER2 expression and tumor HER mRNA levels and their association with PFS will be included at the time of presentation.

Our preliminary findings suggest that PTEN alteration, or PIK3CA mutation may not be predictive of clinical response to lapatinib treatment in HER2+ breast cancer patients. The final PFS results with additional markers will provide more clues regarding their relationship to treatment response.

Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-12-28.

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Cancer Research: 73 (24 Supplement)
December 2013
Volume 73, Issue 24 Supplement
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Abstract P4-12-28: HER2-related biomarkers in HER2+ breast cancer patients in Asia Pacific
S-B Kim, J Tsang, T-Y Kim, YS Yap, G Cornelio, G Gong, S Paik, S Lee, T-Y Ng, S Park, H-S Oh, T Yau, SH Lee, JH Lim, Y-J Choi, EM Lee, K-H Park, I-G Do, E-M Yeoh and J Ro
Cancer Res December 15 2013 (73) (24 Supplement) P4-12-28; DOI: 10.1158/0008-5472.SABCS13-P4-12-28

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Abstract P4-12-28: HER2-related biomarkers in HER2+ breast cancer patients in Asia Pacific
S-B Kim, J Tsang, T-Y Kim, YS Yap, G Cornelio, G Gong, S Paik, S Lee, T-Y Ng, S Park, H-S Oh, T Yau, SH Lee, JH Lim, Y-J Choi, EM Lee, K-H Park, I-G Do, E-M Yeoh and J Ro
Cancer Res December 15 2013 (73) (24 Supplement) P4-12-28; DOI: 10.1158/0008-5472.SABCS13-P4-12-28
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