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Epidemiology

Abstract 2740: Familial Hodgkin lymphoma by relationship, sex, age and histology: a joint study from five Nordic countries

Mahdi Fallah, Elham Kharazmi, Eero Pukkala, Jørgen H. Olsen, Laufey Tryggvadottir, Kristina Sundquist, Steinar Tretli and Kari Hemminki
Mahdi Fallah
German Cancer Research Center, Heidelberg, Germany;
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Elham Kharazmi
German Cancer Research Center, Heidelberg, Germany;
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Eero Pukkala
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland;
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Jørgen H. Olsen
Institute of Cancer Epidemiology, Copenhagen, Denmark;
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Laufey Tryggvadottir
Icelandic Cancer Registry, Reykjavik, Iceland;
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Kristina Sundquist
Center for Primary Health Care Research, Lund University, Malmö, Sweden;
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Steinar Tretli
Norwegian Cancer Registry, Oslo, Norway.
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Kari Hemminki
German Cancer Research Center, Heidelberg, Germany;
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DOI: 10.1158/1538-7445.AM2015-2740 Published August 2015
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Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA

Abstract

Background: We aimed to estimate lifetime (0-79 years) cumulative risk (CR) of Hodgkin lymphoma (HL) in relatives of patients with HL by relationship, sex, age and histology.

Design: A population-based cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed in 1955-2009 in Nordic countries was followed for cancer incidence. Standardized incidence ratios (SIRs) were calculated using histology-, age-, sex-, period-, and country-specific incidence rates as the reference.

Results: The overall CR of HL in first-degree relatives of a patient with Hodgkin lymphoma was 0.6%, which represents 3-fold (SIR = 3.3, 95%CI = 2.8-3.9) increase over the general population risk (men 0.3%; women 0.2%). Significantly high CR (1%) was found among sisters with early-onset HL and unlike-sex siblings with HL diagnosed at age 30-59. The familial risk in sisters (9-fold) was higher than in brothers (4.5-fold) or unlike-sex siblings (6-fold). In general, the risk in siblings (6-fold) was higher than in parents/children (2-fold). Very high risk of HL was found for few men with two HL first-degree relatives (3-8%) and for twin brothers (18%). For the first time we found high familial risk of concordant histological subtypes of HL [lymphocyte-rich (81-fold, n = 6) and nodular sclerosis (4.6-fold, n = 22)] and also discordant subtypes.

Conclusions: Lymphocytic-rich histology type of HL showed highest familial risk. The absolute risk of familial HL was generally less than 1.5%, except for men with multiple affected first-degree relatives (3-8%), twin brothers (18%), or brothers with early-onset HL (2%).

Citation Format: Mahdi Fallah, Elham Kharazmi, Eero Pukkala, Jørgen H. Olsen, Laufey Tryggvadottir, Kristina Sundquist, Steinar Tretli, Kari Hemminki. Familial Hodgkin lymphoma by relationship, sex, age and histology: a joint study from five Nordic countries. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2740. doi:10.1158/1538-7445.AM2015-2740

  • ©2015 American Association for Cancer Research.
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Cancer Research: 75 (15 Supplement)
August 2015
Volume 75, Issue 15 Supplement
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Abstract 2740: Familial Hodgkin lymphoma by relationship, sex, age and histology: a joint study from five Nordic countries
Mahdi Fallah, Elham Kharazmi, Eero Pukkala, Jørgen H. Olsen, Laufey Tryggvadottir, Kristina Sundquist, Steinar Tretli and Kari Hemminki
Cancer Res August 1 2015 (75) (15 Supplement) 2740; DOI: 10.1158/1538-7445.AM2015-2740

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Abstract 2740: Familial Hodgkin lymphoma by relationship, sex, age and histology: a joint study from five Nordic countries
Mahdi Fallah, Elham Kharazmi, Eero Pukkala, Jørgen H. Olsen, Laufey Tryggvadottir, Kristina Sundquist, Steinar Tretli and Kari Hemminki
Cancer Res August 1 2015 (75) (15 Supplement) 2740; DOI: 10.1158/1538-7445.AM2015-2740
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