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Molecular and Cellular Biology

Abstract 4874: OASIS: A centralized portal for cancer omics data analysis

Julio Fernandez-Banet, Anthony Esposito, Scott Coffin, Sabine Schefzick, Ying Ding, Keith Ching, Istvan Horvath, Peter Roberts, Paul Rejto and Zhengyan Kan
Julio Fernandez-Banet
Pfizer, Inc., San Diego, CA.
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Anthony Esposito
Pfizer, Inc., San Diego, CA.
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Scott Coffin
Pfizer, Inc., San Diego, CA.
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Sabine Schefzick
Pfizer, Inc., San Diego, CA.
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Ying Ding
Pfizer, Inc., San Diego, CA.
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Keith Ching
Pfizer, Inc., San Diego, CA.
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Istvan Horvath
Pfizer, Inc., San Diego, CA.
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Peter Roberts
Pfizer, Inc., San Diego, CA.
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Paul Rejto
Pfizer, Inc., San Diego, CA.
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Zhengyan Kan
Pfizer, Inc., San Diego, CA.
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DOI: 10.1158/1538-7445.AM2015-4874 Published August 2015
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Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA

Abstract

Advances in cancer research and sequencing technologies have contributed to the proliferation of large-scale cancer omics data sets from both public consortia and privately funded collaborations. There are increasing demands for broadly accessible tools that enable scientists to perform ad hoc analyses of cancer omics data. Here we present OASIS (http://oasis.pfizer.com), an open-access web portal that enables complex analytical queries across somatic mutations, copy number changes (CNV) and gene expression data from public domain and Pfizer funded omics studies. OASIS was designed to perform multidimensional data integration, allowing users to analyze correlations among multiple data types, as well as visualize and compare alterations across different cancers. Users can browse alteration summary reports at the gene and sample level and perform analyses using interactive visualizations. These include the Pan-Cancer Report, a unique tool that provides a high-level overview of genetic variation across multiple cancer types. Through the use of the interactive visualizations researchers can explore differentially expressed genes, identify tumor samples for over expression, investigate the correlation between CNV and expression or survey alteration patterns for a list of genes. Users can explore molecular profiles from the Cancer Cell Line Encyclopedia (CCLE) and the Catalog of Somatic Mutations in Cancer (COSMIC), to identify cell line models of interest. Researchers can also construct complex queries through a user-friendly web interface supported by the Biomart query engine. Programmatic access is also available through web services. OASIS is a powerful tool that enables cancer researchers to perform integrative analyses of large-scale cancer omics data sets, thereby facilitating key steps in oncology drug discovery ranging from target identification to model selection.

Citation Format: Julio Fernandez-Banet, Anthony Esposito, Scott Coffin, Sabine Schefzick, Ying Ding, Keith Ching, Istvan Horvath, Peter Roberts, Paul Rejto, Zhengyan Kan. OASIS: A centralized portal for cancer omics data analysis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4874. doi:10.1158/1538-7445.AM2015-4874

  • ©2015 American Association for Cancer Research.
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Cancer Research: 75 (15 Supplement)
August 2015
Volume 75, Issue 15 Supplement
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Abstract 4874: OASIS: A centralized portal for cancer omics data analysis
Julio Fernandez-Banet, Anthony Esposito, Scott Coffin, Sabine Schefzick, Ying Ding, Keith Ching, Istvan Horvath, Peter Roberts, Paul Rejto and Zhengyan Kan
Cancer Res August 1 2015 (75) (15 Supplement) 4874; DOI: 10.1158/1538-7445.AM2015-4874

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Abstract 4874: OASIS: A centralized portal for cancer omics data analysis
Julio Fernandez-Banet, Anthony Esposito, Scott Coffin, Sabine Schefzick, Ying Ding, Keith Ching, Istvan Horvath, Peter Roberts, Paul Rejto and Zhengyan Kan
Cancer Res August 1 2015 (75) (15 Supplement) 4874; DOI: 10.1158/1538-7445.AM2015-4874
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Cancer Research Online ISSN: 1538-7445
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