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Autophagy is a major pathway for degradation of dysfunctional organelles and misfolded or aggregated proteins, and its defects trigger oxidative stresses to induce cell death, promote liver fibrosis and HCC, and reduce lifespans. Natural component spermidine enhances autophagy flux by depleting cytosolic histone deacetylase 4 and reducing its interaction with autophagy activator microtubule-associated protein MAP1S to dramatically expand lifespans and to prevent liver fibrosis and hepatocellular carcinomas. For details, see article by Yue and colleagues on page 2938.

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Cancer Research: 77 (11)
June 2017
Volume 77, Issue 11
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Issue Highlights

  • Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy
  • Targeting Autocrine CCL5–CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity
  • Expression of Neuroendocrine Factor VGF in Lung Cancer Cells Confers Resistance to EGFR Kinase Inhibitors and Triggers Epithelial-to-Mesenchymal Transition
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Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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