Cancer Res March 1 2017 77 (5) 1049-1050;
A systems biology gene regulatory network approach reveals a drug-evading phenotype in small cell lung cancer that may ultimately inform our understanding of cancer heterogeneity and its impact on relapse.
This study establishes the negative impact of Tim-3 expression on intratumoral PD1+ CD8+ T cells on the outcome of kidney cancer patients, using a novel automated immunofluorescence technology to identify this T-cell subset.
This seminal study reveals a critical role in lymph node metastasis for innate lymphoid cells, a peculiar class of lymphocytes lacking B- or T-cell receptors whose accumulation in the tumor microenvironment promotes a chemokine milieu that drives invasion of cancer cells into lymphatics.
This study identifies a chemokine-directed neutrophil pathway through which tumors of B-cell origin can increase their aggressiveness.
These findings from this study help guide the clinical development of GITR antibodies for cancer immunotherapy by identifying important roles for Treg depletion and costimulatory signaling in this therapeutic approach to engage antitumor T-cell attack.
In the peripheral blood of breast cancer patients at diagnosis, naive T cells may display altered cytokine signals that portend immune dysfunction and future relapse.
IgE antibodies, which mediate anti-parasite responses, have been little explored in cancer therapy, and this seminal report shows how they can be used to extend monoclonal antibody technology confined mainly to IgG at present to powerfully reprogram and recruit macrophages to eradicate cancer cells.
This mechanistic study suggests a novel prognostic marker and therapeutic target for improving the personalized management cervical cancer.
These findings show how a proto-oncogenic long noncoding RNA acts in liver cancer to modulate alternative RNA splicing and malignant progression through upregulation of the splice factor SRSF1.
These findings identify the splicing factor SRSF2 as a determinant of aberrant RNA splicing in cancer, with possible clinical implications as a candidate prognostic factor in hepatoma patients.
A habitual proinflammatory diet during adolescent and early adult years may increase the risk of premenopausal breast cancer.
These findings correlate cetuximab resistance in head and neck cancer with a frequent EGFR genetic polymorphism, potentially illuminating how to overcome this resistance through other methods to target EGFR.
While many EGFR kinase inhibitors exist, the novel compounds described here exhibit improved mutant selectivity and superior potency against brain mestastases in multiple preclinical models of lung cancer.
These provocative findings concerning the antiangiogenic drug sunitinib used to treat kidney cancer reveal how it can also increase risks of nodal invasion and metastasis, suggesting ideas about how treatment failures may occur.
These findings define a positive feedback loop that drives gastric carcinogenesis, as influenced by H. pylori infections that involve stimulation of the procancerous inflammatory cytokine IL6.