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Microenvironment and Immunology

Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire

David Y. Oh, Jason Cham, Li Zhang, Grant Fong, Serena S. Kwek, Mark Klinger, Malek Faham and Lawrence Fong
David Y. Oh
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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Jason Cham
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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Li Zhang
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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Grant Fong
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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Serena S. Kwek
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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Mark Klinger
Adaptive Biotechnologies, South San Francisco, California.
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Malek Faham
Adaptive Biotechnologies, South San Francisco, California.
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Lawrence Fong
Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
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  • For correspondence: lfong@medicine.ucsf.edu
DOI: 10.1158/0008-5472.CAN-16-2324 Published March 2017
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Article Information

Volume 77, Issue 6, pp. 1322-1330

DOI 
https://doi.org/10.1158/0008-5472.CAN-16-2324
PubMed 
28031229

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received August 25, 2016
  • Revision received November 10, 2016
  • Accepted December 5, 2016
  • Published first December 28, 2016.

Article Versions

  • Previous version (December 28, 2016 - 06:04).
  • Previous version (March 2, 2017 - 07:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2016 American Association for Cancer Research.

Author Information

  1. David Y. Oh1,
  2. Jason Cham1,
  3. Li Zhang1,
  4. Grant Fong1,
  5. Serena S. Kwek1,
  6. Mark Klinger2,
  7. Malek Faham2, and
  8. Lawrence Fong1,*
  1. 1Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.
  2. 2Adaptive Biotechnologies, South San Francisco, California.
  1. ↵*Corresponding Author:
    Lawrence Fong, University of California San Francisco, 513 Parnassus Avenue, Room HSE301A, Box 0519, San Francisco, CA 94143-0519. Phone: 415-514-3160; Fax: 415-476-0459; E-mail: lfong{at}medicine.ucsf.edu
  1. D.Y. Oh and J. Cham contributed equally to this article.

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Cancer Research: 77 (6)
March 2017
Volume 77, Issue 6
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Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
David Y. Oh, Jason Cham, Li Zhang, Grant Fong, Serena S. Kwek, Mark Klinger, Malek Faham and Lawrence Fong
Cancer Res March 15 2017 (77) (6) 1322-1330; DOI: 10.1158/0008-5472.CAN-16-2324

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Immune Toxicities Elicted by CTLA-4 Blockade in Cancer Patients Are Associated with Early Diversification of the T-cell Repertoire
David Y. Oh, Jason Cham, Li Zhang, Grant Fong, Serena S. Kwek, Mark Klinger, Malek Faham and Lawrence Fong
Cancer Res March 15 2017 (77) (6) 1322-1330; DOI: 10.1158/0008-5472.CAN-16-2324
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Cancer Research Online ISSN: 1538-7445
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