Cancer Res March 15 2017 77 (6) 1243-1244;
This study uses genomic data to deepen our understanding of the interplay between immune cells within the tumor microenvironment, with a specific focus on myeloid cell-driven modulation of CD8+ T cells and their role in patient survival.
These findings present a mechanistic rationale to relieve the severe bone pain experienced by multiple myeloma patients, with immediate clinical implications for treatment.
Combination therapy using an agonistic antibody can significantly enhance CAR T-cell response, concomitant with reduced numbers of immunosuppressive cell types, suggesting a potentially powerful approach to treat solid cancers with adoptive immunotherapy.
Immumomodulatory aptamers can be targeted directly to tumors by binding to radiation-induced tumor stress products, increasing therapeutic index.
Autoimmune side effects often seen with immune checkpoint inhibitors are associated with rapid increases in the diversity of the circulating T-cell pool.
These findings provide a mechanism-based targeting rationale to inhibit bone metastasis in advanced prostate cancer, a common feature of late stage disease.
Changing ROS levels affects levels of the NF-κB transcription factor RelB, thereby affecting the capability of i.v. ascorbic acid to differentially and usefully influence the radiosensitivity of normal and cancer tissues.
Allelic loss of Rasa1, a gene controlling the Ras pathway, is a frequent occurrence in triple-negative breast cancer.
This study uncovers a positive feedback loop in the metabolism of cancer-associated fibroblasts and epithelial ovarian cancer cells critical for their metastatic progression.
These findings highlight the mechanism behind the increased risk of distant metastatic recurrence in overweight and obese breast cancer patients.
Increased production of the chronic inflammation factor cortisol contributes to the predominance of liver cancer development in males versus females.
Sustained B-cell activation is a dynamic process during lymphomagenesis that may be indicative of occult disease or disease progression in monitoring patients with indolent lymphomas.
These findings suggest a mechanism-based approach to eradicate the most recalcitrant cells in one common type of pediatric brain cancer.
These findings reveal a role for endolysosomal twopore channels in leading edge formation in cancer cells, suggesting their novelty as targets for treatment of invasive tumors.
An antibody that can directly assess receptor signaling distinguishes constitutive and ligand-independent activity of the oncogenic Notch pathway in enabling the malignant growth of basal breast cancers.
These findings suggest that targeting metabolic abnormalities in leukemia cells located in the bone marrow is potentially promising and innovative therapeutic approach.
These findings suggest that cotherapy with a fibrinolytic enzyme could be used to improve diffusion, intratumoral distribution, and overall effectiveness of anticancer nanomedicine.
These findings reveal the utility of a noninvasive PET imaging method to monitor pharmacodynamic responses to cancer drugs that target glutamine breakdown.
Patients who are inherently less efficient at DNA double-strand break repair may be at risk for severe late radiation toxicity.
These results illuminate how mutations in the tumor suppressor gene TSC2 lead to formation of a variety of organ lesions.