Cancer Res April 1 2017 77 (7) 1507-1508;
Combined in vivo murine experiments and mathematical modeling provide a mechanistic understanding of the therapeutic potential of bacterial infections against solid tumors.
A systems approach illuminates the enhanced metabolic plasticity of cancer cells, providing a platform for designing combination cancer therapies to effectively and selectively target cancer cell metabolism.
Unbiased interrogation of complex cellular signal transduction circuits in response to MEK inhibition identifies novel factors that represent potential novel therapeutic targets.
These findings define a prognostic biomarker in lung adenocarcinoma and establish a functional rationale for its future assessment as a therapeutic target.
These results illustrate how extrinsic pathways of immunosuppression governed by melanoma cells dominate the tumor microenvironment, highlighting the need to target extrinsic as well as intrinsic mechanisms of drug resistance.
These findings provide mechanistic insight into how positive stress (termed eustress) restrains malignant development and progression, opening up new perspectives on cancer prevention and treatment.
Despite their high genetic heterogeneity, human melanoma cells show conserved and predominantly homogenous immune gene regulation in response to CTL-based immunotherapy.
Interactions between HIPPO, YAP/TAZ, and the PI3K/AKT pathway may be therapeutically targetable, providing new approaches to treating endometrial cancers and other cancers where the HIPPO pathway is a core oncogenic driver.
These findings define the effects of mutations in a succinate dehydrogenase complex component implicated in the pathogenesis of ∼5% of metastatic melanomas.
Bioinformatics identify CYP27A1, a key cellular cholesterol sensor, as a critical downregulated gene in prostate cells, contributing to their pathogenesis.
This epidemiological study finds that tobacco smoke exposure is associated with increased frequency of somatic gene deletions in childhood ALL, linking parental smoking with the most common type of childhood cancer.
This study establishes a targeted, noninvasive imaging approach for the detection of ovarian cancer tumors with high sensitivity and specificity by exploiting the ability of the prolactin receptor to endocytose specific imaging conjugates.
These findings suggest that antioxidant treatment of FLT3-mutant acute myeloid leukemias can hinder the acquisition of genomic instability and thereby slow leukemic progression.
Low-grade gliomas harbor a targetable metabolic deficiency that compromises a critical mechanism of DNA repair, with implications for therapeutic management of these tumors.
These findings establish a novel potent tumor suppressor in lung adenocarcinoma, shedding light on how chromatin dysregulation promotes lung cancer progression.
Colorectal cancer metastasis is linked to somatic mutations in Eph receptor tyrosine kinases, with implications to improve patient stratification and choice of therapy in primary colon cancer cases.
Use of an integrated approach to study weaknesses in glioma-initiating cells identifies bioelectric function as a possible Achilles' heel in glioblastoma, with implications for improving its therapeutic management.
These findings offer a mechanistic rationale to inhibit MOF acetyltransferase activity as a therapeutic strategy to treat aggressive MLL-rearranged leukemias.
Cancer stem-like cells in heterogeneous colon tumors can maintain their regulation of MAPK signaling pathways whether or not KRAS mutations are present.