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Stromal-derived exosomes promote the evolution of hormonal therapy–resistant cancer stem-like cells (CSC). In tumor-stroma niches of breast cancer, IL6 from cancer-associated fibroblasts (CAF) increases the biogenesis of miRNAs high exosomes, facilitating the transfer of genetic material from the stroma to tumor cells and the conversion of non-CSCs into CSCs. Using immunohistochemical analysis for pan-cytokeratin, we detected the presence of single breast cancer cell clusters surrounded by noncancer cells in human breast cancer xenografts from the coinjection of IL6 high CAFs with ER+ breast cancer cells. For details, see article by Sansone and colleagues on page 1927.

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Cancer Research: 77 (8)
April 2017
Volume 77, Issue 8
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Issue Highlights

  • Evolution of Cancer Stem-like Cells in Endocrine-Resistant Metastatic Breast Cancers Is Mediated by Stromal Microvesicles
  • Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model
  • Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy
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Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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