Article Figures & Data
Files in this Data Supplement:
- Supplementary Methods - Description in full of Supplementary Methods
- Supplementary figures and legends - Supplementary Figures 1-7. Supplementary Fig. S1: Expression of ECM related genes across LUAD subtypes, related to Fig.1. Supplementary Fig. S2: Expression of HMMR, regulation by miR-34A, and correlation with poor prognosis, related to Fig. 2 and 3. Supplementary Fig. S3: Effect of HMMR/Hmmr on lung tumorigenesis, related to Fig. 3. Supplementary Fig. S4: Effect of HMMR on metastasis, related to Fig. 4. Supplementary Fig. S5: Effect of HMMR on seeding and outgrowth in vivo, related to Fig. 5. Supplementary Fig. S6: HA in the lung and brain TME, related to Fig. 6. Supplementary Fig. S7: Mechanism of HMMR mediated outgrowth, related to Fig. 7. Supplementary Fig. S8: un-cropped versions of all western blots.
- Supplementary Table S1 - Extended list of genes (overall FDR p-value<0.05) from ToppGene network analysis from Figure 1. Score=-log p-value; +/- based on fold change.
- Supplementary Table S2 - Predicted HMMR targeting miRNAs. Results are from the combined Cbio and MIRANDA correlation analysis. Provided as Excel file.
- Supplementary Table S3 - Correlation between MIR34A methylation with mir-34a or HMMR expression in concordant LUAD samples from TCGA.