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Review

A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis

Hila Doron, Tobias Pukrop and Neta Erez
Hila Doron
Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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Tobias Pukrop
Department of Internal Medicine III, Hematology and Medical Oncology, University Hospital Regensburg, Regensburg, Germany.
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Neta Erez
Department of Pathology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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  • For correspondence: netaerez@tauex.tau.ac.il
DOI: 10.1158/0008-5472.CAN-18-1805 Published February 2019
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Abstract

Brain metastases are more common than primary CNS tumors and confer grave prognosis on patients, as existing treatments have very limited efficacy. The tumor microenvironment has a central role in facilitating tumorigenesis and metastasis. In recent years, there has been much progress in our understanding of the functional role of the brain metastatic microenvironment. In this review, we discuss the latest advances in brain metastasis research, with special emphasis on the role of the brain microenvironment and neuroinflammation, integrating insights from comparable findings in neuropathologies and primary CNS tumors. In addition, we overview findings on the formation of a hospitable metastatic niche and point out the major gaps in knowledge toward developing new therapeutics that will cotarget the stromal compartment in an effort to improve the treatment and prevention of brain metastases.

  • Received June 12, 2018.
  • Revision received September 22, 2018.
  • Accepted November 16, 2018.
  • Published first January 24, 2019.
  • ©2019 American Association for Cancer Research.
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Cancer Research: 79 (3)
February 2019
Volume 79, Issue 3
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A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Hila Doron, Tobias Pukrop and Neta Erez
Cancer Res February 1 2019 (79) (3) 423-436; DOI: 10.1158/0008-5472.CAN-18-1805

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A Blazing Landscape: Neuroinflammation Shapes Brain Metastasis
Hila Doron, Tobias Pukrop and Neta Erez
Cancer Res February 1 2019 (79) (3) 423-436; DOI: 10.1158/0008-5472.CAN-18-1805
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  • Article
    • Abstract
    • Introduction
    • The Brain Microenvironment
    • Neuroinflammation in Brain Metastasis
    • The BBB and Neuroinflammation in Brain Metastasis
    • The Brain Microenvironment and Targeted Therapeutics
    • Conclusions and Future Perspectives
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
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Cancer Research Online ISSN: 1538-7445
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