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Genome and Epigenome

Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus

Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr, Simon G. Coetzee, Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D. Pharoah, Simon A. Gayther and Alvaro N.A. Monteiro; on behalf of the Ovarian Cancer Association Consortium
Melissa A. Buckley
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.University of South Florida Cancer Biology PhD Program, Tampa, Florida.
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Nicholas T. Woods
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.Department of Oncological Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida.
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Jonathan P. Tyrer
The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
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Gustavo Mendoza-Fandiño
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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Kate Lawrenson
Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
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  • ORCID record for Kate Lawrenson
Dennis J. Hazelett
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
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  • ORCID record for Dennis J. Hazelett
Hamed S. Najafabadi
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
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  • ORCID record for Hamed S. Najafabadi
Anxhela Gjyshi
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.University of South Florida Cancer Biology PhD Program, Tampa, Florida.
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Renato S. Carvalho
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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Paulo C. Lyra
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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Simon G. Coetzee
Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
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  • ORCID record for Simon G. Coetzee
Howard C. Shen
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
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Ally W. Yang
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
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Madalene A. Earp
Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota.
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Sean J. Yoder
Molecular Genomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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  • ORCID record for Sean J. Yoder
Harvey Risch
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
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Georgia Chenevix-Trench
QIMR Berghofer Medical Research Institute, Brisbane, Australia.
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Susan J. Ramus
School of Women's and Children's Health, University of New South Wales, Sydney, Australia.The Kinghorn Cancer Center, Garvan Institute of Medical Research, Darlinghurst, Australia.
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Catherine M. Phelan
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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Gerhard A. Coetzee
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.Van Andel Institute, Grand Rapids, Michigan.
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Houtan Noushmehr
Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan.
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Timothy R. Hughes
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.Canadian Institutes for Advanced Research, Toronto, Ontario, Canada.
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Thomas A. Sellers
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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Ellen L. Goode
Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota.
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Paul D. Pharoah
The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
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Simon A. Gayther
Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
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Alvaro N.A. Monteiro
Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
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  • For correspondence: alvaro.monteiro@moffitt.org
DOI: 10.1158/0008-5472.CAN-17-3864 Published February 2019
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Article Information

Volume 79, Issue 3, pp. 467-481

DOI 
https://doi.org/10.1158/0008-5472.CAN-17-3864
PubMed 
30487138

Published By 
American Association for Cancer Research
Print ISSN 
0008-5472
Online ISSN 
1538-7445
History 
  • Received December 15, 2017
  • Revision received April 11, 2018
  • Accepted November 16, 2018
  • Published first February 1, 2019.

Article Versions

  • Previous version (November 28, 2018 - 07:09).
  • Previous version (January 24, 2019 - 06:23).
  • You are viewing the most recent version of this article.
Copyright & Usage 
©2018 American Association for Cancer Research.

Author Information

  1. Melissa A. Buckley1,2,
  2. Nicholas T. Woods1,3,
  3. Jonathan P. Tyrer4,
  4. Gustavo Mendoza-Fandiño1,
  5. Kate Lawrenson5,
  6. Dennis J. Hazelett6,7,8,
  7. Hamed S. Najafabadi9,10,
  8. Anxhela Gjyshi1,2,
  9. Renato S. Carvalho1,
  10. Paulo C. Lyra Jr1,
  11. Simon G. Coetzee8,
  12. Howard C. Shen6,
  13. Ally W. Yang9,
  14. Madalene A. Earp11,
  15. Sean J. Yoder12,
  16. Harvey Risch13,
  17. Georgia Chenevix-Trench14,
  18. Susan J. Ramus15,16,
  19. Catherine M. Phelan1,†,
  20. Gerhard A. Coetzee6,17,
  21. Houtan Noushmehr18,
  22. Timothy R. Hughes9,19,20,
  23. Thomas A. Sellers1,
  24. Ellen L. Goode11,
  25. Paul D. Pharoah4,
  26. Simon A. Gayther5,21, and
  27. Alvaro N.A. Monteiro1,*; on behalf of the Ovarian Cancer Association Consortium
  1. 1Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  2. 2University of South Florida Cancer Biology PhD Program, Tampa, Florida.
  3. 3Department of Oncological Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida.
  4. 4The Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
  5. 5Women's Cancer Program at the Samuel Oschin Comprehensive, Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  6. 6Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
  7. 7Department of Urology, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
  8. 8Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  9. 9Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
  10. 10Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
  11. 11Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota.
  12. 12Molecular Genomics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
  13. 13Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
  14. 14QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  15. 15School of Women's and Children's Health, University of New South Wales, Sydney, Australia.
  16. 16The Kinghorn Cancer Center, Garvan Institute of Medical Research, Darlinghurst, Australia.
  17. 17Van Andel Institute, Grand Rapids, Michigan.
  18. 18Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan.
  19. 19Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
  20. 20Canadian Institutes for Advanced Research, Toronto, Ontario, Canada.
  21. 21Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
  1. ↵*Corresponding Author:
    Alvaro N.A. Monteiro, H. Lee Moffitt Cancer Center & Research Institute, 12902 Magnolia Drive, Tampa, FL 33612. Phone: 813-745-6321; Fax: 813-903-6847; E-mail: alvaro.monteiro{at}moffitt.org
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Cancer Research: 79 (3)
February 2019
Volume 79, Issue 3
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Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus
Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr, Simon G. Coetzee, Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D. Pharoah, Simon A. Gayther and Alvaro N.A. Monteiro on behalf of the Ovarian Cancer Association Consortium
Cancer Res February 1 2019 (79) (3) 467-481; DOI: 10.1158/0008-5472.CAN-17-3864

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Functional Analysis and Fine Mapping of the 9p22.2 Ovarian Cancer Susceptibility Locus
Melissa A. Buckley, Nicholas T. Woods, Jonathan P. Tyrer, Gustavo Mendoza-Fandiño, Kate Lawrenson, Dennis J. Hazelett, Hamed S. Najafabadi, Anxhela Gjyshi, Renato S. Carvalho, Paulo C. Lyra Jr, Simon G. Coetzee, Howard C. Shen, Ally W. Yang, Madalene A. Earp, Sean J. Yoder, Harvey Risch, Georgia Chenevix-Trench, Susan J. Ramus, Catherine M. Phelan, Gerhard A. Coetzee, Houtan Noushmehr, Timothy R. Hughes, Thomas A. Sellers, Ellen L. Goode, Paul D. Pharoah, Simon A. Gayther and Alvaro N.A. Monteiro on behalf of the Ovarian Cancer Association Consortium
Cancer Res February 1 2019 (79) (3) 467-481; DOI: 10.1158/0008-5472.CAN-17-3864
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Cancer Research Online ISSN: 1538-7445
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