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Molecular and Cellular Pathobiology

VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor

Hong Gao, Yi Le, Xiaoming Wu, Leslie E. Silberstein, Roger W. Giese and Zhenglun Zhu
Hong Gao
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Yi Le
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Xiaoming Wu
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Leslie E. Silberstein
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Roger W. Giese
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Zhenglun Zhu
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DOI: 10.1158/0008-5472.CAN-09-2668
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Abstract

Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. Aberrant activations of LEF1/TCF-mediated transcription have been implicated in a variety of malignancies. Our recent studies on vertebrate embryogenesis identified Xom, a homeobox protein of the bone morphogenetic protein 4 pathway, as a novel LEF/TCF-associated transcriptional modulator. Here, we report that VentX, a human Xom homologue, is a LEF/TCF-associated inhibitor of canonical Wnt/β-catenin signaling and a negative regulator of cell proliferation. VentX is predominately expressed in hematopoietic cells, and its expression is significantly downregulated in chronic lymphocytic leukemia. Altered expression of VentX is associated with corresponding changes of LEF/TCF target oncogenes such as cyclin D1, suggesting a potential role of VentX in the clinical behavior of hematopoietic malignancies. Cancer Res; 70(1); 202–11

Keywords
  • Tumor suppressor
  • Wnt
  • BMP
  • LEF/TCF
  • Leukemia
  • VentX

Footnotes

  • Received July 22, 2009.
  • Revision received September 21, 2009.
  • Accepted October 10, 2009.
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Published OnlineFirst December 22, 2009
doi: 10.1158/0008-5472.CAN-09-2668

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VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor
Hong Gao, Yi Le, Xiaoming Wu, Leslie E. Silberstein, Roger W. Giese and Zhenglun Zhu
Cancer Res December 22 2009 DOI: 10.1158/0008-5472.CAN-09-2668

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VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor
Hong Gao, Yi Le, Xiaoming Wu, Leslie E. Silberstein, Roger W. Giese and Zhenglun Zhu
Cancer Res December 22 2009 DOI: 10.1158/0008-5472.CAN-09-2668
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Cancer Research Online ISSN: 1538-7445
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