Skip to main content
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in

Search

  • Advanced search
Cancer Research
Cancer Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Focus on Computer Resources
    • 75th Anniversary
    • Meeting Abstracts
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citations
    • Author/Keyword
  • News
    • Cancer Discovery News
Research Article

19p13.1 is a triple negative-specific breast cancer susceptibility locus

Kristen N. Stevens, Zachary Fredericksen, Celine M Vachon, Xianshu Wang, Sara Margolin, Annika Lindblom, Heli Nevanlinna, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Jenny Chang-Claude, Alina Vrieling, Dieter Flesch-Janys, Hans-Peter Sinn, Shan Wang-Gohrke, Stefan Nickels, Hiltrud Brauch, Yon-Dschun Ko, Hans-Peter Fischer, The GENICA Network, Rita K. Schmutzler, Alfons Meindl, Claus R. Bartram, Sarah Schott, Christoph Engel, Andrew K. Godwin, JoEllen Weaver, Harsh B Pathak, Priyanka Sharma, Hermann Brenner, Heiko Muller, Volker Arndt, Christa Stegmaier, Penelope Miron, Drakoulis Yannoukakos, Alexandra Stavropoulou, George Fountzilas, Helen J Gogas, Ruth Swann, Miriam Dwek, Katherine Anne Perkins, Roger L. Milne, Javier Benítez, M. Pilar Zamora, José Ignacio Arias Pérez, Stig E. Bojesen, Sune F. Nielsen, Borge G. Nordestgaard, Henrik Flyger, Pascal Guénel, Thérèse Truong, Florence Menegaux, Emilie Cordina-Duverger, Barbara Burwinkel, Frederick Marmé, Andreas Schneeweiss, Christof Sohn, Elinor Sawyer, Ian Tomlinson, Michael J Kerin, Julian Peto, Nichola Johnson, Olivia Fletcher, Isabel dos Santos Silva, Peter A Fasching, Matthias W Beckmann, Arndt Hartmann, Arif B. Ekici, Artitaya Lophatananon, Kenneth Muir, Puttisak Puttawibul, Surapon Wiangnon, Marjanka K. Schmidt, Annegien Broeks, Linde M Braaf, Efraim H. Rosenberg, John L. Hopper, Carmel Apicella, Daniel J. Park, Melissa C. Southey, Anthony J Swerdlow, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Chen-Yang Shen, Jyh-Cherng Yu, Huan-Ming Hsu, Chia-Ni Hsiung, Ute Hamann, Thomas Dünnebier, Thomas Rüdiger, Hans Ulrich Ulmer, Paul D. P. Pharoah, Alison M Dunning, Manjeet K. Humphreys, Qin Wang, Angela Cox, Simon S. Cross, Malcolm W.R. Reed, Per Hall, Kamila Czene, Christine B Ambrosone, Foluso Ademuyiwa, Helena Hwang, Diana M. Eccles, Montserrat Garcia-Closas, Jonine D. Figueroa, Mark E. Sherman, Jolanta Lissowska, Peter Devilee, Caroline Seynaeve, R.A.E.M Tollenaar, Maartje J Hooning, Irene L. Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Esther M. John, Alexander Miron, Grethe Grenaker Alnaes, Vessela Kristensen, Anne-Lise Borresen-Dale, Graham G. Giles, Laura Baglietto, Catriona A McLean, Gianluca Severi, Matthew L. Kosel, V. Shane Pankratz, Susan Slager, Janet E. Olson, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Diether Lambrechts, Sigrid Hatse, Anne-Sophie Dieudonne, Marie-Rose Christiaens, Georgia Chenevix-Trench, kConFab Investigators, AOCS Group, Jonathan Beesley, Xiaoqing Chen, Arto Mannermaa, Veli-Matti Kosma, Jaana M Hartikainen, Ylermi Soini, Douglas F. Easton and Fergus J. Couch
Kristen N. Stevens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zachary Fredericksen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Celine M Vachon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xianshu Wang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sara Margolin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annika Lindblom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heli Nevanlinna
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dario Greco
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristiina Aittomäki
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carl Blomqvist
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jenny Chang-Claude
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alina Vrieling
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dieter Flesch-Janys
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hans-Peter Sinn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shan Wang-Gohrke
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefan Nickels
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hiltrud Brauch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yon-Dschun Ko
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hans-Peter Fischer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
The GENICA Network
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rita K. Schmutzler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alfons Meindl
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Claus R. Bartram
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah Schott
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christoph Engel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew K. Godwin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
JoEllen Weaver
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Harsh B Pathak
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Priyanka Sharma
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hermann Brenner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Heiko Muller
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Volker Arndt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christa Stegmaier
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Penelope Miron
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Drakoulis Yannoukakos
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandra Stavropoulou
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
George Fountzilas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helen J Gogas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ruth Swann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miriam Dwek
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katherine Anne Perkins
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roger L. Milne
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Javier Benítez
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M. Pilar Zamora
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
José Ignacio Arias Pérez
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stig E. Bojesen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sune F. Nielsen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Borge G. Nordestgaard
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Henrik Flyger
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pascal Guénel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thérèse Truong
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Florence Menegaux
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Emilie Cordina-Duverger
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Barbara Burwinkel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frederick Marmé
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andreas Schneeweiss
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christof Sohn
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elinor Sawyer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ian Tomlinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael J Kerin
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julian Peto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nichola Johnson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Olivia Fletcher
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabel dos Santos Silva
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter A Fasching
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthias W Beckmann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arndt Hartmann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arif B. Ekici
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Artitaya Lophatananon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kenneth Muir
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Puttisak Puttawibul
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Surapon Wiangnon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marjanka K. Schmidt
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Annegien Broeks
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linde M Braaf
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Efraim H. Rosenberg
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John L. Hopper
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmel Apicella
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel J. Park
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Melissa C. Southey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anthony J Swerdlow
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alan Ashworth
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nick Orr
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Minouk J Schoemaker
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hoda Anton-Culver
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Argyrios Ziogas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Leslie Bernstein
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christina Clarke Dur
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chen-Yang Shen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jyh-Cherng Yu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huan-Ming Hsu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Chia-Ni Hsiung
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ute Hamann
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Dünnebier
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Rüdiger
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hans Ulrich Ulmer
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul D. P. Pharoah
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alison M Dunning
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manjeet K. Humphreys
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qin Wang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Angela Cox
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simon S. Cross
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Malcolm W.R. Reed
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Per Hall
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kamila Czene
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine B Ambrosone
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Foluso Ademuyiwa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Helena Hwang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diana M. Eccles
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Montserrat Garcia-Closas
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonine D. Figueroa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark E. Sherman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jolanta Lissowska
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Devilee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Caroline Seynaeve
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R.A.E.M Tollenaar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maartje J Hooning
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Irene L. Andrulis
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia A Knight
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gord Glendon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Marie Mulligan
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Winqvist
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katri Pylkäs
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arja Jukkola-Vuorinen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mervi Grip
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Esther M. John
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexander Miron
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grethe Grenaker Alnaes
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vessela Kristensen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne-Lise Borresen-Dale
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Graham G. Giles
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura Baglietto
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Catriona A McLean
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gianluca Severi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew L. Kosel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
V. Shane Pankratz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Susan Slager
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Janet E. Olson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paolo Radice
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paolo Peterlongo
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Siranoush Manoukian
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Monica Barile
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Diether Lambrechts
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sigrid Hatse
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne-Sophie Dieudonne
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marie-Rose Christiaens
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georgia Chenevix-Trench
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
kConFab Investigators
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AOCS Group
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan Beesley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaoqing Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arto Mannermaa
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Veli-Matti Kosma
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jaana M Hartikainen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ylermi Soini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Douglas F. Easton
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Fergus J. Couch
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/0008-5472.CAN-11-3364
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.

  • Received October 10, 2011.
  • Revision received December 30, 2011.
  • Accepted January 19, 2012.
  • Copyright © 2012, American Association for Cancer Research.
Next
Back to top

Published OnlineFirst February 13, 2012
doi: 10.1158/0008-5472.CAN-11-3364

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
19p13.1 is a triple negative-specific breast cancer susceptibility locus
(Your Name) has forwarded a page to you from Cancer Research
(Your Name) thought you would be interested in this article in Cancer Research.
Citation Tools
19p13.1 is a triple negative-specific breast cancer susceptibility locus
Kristen N. Stevens, Zachary Fredericksen, Celine M Vachon, Xianshu Wang, Sara Margolin, Annika Lindblom, Heli Nevanlinna, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Jenny Chang-Claude, Alina Vrieling, Dieter Flesch-Janys, Hans-Peter Sinn, Shan Wang-Gohrke, Stefan Nickels, Hiltrud Brauch, Yon-Dschun Ko, Hans-Peter Fischer, The GENICA Network, Rita K. Schmutzler, Alfons Meindl, Claus R. Bartram, Sarah Schott, Christoph Engel, Andrew K. Godwin, JoEllen Weaver, Harsh B Pathak, Priyanka Sharma, Hermann Brenner, Heiko Muller, Volker Arndt, Christa Stegmaier, Penelope Miron, Drakoulis Yannoukakos, Alexandra Stavropoulou, George Fountzilas, Helen J Gogas, Ruth Swann, Miriam Dwek, Katherine Anne Perkins, Roger L. Milne, Javier Benítez, M. Pilar Zamora, José Ignacio Arias Pérez, Stig E. Bojesen, Sune F. Nielsen, Borge G. Nordestgaard, Henrik Flyger, Pascal Guénel, Thérèse Truong, Florence Menegaux, Emilie Cordina-Duverger, Barbara Burwinkel, Frederick Marmé, Andreas Schneeweiss, Christof Sohn, Elinor Sawyer, Ian Tomlinson, Michael J Kerin, Julian Peto, Nichola Johnson, Olivia Fletcher, Isabel dos Santos Silva, Peter A Fasching, Matthias W Beckmann, Arndt Hartmann, Arif B. Ekici, Artitaya Lophatananon, Kenneth Muir, Puttisak Puttawibul, Surapon Wiangnon, Marjanka K. Schmidt, Annegien Broeks, Linde M Braaf, Efraim H. Rosenberg, John L. Hopper, Carmel Apicella, Daniel J. Park, Melissa C. Southey, Anthony J Swerdlow, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Chen-Yang Shen, Jyh-Cherng Yu, Huan-Ming Hsu, Chia-Ni Hsiung, Ute Hamann, Thomas Dünnebier, Thomas Rüdiger, Hans Ulrich Ulmer, Paul D. P. Pharoah, Alison M Dunning, Manjeet K. Humphreys, Qin Wang, Angela Cox, Simon S. Cross, Malcolm W.R. Reed, Per Hall, Kamila Czene, Christine B Ambrosone, Foluso Ademuyiwa, Helena Hwang, Diana M. Eccles, Montserrat Garcia-Closas, Jonine D. Figueroa, Mark E. Sherman, Jolanta Lissowska, Peter Devilee, Caroline Seynaeve, R.A.E.M Tollenaar, Maartje J Hooning, Irene L. Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Esther M. John, Alexander Miron, Grethe Grenaker Alnaes, Vessela Kristensen, Anne-Lise Borresen-Dale, Graham G. Giles, Laura Baglietto, Catriona A McLean, Gianluca Severi, Matthew L. Kosel, V. Shane Pankratz, Susan Slager, Janet E. Olson, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Diether Lambrechts, Sigrid Hatse, Anne-Sophie Dieudonne, Marie-Rose Christiaens, Georgia Chenevix-Trench, kConFab Investigators, AOCS Group, Jonathan Beesley, Xiaoqing Chen, Arto Mannermaa, Veli-Matti Kosma, Jaana M Hartikainen, Ylermi Soini, Douglas F. Easton and Fergus J. Couch
Cancer Res February 13 2012 DOI: 10.1158/0008-5472.CAN-11-3364

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
19p13.1 is a triple negative-specific breast cancer susceptibility locus
Kristen N. Stevens, Zachary Fredericksen, Celine M Vachon, Xianshu Wang, Sara Margolin, Annika Lindblom, Heli Nevanlinna, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Jenny Chang-Claude, Alina Vrieling, Dieter Flesch-Janys, Hans-Peter Sinn, Shan Wang-Gohrke, Stefan Nickels, Hiltrud Brauch, Yon-Dschun Ko, Hans-Peter Fischer, The GENICA Network, Rita K. Schmutzler, Alfons Meindl, Claus R. Bartram, Sarah Schott, Christoph Engel, Andrew K. Godwin, JoEllen Weaver, Harsh B Pathak, Priyanka Sharma, Hermann Brenner, Heiko Muller, Volker Arndt, Christa Stegmaier, Penelope Miron, Drakoulis Yannoukakos, Alexandra Stavropoulou, George Fountzilas, Helen J Gogas, Ruth Swann, Miriam Dwek, Katherine Anne Perkins, Roger L. Milne, Javier Benítez, M. Pilar Zamora, José Ignacio Arias Pérez, Stig E. Bojesen, Sune F. Nielsen, Borge G. Nordestgaard, Henrik Flyger, Pascal Guénel, Thérèse Truong, Florence Menegaux, Emilie Cordina-Duverger, Barbara Burwinkel, Frederick Marmé, Andreas Schneeweiss, Christof Sohn, Elinor Sawyer, Ian Tomlinson, Michael J Kerin, Julian Peto, Nichola Johnson, Olivia Fletcher, Isabel dos Santos Silva, Peter A Fasching, Matthias W Beckmann, Arndt Hartmann, Arif B. Ekici, Artitaya Lophatananon, Kenneth Muir, Puttisak Puttawibul, Surapon Wiangnon, Marjanka K. Schmidt, Annegien Broeks, Linde M Braaf, Efraim H. Rosenberg, John L. Hopper, Carmel Apicella, Daniel J. Park, Melissa C. Southey, Anthony J Swerdlow, Alan Ashworth, Nick Orr, Minouk J Schoemaker, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Chen-Yang Shen, Jyh-Cherng Yu, Huan-Ming Hsu, Chia-Ni Hsiung, Ute Hamann, Thomas Dünnebier, Thomas Rüdiger, Hans Ulrich Ulmer, Paul D. P. Pharoah, Alison M Dunning, Manjeet K. Humphreys, Qin Wang, Angela Cox, Simon S. Cross, Malcolm W.R. Reed, Per Hall, Kamila Czene, Christine B Ambrosone, Foluso Ademuyiwa, Helena Hwang, Diana M. Eccles, Montserrat Garcia-Closas, Jonine D. Figueroa, Mark E. Sherman, Jolanta Lissowska, Peter Devilee, Caroline Seynaeve, R.A.E.M Tollenaar, Maartje J Hooning, Irene L. Andrulis, Julia A Knight, Gord Glendon, Anna Marie Mulligan, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Esther M. John, Alexander Miron, Grethe Grenaker Alnaes, Vessela Kristensen, Anne-Lise Borresen-Dale, Graham G. Giles, Laura Baglietto, Catriona A McLean, Gianluca Severi, Matthew L. Kosel, V. Shane Pankratz, Susan Slager, Janet E. Olson, Paolo Radice, Paolo Peterlongo, Siranoush Manoukian, Monica Barile, Diether Lambrechts, Sigrid Hatse, Anne-Sophie Dieudonne, Marie-Rose Christiaens, Georgia Chenevix-Trench, kConFab Investigators, AOCS Group, Jonathan Beesley, Xiaoqing Chen, Arto Mannermaa, Veli-Matti Kosma, Jaana M Hartikainen, Ylermi Soini, Douglas F. Easton and Fergus J. Couch
Cancer Res February 13 2012 DOI: 10.1158/0008-5472.CAN-11-3364
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • PHF5A Epigenetically Promotes Breast Cancer Progression
  • β-catenin in enzalutamide resistance
  • Integrated genomic analysis with MVisAGe
Show more Research Article
  • Home
  • Alerts
  • Feedback
Facebook  Twitter  LinkedIn  YouTube  RSS

Articles

  • Online First
  • Current Issue
  • Past Issues
  • Meeting Abstracts

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2018 by the American Association for Cancer Research.

Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

Advertisement