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Review

Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging

S. Zackrisson, S.M.W.Y. van de Ven and S.S. Gambhir
S. Zackrisson
Authors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden
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S.M.W.Y. van de Ven
Authors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden
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S.S. Gambhir
Authors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, SwedenAuthors' Affiliations: Departments of Radiology, Bioengineering, and Materials Science & Engineering, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, California; and Diagnostic Radiology, Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden
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DOI: 10.1158/0008-5472.CAN-13-2387
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Abstract

Photoacoustic imaging (PAI) has the potential for real-time molecular imaging at high resolution and deep inside the tissue, using nonionizing radiation and not necessarily depending on exogenous imaging agents, making this technique very promising for a range of clinical applications. The fact that PAI systems can be made portable and compatible with existing imaging technologies favors clinical translation even more. The breadth of clinical applications in which photoacoustics could play a valuable role include: noninvasive imaging of the breast, sentinel lymph nodes, skin, thyroid, eye, prostate (transrectal), and ovaries (transvaginal); minimally invasive endoscopic imaging of gastrointestinal tract, bladder, and circulating tumor cells (in vivo flow cytometry); and intraoperative imaging for assessment of tumor margins and (lymph node) metastases. In this review, we describe the basics of PAI and its recent advances in biomedical research, followed by a discussion of strategies for clinical translation of the technique. Cancer Res; 74(4); 1–26. ©2014 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/).

  • Received August 19, 2013.
  • Revision received September 9, 2013.
  • Accepted November 25, 2013.
  • ©2014 American Association for Cancer Research.
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Published OnlineFirst February 10, 2014
doi: 10.1158/0008-5472.CAN-13-2387

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Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging
S. Zackrisson, S.M.W.Y. van de Ven and S.S. Gambhir
Cancer Res February 10 2014 DOI: 10.1158/0008-5472.CAN-13-2387

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Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging
S. Zackrisson, S.M.W.Y. van de Ven and S.S. Gambhir
Cancer Res February 10 2014 DOI: 10.1158/0008-5472.CAN-13-2387
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Cancer Research Online ISSN: 1538-7445
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