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Research Article

Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism

Min Cheng, Liting Qian, Guodong Shen, Geng Bian, Tingjuan Xu, Weiping Xu, Gan Shen and Shilian Hu
Min Cheng
Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Gerontology Institute of Anhui Province
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  • For correspondence: chengmin@ustc.edu.cn
Liting Qian
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Guodong Shen
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Geng Bian
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Tingjuan Xu
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Weiping Xu
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Gan Shen
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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Shilian Hu
Anhui Province Hospital Affiliated Anhui Medical University, Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy
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DOI: 10.1158/0008-5472.CAN-13-2462
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Abstract

Commensal bacteria are crucial to maintain immune homeostasis in mucosal tissues and disturbances in their ecology can impact disease susceptibility. Here we report evidence that commensal bacteria shape the efficiency of immune surveillance in mucosal tissues. Antibiotic-treated (Abt) mice were more susceptible to development of engrafted B16/F10 melanoma and Lewis lung carcinoma, exhibiting a shortened mean survival time with more numerous and larger tumor foci in the lungs. The defective anti-tumor response of Abt mice was independent of dehydration caused by antibiotics: host defenses relied upon intact commensal bacteria with no class specificity. Mechanistic investigations revealed a defective induction of the γδT17 cell response in lungs of Abt mice, here more aggressive tumor development was observed, possibly related to a reduction in IL-6 and IL-23 expression there. Adding normal γδT cells or supplementing IL-17 restored the impaired immune surveillance phenotype in Abt mice. Overall, our results demonstrated the importance of commensal bacteria in supporting the host immune response against cancer, defined an important role for γδT17 responses in the mechanism and suggested deleterious effects of antibiotic treatment on cancer susceptibility and progression.

  • Received September 3, 2013.
  • Revision received May 30, 2014.
  • Accepted May 31, 2014.
  • Copyright © 2014, American Association for Cancer Research.
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Published OnlineFirst June 19, 2014
doi: 10.1158/0008-5472.CAN-13-2462

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Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism
Min Cheng, Liting Qian, Guodong Shen, Geng Bian, Tingjuan Xu, Weiping Xu, Gan Shen and Shilian Hu
Cancer Res June 19 2014 DOI: 10.1158/0008-5472.CAN-13-2462

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Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism
Min Cheng, Liting Qian, Guodong Shen, Geng Bian, Tingjuan Xu, Weiping Xu, Gan Shen and Shilian Hu
Cancer Res June 19 2014 DOI: 10.1158/0008-5472.CAN-13-2462
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Cancer Research Online ISSN: 1538-7445
Cancer Research Print ISSN: 0008-5472
Journal of Cancer Research ISSN: 0099-7013
American Journal of Cancer ISSN: 0099-7374

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