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Research Article

Low levels of circulating adiponectin are associated with multiple myeloma risk in overweight and obese individuals

Jonathan N. Hofmann, Brenda M. Birmann, Lauren R. Teras, Ruth M. Pfeiffer, Ye Wang, Demetrius Albanes, Dalsu Baris, Graham A. Colditz, Anneclaire J. De Roos, Graham G Giles, H. Dean Hosgood, Qing Lan, Ola Landgren, Linda M Liao, Nathaniel Rothman, Stephanie J. Weinstein, Michael N. Pollak, Marian L. Neuhouser and Mark P. Purdue
Jonathan N. Hofmann
Division of Cancer Epidemiology and Genetics, National Cancer Institute
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  • For correspondence: hofmannjn@mail.nih.gov
Brenda M. Birmann
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
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Lauren R. Teras
Epidemiology Research Program, American Cancer Society
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Ruth M. Pfeiffer
Division of Cancer Epidemiology and Genetics, National Cancer Institute
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Ye Wang
Oncology Department, McGill University and Segal Cancer Centre, Jewish General Hospital
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Demetrius Albanes
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
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Dalsu Baris
Division of Cancer Epidemiology and Genetics, National Cancer Institute
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Graham A. Colditz
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine and Alvin J. Siteman Cancer Center
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Anneclaire J. De Roos
Department of Environmental and Occupational Health, Drexel University School of Public Health
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Graham G Giles
Cancer Epidemiology Centre, Cancer Council Victoria
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H. Dean Hosgood
Department of Epidemiology and Population Health, Albert Einstein College of Medicine
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Qing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
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Ola Landgren
Myeloma Service, Memorial Sloan Kettering Cancer Center
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Linda M Liao
Division of Cancer Epidemiology and Genetics, National Cancer Institute
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Nathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
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Stephanie J. Weinstein
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
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Michael N. Pollak
Experimental Medicine and Oncology, McGill University
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Marian L. Neuhouser
Division of Public Health Sciences, Cancer Prevention Program, Fred Hutchinson Cancer Research Center
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Mark P. Purdue
Division of Cancer Epidemiology and Genetics, National Cancer Institute
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DOI: 10.1158/0008-5472.CAN-15-2406
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Abstract

The association between obesity and multiple myeloma (MM) risk may be partly attributed to reduced circulating levels of adiponectin in obese individuals. To prospectively evaluate MM risk in relation to adiponectin levels overall and stratified by body mass index and other characteristics, we conducted a pooled investigation of pre-diagnosed peripheral blood samples from 624 MM cases and 1,246 individually matched controls from seven cohorts participating in the MM Cohort Consortium. Analysis of circulating analyte levels measured by enzyme-linked immunosorbent assays revealed that higher total adiponectin levels were associated with reduced MM risk overall (highest quartile vs. lowest: odds ratio [OR]=0.64, 95% confidence interval [CI]=0.47-0.85; Ptrend = 0.001). This association was apparent among cases diagnosed six or more years after blood collection (OR=0.60, CI=0.40-0.90; Ptrend = 0.004) and was similar in magnitude for men and women (OR=0.59 and 0.66, respectively). Interestingly, we observed strong associations among subjects who were overweight (OR=0.41, CI=0.26-0.65) or obese (OR=0.41, CI=0.17-0.98) but not among those with normal weight (OR=1.20, CI=0.73-2.00; overweight/obese vs. normal weight, Pinteraction = 0.04). Our findings provide the strongest epidemiologic evidence to date that adiponectin protects against MM development, particularly among overweight and obese individuals, and offer a method for risk assessment in this susceptible population of heavier patients.

  • Received September 1, 2015.
  • Revision received November 24, 2015.
  • Accepted December 19, 2015.
  • Copyright ©2016, American Association for Cancer Research.
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Published OnlineFirst March 3, 2016
doi: 10.1158/0008-5472.CAN-15-2406

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Low levels of circulating adiponectin are associated with multiple myeloma risk in overweight and obese individuals
Jonathan N. Hofmann, Brenda M. Birmann, Lauren R. Teras, Ruth M. Pfeiffer, Ye Wang, Demetrius Albanes, Dalsu Baris, Graham A. Colditz, Anneclaire J. De Roos, Graham G Giles, H. Dean Hosgood, Qing Lan, Ola Landgren, Linda M Liao, Nathaniel Rothman, Stephanie J. Weinstein, Michael N. Pollak, Marian L. Neuhouser and Mark P. Purdue
Cancer Res March 3 2016 DOI: 10.1158/0008-5472.CAN-15-2406

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Low levels of circulating adiponectin are associated with multiple myeloma risk in overweight and obese individuals
Jonathan N. Hofmann, Brenda M. Birmann, Lauren R. Teras, Ruth M. Pfeiffer, Ye Wang, Demetrius Albanes, Dalsu Baris, Graham A. Colditz, Anneclaire J. De Roos, Graham G Giles, H. Dean Hosgood, Qing Lan, Ola Landgren, Linda M Liao, Nathaniel Rothman, Stephanie J. Weinstein, Michael N. Pollak, Marian L. Neuhouser and Mark P. Purdue
Cancer Res March 3 2016 DOI: 10.1158/0008-5472.CAN-15-2406
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