Perspectives in Cancer Research:

The Multistep Nature of Cancer Development

Emmanuel Farber
Cancer Res 1984 44: 4217-4223. [PDF]  

Basic Sciences:

Glutathione Metabolism as a Determinant of Therapeutic Efficacy: A Review

Bradley A. Arrick and Carl F. Nathan
Cancer Res 1984 44: 4224-4232. [Abstract] [PDF]  

Clotrimazole, an Inhibitor of Epidermal Benzo(a)pyrene Metabolism and DNA Binding and Carcinogenicity of the Hydrocarbon

Hasan Mukhtar, Benjamin J. Del Tito, Jr., Mukul Das, Evan P. Cherniack, Andrew D. Cherniack, and David R. Bickers
Cancer Res 1984 44: 4233-4240. [Abstract] [PDF]  

Cellular Discriminants for a Biological Classification of Human Colon Carcinoma

B. Drewinko, L. Y. Yang, A. Leibovitz, B. Barlogie, D. Lutz, B. Jansson, J. J. Stragand, and J. M. Trujillo
Cancer Res 1984 44: 4241-4253. [Abstract] [PDF]  

In Vivo Dosimetry of 4-Aminobiphenyl in Rats via a Cysteine Adduct in Hemoglobin

Laura C. Green, Paul L. Skipper, Robert J. Turesky, Matthew S. Bryant, and Steven R. Tannenbaum
Cancer Res 1984 44: 4254-4259. [Abstract] [PDF]  

Irreversibility of Low-Grade Superficial Rat Bladder Carcinomas

Seiichiro Ozono, Isao Numata, and Ryoichi Oyasu
Cancer Res 1984 44: 4260-4262. [Abstract] [PDF]  

Tumor and Tissue Distribution of a Methotrexate-Anti-EL4 Immunoglobulin Conjugate in EL4 Lymphoma-bearing Mice

Patrick Uadia, A. Huntley Blair, and Tarunendu Ghose
Cancer Res 1984 44: 4263-4266. [Abstract] [PDF]  

In Vivo Genotoxicity and Acute Hepatotoxicity of 1,2-Dichloroethane in Mice: Comparison of Oral, Intraperitoneal, and Inhalation Routes of Exposure

Richard D. Storer, Nancy M. Jackson, and Rory B. Conolly
Cancer Res 1984 44: 4267-4271. [Abstract] [PDF]  

Enhancement of the Rate of Spontaneous Mutation to 6-Thioguanine Resistance in Mammalian Cells by Polyamine Depletion

Naoyuki Kamatani, Kusuki Nishioka, Toshimi Morita, Yutaka Morita, Fujio Takeuchi, Kunio Matsuta, Yutaro Nishida, and Terumasa Miyamoto
Cancer Res 1984 44: 4272-4275. [Abstract] [PDF]  

Effects of Gastrin on Tumor Growth and Cyclic Nucleotide Metabolism in Xenotransplantable Human Gastric and Colonic Carcinomas in Nude Mice

Hiromichi Sumiyoshi, Wataru Yasui, Atsushi Ochiai, and Eiichi Tahara
Cancer Res 1984 44: 4276-4280. [Abstract] [PDF]  

Polyamine Requirements for Induction of HL-60 Promyelocyte Differentiation by Leukocyte-conditioned Medium and Phorbol Ester

Donald W. Kufe, James Griffin, Thomas Mitchell, and Tim Shafman
Cancer Res 1984 44: 4281-4284. [Abstract] [PDF]  

Oxygen-carrying Perfluorochemical Emulsion as an Adjuvant to Radiation Therapy in Mice

Beverly A. Teicher and Christopher M. Rose
Cancer Res 1984 44: 4285-4288. [Abstract] [PDF]  

Cytotoxic and Antitumor Activity of 1-Nitroacridines as an Aftereffect of Their Interstrand DNA Cross-Linking

Katarzyna Pawlak, Jan W. Pawlak, and Jerzy Konopa
Cancer Res 1984 44: 4289-4296. [Abstract] [PDF]  

Inactivation and Reactivation of Intracellular S-Adenosylhomocysteinase in the Presence of Nucleoside Analogues in Rat Hepatocytes

J-S. Schanche, T. Schanche, P. M. Ueland, and J. A. Montgomery
Cancer Res 1984 44: 4297-4302. [Abstract] [PDF]  

Effects of Quinidine and Related Compounds on Cytotoxicity and Cellular Accumulation of Vincristine and Adriamycin in Drugresistant Tumor Cells

Takashi Tsuruo, Harumi Iida, Yoshiko Kitatani, Keiko Yokota, Shigeru Tsukagoshi, and Yoshio Sakurai
Cancer Res 1984 44: 4303-4307. [Abstract] [PDF]  

Mutagenic Activity of Tumor-associated Macrophages in Salmonella typhimurium Strains TA98 and TA100

Amy M. Fulton, Scott E. Loveless, and Gloria H. Heppner
Cancer Res 1984 44: 4308-4311. [Abstract] [PDF]  

Effects of pH and Temperature on the Stability and Decomposition of N,N'N''-Triethylenethiophosphoramide in Urine and Buffer

Brian E. Cohen, Merrill J. Egorin, M. S. Balachandran Nayar, and Peter L. Gutierrez
Cancer Res 1984 44: 4312-4316. [Abstract] [PDF]  

Metabolism of 1-Nitro[U-4,5,9,10-¹⁴C]pyrene in the F344 Rat

Karam El-Bayoumy and Stephen S. Hecht
Cancer Res 1984 44: 4317-4322. [Abstract] [PDF]  

Repair of DNA Damage Caused by Formaldehyde in Human Cells

Roland C. Grafstrom, Albert Fornace, Jr., and Curtis C. Harris
Cancer Res 1984 44: 4323-4327. [Abstract] [PDF]  

Selection of 9-ß-D-Arabinofuranosyladenine-resistant Human T-Lymphoblasts with Altered Ribonucleotide Reductase Activity

Arnold Fridland
Cancer Res 1984 44: 4328-4332. [Abstract] [PDF]  

Development and Characterization of the BALB/cNIV Mouse Strain

Lawrence J. T. Young, Kenneth B. DeOme, Phyllis B. Blair, Dorothy R. Pitelka, and Robert D. Cardiff
Cancer Res 1984 44: 4333-4336. [Abstract] [PDF]  

Ultrasonic Measurement of Melanosomes for Characterization of Their Physicochemical Structure in B16 and Harding-Passey Melanomas

Ryusuke Kono, Kowichi Jimbow, Hiroyuki Takahashi, and Kazuo Maeda
Cancer Res 1984 44: 4337-4341. [Abstract] [PDF]  

Expression of Ca Antigen in Relation to Cell Cycle in Cultured Human Tumor Cells

Bogdan Czerniak, Zbigniew Darzynkiewicz, Lisa Staiano-Coico, Fritz Herz, and Leopold G. Koss
Cancer Res 1984 44: 4342-4346. [Abstract] [PDF]  

Heat Sensitivity and Thermotolerance in Cells from Five Human Melanoma Xenografts

Einar K. Rofstad, Hilde Midthjell, and Tor Brustad
Cancer Res 1984 44: 4347-4354. [Abstract] [PDF]  

Effects of New Antitumor Bifunctional Intercalators Derived from 7H-Pyridocarbazole on Sensitive and Resistant L1210 Cells

Catherine Esnault, Bernard P. Roques, Alain Jacquemin-Sablon, and Jean Bernard Le Pecq
Cancer Res 1984 44: 4355-4360. [Abstract] [PDF]  

Selenium Inhibition of DNA Synthesis in Mouse Mammary Epithelial Cell Line YN-4

Daniel Medina and Carol J. Oborn
Cancer Res 1984 44: 4361-4365. [Abstract] [PDF]  

Characterization and Significance of Carbamyl Phosphate Phosphatase

Michael J. Black and Mary Ellen Jones
Cancer Res 1984 44: 4366-4376. [Abstract] [PDF]  

Inhibition of Mouse Bladder Tumor Proliferation by Murine Interferon- and Its Synergism with Interferon-ß

Timothy L. Ratliff, Dov Kadmon, Amos Shapiro, Allan J. Jacobs, and W. D. W. Heston
Cancer Res 1984 44: 4377-4381. [Abstract] [PDF]  

Effects of -Difluoromethylornithine and Methylglyoxal Bis(guanylhydrazone) on the Growth of Experimental Renal Adenocarcinoma in Mice

Harry W. Herr, Edward L. Kleinert, Peter S. Conti, Joseph H. Burchenal, and Willet F. Whitmore, Jr.
Cancer Res 1984 44: 4382-4385. [Abstract] [PDF]  

Effects of Tamoxifen on Estrogen-induced Enhancement or Inhibition of Tumor Growth in Mouse Leydig Cell Tumor Lines

Bunzo Sato, Yoshiaki Maeda, Yasuko Nishizawa, Keizo Noma, Susumu Kishimoto, and Keishi Matsumoto
Cancer Res 1984 44: 4386-4391. [Abstract] [PDF]  

Reversal of Acquired Resistance to Doxorubicin in P388 Murine Leukemia Cells by Tamoxifen and Other Triparanol Analogues

A. Ramu, D. Glaubiger, and Z. Fuks
Cancer Res 1984 44: 4392-4395. [Abstract] [PDF]  

Abnormal Response of Xeroderma Pigmentosum Cells to Bleomycin

Myra M. Hurt and Robb E. Moses
Cancer Res 1984 44: 4396-4402. [Abstract] [PDF]  

Lack of Correlation between Natural Killer Activity and Tumor Growth Control in Nude Mice with Different Immune Defects

Øystein Fodstad, Carl T. Hansen, Grace B. Cannon, Charles N. Statham, Gary R. Lichtenstein, and Michael R. Boyd
Cancer Res 1984 44: 4403-4408. [Abstract] [PDF]  

Effect of Oxygen on Misonidazole Chemosensitization and Cytotoxicity in Vitro

R. Timothy Mulcahy
Cancer Res 1984 44: 4409-4413. [Abstract] [PDF]  

Control of Hepatocyte Replication by Two Serum Factors

G. Michalopoulos, K. A. Houck, M. L. Dolan, and N. C. Luetteke
Cancer Res 1984 44: 4414-4419. [Abstract] [PDF]  

Comparison of the Mutagenic and Clastogenic Activity of Amsacrine and Other DNA-intercalating Drugs in Cultured V79 Chinese Hamster Cells

William R. Wilson, Noelene M. Harris, and Lynnette R. Ferguson
Cancer Res 1984 44: 4420-4431. [Abstract] [PDF]  

HNK-1-defined Antigen Detected in Paraffin-embedded Neuroectoderm Tumors and Those Derived from Cells of the Amine Precursor Uptake and Decarboxylation System

Jean-Michel Caillaud, Souad Benjelloun, Jacques Bosq, Karim Braham, and Marc Lipinski
Cancer Res 1984 44: 4432-4439. [Abstract] [PDF]  

Decreased Cell Kill of Vincristine and Methotrexate against 9L Rat Brain Tumor Cells in Vitro Caused by -Difluoromethylornithine-induced Polyamine Depletion

Leena Alhonen-Hongisto, David T. Hung, Dennis F. Deen, and Laurence J. Marton
Cancer Res 1984 44: 4440-4442. [Abstract] [PDF]  

Alteration in Pyruvate Metabolism in the Liver of Tumor-bearing Rats

Jeffry D. Shearer, Gordon P. Buzby, James L. Mullen, Elizabeth Miller, and Michael D. Caldwell
Cancer Res 1984 44: 4443-4446. [Abstract] [PDF]  

DNA Strand Scission and Cross-Linking by Diaziridinylbenzoquinone (Diaziquone) in Human Cells and Relation to Cell Killing

Leszek Szmigiero, Leonard C. Erickson, Regina A. Ewig, and Kurt W. Kohn
Cancer Res 1984 44: 4447-4452. [Abstract] [PDF]  

Mechanisms of DNA Strand Breakage and Interstrand Cross-Linking by Diaziridinylbenzoquinone (Diaziquone) in Isolated Nuclei from Human Cells

Leszek Szmigiero and Kurt W. Kohn
Cancer Res 1984 44: 4453-4457. [Abstract] [PDF]  

Efflux of Adenine Nucleotides in Mitochondria from Rat Tumor Cells of Varying Growth Rates

Brad W. C. Lau and Samuel H. P. Chan
Cancer Res 1984 44: 4458-4464. [Abstract] [PDF]  

Potent Activation of Mouse Macrophages by Recombinant Interferon-

Luigi Varesio, Elisabetta Blasi, Gary B. Thurman, James E. Talmadge, Robert H. Wiltrout, and Ronald B. Herberman
Cancer Res 1984 44: 4465-4469. [Abstract] [PDF]  

Constitutive Production and Release of a Lymphokine with Macrophage-activating Factor Activity Distinct from -Interferon by a Human T-Cell Leukemia Virus-positive Cell Line

Eugenie S. Kleinerman, Randy Zicht, Prem S. Sarin, Robert C. Gallo, and Isaiah J. Fidler
Cancer Res 1984 44: 4470-4475. [Abstract] [PDF]  

Metabolism of a Transformation-sensitive Amino Acid Fucoside in Normal and Simian Virus 40-transformed Human Embryonic Lung Cells

Sheldon M. Steiner and Phillip A. Morton
Cancer Res 1984 44: 4476-4479. [Abstract] [PDF]  

Characterization of the Effector Cells Mediating an "Innocent Bystander" Cytotoxicity Reaction Induced by a Syngeneic Mammary Adenocarcinoma in Mice

Ronald D. Paul, Ranga Padmanabhan, and Diana M. Lopez
Cancer Res 1984 44: 4480-4486. [Abstract] [PDF]  

Functional and Morphological Characteristics of Transplantable Rat Pituitary Tumors Established in Nude Mice

Susumu Makino, Hiroshi Mori, Kiyoshi Koizumi, Hirohumi Yamashita, Yoshiyuki Hayashi, Toshihiro Aono, and Keishi Matsumoto
Cancer Res 1984 44: 4487-4495. [Abstract] [PDF]  

Immunohistology of Normal and Ovarian Cancer Tissue with a Monoclonal Antibody to Placental Alkaline Phosphatase

Christopher A. Sunderland, John O. Davies, and Gordon M. Stirrat
Cancer Res 1984 44: 4496-4502. [Abstract] [PDF]  

Long-Term Cultivation of a Human Colony-stimulating Factor-producing Cell Line in a Protein-free Chemically Defined Medium

Tetsuro Okabe and Fumimaro Takaku
Cancer Res 1984 44: 4503-4506. [Abstract] [PDF]  

Comparative Studies of Heat Sensitivity of Several Rat Hepatoma Cell Lines and Hepatocytes in Primary Culture

Dennis H. J. Schamhart, Wim Berendsen, Johannes van Rijn, and Roeland van Wijk
Cancer Res 1984 44: 4507-4516. [Abstract] [PDF]  

Morphological and Histological Characteristics of Mammary Dysplasias Occurring in Cell Dissociation-derived Murine Mammary Outgrowths

Stephen P. Ethier, Laurel M. Adams, and Robert L. Ullrich
Cancer Res 1984 44: 4517-4522. [Abstract] [PDF]  

Factors Influencing Expression of Mammary Ductal Dysplasia in Cell Dissociation-derived Murine Mammary Outgrowths

Stephen P. Ethier and Robert L. Ullrich
Cancer Res 1984 44: 4523-4527. [Abstract] [PDF]  

Identification of a Human Cancer-associated Antigen Defined with Monoclonal Antibody

Malaya Bhattacharya, Sunil K. Chatterjee, and Joseph J. Barlow
Cancer Res 1984 44: 4528-4534. [Abstract] [PDF]  

Induction of Major Chromosome Aberrations in Chinese Hamster Ovary Cells by -Difluoromethylornithine

Pirkko Pohjanpelto and Sakari Knuutila
Cancer Res 1984 44: 4535-4539. [Abstract] [PDF]  

Identification of Human Leukemic Glucocorticoid Receptors Using Affinity Labeling and Anti-Human Glucocorticoid Receptor Antibodies

Jeffrey M. Harmon, Howard J. Eisen, Steven T. Brower, S. Stoney Simons, Jr., Carol L. Langley, and E. Brad Thompson
Cancer Res 1984 44: 4540-4547. [Abstract] [PDF]  

Characterization of -Glutamyltranspeptidase in Murine Cervical Cancer by Biochemical and Immunological Techniques

Yu Fang Chen and Stephen Haskill
Cancer Res 1984 44: 4548-4552. [Abstract] [PDF]  

Continuous Culture and Soft Agarose Cloning of Multiple Human Breast Carcinoma Cell Lines in Serum-free Medium

Fabien Calvo, Martin Brower, and Desmond N. Carney
Cancer Res 1984 44: 4553-4559. [Abstract] [PDF]  

Characterization of a Human, Sex Steroid-responsive Transitional Cell Carcinoma Maintained as a Tumor Line (R198) in Athymic Nude Mice

Lola M. Reid, Irwin Leav, Paul W. L. Kwan, Percy Russell, and Frederick B. Merk
Cancer Res 1984 44: 4560-4573. [Abstract] [PDF]  

Sodium Butyrate Induction of Milk-related Antigens in Human MCF-7 Breast Carcinoma Cells

Miyako Abe and Donald W. Kufe
Cancer Res 1984 44: 4574-4577. [Abstract] [PDF]  

Selective Antitumor Effect on L10 Hepatocarcinoma Cells of a Potent Immunoconjugate Composed of the A Chain of Abrin and a Monoclonal Antibody to a Hepatoma-associated Antigen

Kou M. Hwang, Kenneth A. Foon, Puying H. Cheung, J. W. Pearson, and Robert K. Oldham
Cancer Res 1984 44: 4578-4586. [Abstract] [PDF]  

Be13, a Human T-Leukemia Cell Line Highly Sensitive to Dexamethasone-induced Cytolysis

Uri Galili, Aviva Peleg, Yoram Milner, and Naomi Galili
Cancer Res 1984 44: 4594-4601. [Abstract] [PDF]  

Plasma Clearance and Tissue Distribution of Partially Thiolated Polycytidylic Acid and Its Degradation Products in Rodents

Mei-Ping Kung, Yau-Kwan Ho, David Lalka, and Thomas J. Bardos
Cancer Res 1984 44: 4602-4606. [Abstract] [PDF]  

Effects of the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate on Neurite Outgrowth from Chick Embryo Sensory Ganglia

L. Hsu, D. Natyzak, and Jeffrey D. Laskin
Cancer Res 1984 44: 4607-4614. [Abstract] [PDF]  

Metabolism and Binding of Cyclophosphamide and Its Metabolite Acrolein to Rat Hepatic Microsomal Cytochrome P-450

A. J. Marinello, S. K. Bansal, B. Paul, P. L. Koser, J. Love, R. F. Struck, and H. L. Gurtoo
Cancer Res 1984 44: 4615-4621. [Abstract] [PDF]  

Selection and Rejection of Retrovirus-expressing Tumor Cells from a Heterogeneous Murine Leukemia Virus-infected Cell Population

B. Zbar, N. Terata, A. Nagai, Y. Tanio, and J. Hovis
Cancer Res 1984 44: 4622-4629. [Abstract] [PDF]  

Dose Response of Monoclonal Tumor Induction with 3-Methylcholanthrene in Mosaic Mice

Hiroshi Tanooka and Kazuhiko Tanaka
Cancer Res 1984 44: 4630-4632. [Abstract] [PDF]  

Basic Science:

Expression of Drug Sensitivity and Tumorigenicity in Intraspecies Hybrids between 9-Hydroxyellipticine-sensitive and -resistant Cells

Jean-Jacques Rémy, Jean Belehradek, and Alain Jacquemin-Sablon
Cancer Res 1984 44: 4587-4593. [Abstract] [PDF]  

Clinical and Epidemiological Investigations:

Dietary Fat and the Risk of Colorectal Cancer

Grant N. Stemmermann, Abraham M. Y. Nomura, and Lance K. Heilbrun
Cancer Res 1984 44: 4633-4637. [Abstract] [PDF]  

Cancer and Other Causes of Death among Embalmers

Judy Walrath and Joseph F. Fraumeni, Jr.
Cancer Res 1984 44: 4638-4641. [Abstract] [PDF]  

Immunoassay for Melanoma-associated Proteoglycan in the Sera of Patients Using Monoclonal and Polyclonal Antibodies

Alonzo H. Ross, Meenhard Herlyn, Carolyn S. Ernst, Dupont Guerry, Jeanette Bennicelli, Barbara F. D. Ghrist, Barbara Atkinson, and Hilary Koprowski
Cancer Res 1984 44: 4642-4647. [Abstract] [PDF]  

Prediction of Response to Chemotherapy in Acute Leukemia by in Vitro Drug Sensitivity Testing on Leukemic Stem Cells

Anita Gustavsson and Tor Olofsson
Cancer Res 1984 44: 4648-4652. [Abstract] [PDF]  

Expression of Ductal Carcinoma Antigen in Breast Cancer Sera as Defined Using Monoclonal Antibody F36/22

Lawrence D. Papsidero, Takuma Nemoto, Gary A. Croghan, and T. Ming Chu
Cancer Res 1984 44: 4653-4657. [Abstract] [PDF]  

Immunoglobulin Gene Rearrangement in Acute Myelogenous Leukemia

Kyungsae Ha, Mark Minden, Nobumichi Hozumi, and Erwin W. Gelfand
Cancer Res 1984 44: 4658-4660. [Abstract] [PDF]  

Effects on Human Peripheral Lymphocytes of in Vivo Administration of 9-ß-D-Arabinofuranosyl-2-fluoroadenine-5'-monophosphate (NSC 312887), a New Purine Antimetabolite

David H. Boldt, Daniel D. Von Hoff, John G. Kuhn, and Marla Hersh
Cancer Res 1984 44: 4661-4666. [Abstract] [PDF]  

Phase I-II Trial of High-Dose Calcium Leucovorin and 5-Fluorouracil in Advanced Colorectal Cancer

Stefan Madajewicz, Nicholas Petrelli, Youcef M. Rustum, Joel Campbell, Lemuel Herrera, Arnold Mittelman, April Perry, and Patrick J. Creaven
Cancer Res 1984 44: 4667-4669. [Abstract] [PDF]  

Estradiol and Progesterone Receptors in Malignant Gastrointestinal Tumors

Vincenzo Sica, Ernesto Nola, Enrico Contieri, Rodolfo Bova, Maria Teresa Masucci, Nicola Medici, Antonella Petrillo, Alessandro Weisz, Anna Maria Molinari, and Giovanni Alfredo Puca
Cancer Res 1984 44: 4670-4674. [Abstract] [PDF]  

Relationship of Urinary Polyamines to Tumor Activity and Tumor Volume in Patients

Yoav Horn, Stuart L. Beal, Natalio Walach, Warren P. Lubich, Lina Spigel, and Laurence J. Marton
Cancer Res 1984 44: 4675-4678. [Abstract] [PDF]  

Distribution of Human Class I (HLA-A,B,C) Histocompatibility Antigens in Normal and Malignant Tissues of Nonlymphoid Origin

P. G. Natali, A. Bigotti, M. R. Nicotra, M. Viora, D. Manfredi, and S. Ferrone
Cancer Res 1984 44: 4679-4687. [Abstract] [PDF]  

Quantitative Changes in Adenosine Deaminase Isoenzymes in Human Colorectal Adenocarcinomas

Joop ten Kate, Juul T. Wijnen, René G. M. van der Goes, René Quadt, Gerrit Griffioen, Fred T. Bosman, and P. Meera Khan
Cancer Res 1984 44: 4688-4692. [Abstract] [PDF]  

Letter to the Editor:

Governance of Science at the National Cancer Institute: Perceptions and Opportunities in Oncogene Research

Peter J. Fischinger and Vincent T. DeVita, Jr.
Cancer Res 1984 44: 4693-4696. [Abstract] [PDF]  

Articles:

Special Announcement

Cancer Res 1984 44: 4697 [PDF]  

Announcements

Cancer Res 1984 44: 4698-4699. [PDF]  

Recent Death

Cancer Res 1984 44: 4699 [PDF]  

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