Special Lecture:

The Origins of Human Cancer: Molecular Mechanisms of Carcinogenesis and Their Implications for Cancer Prevention and Treatment—Twenty-seventh G. H. A. Clowes Memorial Award Lecture

I. Bernard Weinstein
Cancer Res 1988 48: 4135-4143. [Abstract] [PDF]  

Carcinogenesis:

Comparative Study of DNA Damage and Repair Induced by Ten N-Nitroso Compounds in Primary Cultures of Human and Rat Hepatocytes

Antonietta Martelli, Luigi Robbiano, Gian Massimo Gazzaniga, and Giovanni Brambilla
Cancer Res 1988 48: 4144-4152. [Abstract] [PDF]  

Comparative Developmental and Phenotypic Properties of Altered Hepatocyte Foci and Hepatic Tumors in Rats

Carl Peraino, Bruce A. Carnes, Fred J. Stevens, Everett F. Staffeldt, John J. Russell, Aldona Prapuolenis, Jeanne A. Blomquist, Stan D. Vesselinovitch, and Robert R. Maronpot
Cancer Res 1988 48: 4171-4178. [Abstract] [PDF]  

Detection of O⁶-Methyldeoxyguanosine in Human Placental DNA

Peter G. Foiles, Lisa M. Miglietta, Shobha A. Akerkar, Richard B. Everson, and Stephen S. Hecht
Cancer Res 1988 48: 4184-4188. [Abstract] [PDF]  

Similar, Potent Tumor-promoting Activity of All Isomers of Teleocidins A and B in a Two-Stage Carcinogenesis Experiment on the Skin of CD-1 Mice

Hirota Fujiki, Masami Suganuma, Mitsuo Ninomiya, Shigeru Yoshizawa, Katsumi Yamashita, Shozo Takayama, Yukio Hitotsuyanagi, Shin-ichiro Sakai, Koichi Shudo, and Takashi Sugimura
Cancer Res 1988 48: 4211-4214. [Abstract] [PDF]  

Factors Regulating Activation and DNA Alkylation by 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and Nitrosodimethylamine in Rat Lung and Isolated Lung Cells, and the Relationship to Carcinogenicity

Theodora R. Devereux, Marshall W. Anderson, and Steven A. Belinsky
Cancer Res 1988 48: 4215-4221. [Abstract] [PDF]  

Increased Ornithine Decarboxylase Activity in Cultured Cells Exposed to Low Energy Modulated Microwave Fields and Phorbol Ester Tumor Promoters

Craig V. Byus, K. Kartun, S. Pieper, and W. Ross Adey
Cancer Res 1988 48: 4222-4226. [Abstract] [PDF]  

Induction of Repair Synthesis of DNA in Mammary and Urinary Bladder Epithelial Cells by N-Hydroxy Derivatives of Carcinogenic Arylamines

Ching Y. Wang, Hideyuki Yamada, Kenneth C. Morton, Kim Zukowski, Mei-Sie Lee, and Charles M. King
Cancer Res 1988 48: 4227-4232. [Abstract] [PDF]  

Comparative Tumorigenicity of 1-Nitropyrene, 1-Nitrosopyrene, and 1-Aminopyrene Administered by Gavage to Sprague-Dawley Rats

Karam El-Bayoumy, Abraham Rivenson, Bruce Johnson, Joann DiBello, Patricia Little, and Stephen S. Hecht
Cancer Res 1988 48: 4256-4260. [Abstract] [PDF]  

Oxidative Metabolism of 1-Nitropyrene by Rabbit Liver Microsomes and Purified Microsomal Cytochrome P-450 Isozymes

Paul C. Howard, Kimberly A. Reed, and Dennis R. Koop
Cancer Res 1988 48: 4261-4265. [Abstract] [PDF]  

Influence of Dietary Fat, Caloric Restriction, and Voluntary Exercise on N-Nitrosomethylurea-induced Mammary Tumorigenesis in Rats

Leonard A. Cohen, Keewhan Choi, and Chung-Xiou Wang
Cancer Res 1988 48: 4276-4283. [Abstract] [PDF]  

Biochemistry and Biophysics:

Increased Levels of DNA Lesions Induced by Leucovorin-5-Fluoropyrimidine in Human Colon Adenocarcinoma

Ulf Lönn and Sigrid Lönn
Cancer Res 1988 48: 4153-4157. [Abstract] [PDF]  

Purification of a Low Molecular Weight Factor That Induces Differentiation and Inhibits Growth in Myeloid Leukemia Cells

Kazuyasu Nakaya, Noriko Kumakawa, Hironobu Iinuma, and Yasuharu Nakamura
Cancer Res 1988 48: 4201-4205. [Abstract] [PDF]  

Mechanism of Alteration of Poly(Adenosine Diphosphate-Ribose) Metabolism by Hyperthermia

Göran G. Jonsson, Elaine L. Jacobson, and Myron K. Jacobson
Cancer Res 1988 48: 4233-4239. [Abstract] [PDF]  

Effect of Hyperthermia on Poly(Adenosine Diphosphate-Ribose) Glycohydrolase

Göran G. Jonsson, Luc Menard, Elaine L. Jacobson, Guy G. Poirier, and Myron K. Jacobson
Cancer Res 1988 48: 4240-4243. [Abstract] [PDF]  

Regulatory Effects of Cell Density on the Binding of Transforming Growth Factor ß, Epidermal Growth Factor, Platelet-derived Growth Factor, and Fibroblast Growth Factor

Angie Rizzino, Peter Kazakoff, Eric Ruff, Charles Kuszynski, and John Nebelsick
Cancer Res 1988 48: 4266-4271. [Abstract] [PDF]  

Effect of Thymidine on Uptake, DNA Alkylation, and DNA Repair in L1210 Cells Treated with 1,3-Bis(2-chloroethyl)-1-nitrosourea or 3'-[3-(2-Chloroethyl)-3-nitrosoureido]-3'-deoxythymidine

E. Michael August and William H. Prusoff
Cancer Res 1988 48: 4272-4275. [Abstract] [PDF]  

Biochemical Characterization of Tyrosine Kinase and Phosphotyrosine Phosphatase Activities of HL-60 Leukemia Cells

David A. Frank and Alan C. Sartorelli
Cancer Res 1988 48: 4299-4306. [Abstract] [PDF]  

Endocrinology:

Glandular Kallikrein in Estrogen-induced Pituitary Tumors: Time Course of Induction and Correlation with Prolactin

Mary Ann Hatala and C. Andrew Powers
Cancer Res 1988 48: 4158-4162. [Abstract] [PDF]  

Genetic Instability and the Development of Steroid Hormone Insensitivity in Cultured T 47D Human Breast Cancer Cells

Roger R. Reddel, Ian E. Alexander, Masafumi Koga, John Shine, and Robert L. Sutherland
Cancer Res 1988 48: 4340-4347. [Abstract] [PDF]  

Preclinical Pharmacology and Experimental Therapeutics:

Adoptive Immunotherapy by Pantropic Killer Cells Recovered from OK-432-injected Tumor Sites in Mice

Motoo Saito, Masaki Nanjo, Motoyuki Kataoka, Yoichiro Moriya, Yutaka Sugawara, Takeshi Yoshida, and Nakao Ishida
Cancer Res 1988 48: 4163-4167. [Abstract] [PDF]  

Selective Accumulation of 3',5'-Dioctanoyl-5-fluoro-2'-deoxyuridine (FdUrd-C8) and Sustained Release of Its Active Metabolites in VX-2 Rabbit Hepatoma following Intraarterial Administration of FdUrd-C8 Solution in Lipiodol

Takeo Kawaguchi, Shoji Fukushima, Yoshiki Hayashi, Mika Kaneko, and Masahiro Nakano
Cancer Res 1988 48: 4179-4183. [Abstract] [PDF]  

Experimental Chemotherapy of Human Medulloblastoma Cell Lines and Transplantable Xenografts with Bifunctional Alkylating Agents

Henry S. Friedman, O. Michael Colvin, Stephen X. Skapek, Susan M. Ludeman, Gertrude B. Elion, S. Clifford Schold, Jr., Phillip F. Jacobsen, Lawrence H. Muhlbaier, and Darell D. Bigner
Cancer Res 1988 48: 4189-4195. [Abstract] [PDF]  

Effect of Cyclophosphamide on the Pathophysiology of RIF-1 Solid Tumors

Paul G. Braunschweiger
Cancer Res 1988 48: 4206-4210. [Abstract] [PDF]  

Synergistic Cytotoxicity and DNA Strand Break Formation by Bromodeoxyuridine and Bleomycin in Human Tumor Cells

Stephen P. Ackland, Richard L. Schilsky, Michael A. Beckett, and Ralph R. Weichselbaum
Cancer Res 1988 48: 4244-4249. [Abstract] [PDF]  

Important Role of Serotonin in the Antitumor Effects of Recombinant Human Tumor Necrosis Factor- in Mice

Toshitaka Manda, Fusako Nishigaki, Jo Mori, and Kyoichi Shimomura
Cancer Res 1988 48: 4250-4255. [Abstract] [PDF]  

Flow Cytometric Analysis by Bromodeoxyuridine/DNA Assay of Cell Cycle Perturbation of Methotrexate-treated Mouse L1210 Leukemia Cells

Masahito Tsurusawa, Makoto Niwa, Naoyuki Katano, and Takeo Fujimoto
Cancer Res 1988 48: 4288-4293. [Abstract] [PDF]  

Preclinical Pharmacology of Arabinosyl-5-azacytidine in Nonhuman Primates

Richard L. Heideman, Frank M. Balis, Cynthia McCully, and David G. Poplack
Cancer Res 1988 48: 4294-4298. [Abstract] [PDF]  

Preclinical Studies on the Pharmacokinetic Properties of Human Monoclonal Antibodies to Colorectal Cancer and Their Use for Detection of Tumors

Richard P. McCabe, Leona C. Peters, Martin V. Haspel, Nicholas Pomato, Jorge A. Carrasquillo, and Michael G. Hanna, Jr.
Cancer Res 1988 48: 4348-4353. [Abstract] [PDF]  

Partial Prevention of Procarbazine Induced Germinal Cell Aplasia in Rats by Sequential GnRH Antagonist and Testosterone Administration

L. M. Pogach, Y. Lee, S. Gould, W. Giglio, and H. F. S. Huang
Cancer Res 1988 48: 4354-4360. [Abstract] [PDF]  

In Vivo and in Vitro Enhanced Antitumor Effects by Pentoxifylline in Human Cancer Cells Treated with Thiotepa

Howard J. Fingert, Anthony T. Pu, Zuying Chen, Paul B. Googe, Michael C. Alley, and Arthur B. Pardee
Cancer Res 1988 48: 4375-4381. [Abstract] [PDF]  

Necrotizing Effect of Ethanedimethanesulfonate on Spontaneously Occurring Leydig Cell Tumors in Old F344 Rats

Sotokichi Morii, Yuji Naka, Toshihiko Inui, and Hiroshi Shintani
Cancer Res 1988 48: 4395-4398. [Abstract] [PDF]  

Tumor Biology:

Iron Nutrition and Tumor Growth: Decreased Tumor Growth in Iron-deficient Mice

Hie-Won L. Hann, Mark W. Stahlhut, and Baruch S. Blumberg
Cancer Res 1988 48: 4168-4170. [Abstract] [PDF]  

Comparison of Combinations of Interferons with Tumor Specific and Nonspecific Monoclonal Antibodies as Therapy for Murine B- and T-Cell Lymphomas

Teresa Y. Basham, Michael A. Palladino, Christopher C. Badger, Irwin D. Bernstein, Ronald Levy, and Thomas C. Merigan
Cancer Res 1988 48: 4196-4200. [Abstract] [PDF]  

Production of Bone-resorbing Activity Corresponding to Interleukin-1 by Adult T-Cell Leukemia Cells in Humans

Fumihiko Shirakawa, Uki Yamashita, Yoshiya Tanaka, Kennichi Watanaba, Kanji Sato, Joji Haratake, Takashi Fujihira, Susumu Oda, and Sumiya Eto
Cancer Res 1988 48: 4284-4287. [Abstract] [PDF]  

Metastatic Potential Prediction by a Visual Grading System of Cell Motility: Prospective Validation in the Dunning R-3327 Prostatic Adenocarcinoma Model

James L. Mohler, Alan W. Partin, John T. Isaacs, and Donald S. Coffey
Cancer Res 1988 48: 4312-4317. [Abstract] [PDF]  

Multiparametric Evaluation (SAMBA) of Growth Fraction (Monoclonal Ki67) in Breast Carcinoma Tissue Sections

Colette Charpin, Lucile Andrac, Hélène Vacheret, Marie Christine Habib, Bénédicte Devictor, Marie Noëlle Lavaut, and Maurice Toga
Cancer Res 1988 48: 4368-4374. [Abstract] [PDF]  

Extrapulmonary, Tissue-specific Metastasis Formation in Nude Mice Injected with FEMX-I Human Melanoma Cells

Øystein Fodstad, Inge Kjønniksen, Steinar Aamdal, Jahn M. Nesland, Michael R. Boyd, and Alexander Pihl
Cancer Res 1988 48: 4382-4388. [Abstract] [PDF]  

Differentiation-induced ML-1 Cells as Targets for Transformation by a Chemical Carcinogen

X-P. Guan and A. Bloch
Cancer Res 1988 48: 4389-4394. [Abstract] [PDF]  

Molecular Biology and Genetics:

Indistinguishable Patterns of Protooncogene Expression in Two Distinct but Closely Related Tumors: Ewing's Sarcoma and Neuroepithelioma

Catherine McKeon, Carol J. Thiele, Robert A. Ross, Michael Kwan, Timothy J. Triche, James S. Miser, and Mark A. Israel
Cancer Res 1988 48: 4307-4311. [Abstract] [PDF]  

In Situ Hybridization Analysis of Acquisition and Loss of the Human Multidrug-Resistance Gene

Ding-Wu Shen, Ira Pastan, and Michael M. Gottesman
Cancer Res 1988 48: 4334-4339. [Abstract] [PDF]  

Immunology:

Tumor-associated Membrane Sialoglycoprotein on Human Small Cell Lung Carcinoma Identified by the IgG2a Monoclonal Antibody SWA20

Robert Waibel, Carl J. O'Hara, Alan Smith, and Rolf A. Stahel
Cancer Res 1988 48: 4318-4323. [Abstract] [PDF]  

Localization and Imaging of Radiolabeled Monoclonal Antibodies against Colorectal Carcinoma in Tumor-bearing Nude Mice

Donald Buchsbaum, Ricardo Lloyd, Jack Juni, Ira Wollner, Pamela Brubaker, David Hanna, Judith Spicker, Felissa Burns, Zenon Steplewski, David Colcher, Jeffrey Schlom, Franz Buchegger, and Jean-Pierre Mach
Cancer Res 1988 48: 4324-4333. [Abstract] [PDF]  

Immunoglobulin G3 Monoclonal Antibody Directed to Tn Antigen (Tumor-associated -N-Acetylgalactosaminyl Epitope) That Does Not Cross-React with Blood Group A Antigen

Hélio K. Takahashi, Rikiya Metoki, and Sen-itiroh Hakomori
Cancer Res 1988 48: 4361-4367. [Abstract] [PDF]  

Epidemiological:

Colorectal Cancer Risk, Chronic Illnesses, Operations, and Medications: Case Control Results from the Melbourne Colorectal Cancer Study

Gabriel A. Kune, Susan Kune, and Lyndsey F. Watson
Cancer Res 1988 48: 4399-4404. [Abstract] [PDF]  

Bladder Cancer in Relation to Cigarette Smoking

Annamma Augustine, James R. Hebert, Geoffrey C. Kabat, and Ernst L. Wynder
Cancer Res 1988 48: 4405-4408. [Abstract] [PDF]  

Clinical:

Laboratory Correlates of Adoptive Immunotherapy with Recombinant Interleukin-2 and Lymphokine-activated Killer Cells in Humans

D. H. Boldt, B. J. Mills, B. T. Gemlo, H. Holden, J. Mier, E. Paietta, J. D. McMannis, L. V. Escobedo, I. Sniecinski, A. A. Rayner, M. J. Hawkins, M. B. Atkins, N. Ciobanu, and T. M. Ellis
Cancer Res 1988 48: 4409-4416. [Abstract] [PDF]  

Immunospecific Saturable Clearance Mechanisms for Indium-111-labeled Anti-Melanoma Monoclonal Antibody 96.5 in Humans

James L. Murray, Lamk M. Lamki, Linda J. Shanken, Mary E. Blake, Carl E. Plager, Robert S. Benjamin, Sally Schweighardt, Michael W. Unger, and Michael G. Rosenblum
Cancer Res 1988 48: 4417-4422. [Abstract] [PDF]  

Acodazole Hydrochloride: Phase I Trial, Pharmacokinetics, and Evaluation of Cardiotoxicity in Dogs

Richard Pazdur, Guy G. Chabot, Colin A. Campbell, Michael H. Lehmann, Robert A. Kloner, and Laurence H. Baker
Cancer Res 1988 48: 4423-4426. [Abstract] [PDF]  

Activity of the Human Blood Group ABO, Se, H, Le, and X Gene-encoded Glycosyltransferases in Normal and Malignant Bladder Urothelium

Torben F. Ørntoft, Hans Wolf, and Winifred M. Watkins
Cancer Res 1988 48: 4427-4433. [Abstract] [PDF]  

Meeting Report:

Seventh Annual Sapporo Cancer Seminar: Primary and Secondary Prevention of Cancer

Cancer Res 1988 48: 4434-4436. [PDF]  

Articles:

Announcements

Cancer Res 1988 48: 4437-4438. [PDF]  

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