Perspectives in Cancer Research:

Acid pH in Tumors and Its Potential for Therapeutic Exploitation

Ian F. Tannock and Daniela Rotin
Cancer Res 1989 49: 4373-4384. [Abstract] [PDF]  

Basic Sciences:

DNA Topoisomerase I-mediated DNA Cleavage and Cytotoxicity of Camptothecin Analogues

Yaw-Huei Hsiang, Leroy F. Liu, Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindar Manikumar, Stanley Kirschenbaum, Robert Silber, and Milan Potmesil
Cancer Res 1989 49: 4385-4389. [Abstract] [PDF]  

Comparison of in Vivo Activation of Triamcinolone Acetonide- and RU 38486-Receptor Complexes in the CEM-C7 and IM-9 Human Leukemic Cell Lines

Thomas J. Schmidt
Cancer Res 1989 49: 4390-4395. [Abstract] [PDF]  

Significant Increase in the Antibody to Gal1-3Gal Structure in Sera of Patients with Hepatocellular Carcinoma after Transcatheter Arterial Embolization

Masuo Kashiwagi, Yusei Ikeda, Masao Iwamori, Gotaro Toda, and Yoshitaka Nagai
Cancer Res 1989 49: 4396-4401. [Abstract] [PDF]  

Loss of Constitutional Heterozygosity in Colorectal Tumors from Patients with Familial Polyposis Coli and Those with Nonpolyposis Colorectal Carcinoma

Masayuki Sasaki, Mieko Okamoto, Chieko Sato, Kenji Sugio, Jun-ichi Soejima, Takeo Iwama, Tatsuro Ikeuchi, Akira Tonomura, Michiko Miyaki, and Takehiko Sasazuki
Cancer Res 1989 49: 4402-4406. [Abstract] [PDF]  

Identification of Sulfate and Glucuronic Acid Conjugates of the 5-Hydroxy Derivative as Major Metabolites of 2-Amino-3-methylimidazo[4,5-f]quinoline in Rats

Howard J. Luks, Thomas E. Spratt, M. Thaddeus Vavrek, Suzanne F. Roland, and John H. Weisburger
Cancer Res 1989 49: 4407-4411. [Abstract] [PDF]  

Relationship of Spontaneous Regional Lymph Node Metastases to Dose of Local Irradiation of Primary B16 Melanomas

S. David Nathanson, Patricia Westrick, Patricia Anaya, Fred W. Hetzel, and Gordon Jacobsen
Cancer Res 1989 49: 4412-4416. [Abstract] [PDF]  

Modification of myc Gene Amplification in Human Somatic Cell Hybrids

Deborah S. Iman and Jerry W. Shay
Cancer Res 1989 49: 4417-4422. [Abstract] [PDF]  

Inotropic and Vasoactive Drug Treatment of Interleukin 2 Induced Hypotension in Sheep

Stuart Zeilender, Donald Davis, R. Paul Fairman, and Frederick L. Glauser
Cancer Res 1989 49: 4423-4426. [Abstract] [PDF]  

In Vitro Neoplastic Progression of Rat Tracheal Epithelial Cells Transformed by Diverse Carcinogens

Cheryl Walker and Paul Nettesheim
Cancer Res 1989 49: 4427-4430. [Abstract] [PDF]  

In Vitro Evaluation of 6-Thioguanine and -Interferon as a Therapeutic Combination in HL-60 and Natural Killer Cells

Yu Ying Tan, Lois B. Epstein, and R. Douglas Armstrong
Cancer Res 1989 49: 4431-4434. [Abstract] [PDF]  

Effects of the pH Dependence of 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide-Formazan Absorption on Chemosensitivity Determined by a Novel Tetrazolium-based Assay

Jane A. Plumb, R. Milroy, and S.B. Kaye
Cancer Res 1989 49: 4435-4440. [Abstract] [PDF]  

Correlation of Ether Lipid Content of Human Leukemia Cell Lines and Their Susceptibility to 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine

Marie C. Chabot, Robert L. Wykle, Edward J. Modest, and Larry W. Daniel
Cancer Res 1989 49: 4441-4445. [Abstract] [PDF]  

Comparison of DNA Adducts and Sister Chromatid Exchange in Lung Cancer Cases and Controls

F. Perera, J. Mayer, A. Jaretzki, S. Hearne, D. Brenner, T. L. Young, H. K. Fischman, M. Grimes, S. Grantham, M. X. Tang, W-Y. Tsai, and R. M. Santella
Cancer Res 1989 49: 4446-4451. [Abstract] [PDF]  

Resistance to Etoposide Induced by Three Glucose-regulated Stresses in Chinese Hamster Ovary Cells

Christine S. Hughes, Jun Wen Shen, and John R. Subjeck
Cancer Res 1989 49: 4452-4454. [Abstract] [PDF]  

Synthetic Lipid Second Messenger sn-1,2-Didecanoylglycerol: A Complete Tumor Promoter in Mouse Skin

Robert C. Smart, Kevin J. Mills, Laura A. Hansen, and Allan H. Conney
Cancer Res 1989 49: 4455-4458. [Abstract] [PDF]  

Purification and Further Characterization of a Non-Tumor Necrosis Factor or ß Differentiation-inducing Cytokine, P48

Julie A. Leftwich and Robert E. Hall
Cancer Res 1989 49: 4459-4465. [Abstract] [PDF]  

Comparative Antitumor Properties in Rodents of Irreversible Inhibitors of L-Ornithine Decarboxylase, Used as Such or as Prodrugs

Nicole Claverie and Pierre S. Mamont
Cancer Res 1989 49: 4466-4471. [Abstract] [PDF]  

Chemopreventive Efficacy of Combined Retinoid and Tamoxifen Treatment following Surgical Excision of a Primary Mammary Cancer in Female Rats

Thomas A. Ratko, Carol J. Detrisac, Nancy M. Dinger, Cathy F. Thomas, Gary J. Kelloff, and Richard C. Moon
Cancer Res 1989 49: 4472-4476. [Abstract] [PDF]  

Reduction of Intracellular pH as a Possible Mechanism for Killing Cells in Acidic Regions of Solid Tumors: Effects of Carbonylcyanide-3-chlorophenylhydrazone

Ken J. Newell and Ian F. Tannock
Cancer Res 1989 49: 4477-4482. [Abstract] [PDF]  

Induction of Protein Kinase C in Mouse Melanoma Cells by Retinoic Acid

Richard M. Niles and Barbara P. Loewy
Cancer Res 1989 49: 4483-4487. [Abstract] [PDF]  

Rearrangement of T-Cell Receptor Chain Gene as a Marker of Lineage and Clonality in T-Cell Lymphoproliferative Disorders

Nobuhiro Kimura, Yoshihiro Takihara, Tomi Akiyoshi, Takahisa Yoshida, Koichi Ohshima, Takashi Kawara, Shusuke Hisano, Mitsuo Kozuru, Makoto Okumura, and Masahiro Kikuchi
Cancer Res 1989 49: 4488-4492. [Abstract] [PDF]  

Modulation of Diamide Toxicity in Thermotolerant Cells by Inhibition of Protein Synthesis

Michael L. Freeman and Michael J. Meredith
Cancer Res 1989 49: 4493-4498. [Abstract] [PDF]  

Characterization of a K562 Multidrug-resistant Cell Line

Saul Yanovich, Robert E. Hall, and David A. Gewirtz
Cancer Res 1989 49: 4499-4503. [Abstract] [PDF]  

Comparison of Sister Chromatid Exchanges in Spleen and Thymus Lymphocytes from AKR, C57BL/6N x DBA/2J F₁, and CBA Mice following in Vivo Exposure to N-Methyl-N-nitrosourea

Robin E. Neft, Henry M. Schol, and Daniel A. Casciano
Cancer Res 1989 49: 4504-4508. [Abstract] [PDF]  

Drug Treatments for Metastasis of the Lewis Lung Carcinoma: Lack of Correlation between Inhibition of Lung Metastasis and Survival

Ronald L. Merriman, Katherine A. Shackelford, Lee R. Tanzer, Jack B. Campbell, Kerry G. Bemis, and Ken Matsumoto
Cancer Res 1989 49: 4509-4516. [Abstract] [PDF]  

Biochemical and Growth Inhibitory Effects of the erythro and threo Isomers of -Fluoromethotrexate, a Methotrexate Analogue Defective in Polyglutamylation

John J. McGuire, Michael Graber, Nicholas Licato, Claudius Vincenz, James K. Coward, Zenia Nimec, and John Galivan
Cancer Res 1989 49: 4517-4525. [Abstract] [PDF]  

Isolation of Two Chinese Hamster Ovary Cell Mutants Hypersensitive to Topoisomerase II Inhibitors and Cross-Resistant to Peroxides

Stella M. Davies, Sally L. Davies, Adrian L. Harris, and Ian D. Hickson
Cancer Res 1989 49: 4526-4530. [Abstract] [PDF]  

Structure-dependent Induction of Aryl Hydrocarbon Hydroxylase in Human Breast Cancer Cell Lines and Characterization of the Ah Receptor

M. Harris, J. Piskorska-Pliszczynska, T. Zacharewski, M. Romkes, and S. Safe
Cancer Res 1989 49: 4531-4535. [Abstract] [PDF]  

Tumor-reactive Human Immunoglobulin G Monoclonal Antibody from a Melanoma Patient

June Kan-Mitchell, Wain L. White, and Malcolm S. Mitchell
Cancer Res 1989 49: 4536-4541. [Abstract] [PDF]  

Multidrug Resistance in Mitoxantrone-selected HL-60 Leukemia Cells in the Absence of P-Glycoprotein Overexpression

W. Graydon Harker, D. Lynn Slade, William S. Dalton, Paul S. Meltzer, and Jeffrey M. Trent
Cancer Res 1989 49: 4542-4549. [Abstract] [PDF]  

ABH Blood Group Antigen Expression, Synthesis, and Degradation in Human Colonic Adenocarcinoma Cell Lines

Rajvir Dahiya, Steven H. Itzkowitz, James C. Byrd, and Young S. Kim
Cancer Res 1989 49: 4550-4556. [Abstract] [PDF]  

Comparative Morphometric Study of Tumor Vasculature in Human Squamous Cell Carcinomas and Their Xenotransplants in Athymic Nude Mice

S. Lauk, A. Zietman, S. Skates, R. Fabian, and H. D. Suit
Cancer Res 1989 49: 4557-4561. [Abstract] [PDF]  

Detection of Ki-ras Messenger RNA in Normal and Chemically Transformed Hamster Oral Keratinocytes

David T. W. Wong, Robert Gertz, Phoebe Chow, Allen L. C. Chang, Jim McBride, Tao Chiang, Karekine Matossian, George Gallagher, and Gerald Shklar
Cancer Res 1989 49: 4562-4567. [Abstract] [PDF]  

Two New Monoclonal Antibodies, EPB-1 and EPB-2, Reactive with Human Lymphoma

Elizabeth J. Pawlak-Byczkowska, Hans J. Hansen, Arnold S. Dion, and David M. Goldenberg
Cancer Res 1989 49: 4568-4577. [Abstract] [PDF]  

Tumor Necrosis Treatment of ME-180 Human Cervical Carcinoma Model with ¹³¹I-Labeled TNT-1 Monoclonal Antibody

Feng-Ming Chen, Clive R. Taylor, and Alan L. Epstein
Cancer Res 1989 49: 4578-4585. [Abstract] [PDF]  

Effects of Oral versus Topical Administration of Cyclosporine on Phorbol Ester Promotion of Murine Epidermal Carcinogenesis

Kinichi Yokota, Thomas J. Gill, III, and Hisashi Shinozuka
Cancer Res 1989 49: 4586-4590. [Abstract] [PDF]  

Alterations in Langerhans Cells and Thy-1⁺ Dendritic Epidermal Cells in Murine Epidermis during the Evolution of Ultraviolet Radiation-induced Skin Cancers

Joseph Alcalay, Janet N. Craig, and Margaret L. Kripke
Cancer Res 1989 49: 4591-4596. [Abstract] [PDF]  

Importance of Lyt 2⁺ T-Cells in the Curative Effectiveness of a Low Dose of Melphalan for Mice Bearing a Large MOPC-315 Tumor

Margalit B. Mokyr, Edward Barker, Larry M. Weiskirch, Blaine Y. Takesue, and Joseph M. Pyle
Cancer Res 1989 49: 4597-4606. [Abstract] [PDF]  

Intracellular Distribution and Pharmacokinetics of Daunorubicin in Anthracycline-sensitive and -resistant HL-60 Cells

Alexander A. Hindenburg, James E. Gervasoni, Jr., Sindu Krishna, Valerie J. Stewart, Michelle Rosado, Jose Lutzky, Kapil Bhalla, Michael A. Baker, and Robert N. Taub
Cancer Res 1989 49: 4607-4614. [Abstract] [PDF]  

Expression of Type IV Collagenase and Procollagen Genes and Its Correlation with the Tumorigenic, Invasive, and Metastatic Abilities of Oncogene-transformed Human Bronchial Epithelial Cells

Hitoshi Ura, R. Daniel Bonfil, Reuven Reich, Roger Reddel, Andrea Pfeifer, Curtis C. Harris, and Andres J. P. Klein-Szanto
Cancer Res 1989 49: 4615-4621. [Abstract] [PDF]  

Clinical and Epidemiological Investigations:

Case-Control Study of Female Hormones and Eye Melanoma

Patricia Hartge, Margaret A. Tucker, Jerry A. Shields, James Augsburger, Robert N. Hoover, and Joseph F. Fraumeni, Jr.
Cancer Res 1989 49: 4622-4625. [Abstract] [PDF]  

Chromosome Sensitivity to Bleomycin-induced Mutagenesis, an Independent Risk Factor for Upper Aerodigestive Tract Cancers

Margaret R. Spitz, John J. Fueger, Nancy A. Beddingfield, John F. Annegers, T. C. Hsu, Guy R. Newell, and Stimson P. Schantz
Cancer Res 1989 49: 4626-4628. [Abstract] [PDF]  

Biochemical Epidemiology of Colon Cancer: Effect of Types of Dietary Fiber on Fecal Mutagens, Acid, and Neutral Sterols in Healthy Subjects

Bandaru Reddy, Althea Engle, Spiros Katsifis, Barbara Simi, Hans-Peter Bartram, Peter Perrino, and Clare Mahan
Cancer Res 1989 49: 4629-4635. [Abstract] [PDF]  

Phase I Trial of N-(Phosphonacetyl)-L-aspartate, Methotrexate, and 5-Fluorouracil with Leucovorin Rescue in Patients with Advanced Cancer

Nancy Kemeny, Andrew Schneider, Daniel S. Martin, Joseph Colofiore, Robert C. Sawyer, Susan Derby, and Barbara Salvia
Cancer Res 1989 49: 4636-4639. [Abstract] [PDF]  

Phase I and Pharmacodynamic Study of Taxol in Refractory Acute Leukemias

Eric K. Rowinsky, Philip J. Burke, Judith E. Karp, Robert W. Tucker, David S. Ettinger, and Ross C. Donehower
Cancer Res 1989 49: 4640-4647. [Abstract] [PDF]  

Phase I Clinical and Pharmacokinetic Trial of Brequinar Sodium (DUP 785; NSC 368390)

Carlos L. Arteaga, Thomas D. Brown, John G. Kuhn, Huey-Shin L. Shen, Timothy J. O'Rourke, Kenneth Beougher, H. James Brentzel, Daniel D. Von Hoff, and Geoffrey R. Weiss
Cancer Res 1989 49: 4648-4653. [Abstract] [PDF]  

High-Dose Cyclophosphamide or Melphalan with Escalating Doses of Mitoxantrone and Autologous Bone Marrow Transplantation for Refractory Solid Tumors

Paula O. M. Mulder, Dirk T. Sleijfer, Pax H. B. Willemse, Elisabeth G. E. de Vries, Donald R. A. Uges, and Nanno H. Mulder
Cancer Res 1989 49: 4654-4658. [Abstract] [PDF]  

Elimination of Malignant Clonogenic Breast Cancer Cells from Human Bone Marrow

Ian C. Anderson, Elizabeth J. Shpall, David S. Leslie, Kjell Nustad, John Ugelstad, William P. Peters, and Robert C. Bast, Jr.
Cancer Res 1989 49: 4659-4664. [Abstract] [PDF]  

Activation of Tumoricidal Properties in Monocytes from Cancer Patients following Intravenous Administration of Liposomes Containing Muramyl Tripeptide Phosphatidylethanolamine

Eugenie S. Kleinerman, James L. Murray, John S. Snyder, Joan E. Cunningham, and Isaiah J. Fidler
Cancer Res 1989 49: 4665-4670. [Abstract] [PDF]  

Letter to the Editor:

Correspondence re: Michael A. Bender et al., Normal G₂ Chromosomal Radiosensitivity and Cell Survival in the Cancer Family Syndrome. Cancer Res., 48: 2579–2584, 1988.

Katherine K. Sanford, Ram Parshad, and Robert E. Tarone
Cancer Res 1989 49: 4671-4672. [PDF]  

Correspondence re: Michael A. Bender et al., Normal G₂ Chromosomal Radiosensitivity and Cell Survival in the Cancer Family Syndrome. Cancer Res., 48: 2579–2584, 1988—Reply

Michael A. Bender and Michael V. Viola
Cancer Res 1989 49: 4672-4673. [PDF]  

Articles:

Announcements

Cancer Res 1989 49: 4674-4675. [PDF]  

Calendar of Events

Cancer Res 1989 49: 4675 [PDF]  

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