Announcement:

Third Conference on Radioimmunodetection and Radioimmunotherapy of Cancer: Princeton, New Jersey, November 15–17, 1990

Cancer Res 1990 50: NP [PDF]  

Articles:

Introduction to the Second Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

David M. Goldenberg
Cancer Res 1990 50: 778s-779s. [PDF]  

Radiochemistry of Antibodies:

Development of Radiochemically Pure Antibodies

W. C. Eckelman
Cancer Res 1990 50: 780s-782s. [Abstract] [PDF]  

Improving the Tumor Retention of Radioiodinated Antibody: Aryl Carbohydrate Adducts

Seham A. Ali, Stephen D. Warren, Karen Y. Richter, Christopher C. Badger, Janet F. Eary, Oliver W. Press, Kenneth A. Krohn, Irwin D. Bernstein, and Wil B. Nelp
Cancer Res 1990 50: 783s-788s. [Abstract] [PDF]  

Stable Bifunctional Chelates of Metals Used in Radiotherapy

Min K. Moi, Sally J. DeNardo, and Claude F. Meares
Cancer Res 1990 50: 789s-793s. [Abstract] [PDF]  

Preclinical Evaluation of an "Instant" ^99mTc-labeling Kit for Antibody Imaging

Hans J. Hansen, Anastasia L. Jones, Robert M. Sharkey, Ruth Grebenau, Nancy Blazejewski, Arthur Kunz, Michael J. Buckley, Edward S. Newman, Frank Ostella, and David M. Goldenberg
Cancer Res 1990 50: 794s-798s. [Abstract] [PDF]  

^99mTc Labeling of Proteins: Initial Evaluation of a Novel Diaminedithiol Bifunctional Chelating Agent

Kwamena E. Baidoo, Ursula Scheffel, and Susan Z. Lever
Cancer Res 1990 50: 799s-803s. [Abstract] [PDF]  

Disulfide Bond-targeted Radiolabeling: Tumor Specificity of a Streptavidinbiotinylated Monoclonal Antibody Complex

Renato B. del Rosario and Richard L. Wahl
Cancer Res 1990 50: 804s-808s. [Abstract] [PDF]  

Experimental Studies of Radioimmunodetection:

Experimental Studies of Radioimmunodetection of Cancer: An Overview

Howard Sands
Cancer Res 1990 50: 809s-813s. [Abstract] [PDF]  

Physiological Barriers to Delivery of Monoclonal Antibodies and Other Macromolecules in Tumors

Rakesh K. Jain
Cancer Res 1990 50: 814s-819s. [Abstract] [PDF]  

Innovations That Influence the Pharmacology of Monoclonal Antibody Guided Tumor Targeting

Jeffrey Schlom, Patricia Horan Hand, John W. Greiner, David Colcher, Shashi Shrivastav, Jorge A. Carrasquillo, James C. Reynolds, Steven M. Larson, and Andrew Raubitschek
Cancer Res 1990 50: 820s-827s. [Abstract] [PDF]  

Comparison of Tumor Targeting in Nude Mice by Murine Monoclonal Antibodies Directed against Different Human Colorectal Cancer Antigens

Robert M. Sharkey, David V. Gold, Rosarito Aninipot, Rae Vagg, Cathy Ballance, Edward S. Newman, Frank Ostella, Hans J. Hansen, and David M. Goldenberg
Cancer Res 1990 50: 828s-834s. [Abstract] [PDF]  

Pharmacokinetics of ^99mTc-Metallothionein-B72.3 and Its F(ab')₂ Fragment

Beverly A. Brown, Cynthia B. Dearborn, Cynthia A. Drozynski, and Howard Sands
Cancer Res 1990 50: 835s-839s. [Abstract] [PDF]  

Mechanisms of Tissue Uptake and Metabolism of Radiolabeled Antibody—Role of Antigen:Antibody Complex Formation

J. David Beatty, Barbara G. Beatty, Margaret O'Conner-Tressel, Tulan Do, and Raymond J. Paxton
Cancer Res 1990 50: 840s-845s. [Abstract] [PDF]  

Mechanism of Decreasing Liver Uptake of ¹¹¹In-labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody by Specific Antibody Pretreatment in Tumor Bearing Mice

Barbara G. Beatty, Margaret O'Conner-Tressel, Tulan Do, Raymond J. Paxton, and J. David Beatty
Cancer Res 1990 50: 846s-851s. [Abstract] [PDF]  

Uptake and Metabolism of ¹¹¹In-labeled Monoclonal Antibody B6.2 by the Rat Liver

Peter L. Jones, Beverly A. Brown, and Howard Sands
Cancer Res 1990 50: 852s-856s. [Abstract] [PDF]  

Site-specifically Radioiodinated Antibody for Targeting Tumors

Douglas W. Rea, Michiel E. Ultee, Benjamin A. Belinka, Jr., Daniel J. Coughlin, and Vernon L. Alvarez
Cancer Res 1990 50: 857s-861s. [Abstract] [PDF]  

Radiolocalization of Monoclonal Antibodies in Hepatic Metastases from Human Colon Cancer in Congenitally Athymic Mice

Kazuhiko Yoshida, Michel Rivoire, Chaitanya Divgi, Sydney Welt, Alfred M. Cohen, and Elin R. Sigurdson
Cancer Res 1990 50: 862s-865s. [Abstract] [PDF]  

Monoclonal Antibody Targeting of Human Non-Small Cell Carcinoma of the Lung

Rhona Stein, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1990 50: 866s-868s. [Abstract] [PDF]  

Carcinoembryonic Antigen and -Fetoprotein Expression and Monoclonal Antibody Targeting in a Human Hepatoma/Nude Mouse Model

Zhifu F. Wang, Rhona Stein, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1990 50: 869s-872s. [Abstract] [PDF]  

Comparative Pharmacokinetics of a Murine Monoclonal Antibody to a Rat Colon Tumor in Rats and Nude Mice

Jorge Laborda, Jean-Yves Douillard, Elaine F. Lizzio, and Thomas Hoffman
Cancer Res 1990 50: 873s-876s. [Abstract] [PDF]  

Radioimmunodetection of Hepatic Metastases from Human Colon Cancer in Nude Mice with a Gamma-detecting Probe

Michel Rivoire, Kazuhiko Yoshida, Chaitanya Divgi, Sydney Welt, Alfred Cohen, and Elin R. Sigurdson
Cancer Res 1990 50: 877s-879s. [Abstract] [PDF]  

Patterns of Antigen Distribution in Human Carcinomas

M. Jules Mattes, Pierre P. Major, David M. Goldenberg, Arnold S. Dion, Robert V. P. Hutter, and Kenneth M. Klein
Cancer Res 1990 50: 880s-884s. [Abstract] [PDF]  

Use of Whole-Body Autoradiography in Cancer Targeting with Radiolabeled Antibodies

Irwin Fand, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1990 50: 885s-891s. [Abstract] [PDF]  

Clinical Studies of Radioimmunodetection:

Clinical Radioimmunodetection, 1978–1988: Overview and Suggestions for Standardization of Clinical Trials

Steven M. Larson
Cancer Res 1990 50: 892s-898s. [Abstract] [PDF]  

Tumor Immunoscintigraphy by Means of Radiolabeled Monoclonal Antibodies: Multicenter Studies of the Italian National Research Council—Special Project "Biomedical Engineering"

Antonio G. Siccardi
Cancer Res 1990 50: 899s-903s. [Abstract] [PDF]  

Radioimaging of Melanoma Using ^99mTc-labeled Fab Fragment Reactive with a High Molecular Weight Melanoma Antigen

Lamk M. Lamki, Alexander A. Zukiwski, L. Joy Shanken, Sewa S. Legha, Robert S. Benjamin, Carl E. Plager, Darrell F. Salk, Robert W. Schroff, and James L. Murray
Cancer Res 1990 50: 904s-908s. [Abstract] [PDF]  

Clinical Studies of Cancer Radioimmunodetection with Carcinoembryonic Antigen Monoclonal Antibody Fragments Labeled with ¹²³I or ^99mTc

David M. Goldenberg, Hildegard Goldenberg, Robert M. Sharkey, Edith Higginbotham-Ford, Robert E. Lee, Lawrence C. Swayne, Karen A. Burger, Diane Tsai, Jo Ann Horowitz, Thomas C. Hall, Carl M. Pinsky, and Hans J. Hansen
Cancer Res 1990 50: 909s-921s. [Abstract] [PDF]  

Presurgical Imaging with Indium-labeled Anti-Carcinoembryonic Antigen for Colon Cancer Staging

J. David Beatty, Lawrence E. Williams, David Yamauchi, Blaine A. Morton, L. Robert Hill, Barbara G. Beatty, Raymond J. Paxton, Bruce Merchant, and John E. Shively
Cancer Res 1990 50: 922s-926s. [Abstract] [PDF]  

Breast Tumor Radioimmunodetection with a ¹¹¹In-labeled Monoclonal Antibody (MA5) against a Mucin-like Antigen

Pierre P. Major, Arnold S. Dion, Charlene J. Williams, M. Jules Mattes, Taqui Wang, and Leonard Rosenthall
Cancer Res 1990 50: 927s-931s. [Abstract] [PDF]  

Human Biodistribution of ¹¹¹In-labeled B72.3 Monoclonal Antibody

Steven J. Harwood, Robert G. Carroll, William B. Webster, Linda M. Zangara, David L. Laven, Michele A. Morrissey, and Barbara J. Sinni
Cancer Res 1990 50: 932s-936s. [Abstract] [PDF]  

Immunolymphoscintigraphy and Immunoscintigraphy of Ovarian and Fallopian Tube Cancer Using F(ab')₂ Fragments of Monoclonal Antibody OC 125

Pentti Lehtovirta, Kalevi J. A. Kairemo, Kristian Liewendahl, and Markku Seppälä
Cancer Res 1990 50: 937s-940s. [Abstract] [PDF]  

Lymphoscintigraphy in Melanoma: Initial Evaluation of a Low Protein Dose Monoclonal Antibody Cocktail

Richard L. Wahl, Monica Liebert, John Headington, Barry S. Wilson, Barry L. Shulkin, Jon W. Johnson, Shirley Mallette, Ronald B. Natale, William Coon, Mary East, Robertson Davenport, M. B. Brown, John T. Niederhuber, and Neil A. Swanson
Cancer Res 1990 50: 941s-948s. [Abstract] [PDF]  

Immunolymphoscintigraphy with ^99mTc-labeled Monoclonal Antibody (BW 431/26) Reacting with Carcinoembryonic Antigen in Breast Cancer

Kalevi J. A. Kairemo
Cancer Res 1990 50: 949s-954s. [Abstract] [PDF]  

Radioimmunodetection in Rhabdo- and Leiomyosarcoma with ¹¹¹In-Anti-Myosin Monoclonal Antibody Complex

André Planting, Jaap Verweij, Peter Cox, Mike Pillay, and Gerrit Stoter
Cancer Res 1990 50: 955s-957s. [Abstract] [PDF]  

Detection of Thrombophlebitis with ¹¹¹In-labeled Anti-Fibrin Antibody: Preliminary Results

Abass Alavi, Naresh Gupta, Harold I. Palevsky, Mark A. Kelley, Allison D. Jatlow, Ann A. Byar, and Harvey J. Berger
Cancer Res 1990 50: 958s-961s. [Abstract] [PDF]  

Prospects for Therapy, I: Experimental:

Radioimmunotherapy in Experimental Animal Models: Principles Derived from Models

David A. Scheinberg and Mette Strand
Cancer Res 1990 50: 962s-963s. [Abstract] [PDF]  

Biological Considerations for Radioimmunotherapy

Robert M. Sharkey, Rosalyn D. Blumenthal, Hans J. Hansen, and David M. Goldenberg
Cancer Res 1990 50: 964s-969s. [Abstract] [PDF]  

Current Status of Animal Radioimmunotherapy

Barry W. Wessels
Cancer Res 1990 50: 970s-973s. [Abstract] [PDF]  

Targeting and Therapy of Human Glioma Xenografts in Vivo Utilizing Radiolabeled Antibodies

Jeffery A. Williams, Barry W. Wessels, James A. Edwards, Kenneth A. Kopher, Philip M. Wanek, Moody D. Wharam, Stanley E. Order, and Jerry L. Klein
Cancer Res 1990 50: 974s-979s. [Abstract] [PDF]  

Imaging and Therapy of Small Cell Carcinoma Xenografts Using ¹³¹I-labeled Monoclonal Antibody SWA11

Alan Smith, Peter Groscurth, Robert Waibel, Gerrit Westera, and Rolf A. Stahel
Cancer Res 1990 50: 980s-984s. [Abstract] [PDF]  

Radioimmunotherapy of Peritoneal Human Colon Cancer Xenografts with Site-specifically Modified ²¹²Bi-labeled Antibody

R. Bruce Simonson, Michiel E. Ultee, Jo A. Hauler, and Vernon L. Alvarez
Cancer Res 1990 50: 985s-988s. [Abstract] [PDF]  

Radioimmunotherapy of Human Colon Carcinomatosis Xenograft with ⁹⁰Y-ZCE025 Monoclonal Antibody: Toxicity and Tumor Phenotype Studies

Jose M. Esteban, David M. Hyams, Barbara G. Beatty, Bruce Merchant, and J. David Beatty
Cancer Res 1990 50: 989s-992s. [Abstract] [PDF]  

Comparative Binding and Preclinical Localization and Therapy Studies with Radiolabeled Human Chimeric and Murine 17-1A Monoclonal Antibodies

Donald J. Buchsbaum, Pamela G. Brubaker, David E. Hanna, Arthur A. Glatfelter, Valeri H. Terry, Dianne M. Guilbault, and Zenon Steplewski
Cancer Res 1990 50: 993s-999s. [Abstract] [PDF]  

Tumor Spheroid Model for the Biologically Targeted Radiotherapy of Neuroblastoma Micrometastases

K. A. Walker, R. Mairs, T. Murray, T. E. Hilditch, T. E. Wheldon, A. Gregor, and I. M. Hann
Cancer Res 1990 50: 1000s-1002s. [Abstract] [PDF]  

Use of Hematopoietic Growth Factors to Control Myelosuppression Caused by Radioimmunotherapy

R. D. Blumenthal, R. M. Sharkey, L. M. Quinn, and D. M. Goldenberg
Cancer Res 1990 50: 1003s-1007s. [Abstract] [PDF]  

Role of Bone Marrow Transplantation in ⁹⁰Y Antibody Therapy of Colon Cancer Xenografts in Nude Mice

Blaine A. Morton, Barbara G. Beatty, Angeles P. Mison, Philip M. Wanek, and J. David Beatty
Cancer Res 1990 50: 1008s-1010s. [Abstract] [PDF]  

Prospects for Therapy, II: Clinical:

Radiolabeled Antibodies: Results and Potential in Cancer Therapy

S. E. Order, A. M. Sleeper, G. B. Stillwagon, J. L. Klein, and P. K. Leichner
Cancer Res 1990 50: 1011s-1013s. [Abstract] [PDF]  

Fractionated Radioimmunotherapy of B-Cell Malignancies with ¹³¹I-Lym-1

Gerald L. DeNardo, Sally J. DeNardo, Lois F. O'Grady, Norman B. Levy, Gregory P. Adams, and Stanley L. Mills
Cancer Res 1990 50: 1014s-1016s. [Abstract] [PDF]  

High Dose Radiolabeled Antibody Therapy of Lymphoma

Irwin D. Bernstein, Janet F. Eary, Christopher C. Badger, Oliver W. Press, Fredrick R. Appelbaum, Paul J. Martin, Kenneth A. Krohn, Wil B. Nelp, Bruce Porter, Darrell Fisher, Richard Miller, Sherrie Brown, Ronald Levy, and E. Donnall Thomas
Cancer Res 1990 50: 1017s-1021s. [Abstract] [PDF]  

Radioimmunotherapy of Human B-Cell Lymphoma with ⁹⁰Y-conjugated Antiidiotype Monoclonal Antibody

Barbara A. Parker, Artemios B. Vassos, Samuel E. Halpern, Richard A. Miller, Homer Hupf, Diane G. Amox, Joseph L. Simoni, Robin J. Starr, Mark R. Green, and Ivor Royston
Cancer Res 1990 50: 1022s-1028s. [Abstract] [PDF]  

Estimation of Monoclonal Antibody-associated ⁹⁰Y Activity Needed to Achieve Certain Tumor Radiation Doses in Colorectal Cancer Patients

Lawrence E. Williams, Barbara G. Beatty, J. David Beatty, Jeffrey Y. C. Wong, Raymond J. Paxton, and John E. Shively
Cancer Res 1990 50: 1029s-1030s. [Abstract] [PDF]  

Intraperitoneal Immunoconjugates

Thomas W. Griffin, Jeffrey Collins, Faran Bokhari, Mark Stochl, A. Bertrand Brill, Tsunao Ito, Georgette Emond, and Howard Sands
Cancer Res 1990 50: 1031s-1038s. [Abstract] [PDF]  

Tumor, Red Marrow, and Organ Dosimetry for ¹³¹I-labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody

Jeffry A. Siegel, David A. Pawlyk, Robert E. Lee, Norma L. Sasso, Jo Ann Horowitz, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1990 50: 1039s-1042s. [Abstract] [PDF]  

Dosimetric Model for Antibody Targeted Radionuclide Therapy of Tumor Cells in Cerebrospinal Fluid

W. T. Millar and A. Barrett
Cancer Res 1990 50: 1043s-1048s. [Abstract] [PDF]  

Host Responses and Complications:

Anticipating, Recognizing, and Preventing Hazards Associated with in Vivo Use of Monoclonal Antibodies: Special Considerations Related to Human Anti-Mouse Antibodies

Thomas Hoffman
Cancer Res 1990 50: 1049s-1050s. [Abstract] [PDF]  

Immunoglobulin Class and Immunoglobulin G Subclass Analysis of Human Anti-Mouse Antibody Response during Monoclonal Antibody Treatment of Cancer Patients

Herve M. Blottière, J. Y. Douillard, H. Koprowski, and Z. Steplewski
Cancer Res 1990 50: 1051s-1054s. [Abstract] [PDF]  

Human Immune Response to Anti-Carcinoembryonic Antigen Murine Monoclonal Antibodies

Michele J. Losman, Robert L. DeJager, Marc Monestier, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1990 50: 1055s-1058s. [Abstract] [PDF]  

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