Advances in Brief:

Expression of Mutated Epidermal Growth Factor Receptor by Non-Small Cell Lung Carcinomas

Irma E. Garcia de Palazzo, Gregory P. Adams, Padma Sundareshan, Albert J. Wong, Joseph R. Testa, Darell D. Bigner, and Louis M. Weiner
Cancer Res 1993 53: 3217-3220. [Abstract] [PDF]  

Localization of a Novel Multidrug Resistance-associated Gene in the HT1080/DR4 and H69AR Human Tumor Cell Lines

Marilyn L. Slovak, Jennifer Pelkey Ho, Gabu Bhardwaj, Ebba U. Kurz, Roger G. Deeley, and Susan P.C. Cole
Cancer Res 1993 53: 3221-3225. [Abstract] [PDF]  

The p53-binding Protein MDM2 Gene Is Differentially Expressed in Human Breast Carcinoma

M. Saeed Sheikh, Zhi-Ming Shao, Arif Hussain, and Joseph A. Fontana
Cancer Res 1993 53: 3226-3228. [Abstract] [PDF]  

MCF7/LCC2: A 4-Hydroxytamoxifen Resistant Human Breast Cancer Variant That Retains Sensitivity to the Steroidal Antiestrogen ICI 182,780

Nils Brünner, Thomas L. Frandsen, Claus Holst-Hansen, Mian Bei, Erik W. Thompson, Alan E. Wakeling, Marc E. Lippman, and Robert Clarke
Cancer Res 1993 53: 3229-3232. [Abstract] [PDF]  

Identification of a Cell-Surface Antigen (LEA.135) Associated with Favorable Prognosis in Human Breast Cancer

S. Ashraf Imam, Esperanza F. Esteban, Ren S. Chen, Robert D. Cardiff, and Clive R. Taylor
Cancer Res 1993 53: 3233-3236. [Abstract] [PDF]  

Effect of ERCC-1 Overexpression on Sensitivity of Chinese Hamster Ovary Cells to DNA Damaging Agents

Jonathan Bramson and Lawrence C. Panasci
Cancer Res 1993 53: 3237-3240. [Abstract] [PDF]  

Decreased E-Cadherin Immunoreactivity Correlates with Poor Survival in Patients with Bladder Tumors

Pierre Paul Bringuier, Rainy Umbas, H. Ewout Schaafsma, Herbert F. M. Karthaus, Frans M. J. Debruyne, and Jack A. Schalken
Cancer Res 1993 53: 3241-3245. [Abstract] [PDF]  

Preferential Induction of c-fos versus c-jun Protooncogene during the Immediate Early Response of Pig Skin to -Rays

Michèle Martin, Philippe Pinton, Françoise Crechet, Jean-Louis Lefaix, and François Daburon
Cancer Res 1993 53: 3246-3249. [Abstract] [PDF]  

Potent Intracellular Oxidative Stress Exerted by the Carcinogen 4-Nitroquinoline-N-oxide

Tatsuo Nunoshiba and Bruce Demple
Cancer Res 1993 53: 3250-3252. [Abstract] [PDF]  

Constitutive Overexpression of DNA Binding Activity to the Distal CCAAT Box of Human Thymidine Kinase Promoter in Human Tumor Cell Lines

Zee-Fen Chang and Su-Mei Cheng
Cancer Res 1993 53: 3253-3256. [Abstract] [PDF]  

A Mutant p53 Tumor Suppressor Protein Is a Target for Peptide-induced CD8⁺ Cytotoxic T-Cells

Michael Yanuck, David P. Carbone, C. David Pendleton, Taku Tsukui, Stefan F. Winter, John D. Minna, and Jay A. Berzofsky
Cancer Res 1993 53: 3257-3261. [Abstract] [PDF]  

Selective Enhancement of Vincristine Cytotoxicity in Multidrug-resistant Tumor Cells by Dilantin (Phenytoin)

Ram Ganapathi, Aleck Hercbergs, Dale Grabowski, and Jeanne Ford
Cancer Res 1993 53: 3262-3265. [Abstract] [PDF]  

Perspectives in Cancer Research:

Two Competing Influences That May Explain Concomitant Tumor Resistance

Richmond T. Prehn
Cancer Res 1993 53: 3266-3269. [Abstract] [PDF]  

Biochemistry and Biophysics:

Fidelity of DNA Replication by Extracts of Normal and Malignantly Transformed Human Cells

Jayne C. Boyer, David C. Thomas, Veronica M. Maher, Justin J. McCormick, and Thomas A. Kunkel
Cancer Res 1993 53: 3270-3275. [Abstract] [PDF]  

Carcinogenesis:

Mechanisms of Inhibition of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Bioactivation in Mouse by Dietary Phenethyl Isothiocyanate

Theresa J. Smith, Zuyu Guo, Chi Li, Shu M. Ning, Paul E. Thomas, and Chung S. Yang
Cancer Res 1993 53: 3276-3282. [Abstract] [PDF]  

Proliferation of Human Colonic Mucosa as an Intermediate Biomarker of Carcinogenesis: Effects of Butyrate, Deoxycholate, Calcium, Ammonia, and pH

Hans-Peter Bartram, Wolfgang Scheppach, Hermann Schmid, Andrea Hofmann, Gerda Dusel, Frank Richter, Astrid Richter, and Heinrich Kasper
Cancer Res 1993 53: 3283-3288. [Abstract] [PDF]  

Heterogeneity in Lineage Derivation of Philadelphia-positive Acute Lymphoblastic Leukemia Expressing p190^BCR-ABL or p210^BCR-ABL: Determination by Analysis of Individual Colonies with the Polymerase Chain Reaction

Zeev Estrov, Moshe Talpaz, Hagop M. Kantarjian, Theodore F. Zipf, Kenneth L. McClain, and Razelle Kurzrock
Cancer Res 1993 53: 3289-3293. [Abstract] [PDF]  

Dose-dependent Differences in the Profile of Mutations Induced by (+)-7R,8S-Dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in the Coding Region of the Hypoxanthine (Guanine) Phosphoribosyltransferase Gene in Chinese Hamster V-79 Cells

S-J. C. Wei, R. L. Chang, N. Bhachech, X. X. Cui, K. A. Merkler, C-Q. Wong, E. Hennig, H. Yagi, D. M. Jerina, and A. H. Conney
Cancer Res 1993 53: 3294-3301. [Abstract] [PDF]  

Experimental Therapeutics:

Modulation of Cisplatin Sensitivity and Accumulation by Amphotericin B in Cisplatin-resistant Human Lung Cancer Cell Lines

Toshihiko Morikage, Tohru Ohmori, Kazuto Nishio, Yasuhiro Fujiwara, Yuichiro Takeda, and Nagahiro Saijo
Cancer Res 1993 53: 3302-3307. [Abstract] [PDF]  

Boron Neutron Capture Therapy of Intracerebral Melanoma Using Boronophenylalanine as a Capture Agent

Khalid Z. Matalka, Michael Q. Bailey, Rolf F. Barth, Alfred E. Staubus, Albert H. Soloway, Melvin L. Moeschberger, Jeffrey A. Coderre, and Einar K. Rofstad
Cancer Res 1993 53: 3308-3313. [Abstract] [PDF]  

Penetration of Mitomycin C in Human Bladder

M. Guillaume Wientjes, Robert A. Badalament, Robert C. Wang, Faiqa Hassan, and Jessie L-S. Au
Cancer Res 1993 53: 3314-3320. [Abstract] [PDF]  

bcl-2 Modulation of Apoptosis Induced by Anticancer Drugs: Resistance to Thymidylate Stress Is Independent of Classical Resistance Pathways

Thomas C. Fisher, Anne E. Milner, Christopher D. Gregory, Ann L. Jackman, G. Wynne Aherne, John A. Hartley, Caroline Dive, and John A. Hickman
Cancer Res 1993 53: 3321-3326. [Abstract] [PDF]  

Immunology:

Regulation and Heteromeric Structure of the Fibroblast Activation Protein in Normal and Transformed Cells of Mesenchymal and Neuroectodermal Origin

Wolfgang J. Rettig, Pilar Garin-Chesa, John H. Healey, Sai L. Su, Harvey L. Ozer, Manfred Schwab, Anthony P. Albino, and Lloyd J. Old
Cancer Res 1993 53: 3327-3335. [Abstract] [PDF]  

Preparation and Characterization of Monoclonal Antibody Conjugates of the Calicheamicins: A Novel and Potent Family of Antitumor Antibiotics

Lois M. Hinman, Philip R. Hamann, Roslyn Wallace, Ana T. Menendez, Frederick E. Durr, and Janis Upeslacis
Cancer Res 1993 53: 3336-3342. [Abstract] [PDF]  

Differential Expression of Cell Adhesion Molecules CD54/CD11a and CD58/CD2 by Human Melanoma Cells and Functional Role in Their Interaction with Cytotoxic Cells

Maresa Altomonte, Annunziata Gloghini, Giulio Bertola, Aldo Gasparollo, Antonino Carbone, Soldano Ferrone, and Michele Maio
Cancer Res 1993 53: 3343-3348. [Abstract] [PDF]  

Selective Loss of Human Leukocyte Class I Allospecificities and Staining of Melanoma Cells by Monoclonal Antibodies Recognizing Monomorphic Determinants of Class I Human Leukocyte Antigens

Toshiro Kageshita, Zhigang Wang, Lido Calorini, Akira Yoshii, Toru Kimura, Tomomichi Ono, Sebastiano Gattoni-Celli, and Soldano Ferrone
Cancer Res 1993 53: 3349-3354. [Abstract] [PDF]  

Self-Reactive Antibody Expression by Human Carcinoma Cells Engineered with Monoclonal Antibody Genes

F. James Primus, Margaret D. Finch, Ann Maria Masci, Jeffrey Schlom, and S. V. S. Kashmiri
Cancer Res 1993 53: 3355-3361. [Abstract] [PDF]  

Sensitivity of Tumoricidal Function in Macrophages from Different Anatomical Sites of Cancer Patients to Modulation of Arachidonic Acid Metabolism

Donald P. Braun, Mi-Chung Ahn, Jules E. Harris, Elton Chu, Larry Casey, George Wilbanks, and Kalliopi P. Siziopikou
Cancer Res 1993 53: 3362-3368. [Abstract] [PDF]  

Molecular Biology and Genetics:

p53 Is Mutated in a Subset of Advanced-Stage Prostate Cancers

Robert Bookstein, Donal MacGrogan, Susan G. Hilsenbeck, Francis Sharkey, and D. Craig Allred
Cancer Res 1993 53: 3369-3373. [Abstract] [PDF]  

Mutations in p53 Are Frequent in the Preneoplastic Stage of Mouse Mammary Tumor Development

D. Joseph Jerry, Michelle A. Ozbun, Frances S. Kittrell, David P. Lane, Daniel Medina, and Janet S. Butel
Cancer Res 1993 53: 3374-3381. [Abstract] [PDF]  

Detailed Deletion Mapping of Chromosome 17q in Ovarian and Breast Cancers: 2-cM Region on 17q21.3 Often and Commonly Deleted in Tumors

Hiroko Saito, Johji Inazawa, Susumu Saito, Fujio Kasumi, Sumiko Koi, Satoru Sagae, Ryuichi Kudo, Junko Saito, Kiichiro Noda, and Yusuke Nakamura
Cancer Res 1993 53: 3382-3385. [Abstract] [PDF]  

Tumor Biology:

Effects of Transforming Growth Factor ß1 on Growth and Apoptosis of Human Acute Myelogenous Leukemia Cells

Raymond Taetle, Claire Payne, Betty Dos Santos, Melinda Russell, and Patricia Segarini
Cancer Res 1993 53: 3386-3393. [Abstract] [PDF]  

Nuclear Matrix Proteins in Normal and Breast Cancer Cells

Parvinderjit S. Khanuja, Jeffrey E. Lehr, Herbert D. Soule, Suresh K. Gehani, Anthony C. Noto, Sajal Choudhury, Ruey Chen, and Kenneth J. Pienta
Cancer Res 1993 53: 3394-3398. [Abstract] [PDF]  

Insulin-like Growth Factor-I and Human Lung Fibroblast-derived Insulin-like Growth Factor-I Stimulate the Proliferation of Human Lung Carcinoma Cells in Vitro

David P. Ankrapp and David R. Bevan
Cancer Res 1993 53: 3399-3404. [Abstract] [PDF]  

Arachidonic Acid, a Growth Signal in Murine P815 Mastocytoma Cells

Russell D. Butcher, Stanley J. Wojcik, Thierry Lints, Theresa Wilson, Philip C. Schofield, and Ray Ralph
Cancer Res 1993 53: 3405-3410. [Abstract] [PDF]  

The 72 kDa Type IV Collagenase Is Modulated via Differential Expression of _vß₃ and ₅ß₁ Integrins during Human Melanoma Cell Invasion

Richard E. B. Seftor, Elisabeth A. Seftor, William G. Stetler-Stevenson, and Mary J. C. Hendrix
Cancer Res 1993 53: 3411-3415. [Abstract] [PDF]  

Comparison of O⁶-Methylguanine-DNA Methyltransferase Activity in Brain Tumors and Adjacent Normal Brain

John R. Silber, Beth A. Mueller, Timothy G. Ewers, and Mitchel S. Berger
Cancer Res 1993 53: 3416-3420. [Abstract] [PDF]  

Correlation between E-Cadherin Expression and Invasiveness in Vitro in a Human Esophageal Cancer Cell Line

Yuichiro Doki, Hitoshi Shiozaki, Hideaki Tahara, Masatoshi Inoue, Hiroshi Oka, Keisuke Iihara, Takatoshi Kadowaki, Masatoshi Takeichi, and Takesada Mori
Cancer Res 1993 53: 3421-3426. [Abstract] [PDF]  

Characteristic Mucinous Ovarian Cancer Antigen Is Expressed in Malignantly Transformed Bloom's Syndrome Cells

Yukimasa Shiraishi, Keizo Yamamoto, and Hiroaki Soma
Cancer Res 1993 53: 3427-3432. [Abstract] [PDF]  

Virology:

Lymphomagenesis in AKR.Fv-1^b Congenic Mice

Nechama Haran-Ghera, Alpha Peled, B. Kay Brightman, and Hung Fan
Cancer Res 1993 53: 3433-3438. [Abstract] [PDF]  

Meeting Report:

Environmental Skin Cancer: Mechanisms, Models and Human Relevance

Hasan Mukhtar and David R. Bickers
Cancer Res 1993 53: 3439-3442. [PDF]  

Articles:

Announcements

Cancer Res 1993 53: 3443-3446. [PDF]  

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