Advances in Brief:

A Retroviral Wild-type p53 Expression Vector Penetrates Human Lung Cancer Spheroids and Inhibits Growth by Inducing Apoptosis

Toshiyoshi Fujiwara, Elizabeth A. Grimm, Tapas Mukhopadhyay, De Wei Cai, Laurie B. Owen-Schaub, and Jack A. Roth
Cancer Res 1993 53: 4129-4133. [Abstract] [PDF]  

Interleukin 10 Transfected into Chinese Hamster Ovary Cells Prevents Tumor Growth and Macrophage Infiltration

Günther Richter, Sabine Krüger-Krasagakes, Gabriela Hein, Christoph Hüls, Edgar Schmitt, Tibor Diamantstein, and Thomas Blankenstein
Cancer Res 1993 53: 4134-4137. [Abstract] [PDF]  

Histologically Benign or Low-Grade Malignant Tumors Adjacent to High-Grade Ovarian Carcinomas Contain Molecular Characteristics of High-Grade Carcinomas

Jianping Zheng, Minghong Wan, Susan Zweizig, Mihaela Velicescu, Mimi C. Yu, and Louis Dubeau
Cancer Res 1993 53: 4138-4142. [Abstract] [PDF]  

Modulation of in Vitro Invasion of Human Glioblastoma Cells by Urokinase-type Plasminogen Activator Receptor Antibody

Sanjeeva Mohanam, Raymond Sawaya, Ian McCutcheon, Francis Ali-Osman, Douglas Boyd, and Jasti S. Rao
Cancer Res 1993 53: 4143-4147. [Abstract] [PDF]  

Multiple Breakpoints within the BCL-1 Locus in B-Cell Lymphoma: Rearrangements of the Cyclin D1 Gene

Carla J. de Boer, Sabine Loyson, Philip M. Kluin, Hanneke C. Kluin-Nelemans, Ed Schuuring, and Johan H. J. M van Krieken
Cancer Res 1993 53: 4148-4152. [Abstract] [PDF]  

Oxidative Damage of Nuclear DNA in Liver of Rats Exposed to Psychological Stress

Shuichi Adachi, Ken Kawamura, and Kazuo Takemoto
Cancer Res 1993 53: 4153-4155. [Abstract] [PDF]  

Inwardly Rectifying K⁺ Channels and Volume-regulated Anion Channels in Multidrug-resistant Small Cell Lung Cancer Cells

J. Jirsch, R. G. Deeley, S. P. C. Cole, A. J. Stewart, and D. Fedida
Cancer Res 1993 53: 4156-4160. [Abstract] [PDF]  

Relationship of Endothelial Cell Proliferation to Tumor Vascularity in Human Breast Cancer

Stephen B. Fox, Kevin C. Gatter, Roy Bicknell, James J. Going, Peter Stanton, Tim G. Cooke, and Adrian L. Harris
Cancer Res 1993 53: 4161-4163. [Abstract] [PDF]  

Loss of a p53-associated G1 Checkpoint Does Not Decrease Cell Survival following DNA Damage

William J. Slichenmyer, William G. Nelson, Robbert J. Slebos, and Michael B. Kastan
Cancer Res 1993 53: 4164-4168. [Abstract] [PDF]  

IA-1, a New Marker for Neuroendocrine Differentiation in Human Lung Cancer Cell Lines

Michael S. Lan, Edward K. Russell, Jia Lu, Bruce E. Johnson, and Abner Louis Notkins
Cancer Res 1993 53: 4169-4171. [Abstract] [PDF]  

Nickel Induces a Signature Mutation for Oxygen Free Radical Damage

Leila K. Tkeshelashvili, Thomas M. Reid, Timothy J. McBride, and Lawrence A. Loeb
Cancer Res 1993 53: 4172-4174. [Abstract] [PDF]  

Biochemistry and Biophysics:

Growth Inhibition of Human Lung Cancer Cell Lines by Interleukin 6 in Vitro: A Possible Role in Tumor Growth via an Autocrine Mechanism

Hajime Takizawa, Takayuki Ohtoshi, Ken Ohta, Naomi Yamashita, Shunsei Hirohata, Koichi Hirai, Keiichi Hiramatsu, and Koji Ito
Cancer Res 1993 53: 4175-4181. [Abstract] [PDF]  

Carcinogenesis:

Inhibitory Effect of Caffeic Acid Esters on Azoxymethane-induced Biochemical Changes and Aberrant Crypt Foci Formation in Rat Colon

Chinthalapally V. Rao, Dhimant Desai, Barbara Simi, Nalini Kulkarni, Shantu Amin, and Bandaru S. Reddy
Cancer Res 1993 53: 4182-4188. [Abstract] [PDF]  

Expression of Mutated p53 Occurs in Tumor-distant Epithelia of Head and Neck Cancer Patients: A Possible Molecular Basis for the Development of Multiple Tumors

Matthias Nees, Nils Homann, Hilde Discher, Thomas Andl, Christel Enders, Christel Herold-Mende, Antje Schuhmann, and Franz X. Bosch
Cancer Res 1993 53: 4189-4196. [Abstract] [PDF]  

Differential Expression of CD44 Splice Variants in Intestinal- and Diffuse-Type Human Gastric Carcinomas and Normal Gastric Mucosa

Karl-Heinz Heider, Jobst Dämmrich, Petra Skroch-Angel, Hans-Konrad Müller-Hermelink, H. Peter Vollmers, Peter Herrlich, and Helmut Ponta
Cancer Res 1993 53: 4197-4203. [Abstract] [PDF]  

Reduction in the Expression of Glucose Transporter Protein GLUT 2 in Preneoplastic and Neoplastic Hepatic Lesions and Reexpression of GLUT 1 in Late Stages of Hepatocarcinogenesis

Rainer Grobholz, Hans Jörg Hacker, Bernard Thorens, and Peter Bannasch
Cancer Res 1993 53: 4204-4211. [Abstract] [PDF]  

Interaction between Ultraviolet A and Ultraviolet B Radiations in Skin Cancer Induction in Hairless Mice

Rob J. W. Berg, Frank R. de Gruijl, and Jan C. van der Leun
Cancer Res 1993 53: 4212-4217. [Abstract] [PDF]  

Induction of Renal Pelvic Carcinoma by Phenacetin in Hydronephrosis-bearing Rats of the SD/cShi Strain

Takashi Murai, Satoru Mori, Setsuko Machino, Motoko Hosono, Yasuyoshi Takeuchi, Tadao Ohara, Susumu Makino, Reiji Takeda, Yoshiyuki Hayashi, Hiroyuki Iwata, Shinji Yamamoto, Hiroshi Ito, and Shoji Fukushima
Cancer Res 1993 53: 4218-4223. [Abstract] [PDF]  

Endocrinology:

Effects of Steroid Hormones and Opioid Peptides on the Growth of Androgen-responsive Shionogi Carcinoma (SC115) Cells in Primary Culture

Yi Jiang, Joanne Weinberg, Darcy A. Wilkinson, and Joanne T. Emerman
Cancer Res 1993 53: 4224-4229. [Abstract] [PDF]  

Epidemiology:

Reduced Risk of Colon Cancer with High Intake of Vitamin E: The Iowa Women's Health Study

Roberd M. Bostick, John D. Potter, David R. McKenzie, Thomas A. Sellers, Lawrence H. Kushi, Kristi A. Steinmetz, and Aaron R. Folsom
Cancer Res 1993 53: 4230-4237. [Abstract] [PDF]  

Experimental Therapeutics:

Bovine Serum Albumin-Doxorubicin Conjugate Overcomes Multidrug Resistance in a Rat Hepatoma

Kiyoshi Ohkawa, Takashi Hatano, Kyosuke Yamada, Kensuke Joh, Koji Takada, Yutaka Tsukada, and Makoto Matsuda
Cancer Res 1993 53: 4238-4242. [Abstract] [PDF]  

Locus of the Interaction among 5-Fluorouracil, Leucovorin, and Interferon-2a in Colon Carcinoma Cells

Janet A. Houghton, Christopher L. Morton, David A. Adkins, and Atiqur Rahman
Cancer Res 1993 53: 4243-4250. [Abstract] [PDF]  

bcl-2 Protein Inhibits Etoposide-induced Apoptosis through Its Effects on Events Subsequent to Topoisomerase II-induced DNA Strand Breaks and Their Repair

Saori Kamesaki, Hiroshi Kamesaki, Timothy J. Jorgensen, Akihiko Tanizawa, Yves Pommier, and Jeffrey Cossman
Cancer Res 1993 53: 4251-4256. [Abstract] [PDF]  

Contribution of Glutathione Transferase M3-3 to 1,3-Bis(2-chloroethyl)-1-nitrosourea Resistance in a Human Non-Small Cell Lung Cancer Cell Line

Kiflu Berhane, Xiao-Yong Hao, Suzanne Egyházi, Johan Hansson, Ulrik Ringborg, and Bengt Mannervik
Cancer Res 1993 53: 4257-4261. [Abstract] [PDF]  

Inhibition of Tumor Growth and Metastasis of Rodent Tumors by the Angiogenesis Inhibitor O-(Chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470)

Masuo Yamaoka, Toshihiro Yamamoto, Tsuneo Masaki, Shuichi Ikeyama, Katsuichi Sudo, and Takeshi Fujita
Cancer Res 1993 53: 4262-4267. [Abstract] [PDF]  

Effects of Temperature on the Therapeutic Efficacy and Pharmacokinetics of Ifosfamide

G. J. Wiedemann, H. J. Siemens, M. Mentzel, A. Biersack, W. Wössmann, D. Knocks, C. Weiss, and T. Wagner
Cancer Res 1993 53: 4268-4272. [Abstract] [PDF]  

Antitumor Protection from the Murine T-Cell Leukemia/Lymphoma EL4 by the Continuous Subcutaneous Coadministration of Recombinant Macrophage-Colony Stimulating Factor and Interleukin-2

Daniel A. Vallera, Patricia A. Taylor, S. Lea Aukerman, and Bruce R. Blazar
Cancer Res 1993 53: 4273-4280. [Abstract] [PDF]  

Prolonged Depletion of O⁶-Methylguanine DNA Methyltransferase Activity following Exposure to O⁶-Benzylguanine with or without Streptozotocin Enhances 1,3-Bis(2-chloroethyl)-1-nitrosourea Sensitivity in Vitro

Upendra K. Marathi, Roger A. Kroes, M. Eileen Dolan, and Leonard C. Erickson
Cancer Res 1993 53: 4281-4286. [Abstract] [PDF]  

Etoposide-induced Cytotoxicity in Two Human T-Cell Leukemic Lines: Delayed Loss of Membrane Permeability rather than DNA Fragmentation as an Indicator of Programmed Cell Death

Daniel R. Catchpoole and Bernard W. Stewart
Cancer Res 1993 53: 4287-4296. [Abstract] [PDF]  

Inhibition of the Signalling Enzyme Phosphatidylinositol-3-kinase by Antitumor Ether Lipid Analogues

Margareta I. Berggren, Alfred Gallegos, Lynn A. Dressler, Edward J. Modest, and Garth Powis
Cancer Res 1993 53: 4297-4302. [Abstract] [PDF]  

Immunology:

Differential Effect of Human and Mouse ß₂-Microglobulin on the Induction and the Antigenic Profile of Endogenous HLA-A and -B Antigens Synthesized by ß₂-Microglobulin Gene-null FO-1 Melanoma Cells

Zhigang Wang, Xian-zhen Hu, Revati J. Tatake, Soo Y. Yang, Richard A. Zeff, and Soldano Ferrone
Cancer Res 1993 53: 4303-4309. [Abstract] [PDF]  

Cytolysis of Leukemic B-Cells by T-Cells Activated via Two Bispecific Antibodies

H. Bohlen, O. Manzke, B. Patel, G. Moldenhauer, B. Dörken, V. von Fliedner, V. Diehl, and H. Tesch
Cancer Res 1993 53: 4310-4314. [Abstract] [PDF]  

Cross-Reactivity of Anti-CD3/IL-2 Activated Effector Cells Derived from Lymph Nodes Draining Heterologous Clones of a Murine Tumor

Takafumi Matsumura, Robert A. Krinock, Alfred E. Chang, and Suyu Shu
Cancer Res 1993 53: 4315-4321. [Abstract] [PDF]  

Blockade of Epidermal Growth Factor Receptor Function by Bivalent and Monovalent Fragments of 225 Anti-Epidermal Growth Factor Receptor Monoclonal Antibodies

Zhen Fan, Hideo Masui, Ian Altas, and John Mendelsohn
Cancer Res 1993 53: 4322-4328. [Abstract] [PDF]  

Molecular Biology and Genetics:

Collaboration between Growth Factors and Diverse Chemical Carcinogens in Hepatocarcinogenesis of Transforming Growth Factor Transgenic Mice

Hitoshi Takagi, Richard Sharp, Hisashi Takayama, Miriam R. Anver, Jerrold M. Ward, and Glenn Merlino
Cancer Res 1993 53: 4329-4336. [Abstract] [PDF]  

c-myc Expression Correlates with Suppression of c-kit Protooncogene Expression in Small Cell Lung Cancer Cell Lines

Howard Plummer, III, Joseph Catlett, Julie Leftwich, Barbara Armstrong, Patricia Carlson, Thomas Huff, and Geoffrey Krystal
Cancer Res 1993 53: 4337-4342. [Abstract] [PDF]  

Camptothecin Resistance from a Single Mutation Changing Glycine 363 of Human DNA Topoisomerase I to Cysteine

Piero Benedetti, Paola Fiorani, Luisa Capuani, and James C. Wang
Cancer Res 1993 53: 4343-4348. [Abstract] [PDF]  

Recurrent Deletions of Specific Chromosomal Sites in 1p, 3p, 6q, and 9p in Human Malignant Mesothelioma

Takahiro Taguchi, Suresh C. Jhanwar, Jill M. Siegfried, Steven M. Keller, and Joseph R. Testa
Cancer Res 1993 53: 4349-4355. [Abstract] [PDF]  

Loss of Heterozygosity in Familial Breast Carcinomas

Annika Lindblom, Lambert Skoog, Sam Rotstein, Barbro Werelius, Catharina Larsson, and Magnus Nordenskjöld
Cancer Res 1993 53: 4356-4361. [Abstract] [PDF]  

A Codon 248 p53 Mutation Retains Tumor Suppressor Function as Shown by Enhancement of Tumor Growth by Antisense p53

Tapas Mukhopadhyay and Jack A. Roth
Cancer Res 1993 53: 4362-4366. [Abstract] [PDF]  

Tumor Biology:

Monoclonal Antibody FW6 Defines an Epitope on 3/4-monofucosylated Polylactosaminoglycans Expressed by Fetal and Colon Carcinoma-associated Mucins

Franz-Georg Hanisch, Günter Heimbüchel, Stephan Ernst Baldus, Gerhard Uhlenbruck, Rudolf Schmits, Michael Pfreundschuh, Martin Schwonzen, Mathias Vierbuchen, Jacques Bara, and Jasna Peter-Katalinic
Cancer Res 1993 53: 4367-4375. [Abstract] [PDF]  

Chemotaxis and Haptotaxis of Human Malignant Mesothelioma Cells: Effects of Fibronectin, Laminin, Type IV Collagen, and an Autocrine Motility Factor-like Substance

Julius Klominek, Karl-Henrik Robért, and Karl-Gösta Sundqvist
Cancer Res 1993 53: 4376-4382. [Abstract] [PDF]  

MAb U36, a Novel Monoclonal Antibody Successful in Immunotargeting of Squamous Cell Carcinoma of the Head and Neck

A. H. G. J. Schrijvers, Jasper J. Quak, Anne M. Uyterlinde, Marijke van Walsum, Chris J. L. M. Meijer, Gordon B. Snow, and Guus A. M. S. van Dongen
Cancer Res 1993 53: 4383-4390. [Abstract] [PDF]  

Increased Transforming Growth Factor ß Expression Inhibits Cell Proliferation in Vitro, yet Increases Tumorigenicity and Tumor Growth of Meth A Sarcoma Cells

Hsun-Lang Chang, Nancy Gillett, Irene Figari, Alfredo R. Lopez, Michael A. Palladino, and Rik Derynck
Cancer Res 1993 53: 4391-4398. [Abstract] [PDF]  

Cell Cycle Specific Effects of Tumor Necrosis Factor in Monocyte Mediated Leukemic Cell Death and the Role of ß₂-Integrins

Arjan A. van de Loosdrecht, Gert J. Ossenkoppele, Robert H. J. Beelen, Marjolein G. Broekhoven, and Mart M. A. C. Langenhuijsen
Cancer Res 1993 53: 4399-4407. [Abstract] [PDF]  

Establishment of Estrogen Receptor-positive Transplantable Rat Thyroid Tumor Cell Lines in Vivo

Yoshio Hiasa, Yoshiteru Kitahori, Katsunari Yane, Hiroto Nishioka, Kazuhiro Nakahashi, Noboru Konishi, Masato Ohshima, Kumio Okaichi, Takeo Ohnishi, and Jung-Chung Lin
Cancer Res 1993 53: 4408-4412. [Abstract] [PDF]  

Tamoxifen-induced Increase in the Potential Doubling Time of MCF-7 Xenografts as Determined by Bromodeoxyuridine Labeling and Flow Cytometry

Jann N. Sarkaria, David F. C. Gibson, V. Craig Jordan, John F. Fowler, Mary J. Lindstrom, and R. Timothy Mulcahy
Cancer Res 1993 53: 4413-4417. [Abstract] [PDF]  

A Paracrine Migration-stimulating Factor for Metastatic Tumor Cells Secreted by Mouse Hepatic Sinusoidal Endothelial Cells: Identification as Complement Component C3b

Jun-ichi Hamada, Philip G. Cavanaugh, Koichiro Miki, and Garth L. Nicolson
Cancer Res 1993 53: 4418-4423. [Abstract] [PDF]  

Modulation of p145^c-kit Function in Cells of Patients with Acute Myeloblastic Leukemia

Hans-Jörg Bühring, Ronald Herbst, Günter Kostka, Birgit Bossenmaier, Ilse Bartke, Harald Kropshofer, Hubert Kalbacher, Friedrich W. Busch, Claudia A. Müller, Joseph Schlessinger, and Axel Ullrich
Cancer Res 1993 53: 4424-4431. [Abstract] [PDF]  

Virology:

Glucocorticoid Requirement for Growth of Human Papillomavirus 16-transformed Primary Rat Kidney Epithelial Cells: Correlation of Development of Hormone Resistance with Viral RNA Expression and Processing

Alan Pater, Narasimhaswamy S. Belaguli, and Mary M. Pater
Cancer Res 1993 53: 4432-4436. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1993 53: 4437-4439. [PDF]  

Announcements:

Calendar of Events

Cancer Res 1993 53: 4439-4440. [PDF]  

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