Advances in Brief:

Controlled Release, Biodegradable Cytokine Depots: A New Approach in Cancer Vaccine Design

Paul T. Golumbek, Rosa Azhari, Elizabeth M. Jaffee, Hyam I. Levitsky, Audrey Lazenby, Kam Leong, and Drew M. Pardoll
Cancer Res 1993 53: 5841-5844. [Abstract] [PDF]  

Hypoxic Mammalian Cell Radiosensitization by Nitric Oxide

James B. Mitchell, David A. Wink, William DeGraff, Janet Gamson, Larry K. Keefer, and Murali C. Krishna
Cancer Res 1993 53: 5845-5848. [Abstract] [PDF]  

Genomic Instability in Colorectal Cancer: Relationship to Clinicopathological Variables and Family History

Ragnhild A. Lothe, Päivi Peltomäki, Gunn Iren Meling, Lauri A. Aaltonen, Minna Nyström-Lahti, Lea Pylkkänen, Ketil Heimdal, Tone I. Andersen, Pål Møller, Torleiv O. Rognum, Sophie D. Fosså, Tor Haldorsen, Frøydis Langmark, Anton Brøgger, Albert de la Chapelle, and Anne-Lise Børresen
Cancer Res 1993 53: 5849-5852. [Abstract] [PDF]  

Microsatellite Instability Is Associated with Tumors That Characterize the Hereditary Non-Polyposis Colorectal Carcinoma Syndrome

Päivi Peltomäki, Ragnhild A. Lothe, Lauri A. Aaltonen, Lea Pylkkänen, Minna Nyström-Lahti, Raquel Seruca, Leonor David, Ruth Holm, David Ryberg, Aage Haugen, Anton Brøgger, Anne-Lise Børresen, and Albert de la Chapelle
Cancer Res 1993 53: 5853-5855. [Abstract] [PDF]  

Genetic Predisposition to Transplacentally Induced Renal Cell Carcinomas in the Eker Rat

Okio Hino, Hiroaki Mitani, and Alfred G. Knudson
Cancer Res 1993 53: 5856-5858. [Abstract] [PDF]  

EWS/Fli-1 Chimeric Protein Is a Transcriptional Activator

Takatoshi Ohno, Veena N. Rao, E. Shyam, and P. Reddy
Cancer Res 1993 53: 5859-5863. [Abstract] [PDF]  

Antibody Response against the c-erbB-2 Oncoprotein in Breast Carcinoma Patients

Serenella M. Pupa, Sylvie Ménard, Salvatore Andreola, and Maria I. Colnaghi
Cancer Res 1993 53: 5864-5866. [Abstract] [PDF]  

Imaging of Activated Natural Killer Cells in Mice by Positron Emission Tomography: Preferential Uptake in Tumors

Robert J. Melder, Anna Liisa Brownell, Timothy M. Shoup, Gordon L. Brownell, and Rakesh K. Jain
Cancer Res 1993 53: 5867-5871. [Abstract] [PDF]  

Analysis of p53 Antibodies in Patients with Various Cancers Define B-Cell Epitopes of Human p53: Distribution on Primary Structure and Exposure on Protein Surface

R. Lubin, B. Schlichtholz, D. Bengoufa, G. Zalcman, J. Trédaniel, A. Hirsch, C. Caron de Fromentel, C. Preudhomme, P. Fenaux, G. Fournier, P. Mangin, P. Laurent-Puig, G. Pelletier, M. Schlumberger, F. Desgrandchamps, A. Le Duc, J. P. Peyrat, N. Janin, B. Bressac, and T. Soussi
Cancer Res 1993 53: 5872-5876. [Abstract] [PDF]  

Antitumor Effect of Taxol-containing Liposomes in a Taxol-resistant Murine Tumor Model

Amarnath Sharma, Eric Mayhew, and Robert M. Straubinger
Cancer Res 1993 53: 5877-5881. [Abstract] [PDF]  

An Exon 5 Deletion Variant of the Estrogen Receptor Frequently Coexpressed with Wild-Type Estrogen Receptor in Human Breast Cancer

Qiu-Xia Zhang, Åke Borg, and Suzanne A. W. Fuqua
Cancer Res 1993 53: 5882-5884. [Abstract] [PDF]  

Characterization of a DNA Topoisomerase II Gene Rearrangement in Adriamycin-resistant P388 Leukemia: Expression of a Fusion Messenger RNA Transcript Encoding Topoisomerase II and the Retinoic Acid Receptor Locus

J. Peter McPherson, Greg A. Brown, and Gerald J. Goldenberg
Cancer Res 1993 53: 5885-5889. [Abstract] [PDF]  

Special Lecture:

Prevention—Therapy—Basic Science and the Resolution of the Cancer Problem: Presidential Address

Lee W. Wattenberg
Cancer Res 1993 53: 5890-5896. [PDF]  

Biochemistry and Biophysics:

Phospholipase Activation Triggers Apoptosis in Photosensitized Mouse Lymphoma Cells

Munna L. Agarwal, Hedy E. Larkin, S. I. A. Zaidi, Hasan Mukhtar, and Nancy L. Oleinick
Cancer Res 1993 53: 5897-5902. [Abstract] [PDF]  

Compensatory Occurrence of IV²Fuc,II³NeuAc-Gg₄Cer and Human Fetal Antigen Lc₄Cer in Small Cell Carcinomas of the Human Lung

Masao Iwamori, Kazushige Kiguchi, Shirou Nozawa, Setsuo Hirohashi, Yukio Shimosato, and Yoshitaka Nagai
Cancer Res 1993 53: 5903-5907. [Abstract] [PDF]  

Interaction between Replication Forks and Topoisomerase I-DNA Cleavable Complexes: Studies in a Cell-free SV40 DNA Replication System

Yeou-Ping Tsao, Alicia Russo, Gill Nyamuswa, Robert Silber, and Leroy F. Liu
Cancer Res 1993 53: 5908-5914. [Abstract] [PDF]  

Clinical Investigations:

Pharmacokinetics of Recombinant Human Interleukin 3 Administered Subcutaneously and by Continuous Intravenous Infusion in Patients after Chemotherapy for Ovarian Cancer

Bonne Biesma, Rolf Pokorny, John M. Kovarik, Frances A. Duffy, Pax H. B. Willemse, Nanno H. Mulder, and Elisabeth G. E. de Vries
Cancer Res 1993 53: 5915-5919. [Abstract] [PDF]  

Tumor Detection with ¹³¹I-labeled Human Monoclonal antibody COU-1 in Patients with Suspected Colorectal Carcinoma

Henrik Ditzel, Jens W. Rasmussen, Karin Erb, Per Borup-Christensen, Ingrid Titlestad, Erling Lassen, Claus Fenger, Ole Kronborg, and Jens C. Jensenius
Cancer Res 1993 53: 5920-5928. [Abstract] [PDF]  

A Randomized Phase I Trial of Chronic Oral Etoposide with or without Granulocyte-Macrophage Colony-stimulating Factor in Patients with Advanced Malignancies

Don W. Shaffer, Lon S. Smith, Howard A. Burris, Gary M. Clark, John R. Eckardt, Suzanne M. Fields, Geoffrey R. Weiss, David A. Rinaldi, Karen J. Bowen, John G. Kuhn, and Daniel D. Von Hoff
Cancer Res 1993 53: 5929-5933. [Abstract] [PDF]  

Endocrinology:

Expression of a Constitutively Active Estrogen Receptor Variant in the Estrogen Receptor-negative BT-20 Human Breast Cancer Cell Line

Carl G. Castles, Suzanne A. W. Fuqua, Diane M. Klotz, and Steven M. Hill
Cancer Res 1993 53: 5934-5939. [Abstract] [PDF]  

Estradiol Induction of Retinoic Acid Receptors in Human Breast Cancer Cells

Shaun D. Roman, Christopher J. Ormandy, David L. Manning, Roger W. Blamey, Robert I. Nicholson, Robert L. Sutherland, and Christine L. Clarke
Cancer Res 1993 53: 5940-5945. [Abstract] [PDF]  

Experimental Therapeutics:

Teniposide-resistant CEM Cells, Which Express Mutant DNA Topoisomerase II, When Treated with Non-Complex-stabilizing Inhibitors of the Enzyme, Display No Cross-Resistance and Reveal Aberrant Functions of the Mutant Enzyme

Mei Chen and William T. Beck
Cancer Res 1993 53: 5946-5953. [Abstract] [PDF]  

Pharmacokinetics of a Fluorescent Drug Using Laser-induced Fluorescence

Joan K. Frisoli, Eugene G. Tudor, Thomas J. Flotte, Tayyaba Hasan, Thomas F. Deutsch, and Kevin T. Schomacker
Cancer Res 1993 53: 5954-5961. [Abstract] [PDF]  

The Protective Role of Ammonium Trichloro(dioxoethylene-O,O') tellurate in Combination with Several Cytotoxic Drugs Acting by Different Mechanisms of Action

Yona Kalechman, Adi Shani, Iris Sotnik-Barkai, Michael Albeck, and Benjamin Sredni
Cancer Res 1993 53: 5962-5969. [Abstract] [PDF]  

In Vitro Cytotoxicity, Protein Binding, Red Blood Cell Partitioning, and Biotransformation of Oxaliplatin

L. Pendyala and P. J. Creaven
Cancer Res 1993 53: 5970-5976. [Abstract] [PDF]  

Flavonol-stimulated Efflux of 7,12-Dimethylbenz(a)anthracene in Multidrug-resistant Breast Cancer Cells

James M. Phang, C. Michael Poore, Joanna Lopaczynska, and Grace Chao Yeh
Cancer Res 1993 53: 5977-5981. [Abstract] [PDF]  

Sequential Impact of Tiazofurin and Ribavirin on the Enzymic Program of the Bone Marrow

Noemi Prajda, Yuki Hata, Margit Abonyi, Radhey L. Singhal, and George Weber
Cancer Res 1993 53: 5982-5986. [Abstract] [PDF]  

Intoplicine (RP 60475) and Its Derivatives, a New Class of Antitumor Agents Inhibiting Both Topoisomerase I and II Activities

Jean-François Riou, Philippe Fossé, Chi Hung Nguyen, Annette Kragh Larsen, Marie-Christine Bissery, Lucile Grondard, Jean-Marie Saucier, Emile Bisagni, and François Lavelle
Cancer Res 1993 53: 5987-5993. [Abstract] [PDF]  

Effects of Nonionic Detergents on P-Glycoprotein Drug Binding and Reversal of Multidrug Resistance

Tracy Zordan-Nudo, Victor Ling, Zhi Liu, and Elias Georges
Cancer Res 1993 53: 5994-6000. [Abstract] [PDF]  

Immunology:

Suppression of Stress Protein GRP78 Induction in Tumor B/C10ME Eliminates Resistance to Cell Mediated Cytotoxicity

Shunji Sugawara, Kazuyoshi Takeda, Amy Lee, and Gunther Dennert
Cancer Res 1993 53: 6001-6005. [Abstract] [PDF]  

1,25-Dihydroxyvitamin D₃ plus -Interferon Blocks Lung Tumor Production of Granulocyte-Macrophage Colony-stimulating Factor and Induction of Immunosuppressor Cells

M. Rita, I. Young, John Halpin, Jeannie Wang, Mark A. Wright, John Matthews, and Annette Schmidt Pak
Cancer Res 1993 53: 6006-6010. [Abstract] [PDF]  

Molecular Biology and Genetics:

Complementation of the Radiosensitive Phenotype in Severe Combined Immunodeficient Mice by Human Chromosome 8

Cordula U. Kirchgessner, Liana M. Tosto, Kim A. Biedermann, Mary Kovacs, Diana Araujo, Eric J. Stanbridge, and J. Martin Brown
Cancer Res 1993 53: 6011-6016. [Abstract] [PDF]  

Annexin II Expression Is Regulated during Mammalian Cell Cycle

Yungping Chiang, Martin H. Schneiderman, and Jamboor K. Vishwanatha
Cancer Res 1993 53: 6017-6021. [Abstract] [PDF]  

Allelotype Analysis of Mouse Skin Tumors Using Polymorphic Microsatellites: Sequential Genetic Alterations on Chromosomes 6, 7, and 11

Christopher J. Kemp, Frances Fee, and Allan Balmain
Cancer Res 1993 53: 6022-6027. [Abstract] [PDF]  

Infrequency of MDM2 Gene Amplification in Pediatric Solid Tumors and Lack of Association with p53 Mutations in Adult Squamous Cell Carcinomas

Pamela G. Waber, Jun Chen, and Perry D. Nisen
Cancer Res 1993 53: 6028-6030. [Abstract] [PDF]  

Allelic Variation in the Dihydrofolate Reductase Gene at Amino Acid Position 95 Contributes to Antifolate Resistance in Chinese Hamster Cells

Myounghee Yu and Peter W. Melera
Cancer Res 1993 53: 6031-6035. [Abstract] [PDF]  

Tumor Biology:

N-(4-Hydroxyphenyl)retinamide Induces Apoptosis of Malignant Hemopoietic Cell Lines Including Those Unresponsive to Retinoic Acid

Domenico Delia, Antonella Aiello, Luciano Lombardi, Pier Giuseppe Pelicci, Francesco Grignani, Fausto Grignani, Franca Formelli, Sylvie Menard, Alberto Costa, Umberto Veronesi, and Marco A. Pierotti
Cancer Res 1993 53: 6036-6041. [Abstract] [PDF]  

Statistical Analysis of in Vivo Tumor Growth Experiments

Daniel F. Heitjan, Andrea Manni, and Richard J. Santen
Cancer Res 1993 53: 6042-6050. [Abstract] [PDF]  

Inhibition of Invasion of HT1080 Sarcoma Cells Expressing Recombinant Plasminogen Activator Inhibitor 2

Walter E. Laug, Xiang Rong Cao, Yan Bin Yu, Hiroyuki Shimada, and Egbert K. O. Kruithof
Cancer Res 1993 53: 6051-6057. [Abstract] [PDF]  

Z-4',5'-Didehydro-5'-deoxy-5'-fluoroadenosine (MDL 28,842), an Irreversible Inhibitor of S-Adenosylhomocysteine Hydrolase, Suppresses Proliferation of Cultured Keratinocytes and Squamous Carcinoma Cell Lines

Amy S. Paller, Sheryl L. Arnsmeier, Sandra H. Clark, and Bernard L. Mirkin
Cancer Res 1993 53: 6058-6060. [Abstract] [PDF]  

Expression of Calcylin in Human Melanocytic Lesions

Marian A. J. Weterman, Goos N. P. van Muijen, Henri P. J. Bloemers, and Dirk J. Ruiter
Cancer Res 1993 53: 6061-6066. [Abstract] [PDF]  

Virology:

Sequence Analysis of an Immunogenic and Neutralizing Domain of the Human T-Cell Lymphoma/Leukemia Virus Type I gp46 Surface Membrane Protein among Various Primate T-Cell Lymphoma/Leukemia Virus Isolates Including Those from a Patient with Both HTLV-I-associated Myelopathy and Adult T-Cell Leukemia

Michael P. Sherman, Syamalima Dube, Timothy P. Spicer, Timothy D. Kane, Jayne L. Love, Nitin K. Saksena, Robert Iannone, Clarence J. Gibbs, Jr., Richard Yanagihara, Dipak K. Dube, and Bernard J. Poiesz
Cancer Res 1993 53: 6067-6073. [Abstract] [PDF]  

Letters to the Editor:

Correspondence re: M. J. Thun et al., Aspirin Use and Risk of Fatal Cancer. Cancer Res., 53: 1322–1327, 1993

Zane N. Gaut
Cancer Res 1993 53: 6074 [PDF]  

Correspondence re: A. M. Lynch et al., Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, Carcinogens Present in Cooked Beef. Cancer Res., 52: 6216–6223, 1992

Philippe Shubik
Cancer Res 1993 53: 6075 [PDF]  

Correspondence re: A. M. Lynch et al., Intra- and Interindividual Variability in Systemic Exposure in Humans to 2-Amino-3,8-dimethylimidazo[4,5-f]-quinoxaline and 2-Amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, Carcinogens Present in Cooked Beef. Cancer Res., 52: 6216–6223, 1992 — Reply

Anthony M. Lynch, Alan R. Boobis, Donald S. Davies, Stephen Murray, and Nigel Gooderham
Cancer Res 1993 53: 6075-6076. [PDF]  

Articles:

Announcements

Cancer Res 1993 53: 6077-6079. [PDF]  

Erratum

Cancer Res 1993 53: 6079 [PDF]  

Correction

Cancer Res 1993 53: 6079 [PDF]  

Acknowledgment to Reviewers

Cancer Res 1993 53: 6080-6088. [PDF]  

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