Advances in Brief:

Overexpression of a M_r 110,000 Vesicular Protein in Non-P-Glycoprotein-mediated Multidrug Resistance

Rik J. Scheper, Henricus J. Broxterman, George L. Scheffer, Patricia Kaaijk, William S. Dalton, Theodorus H. M. van Heijningen, Coen K. van Kalken, Marilyn L. Slovak, Elisabeth G. E. de Vries, Paul van der Valk, Chris J. L. M. Meijer, and Herbert M. Pinedo
Cancer Res 1993 53: 1475-1479. [Abstract] [PDF]  

Expression of Sulfated Glycoprotein 2 Is Associated with Carcinogenesis Induced by N-Nitroso-N-methylurea in Rat Prostate and Seminal Vesicle

Kenji Kadomatsu, Mario A. Anzano, Michael V. Slayter, Thomas S. Winokur, Joseph M. Smith, and Michael B. Sporn
Cancer Res 1993 53: 1480-1483. [Abstract] [PDF]  

Antibody-targeted Delivery of Doxorubicin Entrapped in Sterically Stabilized Liposomes Can Eradicate Lung Cancer in Mice

Imran Ahmad, Michael Longenecker, John Samuel, and Theresa M. Allen
Cancer Res 1993 53: 1484-1488. [Abstract] [PDF]  

Mutation of K-ras Protooncogene in Human Ovarian Epithelial Tumors of Borderline Malignancy

Samuel Chi-Ho Mok, Debra A. Bell, Robert C. Knapp, Paula M. Fishbaugh, William R. Welch, Michael G. Muto, Ross S. Berkowitz, and Sai-Wah Tsao
Cancer Res 1993 53: 1489-1492. [Abstract] [PDF]  

Cyclin E and Cyclin A as Canadidates for the Restriction Point Protein

Qing-Ping Dou, Andrew H. Levin, Shanchuan Zhao, and Arthur B. Pardee
Cancer Res 1993 53: 1493-1497. [Abstract] [PDF]  

A Homozygous Deletion within the Carbonic Anhydrase-like Domain of the Ptprg Gene in Murine L-Cells

Kishore K. Wary, Zhuangwei Lou, Arthur M. Buchberg, Linda D. Siracusa, Teresa Druck, Sal LaForgia, and Kay Huebner
Cancer Res 1993 53: 1498-1502. [Abstract] [PDF]  

Perspectives in Cancer Research:

Signaling by Integrins: Implications for Tumorigenesis

Martin Alexander Schwartz
Cancer Res 1993 53: 1503-1506. [PDF]  

Biochemistry and Biophysics:

Caffeine Release of Radiation Induced S and G₂ Phase Arrest in V79 Hamster Cells: Increase of Histone Messenger RNA Levels and p34^cdc2 Activation

Jens Hain, Nigel E. A. Crompton, Werner Burkart, and Rolf Jaussi
Cancer Res 1993 53: 1507-1510. [Abstract] [PDF]  

Carcinogenesis:

Presence of Point Mutations in the N-ras Gene in Radiation-transformed Rat Embryo Cells

Chang Hu Chen, Brian Endlich, Reza Salavati, and C. Clifton Ling
Cancer Res 1993 53: 1511-1515. [Abstract] [PDF]  

A Link between ras and Metastatic Behavior of Tumor Cells: ras Induces CD44 Promoter Activity and Leads to Low-Level Expression of Metastasis-specific Variants of CD44 in CREF Cells

Martin Hofmann, Wolfgang Rudy, Ursula Günthert, Stephen G. Zimmer, Volker Zawadzki, Margot Zöller, Rosemarie B. Lichtner, Peter Herrlich, and Helmut Ponta
Cancer Res 1993 53: 1516-1521. [Abstract] [PDF]  

Detection of DNA Adducts in Human Oral Tissue: Correlation of Adduct Levels with Tobacco Smoking and Differential Enhancement of Adducts Using the Butanol Extraction and Nuclease P1 Versions of ³²P Postlabeling

Nigel J. Jones, Alan D. McGregor, and Raymond Waters
Cancer Res 1993 53: 1522-1528. [Abstract] [PDF]  

Glucuronidation of Carcinogen Metabolites by Complementary DNA-expressed Uridine 5'-Diphosphate Glucuronosyltransferases

Peter I. Mackenzie, Louise Rodbourn, and Takashi Iyanagi
Cancer Res 1993 53: 1529-1533. [Abstract] [PDF]  

Clinical Investigations:

Chronopharmacology of High-Dose Busulfan in Children

Gilles Vassal, Dominique Challine, Serge Koscielny, Olivier Hartmann, Alain Deroussent, Isabelle Boland, Dominique Valteau-Couanet, Jean Lemerle, Francis Lévi, and Alain Gouyette
Cancer Res 1993 53: 1534-1537. [Abstract] [PDF]  

Endocrinology:

Interleukin-1 and Interleukin-6 Act Additively to Inhibit Growth of MCF-7 Breast Cancer Cells in Vitro

David N. Danforth, Jr. and Magdalene K. Sgagias
Cancer Res 1993 53: 1538-1545. [Abstract] [PDF]  

Pituitary Tumors in Mice Exposed Prenatally to Diethylstilbestrol

Bruce E. Walker and Lori A. Kurth
Cancer Res 1993 53: 1546-1549. [Abstract] [PDF]  

Experimental Therapeutics:

Pharmacokinetic and Pharmacodynamic Advantages of Pirarubicin over Adriamycin after Intraarterial Hepatic Administration in the Rabbit VX2 Tumor Model

Jean-Nicolas Munck, Marcello Riggi, Philippe Rougier, Guy G. Chabot, Luis H. Ramirez, Zhongxin Zhao, Caroline Bognel, Patrice Ardouin, Patrice Herait, and Alain Gouyette
Cancer Res 1993 53: 1550-1554. [Abstract] [PDF]  

Inhibition of Multidrug Resistance by a New Staurosporine Derivative, NA-382, in Vitro and in Vivo

Ken-ichi Miyamoto, Kosei Inoko, Shinya Wakusawa, Shinji Kajita, Takaaki Hasegawa, Kenzo Takagi, and Masao Koyama
Cancer Res 1993 53: 1555-1559. [Abstract] [PDF]  

Antitumor Activity of the Weekly Intravenous Push Schedule of 5-Fluoro-2'-deoxyuridine ± N-Phosphonacetyl-L-aspartate in Mice Bearing Advanced Colon Carcinoma 26

J. A. M. van Laar, F. A. Durrani, and Y. M. Rustum
Cancer Res 1993 53: 1560-1564. [Abstract] [PDF]  

Protective Effects of Recombinant Human Interleukin-1 in Doxorubicin-treated Normal and Tumor-bearing Mice

David H. Lynch, Abbe S. Rubin, Robert E. Miller, and Douglas E. Williams
Cancer Res 1993 53: 1565-1570. [Abstract] [PDF]  

Tamoxifen Modulation of Cisplatin Sensitivity in Human Malignant Melanoma Cells

Edward F. Mc Clay, Kathleen D. Albright, Jeffrey A. Jones, Randolph D. Christen, and Stephen B. Howell
Cancer Res 1993 53: 1571-1576. [Abstract] [PDF]  

Regression of Human Breast Carcinoma Tumors in Immunodeficient Mice Treated with 9-Nitrocamptothecin: Differential Response of Nontumorigenic and Tumorigenic Human Breast Cells in Vitro

Panayotis Pantazis, Janet A. Early, Anthony J. Kozielski, John T. Mendoza, Hellmuth R. Hinz, and Beppino C. Giovanella
Cancer Res 1993 53: 1577-1582. [Abstract] [PDF]  

In Vitro Cytotoxicity, Cellular Pharmacology, and DNA Lesions Induced by Annamycin, an Anthracycline Derivative with High Affinity for Lipid Membranes

Yi-He Ling, Waldemar Priebe, Li-Ying Yang, Thomas G. Burke, Yves Pommier, and Roman Perez-Soler
Cancer Res 1993 53: 1583-1589. [Abstract] [PDF]  

High-Energy Shock Waves Induce Blood Flow Reduction in Tumors

Fernando Gamarra, Fritz Spelsberg, Gerhard E. H. Kuhnle, and Alwin E. Goetz
Cancer Res 1993 53: 1590-1595. [Abstract] [PDF]  

Prolongation of Drug Exposure in Cerebrospinal Fluid by Encapsulation into DepoFoam

Sinil Kim, Shirin Khatibi, Stephen B. Howell, Cindy McCully, Frank M. Balis, and David G. Poplack
Cancer Res 1993 53: 1596-1598. [Abstract] [PDF]  

Increase in Thermosensitivity of Tumor Cells by Lowering Intracellular pH

Chang W. Song, John C. Lyons, Robert J. Griffin, Carol M. Makepeace, and Edward J. Cragoe, Jr.
Cancer Res 1993 53: 1599-1601. [Abstract] [PDF]  

Immunology:

Properties of a M_r 110,000 Tumor Rejection Antigen of the Chemically Induced BALB/c Meth A Sarcoma

Albert B. De Leo, Matthew Becker, Lina Lu, and Lloyd W. Law
Cancer Res 1993 53: 1602-1607. [Abstract] [PDF]  

Intestinal Intraepithelial Lymphocytes Bind to Colon Cancer Cells by HML-1 and CD11a

Arthur I. Roberts, Sean M. O'Connell, and Ellen C. Ebert
Cancer Res 1993 53: 1608-1611. [Abstract] [PDF]  

Differential Regulation of Carcinoembryonic Antigen and Biliary Glycoprotein by -Interferon

Hiroki Takahashi, Yasuji Okai, Raymond J. Paxton, Laura J. F. Hefta, and John E. Shively
Cancer Res 1993 53: 1612-1619. [Abstract] [PDF]  

Molecular Biology and Genetics:

ras Mutations in 2-Acetylaminofluorene-induced Lung and Liver Tumors from C3H/HeJ and (C3HxA/J)F1 Mice

Yue Wang, Yian Wang, Gary Stoner, and Ming You
Cancer Res 1993 53: 1620-1624. [Abstract] [PDF]  

High Mutation Frequency in ras Genes of Skin Tumors Isolated from DNA Repair Deficient Xeroderma Pigmentosum Patients

Leela Daya-Grosjean, Caroline Robert, Christiane Drougard, Horacio Suarez, and Alain Sarasin
Cancer Res 1993 53: 1625-1629. [Abstract] [PDF]  

Transforming Growth Factor- Production and Autoinduction in a Colorectal Carcinoma Cell Line (DiFi) with an Amplified Epidermal Growth Factor Receptor Gene

Seema Untawale, Mark A. Zorbas, Clague P. Hodgson, Robert J. Coffey, Gary E. Gallick, Susan M. North, David M. Wildrick, Matilde Olive, Mark Blick, Lynn C. Yeoman, and Bruce M. Boman
Cancer Res 1993 53: 1630-1636. [Abstract] [PDF]  

Somatic p53 Mutations in Human Breast Carcinomas in an Icelandic Population: A Prognostic Factor

Steinunn Thorlacius, Anne-Lise Börresen, and Jorunn E. Eyfjörd
Cancer Res 1993 53: 1637-1641. [Abstract] [PDF]  

Ultraviolet-induced Cyclobutane Pyrimidine Dimers Are Selectively Removed from Transcriptionally Active Genes in the Epidermis of the Hairless Mouse

Hendrik J. T. Ruven, Rob J. W. Berg, C. Maud J. Seelen, Joël A. J. M. Dekkers, Paul H. M. Lohman, Leon H. F. Mullenders, and Albert A. van Zeeland
Cancer Res 1993 53: 1642-1645. [Abstract] [PDF]  

p53 Mutations Selected in Vivo When Mouse Mammary Epithelial Cells Form Hyperplastic Outgrowths Are Not Necessary for Establishment of Mammary Cell Lines in Vitro

Michelle A. Ozbun, D. Joseph Jerry, Frances S. Kittrell, Daniel Medina, and Janet S. Butel
Cancer Res 1993 53: 1646-1652. [Abstract] [PDF]  

Splicing Mutations of the p53 Gene in Human Hepatocellular Carcinoma

Ming-Yang Lai, Hua-Chen Chang, Hsin-Pai Li, Chen-Kuo Ku, Pei-Jer Chen, Jin-Chuan Sheu, Guan-Tarng Huang, Po-Huang Lee, and Ding-Shinn Chen
Cancer Res 1993 53: 1653-1656. [Abstract] [PDF]  

Transcriptional Activation of the Mouse mdr3 Gene Coincides with the Appearance of Novel Transcription Initiation Sites in Multidrug-resistant P388 Tumor Cells

Pierre Lepage, Martine Raymond, Alain Nepveu, and Philippe Gros
Cancer Res 1993 53: 1657-1664. [Abstract] [PDF]  

Multiple Mechanisms of Tumorigenesis in Eµ-myc Transgenic Mice

Charles L. Sidman, Terese M. Denial, Jan D. Marshall, and John B. Roths
Cancer Res 1993 53: 1665-1669. [Abstract] [PDF]  

Chromosome 12 Breakpoints Are Cytogenetically Different in Benign and Malignant Lipogenic Tumors: Localization of Breakpoints in Lipoma to 12q15 and in Myxoid Liposarcoma to 12q13.3

Krzysztof Mrózek, Constantine P. Karakousis, and Clara D. Bloomfield
Cancer Res 1993 53: 1670-1675. [Abstract] [PDF]  

Discordant p53 Gene Mutations in Primary Head and Neck Cancers and Corresponding Second Primary Cancers of the Upper Aerodigestive Tract

Kyung Y. Chung, Tapas Mukhopadhyay, Jhingook Kim, Alan Casson, Jae Y. Ro, Helmuth Goepfert, Waun K. Hong, and Jack A. Roth
Cancer Res 1993 53: 1676-1683. [Abstract] [PDF]  

Altered Chromosomal Methylation Patterns Accompany Oncogene-induced Transformation of Human Bronchial Epithelial Cells

Paula M. Vertino, Elisa A. Spillare, Curtis C. Harris, and Stephen B. Baylin
Cancer Res 1993 53: 1684-1689. [Abstract] [PDF]  

Tumor Biology:

E-Cadherin Expression in Primary and Metastatic Gastric Cancer: Down-Regulation Correlates with Cellular Dedifferentiation and Glandular Disintegration

Barbara Mayer, Judith P. Johnson, Florian Leitl, Karl W. Jauch, Markus M. Heiss, Friedrich W. Schildberg, Walter Birchmeier, and Ilona Funke
Cancer Res 1993 53: 1690-1695. [Abstract] [PDF]  

Expression of E-Cadherin Cell Adhesion Molecules in Human Breast Cancer Tissues and Its Relationship to Metastasis

Hiroshi Oka, Hitoshi Shiozaki, Kenji Kobayashi, Masatoshi Inoue, Hideaki Tahara, Tetsurou Kobayashi, Yuuichi Takatsuka, Norihisa Matsuyoshi, Shinji Hirano, Masatoshi Takeichi, and Takesada Mori
Cancer Res 1993 53: 1696-1701. [Abstract] [PDF]  

Protein Interaction of Retinoblastoma Gene Product pRb110 with M_r 73,000 Heat Shock Cognate Protein

Takehito Nihei, Shuji Takahashi, Satoru Sagae, Noriyuki Sato, and Kokichi Kikuchi
Cancer Res 1993 53: 1702-1705. [Abstract] [PDF]  

Expression of Sialyl-Tn Antigens in Normal Squamous Epithelium, Dysplasia, and Squamous Cell Carcinoma in the Esophagus

Yoichi Ikeda, Hiroyuki Kuwano, Kinya Baba, Masahiko Ikebe, Tetuya Matushima, Yousuke Adachi, Masaki Mori, and Keizo Sugimachi
Cancer Res 1993 53: 1706-1708. [Abstract] [PDF]  

Recombinant Human Stem Cell Factor Mediates Chemotaxis of Small-Cell Lung Cancer Cell Lines Aberrantly Expressing the c-kit Protooncogene

Yoshitaka Sekido, Takashi Takahashi, Ryuzo Ueda, Masahide Takahashi, Hiroko Suzuki, Keiko Nishida, Tetsuya Tsukamoto, Toyoaki Hida, Kaoru Shimokata, Krisztina M. Zsebo, and Toshitada Takahashi
Cancer Res 1993 53: 1709-1714. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1993 53: 1715-1716. [PDF]  

Recent Death

Cancer Res 1993 53: 1716 [PDF]  

Calendar of Events

Cancer Res 1993 53: 1717 [PDF]  

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