Advances in Brief:

Both the Cytosols and Detergent Extracts of Breast Cancer Tissues Are Suited to Evaluate the Prognostic Impact of the Urokinase-Type Plasminogen Activator and Its Inhibitor, Plasminogen Activator Inhibitor Type 1

Fritz Jänicke, Lothar Pache, Manfred Schmitt, Kurt Ulm, Christoph Thomssen, Anita Prechtl, and Henner Graeff
Cancer Res 1994 54: 2527-2530. [Abstract] [PDF]  

Interleukin-2-secreting Mouse Fibroblasts Transfected with Genomic DNA from Murine Melanoma Cells Prolong the Survival of Mice with Melanoma

Tae Sung Kim and Edward P. Cohen
Cancer Res 1994 54: 2531-2535. [Abstract] [PDF]  

Phosphoinositide Signaling in Nuclei of Friend Cells: Phospholipase C ß Down-Regulation Is Related to Cell Differentiation

Alberto M. Martelli, Anna M. Billi, R. Stewart Gilmour, Luca M. Neri, Lucia Manzoli, Andrea Ognibene, and Lucio Cocco
Cancer Res 1994 54: 2536-2540. [Abstract] [PDF]  

Elongation Factor 1 Is Enhanced following Exposure to Ionizing Radiation

Mira Jung, Alexei D. Kondratyev, and Anatoly Dritschilo
Cancer Res 1994 54: 2541-2543. [Abstract] [PDF]  

Radiosensitivity of Ataxia-Telangiectasia, X-Linked Agammaglobulinemia, and Related Syndromes Using a Modified Colony Survival Assay

Young K. Huo, Zhijun Wang, Ji-Hong Hong, Luciana Chessa, William H. McBride, Susan L. Perlman, and Richard A. Gatti
Cancer Res 1994 54: 2544-2547. [Abstract] [PDF]  

Evidence for Involvement of BRCA1 in Sporadic Breast Carcinomas

Craig S. Cropp, Heli A. Nevanlinna, Seppo Pyrhönen, Ulf-Håkan Stenman, Paul Salmikangas, Hans Albertsen, Ray White, and Robert Callahan
Cancer Res 1994 54: 2548-2551. [Abstract] [PDF]  

Methylation of the Estrogen Receptor Gene CpG Island Marks Loss of Estrogen Receptor Expression in Human Breast Cancer Cells

Yvonne L. Ottaviano, Jean-Pierre Issa, Fritz F. Parl, Helene S. Smith, Stephen B. Baylin, and Nancy E. Davidson
Cancer Res 1994 54: 2552-2555. [Abstract] [PDF]  

Cross-Resistance to Cisplatin in Cells Resistant to Photofrin-mediated Photodynamic Therapy

Roger A. Moorehead, Steven G. Armstrong, Brian C. Wilson, and Gurmit Singh
Cancer Res 1994 54: 2556-2559. [Abstract] [PDF]  

Developmental Regulation of Genomic Imprinting of the IGF2 Gene in Human Liver

Stella M. Davies
Cancer Res 1994 54: 2560-2562. [Abstract] [PDF]  

Cellular Interactions of CRKL, an SH2–SH3 Adaptor Protein

Johanna ten Hoeve, Vesa Kaartinen, Thoas Fioretos, Leena Haataja, Jan-Willem Voncken, Nora Heisterkamp, and John Groffen
Cancer Res 1994 54: 2563-2567. [Abstract] [PDF]  

Suppression of Tumorigenicity in Human Teratocarcinoma Cell Line PA-1 by Introduction of Chromosome 4

I. Jean McGowan-Jordan, Marsha D. Speevak, David Blakey, and Mario Chevrette
Cancer Res 1994 54: 2568-2572. [Abstract] [PDF]  

Positron Emission Tomography Analysis of Metastatic Tumor Cell Trafficking

Naoto Oku, Chieko Koike, Masaaki Sugawara, Hideo Tsukada, Tatsuro Irimura, and Shoji Okada
Cancer Res 1994 54: 2573-2576. [Abstract] [PDF]  

Androgen-independent Cancer Progression and Bone Metastasis in the LNCaP Model of Human Prostate Cancer

George N. Thalmann, Ploutarchos E. Anezinis, Shi-Ming Chang, Haiyen E. Zhau, E. Edmund Kim, Vicki L. Hopwood, Sen Pathak, Andrew C. von Eschenbach, and Leland W. K. Chung
Cancer Res 1994 54: 2577-2581. [Abstract] [PDF]  

Biochemistry and Biophysics:

Basic Fibroblast Growth Factor Protects Endothelial Cells against Radiation-induced Programmed Cell Death in Vitro and in Vivo

Zvi Fuks, Roger S. Persaud, Alan Alfieri, Maureen McLoughlin, Desiree Ehleiter, Jeffery L. Schwartz, Andrew P. Seddon, Carlos Cordon-Cardo, and Adriana Haimovitz-Friedman
Cancer Res 1994 54: 2582-2590. [Abstract] [PDF]  

Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells against Radiation-induced Apoptosis

Adriana Haimovitz-Friedman, Naomi Balaban, Maureen McLoughlin, Desiree Ehleiter, Joseph Michaeli, Israel Vlodavsky, and Zvi Fuks
Cancer Res 1994 54: 2591-2597. [Abstract] [PDF]  

Characterization of Tumor-associated Neural Cell Adhesion Molecule in Human Serum

Kiyoshi Takamatsu, Bernhard Auerbach, Rita Gerardy-Schahn, Matthias Eckhardt, Gabriele Jaques, and Norbert Madry
Cancer Res 1994 54: 2598-2603. [Abstract] [PDF]  

Homologous and Heterologous Regulation of -Melanocyte-stimulating Hormone Receptors in Human and Mouse Melanoma Cell Lines

Walter Siegrist, Sibylla Stutz, and Alex N. Eberle
Cancer Res 1994 54: 2604-2610. [Abstract] [PDF]  

1-Phosphatidylinositol 4-Kinase: An Enzyme Linked with Proliferation and Malignancy

Maria Teresa Rizzo and George Weber
Cancer Res 1994 54: 2611-2614. [Abstract] [PDF]  

Carcinogenesis:

Differential Expression of Human Wnt Genes 2, 3, 4, and 7B in Human Breast Cell Lines and Normal and Disease States of Human Breast Tissue

Emmanuel L. Huguet, Jill A. McMahon, Andrew P. McMahon, Roy Bicknell, and Adrian L. Harris
Cancer Res 1994 54: 2615-2621. [Abstract] [PDF]  

Inhibition of Cell Proliferation by Ciprofibrate in Glutathione S-Transferase P1-1-positive Rat Hepatic Hyperplastic Nodules

Zhi-Ying Chen, Ying-Fei Liu, Cheng-Yi He, Collin C. White, and David L. Eaton
Cancer Res 1994 54: 2622-2629. [Abstract] [PDF]  

Persistence of Carcinogen-altered Cell Population in Rat Urothelium Which Can Be Promoted to Tumors by Chronic Inflammatory Stimulus

Koji Kawai, Hitoshi Kawamata, Shuji Kemeyama, Alfred Rademaker, and Ryoichi Oyasu
Cancer Res 1994 54: 2630-2632. [Abstract] [PDF]  

Allelic Loss at the Predisposing Gene Locus in Spontaneous and Chemically Induced Renal Cell Carcinomas in the Eker Rat

Yoshiaki Kubo, Hiroaki Mitani, and Okio Hino
Cancer Res 1994 54: 2633-2635. [Abstract] [PDF]  

Clinical Investigations:

Phase I Clinical Trial of Irinotecan (CPT-11), 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin, and Cisplatin in Combination with Fixed Dose of Vindesine in Advanced Non-Small Cell Lung Cancer

Tetsu Shinkai, Hitoshi Arioka, Hiroshi Kunikane, Kenji Eguchi, Yasutsuna Sasaki, Tomohide Tamura, Yuichiro Ohe, Fumihiro Oshita, Makoto Nishio, Atsuya Karato, Hiroaki Okamoto, Hajime Nakashima, Hironobu Ohmatsu, Junichi Shiraishi, Naohiro Nomura, and Nagahiro Saijo
Cancer Res 1994 54: 2636-2642. [Abstract] [PDF]  

Experimental Therapeutics:

Antibody-Indocyanin Conjugates for Immunophotodetection of Human Squamous Cell Carcinoma in Nude Mice

Silvio Folli, Patrick Westermann, Daniel Braichotte, André Pèlegrin, Georges Wagnières, Hubert van den Bergh, and Jean-Pierre Mach
Cancer Res 1994 54: 2643-2649. [Abstract] [PDF]  

Effects of Sonicated Eosinophils on the in Vitro Sensitivity of Human Lymphoma Cells to Glucose Oxidase

Michael K. Samoszuk, Vincent Nguyen, Cherry T. Thomas, and Dawn M. Jacobson
Cancer Res 1994 54: 2650-2653. [Abstract] [PDF]  

Suramin, an Anticancer and Angiosuppressive Agent, Inhibits Endothelial Cell Binding of Basic Fibroblast Growth Factor, Migration, Proliferation, and Induction of Urokinase-Type Plasminogen Activator

Shingo Takano, Stephen Gately, Mary E. Neville, William F. Herblin, Janet L. Gross, Herbert Engelhard, Michael Perricone, Kristi Eidsvoog, and Steven Brem
Cancer Res 1994 54: 2654-2660. [Abstract] [PDF]  

Selective in Vivo Accumulation of N-Acetyl-4-S-cysteaminylphenol in B16F10 Murine Melanoma and Enhancement of Its in Vitro and in Vivo Antimelanoma Effect by Combination of Buthionine Sulfoximine

Frank Alena, Takashi Iwashina, Adrian Gili, and Kowichi Jimbow
Cancer Res 1994 54: 2661-2666. [Abstract] [PDF]  

Interleukin-1 Receptor Blockade Reduces the Number and Size of Murine B16 Melanoma Hepatic Metastases

Fernando Vidal-Vanaclocha, Cristian Amézaga, Aintzane Asumendi, Gilles Kaplanski, and Charles A. Dinarello
Cancer Res 1994 54: 2667-2672. [Abstract] [PDF]  

Novel 6,5-fused Ring Heterocyclic Antifolates: Biochemical and Biological Characterization

John J. McGuire, Vladimir V. Bergoltz, Kathryn J. Heitzman, William H. Haile, Cynthia A. Russell, Wanda E. Bolanowska, Yoshihiko Kotake, Toru Haneda, and Hiroaki Nomura
Cancer Res 1994 54: 2673-2679. [Abstract] [PDF]  

Cellular Pharmacology of Dichloro(ethylenediamine)platinum(II) in Cisplatin-sensitive and Resistant Human Ovarian Carcinoma Cells

Antti P. Jekunen, Doreen K. Hom, John E. Alcaraz, Alan Eastman, and Stephen B. Howell
Cancer Res 1994 54: 2680-2687. [Abstract] [PDF]  

Establishment of New SCID and Nude Mouse Models of Human B Leukemia/Lymphoma and Effective Therapy of the Tumors with Immunotoxin and Monoclonal Antibody: Marked Difference between the SCID and Nude Mouse Models in the Antitumor Efficacy of Monoclonal Antibody

Akira Kawata, Minoru Yoshida, Morihiro Okazaki, Soichiro Yokota, Maurice Barcos, and Ben K. Seon
Cancer Res 1994 54: 2688-2694. [Abstract] [PDF]  

An in Vivo Comparison of Oral 5-Iodo-2'-deoxyuridine and 5-Iodo-2-pyrimidinone-2'-deoxyribose Toxicity, Pharmacokinetics, and DNA Incorporation in Athymic Mouse Tissues and the Human Colon Cancer Xenograft, HCT-116

Timothy J. Kinsella, Keith A. Kunugi, Kathleen A. Vielhuber, William McCulloch, Shwu-Huey Liu, and Yung-Chi Cheng
Cancer Res 1994 54: 2695-2700. [Abstract] [PDF]  

Iododeoxyuridine Chemosensitization of cis-Diamminedichloroplatinum(II) in Human Bladder Cancer Cells

Kwan-Hwa Chi, Keith A. Kunugi, and Timothy J. Kinsella
Cancer Res 1994 54: 2701-2706. [Abstract] [PDF]  

Antiestrogenic Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on 17ß-Estradiol-induced pS2 Expression

Tim R. Zacharewski, Karen L. Bondy, Pamela McDonell, and Zhi Fen Wu
Cancer Res 1994 54: 2707-2713. [Abstract] [PDF]  

Antitumor Activity and Pharmacokinetics in Mice of a Recombinant Immunotoxin Containing a Disulfide-stabilized Fv Fragment

Yoram Reiter, Lee H. Pai, Ulrich Brinkmann, Qing-cheng Wang, and Ira Pastan
Cancer Res 1994 54: 2714-2718. [Abstract] [PDF]  

Intratumoral Generation of 5-Fluorouracil Mediated by an Antibody-Cytosine Deaminase Conjugate in Combination with 5-Fluorocytosine

Philip M. Wallace, John F. MacMaster, Virginia F. Smith, David E. Kerr, Peter D. Senter, and Wesley L. Cosand
Cancer Res 1994 54: 2719-2723. [Abstract] [PDF]  

Depletion of the erbB-2 Gene Product p185 by Benzoquinoid Ansamycins

Penny Miller, Catherine DiOrio, Mikel Moyer, Rodney C. Schnur, Arthur Bruskin, Walter Cullen, and James D. Moyer
Cancer Res 1994 54: 2724-2730. [Abstract] [PDF]  

Immunology:

Cytotoxic T-Lymphocyte Response to Autologous Human Squamous Cell Cancer of the Lung: Epitope Reconstitution with Peptides Extracted from HLA-Aw68

Craig L. Slingluff, Jr., Andrea L. Cox, John M. Stover, Jr., Marcia M. Moore, Donald F. Hunt, and Victor H. Engelhard
Cancer Res 1994 54: 2731-2737. [Abstract] [PDF]  

Antitumor x Anti-CD3 Bifunctional Antibodies Redirect T-Cells Activated in Vivo with Staphylococcal Enterotoxin B to Neutralize Pulmonary Metastases

Christophe Penna, Phillip A. Dean, and Heidi Nelson
Cancer Res 1994 54: 2738-2743. [Abstract] [PDF]  

Characteristics and in Vivo Homing of Long-Term T-Cell Lines and Clones Derived from Tumor-draining Lymph Nodes

Takafumi Matsumura, Jeffrey J. Sussman, Robert A. Krinock, Alfred E. Chang, and Suyu Shu
Cancer Res 1994 54: 2744-2750. [Abstract] [PDF]  

Molecular Biology and Genetics:

Nickel-induced Transformation of Human Cells Causes Loss of the Phosphorylation of the Retinoblastoma Protein

Xinhua Lin, W. Karol Dowjat, and Max Costa
Cancer Res 1994 54: 2751-2754. [Abstract] [PDF]  

The p53-dependent -Ray Response of GADD45

Qimin Zhan, Insoo Bae, Michael B. Kastan, and Albert J. Fornace, Jr.
Cancer Res 1994 54: 2755-2760. [Abstract] [PDF]  

Allelotype of Pancreatic Adenocarcinoma

Albert B. Seymour, Ralph H. Hruban, Mark Redston, Carlos Caldas, Steve M. Powell, Kenneth W. Kinzler, Charles J. Yeo, and Scott E. Kern
Cancer Res 1994 54: 2761-2764. [Abstract] [PDF]  

Genetic Identification of Mcs-1, a Rat Mammary Carcinoma Suppressor Gene

Lih-Ching Hsu, Wendy S. Kennan, Laurie A. Shepel, Howard J. Jacob, Claude Szpirer, Josiane Szpirer, Eric S. Lander, and Michael N. Gould
Cancer Res 1994 54: 2765-2770. [Abstract] [PDF]  

Tumor Biology:

Sensitivity of HER-2/neu Antibodies in Archival Tissue Samples: Potential Source of Error in Immunohistochemical Studies of Oncogene Expression

Michael F. Press, Gene Hung, William Godolphin, and Dennis J. Slamon
Cancer Res 1994 54: 2771-2777. [Abstract] [PDF]  

Spontaneous Transformation of Rat Ovarian Surface Epithelial Cells Results in Well to Poorly Differentiated Tumors with a Parallel Range of Cytogenetic Complexity

Joseph R. Testa, Lori A. Getts, Hernando Salazar, Zemin Liu, Laura M. Handel, Andrew K. Godwin, and Thomas C. Hamilton
Cancer Res 1994 54: 2778-2784. [Abstract] [PDF]  

Induction of Metastatic Ability in a Stably Diploid Benign Rat Mammary Epithelial Cell Line by Transfection with DNA from Human Malignant Breast Carcinoma Cell Lines

Barry R. Davies, Roger Barraclough, and Philip S. Rudland
Cancer Res 1994 54: 2785-2793. [Abstract] [PDF]  

Fibroblast Growth Factor Receptor Gene Expression and Immunoreactivity Are Elevated in Human Glioblastoma Multiforme

Richard S. Morrison, Fumio Yamaguchi, Janet M. Bruner, Mark Tang, Wallace McKeehan, and Mitchel S. Berger
Cancer Res 1994 54: 2794-2799. [Abstract] [PDF]  

Neovascularization in Clinical Stage A Testicular Germ Cell Tumor: Prediction of Metastatic Disease

Dolores Olivarez, Thomas Ulbright, Werner DeRiese, Richard Foster, Terry Reister, Lawrence Einhorn, and George Sledge
Cancer Res 1994 54: 2800-2802. [Abstract] [PDF]  

Human Osteosarcoma Cell Lines Are Dependent on Insulin-like Growth Factor I for in Vitro Growth

Cynthia Chavez Kappel, Maria C. Velez-Yanguas, Steven Hirschfeld, and Lee J. Helman
Cancer Res 1994 54: 2803-2807. [Abstract] [PDF]  

Virology:

Ultrastructural Localization of BHRF1: An Epstein-Barr Virus Gene Product Which Has Homology with bcl-2

Tamas Hickish, David Robertson, Paul Clarke, Mark Hill, Francesca di Stefano, Catherine Clarke, and David Cunningham
Cancer Res 1994 54: 2808-2811. [Abstract] [PDF]  

Meeting Report:

Cell Death in Cancer and Development: AACR Special Conference in Cancer Research

Alan Eastman, Steven Grant, Richard Lock, Thomas Tritton, Nancy Van Houten, and Junying Yuan
Cancer Res 1994 54: 2812-2818. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 2819-2821. [PDF]  

Erratum

Cancer Res 1994 54: 2821 [PDF]  

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