Advances in Brief:

Overexpression of ERK, an EPH Family Receptor Protein Tyrosine Kinase, in Various Human Tumors

Etsuko Kiyokawa, Setsuo Takai, Masamitsu Tanaka, Toshio Iwase, Makoto Suzuki, Yun-Yan Xiang, Yasuhisa Naito, Kiyomi Yamada, Haruhiko Sugimura, and Isamu Kino
Cancer Res 1994 54: 3645-3650. [Abstract] [PDF]  

-Irradiation-induced Micronuclei from Mouse Hepatoma Cells Accumulate High Levels of the Tumor Suppressor Protein p53

Christina Unger, Stefan Kress, Albrecht Buchmann, and Michael Schwarz
Cancer Res 1994 54: 3651-3655. [Abstract] [PDF]  

Expression and Localization of Urokinase-Type Plasminogen Activator in Human Astrocytomas in Vivo

Masaaki Yamamoto, Raymond Sawaya, Sanjeeva Mohanam, Ajay K. Bindal, Janet M. Bruner, Kazunari Oka, Velidi H. Rao, Masamichi Tomonaga, Garth L. Nicolson, and Jasti S. Rao
Cancer Res 1994 54: 3656-3661. [Abstract] [PDF]  

Growth Suppression of Human Head and Neck Cancer Cells by the Introduction of a Wild-Type p53 Gene via a Recombinant Adenovirus

Ta-Jen Liu, Wei-Wei Zhang, Dorothy L. Taylor, Jack A. Roth, Helmuth Goepfert, and Gary L. Clayman
Cancer Res 1994 54: 3662-3667. [Abstract] [PDF]  

Age-dependent Regulation of the Tumorigenic Potential of Neoplastically Transformed Rat Liver Epithelial Cells by the Liver Microenvironment

Karen D. McCullough, William B. Coleman, Gary J. Smith, and Joe W. Grisham
Cancer Res 1994 54: 3668-3671. [Abstract] [PDF]  

Wild-Type but not Mutant APC Associates with the Microtubule Cytoskeleton

Kelly J. Smith, Daniel B. Levy, Pamela Maupin, Thomas D. Pollard, Bert Vogelstein, and Kenneth W. Kinzler
Cancer Res 1994 54: 3672-3675. [Abstract] [PDF]  

The APC Gene Product Associates with Microtubules in Vivo and Promotes Their Assembly in Vitro

Susan Munemitsu, Brian Souza, Oliver Müller, Iris Albert, Bonnee Rubinfeld, and Paul Polakis
Cancer Res 1994 54: 3676-3681. [Abstract] [PDF]  

Genomic Instability of Microsatellite Repeats and Mutations of H-, K-, and N-ras, and p53 Genes in Renal Cell Carcinoma

Toyoaki Uchida, Chieki Wada, Chunxi Wang, Shin Egawa, Hideki Ohtani, and Ken Koshiba
Cancer Res 1994 54: 3682-3685. [Abstract] [PDF]  

Characterization of a Hydroxyurea-resistant Human KB Cell Line with Supersensitivity to 6-Thioguanine

Yun Yen, Susan P. Grill, Ginger E. Dutschman, Chien-Neng Chang, Bing-Sen Zhou, and Yung-Chi Cheng
Cancer Res 1994 54: 3686-3691. [Abstract] [PDF]  

CYP1A1 Genetic Polymorphisms and in Situ Colorectal Cancer

Lakshmi Sivaraman, Mary P. Leatham, Jonathan Yee, Lynne R. Wilkens, Alan F. Lau, and Loïc Le Marchand
Cancer Res 1994 54: 3692-3695. [Abstract] [PDF]  

Recombinant Human Uteroglobin Inhibits the in Vitro Invasiveness of Human Metastatic Prostate Tumor Cells and the Release of Arachidonic Acid Stimulated by Fibroblast-conditioned Medium

J. Leyton, M. J. Manyak, A. B. Mukherjee, L. Miele, G. Mantile, and S. R. Patierno
Cancer Res 1994 54: 3696-3699. [Abstract] [PDF]  

Secretion of Bioactive Granulocyte-Macrophage Colony-stimulating Factor by Human Colorectal Carcinoma Cells

Harald Lahm, Josiane Wyniger, Sylvie Hertig, Aysim Yilmaz, Jürgen R. Fischer, Jean-Claude Givel, and Nicolas Odartchenko
Cancer Res 1994 54: 3700-3702. [Abstract] [PDF]  

Frequent p53 Gene Mutations and Novel Alleles in Familial Breast Cancer

Oleg K. Glebov, Katherine E. McKenzie, Christine A. White, and Saraswati Sukumar
Cancer Res 1994 54: 3703-3709. [Abstract] [PDF]  

Common Regions of Deletion in Chromosome Regions 3p12 and 3p14.2 in Primary Clear Cell Renal Carcinomas

Jan Lubinski, Piotr Hadaczek, Jacek Podolski, Aleksandra Toloczko, Andrzej Sikorski, Peter McCue, Teresa Druck, and Kay Huebner
Cancer Res 1994 54: 3710-3713. [Abstract] [PDF]  

Paradoxical Inhibition of Solid Tumor Cell Growth by bcl2

Jennifer A. Pietenpol, Nickolas Papadopoulos, Sanford Markowitz, James K. V. Willson, Kenneth W. Kinzler, and Bert Vogelstein
Cancer Res 1994 54: 3714-3717. [Abstract] [PDF]  

Cell Cycle Arrests and Radiosensitivity of Human Tumor Cell Lines: Dependence on Wild-Type p53 for Radiosensitivity

Amanda J. McIlwrath, Paul A. Vasey, Gillian M. Ross, and Robert Brown
Cancer Res 1994 54: 3718-3722. [Abstract] [PDF]  

Metabolic Fate of Irinotecan in Humans: Correlation of Glucuronidation with Diarrhea

Elora Gupta, Timothy M. Lestingi, Rosemarie Mick, Jacqueline Ramirez, Everett E. Vokes, and Mark J. Ratain
Cancer Res 1994 54: 3723-3725. [Abstract] [PDF]  

Biochemistry and Biophysics:

A Method for Simultaneous Identification of Human Active and Active-site Alkylated O⁶-Methylguanine-DNA Methyltransferase and Its Possible Application for Monitoring Human Exposure to Alkylating Carcinogens

Teck-Choon Ayi, Hue-Kian Oh, Timothy K-Y. Lee, and Benjamin F. L. Li
Cancer Res 1994 54: 3726-3731. [Abstract] [PDF]  

Paracrine Growth Stimulation by Hepatocyte-derived Insulin-like Growth Factor-1: A Regulatory Mechanism for Carcinoma Cells Metastatic to the Liver

Li Long, John Nip, and Pnina Brodt
Cancer Res 1994 54: 3732-3737. [Abstract] [PDF]  

N-Acetylgalactosamine Glycosylation of MUC1 Tandem Repeat Peptides by Pancreatic Tumor Cell Extracts

Isao Nishimori, Fulvio Perini, Kimberly P. Mountjoy, Sam D. Sanderson, Nicole Johnson, Ronald L. Cerny, Michael L. Gross, J. Darrell Fontenot, and Michael A. Hollingsworth
Cancer Res 1994 54: 3738-3744. [Abstract] [PDF]  

Carcinogenesis:

Mutagenic Specificity of 2-Amino-3-methylimidazo[4,5-f]quinoline and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the supF Shuttle Vector System

Hisashi Endo, Herman A. J. Schut, and Elizabeth G. Snyderwine
Cancer Res 1994 54: 3745-3751. [Abstract] [PDF]  

Clinical Investigations:

p53 Protein Accumulation Detected by Five Different Antibodies: Relationship to Prognosis and Heat Shock Protein 70 in Breast Cancer

Richard M. Elledge, Gary M. Clark, Suzanne A. W. Fuqua, Yi-Yang Yu, and D. Craig Allred
Cancer Res 1994 54: 3752-3757. [Abstract] [PDF]  

Experimental Therapeutics:

p185^c-erbB-2 Signaling Enhances Cisplatin-induced Cytotoxicity in Human Breast Carcinoma Cells: Association between an Oncogenic Receptor Tyrosine Kinase and Drug-induced DNA Repair

Carlos L. Arteaga, Angela R. Winnier, Miriam C. Poirier, Daniel M. Lopez-Larraza, Laura K. Shawver, Stephen D. Hurd, and Stanford J. Stewart
Cancer Res 1994 54: 3758-3765. [Abstract] [PDF]  

Increased Activity and Expression of NAD(P)H:Quinone Acceptor Oxidoreductase in Confluent Cell Cultures and within Multicellular Spheroids

Roger M. Phillips, Aristotle de la Cruz, Robert D. Traver, and Neil W. Gibson
Cancer Res 1994 54: 3766-3771. [Abstract] [PDF]  

ICI D1694 and Idoxuridine: A Synergistic Antitumor Combination

Josie Pressacco, David W. Hedley, and Charles Erlichman
Cancer Res 1994 54: 3772-3778. [Abstract] [PDF]  

Cryptophycin: A New Antimicrotubule Agent Active against Drug-resistant Cells

Charles D. Smith, Xinqun Zhang, Susan L. Mooberry, Gregory M. L. Patterson, and Richard E. Moore
Cancer Res 1994 54: 3779-3784. [Abstract] [PDF]  

Reduction of Intratumoral pH by the Mitochondrial Inhibitor m-Iodobenzylguanidine and Moderate Hyperglycemia

A. Kuin, L. Smets, T. Volk, A. Paans, G. Adams, A. Atema, E. Jähde, A. Maas, M. F. Rajewsky, G. Visser, and P. Wood
Cancer Res 1994 54: 3785-3792. [Abstract] [PDF]  

Preclinical Antitumor Activity of Temozolomide in Mice: Efficacy against Human Brain Tumor Xenografts and Synergism with 1,3-Bis(2-chloroethyl)-1-nitrosourea

Jacqueline Plowman, William R. Waud, Antonis D. Koutsoukos, Lawrence V. Rubinstein, Timothy D. Moore, and Michael R. Grever
Cancer Res 1994 54: 3793-3799. [Abstract] [PDF]  

Immunology:

Defective Cytokine Production following Autologous Stem Cell Transplantation for Solid Tumors and Hematologic Malignancies Regardless of Bone Marrow or Peripheral Origin and Lack of Evidence for a Role for Interleukin-10 in Delayed Immune Reconstitution

Thierry Guillaume, Maryam Sekhavat, Daniel B. Rubinstein, Oussama Hamdan, Pierre Leblanc, and Michel L. Symann
Cancer Res 1994 54: 3800-3807. [Abstract] [PDF]  

Immunotherapy of Liver Metastases of Human Gastric Carcinoma with Interleukin 2-activated Natural Killer Cells

Satoshi Yasumura, Wen-chang Lin, Hideki Hirabayashi, Nikola L. Vujanovic, Ronald B. Herberman, and Theresa L. Whiteside
Cancer Res 1994 54: 3808-3816. [Abstract] [PDF]  

Molecula Biology and Genetics:

Chromosomal Gains and Losses in Uveal Melanomas Detected by Comparative Genomic Hybridization

Michael R. Speicher, Gabriele Prescher, Stanislas du Manoir, Anna Jauch, Bernhard Horsthemke, Norbert Bornfeld, Reinhard Becher, and Thomas Cremer
Cancer Res 1994 54: 3817-3823. [Abstract] [PDF]  

Fluorescence in Situ Hybridization Analysis of 8p Allelic Loss and Chromosome 8 Instability in Human Prostate Cancer

Jill A. Macoska, Tanya M. Trybus, Wael A. Sakr, Margaret C. Wolf, Philip D. Benson, Isaac J. Powell, and J. Edson Pontes
Cancer Res 1994 54: 3824-3830. [Abstract] [PDF]  

Molecular Cloning and Characterization of the Complementary DNA of an M_r 110,000 Antigen Expressed by Human Gastric Carcinoma Cells and Upregulated by -Interferon

Shinya Shimada, Michio Ogawa, Masayuki Takahashi, Jeffrey Schlom, and John W. Greiner
Cancer Res 1994 54: 3831-3836. [Abstract] [PDF]  

The Human DNA Repair Gene, ERCC2 (XPD), Corrects Ultraviolet Hypersensitivity and Ultraviolet Hypermutability of a Shuttle Vector Replicated in Xeroderma Pigmentosum Group D Cells

Engin M. Gözükara, Christopher N. Parris, Christine A. Weber, Edmund P. Salazar, Michael M. Seidman, John F. Watkins, Louise Prakash, and Kenneth H. Kraemer
Cancer Res 1994 54: 3837-3844. [Abstract] [PDF]  

E-Cadherin Gene Mutations Provide Clues to Diffuse Type Gastric Carcinomas

Karl-Friedrich Becker, Michael J. Atkinson, Ulrike Reich, Ingrid Becker, Hjalmar Nekarda, Jörg R. Siewert, and Heinz Höfler
Cancer Res 1994 54: 3845-3852. [Abstract] [PDF]  

Genetic Diagnosis Identifies Occult Lymph Node Metastases Undetectable by the Histopathological Method

Naoko Hayashi, Hirofumi Arakawa, Hiroki Nagase, Akio Yanagisawa, Yo Kato, Hirotoshi Ohta, Sadamu Takano, Michio Ogawa, and Yusuke Nakamura
Cancer Res 1994 54: 3853-3856. [Abstract] [PDF]  

Strand- and Sequence-specific Attenuation of N-Methyl-N'-nitro-N-nitrosoguanidine-induced G·C to A·T Transitions by Expression of Human O⁶-Methylguanine-DNA Methyltransferase in Chinese Hamster Ovary Cells

Jia-Ling Yang, Fu-Pin Hsieh, Ping-Chuan Lee, and Huang-Ju R. Tseng
Cancer Res 1994 54: 3857-3863. [Abstract] [PDF]  

Frequent and Specific Mutations of the Rat p53 Gene in Hepatocarcinomas Induced by Tamoxifen

Paul M. Vancutsem, Philip Lazarus, and Gary M. Williams
Cancer Res 1994 54: 3864-3867. [Abstract] [PDF]  

New T47D Breast Cancer Cell Lines for the Independent Study of Progesterone B- and A-Receptors: Only Antiprogestin-occupied B-Receptors Are Switched to Transcriptional Agonists by cAMP

Carol A. Sartorius, Steve D. Groshong, Louise A. Miller, Roger L. Powell, Lin Tung, Glenn S. Takimoto, and Kathryn B. Horwitz
Cancer Res 1994 54: 3868-3877. [Abstract] [PDF]  

Genomic p53 Mutation in a Chemically Induced Hamster Pancreatic Ductal Adenocarcinoma

Kuo-Wei Chang, Kathy A. Mangold, Susan Hubchak, Sergio Laconi, and Dante G. Scarpelli
Cancer Res 1994 54: 3878-3883. [Abstract] [PDF]  

Tumor Biology:

Differential Proliferative Responses of Syrian Hamster Embryo Fibroblasts to Paraquat-generated Superoxide Radicals Depending on Tumor Suppressor Gene Function

Thomas M. Nicotera, Christopher Privalle, T. C. Wang, Mitsuo Oshimura, and J. Carl Barrett
Cancer Res 1994 54: 3884-3888. [Abstract] [PDF]  

Tumor-forming Ability in Athymic Nude Mice of Human Cell Lines Devoid of Mitochondrial DNA

Réjean Morais, Karen Zinkewich-Péotti, Manon Parent, Hong Wang, Feridoun Babai, and Max Zollinger
Cancer Res 1994 54: 3889-3896. [Abstract] [PDF]  

Determinants of Human Astrocytoma Migration

Alf Giese, Monique D. Rief, Melinda A. Loo, and Michael E. Berens
Cancer Res 1994 54: 3897-3904. [Abstract] [PDF]  

UMSCC38 Cells Amplified at 11q13 for the Folate Receptor Synthesize a Mutant Nonfunctional Folate Receptor

Rebecca B. Orr and Barton A. Kamen
Cancer Res 1994 54: 3905-3911. [Abstract] [PDF]  

Polymorphisms, but Lack of Mutations or Instability, in the Promotor Region of the Mitochondrial Genome in Human Colonic Tumors

Barbara G. Heerdt, Jingshan Chen, Lisa R. Stewart, and Leonard H. Augenlicht
Cancer Res 1994 54: 3912-3915. [Abstract] [PDF]  

Impact of Heterogeneity in the Predictive Value of Kinetic Parameters in Canine Osteosarcoma

Susan M. LaRue, Michael H. Fox, STephen J. Withrow, Barbara E. Powers, Rodney C. Straw, Irene M. Côté, and Edward L. Gillette
Cancer Res 1994 54: 3916-3921. [Abstract] [PDF]  

Expression of CD44 in Normal Human versus Tumor Endometrial Tissues: Possible Implication of Reduced Expression of CD44 in Lymph-Vascular Space Involvement of Cancer Cells

Nobuhiro Fujita, Nobuo Yaegashi, Yoshihiro Ide, Shinji Sato, Masataka Nakamura, Isamu Ishiwata, and Akira Yajima
Cancer Res 1994 54: 3922-3928. [Abstract] [PDF]  

Decreased E-Cadherin Expression Is Associated with Poor Prognosis in Patients with Prostate Cancer

Rainy Umbas, William B. Isaacs, Pierre P. Bringuier, H. Ewout Schaafsma, Herbert F. M. Karthaus, Gosse O. N. Oosterhof, Frans M. J. Debruyne, and Jack A. Schalken
Cancer Res 1994 54: 3929-3933. [Abstract] [PDF]  

Absence of N-ras Mutations in Myeloid and Lymphoid Blast Crisis of Chronic Myeloid Leukemia

F. Watzinger, A. Gaiger, H. Karlic, R. Becher, K. Pillwein, and T. Lion
Cancer Res 1994 54: 3934-3938. [Abstract] [PDF]  

Lack of a Correlation between Radiosensitivity and DNA Double-Strand Break Induction or Rejoining in Six Human Tumor Cell Lines

Peggy L. Olive, Judit P. Banáth, and H. Susan MacPhail
Cancer Res 1994 54: 3939-3946. [Abstract] [PDF]  

Letter to the Editor:

Correspondence re: Z. Ram et al., In Situ Retroviral-mediated Gene Transfer for the Treatment of Brain Tumors in Rats. Cancer Res., 53: 83–88, 1993

Gary Goldberg and John S. Bertram
Cancer Res 1994 54: 3947-3948. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 3949-3952. [PDF]  

Errata

Cancer Res 1994 54: 3952-3953. [PDF]  

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