Advances in Brief:

Immunohistochemical Staining of Human Spermidine/Spermine N¹-Acetyltransferase Superinduced in Response to Treatment with Antitumor Polyamine Analogues

Robert A. Casero, Jr., Edward W. Gabrielson, and Anthony E. Pegg
Cancer Res 1994 54: 3955-3958. [Abstract] [PDF]  

Induction and Expression of Amphiregulin in Human Pancreatic Cancer

Matthias Ebert, Munehiro Yokoyama, Michael S. Kobrin, Helmut Friess, Martha E. Lopez, Markus W. Büchler, Gibbs R. Johnson, and Murray Korc
Cancer Res 1994 54: 3959-3962. [Abstract] [PDF]  

Treatment of Malignant Gliomas Using Ganciclovir-hypersensitive, Ribonucleotide Reductase-deficient Herpes Simplex Viral Mutant

Toshihiro Mineta, Samuel D. Rabkin, and Robert L. Martuza
Cancer Res 1994 54: 3963-3966. [Abstract] [PDF]  

Phosphorylation of Ornithine Decarboxylase at Both Serine and Threonine Residues in the ODC-overproducing, Abelson Virus-transformed RAW264 Cell Line

Laura L. Worth, Barbara J. Cochran, and Mari K. Haddox
Cancer Res 1994 54: 3967-3970. [Abstract] [PDF]  

Determination of a Putative Recombinogenic Human Hepatitis B Virus Sequence and Its Binding Cellular Protein

Kazunori Kajino, Yasuo Hotta, and Okio Hino
Cancer Res 1994 54: 3971-3973. [Abstract] [PDF]  

Improved Detection of the Early Stages of Colon Cancer by Determining Both Free Circulating and Immune Complex-bound Antigens Reactive with Monoclonal Antibody

Samuel J. Chester, Yow-Pin Lim, Michael P. Vezeridis, and Douglas C. Hixson
Cancer Res 1994 54: 3974-3978. [Abstract] [PDF]  

Isolation of Human nm23 Genomes and Analysis of Loss of Heterozygosity in Primary Colorectal Carcinomas Using a Specific Genomic Probe

Kazuya Okada, Takeshi Urano, Takanori Goi, Hideo Baba, Akio Yamaguchi, Koichi Furukawa, and Hiroshi Shiku
Cancer Res 1994 54: 3979-3982. [Abstract] [PDF]  

Replication Error-Type Genetic Instability at 1q42–43 in Human Male Germ Cell Tumors

V. V. V. S. Murty, Rong-Guo Li, Susan Mathew, Victor E. Reuter, David L. Bronson, George J. Bosl, and R. S. K. Chaganti
Cancer Res 1994 54: 3983-3985. [Abstract] [PDF]  

Cytogenetic Characterization of Tenosynovial Giant Cell Tumors (Nodular Tenosynovitis)

Paola Dal Cin, Raf Sciot, Ignace Samson, Luc De Smet, Ivo De Wever, Boudewijn Van Damme, and Herman Van Den Berghe
Cancer Res 1994 54: 3986-3987. [Abstract] [PDF]  

CD44 Mediates Human Glioma Cell Adhesion and Invasion in Vitro

Abderrahim Merzak, Shahriar Koocheckpour, and Geoffrey J. Pilkington
Cancer Res 1994 54: 3988-3992. [Abstract] [PDF]  

Development and Characterization of Suramin-resistant Chinese Hamster Fibrosarcoma Cells: Drug-dependent Formation of Multicellular Spheroids and a Greatly Enhanced Metastatic Potential

Sophie Lelièvre and Annette Kragh Larsen
Cancer Res 1994 54: 3993-3997. [Abstract] [PDF]  

Aneuploidy and Aneusomy of Chromosome 7 Detected by Fluorescence in Situ Hybridization Are Markers of Poor Prognosis in Prostate Cancer

Antonio Alcaraz, Satoru Takahashi, James A. Brown, John F. Herath, Erik J. Bergstralh, Jeffrey J. Larson-Keller, Michael M. Lieber, and Robert B. Jenkins
Cancer Res 1994 54: 3998-4002. [Abstract] [PDF]  

A Region of Homozygous Deletion on Chromosome 9p21–22 in Primary Nasopharyngeal Carcinoma

Dolly P. Huang, Kwok-Wai Lo, C. Andrew van Hasselt, John K. S. Woo, Peter H. K. Choi, Sing-Fai Leung, Siu-Tim Cheung, Paul Cairns, David Sidransky, and Joseph C. K. Lee
Cancer Res 1994 54: 4003-4006. [Abstract] [PDF]  

Deletion Mapping of a Putative Tumor Suppressor Gene on Chromosome 4 in Mouse Lung Tumors

Christopher R. Herzog, Roger W. Wiseman, and Ming You
Cancer Res 1994 54: 4007-4010. [Abstract] [PDF]  

Biochemistry and Biophysics:

Metabolic Consequences of a Reversed pH Gradient in Rat Tumors

Marion Stubbs, Loreta Rodrigues, Franklyn A. Howe, Jian Wang, Kyu-Shik Jeong, Richard L. Veech, and John R. Griffiths
Cancer Res 1994 54: 4011-4016. [Abstract] [PDF]  

Characterization of a Membrane-bound Metalloendoprotease of Rat C6 Glioblastoma Cells

Verena R. Amberger, Paolo A. Paganetti, Harald Seulberger, Joyce A. Eldering, and Martin E. Schwab
Cancer Res 1994 54: 4017-4025. [Abstract] [PDF]  

Metabolism of Taxol by Human Hepatic Microsomes and Liver Slices: Participation of Cytochrome P450 3A4 and an Unknown P450 Enzyme

James W. Harris, Atiqur Rahman, Bok-Ryang Kim, F. Peter Guengerich, and Jerry M. Collins
Cancer Res 1994 54: 4026-4035. [Abstract] [PDF]  

Use of Model Cell Lines to Study the Biosynthesis and Biological Role of Cancer-associated Sialosyl-Tn Antigen

Shunichiro Ogata, Anli Chen, and Steven H. Itzkowitz
Cancer Res 1994 54: 4036-4044. [Abstract] [PDF]  

Carcinogenesis:

Nickel(II) Interferes with the Incision Step in Nucleotide Excision Repair in Mammalian Cells

Andrea Hartwig, Leon H. F. Mullenders, Regina Schlepegrell, Ursula Kasten, and Detmar Beyersmann
Cancer Res 1994 54: 4045-4051. [Abstract] [PDF]  

Enhanced Cytochrome P450 (Cyp1b1) Expression, Aryl Hydrocarbon Hydroxylase Activity, Cytotoxicity, and Transformation of C3H 10T1/2 Cells by Dimethylbenz(a)anthracene in Conditioned Medium

Zhiyuan Shen, Robert L. Wells, and Mortimer M. Elkind
Cancer Res 1994 54: 4052-4056. [Abstract] [PDF]  

Growth Inhibition of HT-29 Human Colon Cancer Cells by Analogues of 1,25-Dihydroxyvitamin D₃

Mohsen Shabahang, Robert R. Buras, Fatemeh Davoodi, Lisa M. Schumaker, Russell J. Nauta, Milan R. Uskokovic, Richard V. Brenner, and Stephen R. T. Evans
Cancer Res 1994 54: 4057-4064. [Abstract] [PDF]  

Clinical Investigations:

Prognostic Relevance of Plasminogen Activators and Their Inhibitors in Colorectal Cancer

Sjam Ganesh, Cornelis F. M. Sier, Gerrit Griffioen, Hans J. M. Vloedgraven, Anton de Boer, Kees Welvaart, Cornelis J. H. van de Velde, Johan H. J. M. van Krieken, Jan H. Verheijen, Cornelis B. H. W. Lamers, and Hein W. Verspaget
Cancer Res 1994 54: 4065-4071. [Abstract] [PDF]  

Relationships between the Formation of O⁶-Methyldeoxyguanosine by 1-p-Carboxyl-3,3-dimethylphenyltriazene in DNA and O⁶-Alkylguanine-DNA Alkyltransferase in Human Peripheral Leukocytes

Siow Ming Lee, Peter J. O'Connor, Nicholas Thatcher, Derek Crowther, Geoffrey P. Margison, and Donald P. Cooper
Cancer Res 1994 54: 4072-4076. [Abstract] [PDF]  

Sensitive Enzymatic Cycling Assay for Glutathione: Measurements of Glutathione Content and Its Modulation by Buthionine Sulfoximine in Vivo and in Vitro in Human Colon Cancer

Sosamma J. Berger, David Gosky, Elizabeth Zborowska, James K. V. Willson, and Nathan A. Berger
Cancer Res 1994 54: 4077-4083. [Abstract] [PDF]  

Phase I Trial of Recombinant Macrophage Colony-stimulating Factor and Recombinant -Interferon: Toxicity, Monocytosis, and Clinical Effects

Louis M. Weiner, Wei Li, Michele Holmes, Robert B. Catalano, Monica Dovnarsky, Kristin Padavic, and R. Katherine Alpaugh
Cancer Res 1994 54: 4084-4090. [Abstract] [PDF]  

Endocrinology:

Antiproliferative Effects of Luteinizing Hormone-releasing Hormone (LHRH) Agonists on Human Androgen-independent Prostate Cancer Cell Line DU 145: Evidence for an Autocrine-inhibitory LHRH Loop

Donatella Dondi, Patrizia Limonta, Roberta M. Moretti, Marina Montagnani Marelli, Enrico Garattini, and Marcella Motta
Cancer Res 1994 54: 4091-4095. [Abstract] [PDF]  

Detection of Discrete Androgen Receptor Epitopes in Prostate Cancer by Immunostaining: Measurement by Color Video Image Analysis

Wayne D. Tilley, Sylvia S. Lim-Tio, David J. Horsfall, James O. Aspinall, Villis R. Marshall, and John M. Skinner
Cancer Res 1994 54: 4096-4102. [Abstract] [PDF]  

Epidemiology:

Glutathione S-Transferase M1 and Its Variants A and B as Host Factors of Bladder Cancer Susceptibility: A Case-Control Study

Jürgen Brockmöller, Reinhold Kerb, Nikolaos Drakoulis, Beate Staffeldt, and Ivar Roots
Cancer Res 1994 54: 4103-4111. [Abstract] [PDF]  

Experimental Therapeutics:

Effects of N-(4-Hydroxyphenyl)retinamide Supplementation on Vitamin A Metabolism

Kevin C. Lewis, Loren A. Zech, and James M. Phang
Cancer Res 1994 54: 4112-4117. [Abstract] [PDF]  

Schedule Dependency of Orally Administered Bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) in Vivo

Mark J. McKeage, Lloyd R. Kelland, Frances E. Boxall, Melanie R. Valenti, Mervyn Jones, Phyllis M. Goddard, Jean Gwynne, and Kenneth R. Harrap
Cancer Res 1994 54: 4118-4122. [Abstract] [PDF]  

Overexpression of the RI Subunit of Protein Kinase A Confers Hypersensitivity to Topoisomerase II Inhibitors and 8-Chloro-cyclic Adenosine 3',5'-Monophosphate in Chinese Hamster Ovary Cells

Phillip S. North, Sally L. Davies, Fortunato Ciardiello, Vincenzo Damiano, Caterina Bianco, Stefano Pepe, A. Raffaele Bianco, Adrian L. Harris, Ian D. Hickson, and Giampaolo Tortora
Cancer Res 1994 54: 4123-4128. [Abstract] [PDF]  

Hyperthermia Can Reduce Cytotoxicity from Etoposide without a Corresponding Reduction in the Number of Topoisomerase II-DNA Cleavable Complexes

Joseph R. Dynlacht, Rosemary S. L. Wong, Norman Albright, and William C. Dewey
Cancer Res 1994 54: 4129-4137. [Abstract] [PDF]  

Development and Molecular Characterization of a 2',2'-Difluorodeoxycytidine-resistant Variant of the Human Ovarian Carcinoma Cell Line A2780

Veronique W. T. Ruiz van Haperen, Gijsbert Veerman, Staffan Eriksson, Epie Boven, Alexander P. A. Stegmann, Mario Hermsen, Jan B. Vermorken, Herbert M. Pinedo, and Godefridus J. Peters
Cancer Res 1994 54: 4138-4143. [Abstract] [PDF]  

Immunology:

Retinoic Acid-stimulated Intercellular Adhesion Molecule-1 Expression on SK-N-SH Cells: Calcium/Calmodulin-dependent Pathway

Marlène Bouillon and Marie Audette
Cancer Res 1994 54: 4144-4149. [Abstract] [PDF]  

Taxol Induces the Hematopoietic Growth Factor Granulocyte-Macrophage Colony-stimulating Factor in Murine B-Cells by Stabilization of Granulocyte-Macrophage Colony-stimulating Factor Nuclear RNA

Dov H. Pluznik, Nancy S. Lee, and Tomohiro Sawada
Cancer Res 1994 54: 4150-4154. [Abstract] [PDF]  

Insertion Signal Sequence Fused to Minimal Peptides Elicits Specific CD8⁺ T-Cell Responses and Prolongs Survival of Thymoma-bearing Mice

Boris R. Minev, Barbra J. McFarland, Paul J. Spiess, Steven A. Rosenberg, and Nicholas P. Restifo
Cancer Res 1994 54: 4155-4161. [Abstract] [PDF]  

Immunoscintigraphy of Human Mammary Carcinoma Xenografts Using Monoclonal Antibodies 12H12 and BM-2 Labeled with ^99mTc and Radioiodine

Tim H. Brümmendorf, Sepp Kaul, Jochen Schuhmacher, Richard P. Baum, Ronald Matys, Gábor Klivényi, Stefan Adams, and Gunther Bastert
Cancer Res 1994 54: 4162-4168. [Abstract] [PDF]  

Molecular Biology and Genetics:

Mice Transgenic for the Human Carcinoembryonic Antigen Gene Maintain Its Spatiotemporal Expression Pattern

Anne-Marie Eades-Perner, Herman van der Putten, Antje Hirth, John Thompson, Michael Neumaier, Sabine von Kleist, and Wolfgang Zimmermann
Cancer Res 1994 54: 4169-4176. [Abstract] [PDF]  

Deletions of Chromosome 13q, Mutations in Retinoblastoma 1, and Retinoblastoma Protein State in Human Hepatocellular Carcinoma

Xue Zhang, Hong-Ji Xu, Yoshinori Murakami, Richard Sachse, Kazuo Yashima, Setsuo Hirohashi, Shi-Xue Hu, William F. Benedict, and Takao Sekiya
Cancer Res 1994 54: 4177-4182. [Abstract] [PDF]  

A Homozygous Deletion in a Small Cell Lung Cancer Cell Line Involving a 3p21 Region with a Marked Instability in Yeast Artificial Chromosomes

Klaas Kok, Anke van den Berg, Patrick M. J. F. Veldhuis, Anneke Y. van der Veen, Marion Franke, Eric F. P. M. Schoenmakers, Miriam M. F. Hulsbeek, Annemarie H. van der Hout, Lou de Leij, Wim van de Ven, and Charles H. C. M. Buys
Cancer Res 1994 54: 4183-4187. [Abstract] [PDF]  

Frequent Genetic Alterations at the Distal Region of Chromosome 1p in Human Hepatocellular Carcinomas

Shiou-Hwei Yeh, Pei-Jer Chen, Hui-Ling Chen, Ming-Yang Lai, Chu-Chang Wang, and Ding-Shinn Chen
Cancer Res 1994 54: 4188-4192. [Abstract] [PDF]  

The 6-Kilobase c-erbB2 Promoter Contains Positive and Negative Regulatory Elements Functional in Human Mammary Cell Lines

Madeleine Grooteclaes, Françoise Pasleau, Huguette Dijkmans, Paulette Berzi, Adelin Albert, and Rosita Winkler-Gol
Cancer Res 1994 54: 4193-4199. [Abstract] [PDF]  

Evidence for a Gene on 17p13.3, Distal to TP53, as a Target for Allele Loss in Breast Tumors without p53 Mutations

Renée S. Cornelis, Margreethe van Vliet, Carla B. J. Vos, Anne-Marie Cleton-Jansen, Marc J. van de Vijver, Johannes L. Peterse, P. Meera Khan, Anne-Lise Børresen, Cees J. Cornelisse, and Peter Devilee
Cancer Res 1994 54: 4200-4206. [Abstract] [PDF]  

Kinds and Locations of Mutations Induced in the Hypoxanthine-Guanine Phosphoribosyltransferase Gene of Human T-Lymphocytes by 1-Nitrosopyrene, Including Those Caused by V(D)J Recombinase

W. Glenn McGregor, Veronica M. Maher, and J. Justin McCormick
Cancer Res 1994 54: 4207-4213. [Abstract] [PDF]  

Tumor Biology:

Regulation of Apoptosis by Low Serum in Cells of Different Stages of Neoplastic Progression: Enhanced Susceptibility after Loss of a Senescence Gene and Decreased Susceptibility after Loss of a Tumor Suppressor Gene

Gloria A. Preston, Jason E. Lang, Robert R. Maronpot, and J. Carl Barrett
Cancer Res 1994 54: 4214-4223. [Abstract] [PDF]  

Inhibition of Tumor Growth in Liver Epithelial Cells Transfected with a Transforming Growth Factor Antisense Gene

A. Douglas Laird, Pamela I. Brown, and Nelson Fausto
Cancer Res 1994 54: 4224-4232. [Abstract] [PDF]  

Markedly Increased Amounts of Messenger RNAs for Vascular Endothelial Growth Factor and Placenta Growth Factor in Renal Cell Carcinoma Associated with Angiogenesis

Atsushi Takahashi, Hiroki Sasaki, Sun Jin Kim, Ken-ichi Tobisu, Tadao Kakizoe, Taiji Tsukamoto, Yoshiaki Kumamoto, Takashi Sugimura, and Masaaki Terada
Cancer Res 1994 54: 4233-4237. [Abstract] [PDF]  

CD44H Expression by Human Neuroblastoma Cells: Relation to MYCN Amplification and Lineage Differentiation

Nicole Gross, Christine Beretta, Geneviève Peruisseau, David Jackson, David Simmons, and Daniel Beck
Cancer Res 1994 54: 4238-4242. [Abstract] [PDF]  

Meeting Report:

Interactions of Cancer Susceptibility Genes and Environmental Carcinogens: American Association for Cancer Research (AACR)-International Agency for Research on Cancer (IARC) Joint Conference

F. P. Li and R. Montesano
Cancer Res 1994 54: 4243-4247. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 4248-4251. [PDF]  

Erratum:

The deviations of observed and predicted nadir counts (residuals) were compared to the predicted nadir counts

Cancer Res 1994 54: 4251 [PDF]  

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