Advances in Brief:

Seminal Ribonuclease Inhibits Tumor Growth and Reduces the Metastatic Potential of Lewis Lung Carcinoma

Paolo Laccetti, Daniela Spalletti-Cernia, Giuseppe Portella, Paola De Corato, Giuseppe D'Alessio, and Giancarlo Vecchio
Cancer Res 1994 54: 4253-4256. [Abstract] [PDF]  

Increased Copy Number at 20q13 in Breast Cancer: Defining the Critical Region and Exclusion of Candidate Genes

Minna M. Tanner, Mika Tirkkonen, Anne Kallioniemi, Colin Collins, Trond Stokke, Ritva Karhu, Dave Kowbel, Feridan Shadravan, Mary Hintz, Wen-Lin Kuo, Frederic M. Waldman, Jorma J. Isola, Joe W. Gray, and Olli-P. Kallioniemi
Cancer Res 1994 54: 4257-4260. [Abstract] [PDF]  

Suppression of Fibrosarcoma Metastasis by Elevated Expression of Manganese Superoxide Dismutase

S. E. Safford, T. D. Oberley, M. Urano, and D. K. St. Clair
Cancer Res 1994 54: 4261-4265. [Abstract] [PDF]  

Gene Therapy Targeted by Radiation Preferentially Radiosensitizes Tumor Cells

Ralph R. Weichselbaum, Dennis E. Hallahan, Michael A. Beckett, Helena J. Mauceri, Henry Lee, Vikas P. Sukhatme, and Donald W. Kufe
Cancer Res 1994 54: 4266-4269. [Abstract] [PDF]  

Antiproliferative Effects of Enediynes on AIDS-derived Kaposi's Sarcoma Cells

Jacques Corbeil, Douglas D. Richman, Wolfgang Wrasidlo, K. C. Nicolaou, and David J. Looney
Cancer Res 1994 54: 4270-4273. [Abstract] [PDF]  

A Tumor Suppressor Gene on Chromosome 1p32-pter Controls the Amplification of MYC Family Genes in Breast Cancer

Ivan Bièche, Marie-Hélène Champème, and Rosette Lidereau
Cancer Res 1994 54: 4274-4276. [Abstract] [PDF]  

ALL-1 Tandem Duplication in Acute Myeloid Leukemia with a Normal Karyotype Involves Homologous Recombination between Alu Elements

Steven A. Schichman, Michael A. Caligiuri, Matthew P. Strout, Stephen L. Carter, Yansong Gu, Eli Canaani, Clara D. Bloomfield, and Carlo M. Croce
Cancer Res 1994 54: 4277-4280. [Abstract] [PDF]  

Prostatic Tumor Regrowth after Initially Successful Castration Therapy May Be Related to a Decreased Apoptotic Cell Death Rate

Marene Landström, Jan-Erik Damber, and Anders Bergh
Cancer Res 1994 54: 4281-4284. [Abstract] [PDF]  

Unscheduled Expression of Cyclin B1 and Cyclin E in Several Leukemic and Solid Tumor Cell Lines

Jianping Gong, Barbara Ardelt, Frank Traganos, and Zbigniew Darzynkiewicz
Cancer Res 1994 54: 4285-4288. [Abstract] [PDF]  

Simultaneous Analysis of DNA Replication and Apoptosis during Treatment of HL-60 Cells with Camptothecin and Hyperthermia and Mitogen Stimulation of Human Lymphocytes

Xun Li, Frank Traganos, and Zbigniew Darzynkiewicz
Cancer Res 1994 54: 4289-4293. [Abstract] [PDF]  

Allelotype of Endometrial Carcinoma

Takafumi Fujino, John I. Risinger, N. Keith Collins, Fu-shing Liu, Hiroshi Nishii, Hiroyuki Takahashi, Eva-Marie Westphal, J. Carl Barrett, Hiroshi Sasaki, Matthew F. Kohler, Andrew Berchuck, and Jeff Boyd
Cancer Res 1994 54: 4294-4298. [Abstract] [PDF]  

Amplification of Multiple Genes from Chromosomal Region 12q13-14 in Human Malignant Gliomas: Preliminary Mapping of the Amplicons Shows Preferential Involvement of CDK4, SAS, and MDM2

Guido Reifenberger, Julia Reifenberger, Koichi Ichimura, Paul S. Meltzer, and V. Peter Collins
Cancer Res 1994 54: 4299-4303. [Abstract] [PDF]  

Distribution of Intestine-associated Lymphoid Tissue, Aberrant Crypt Foci, and Tumors in the Large Bowel of 1,2-Dimethylhydrazine-treated Mice

John W. Carter, Hugh K. Lancaster, W. Elaine Hardman, and Ivan L. Cameron
Cancer Res 1994 54: 4304-4307. [Abstract] [PDF]  

Human Chromosome 3 Corrects Mismatch Repair Deficiency and Microsatellite Instability and Reduces N-Methyl-N'-nitro-N-nitrosoguanidine Tolerance in Colon Tumor Cells with Homozygous hMLH1 Mutation

Minoru Koi, Asad Umar, Dharam P. Chauhan, Sajeev P. Cherian, John M. Carethers, Thomas A. Kunkei, and C. Richard Boland
Cancer Res 1994 54: 4308-4312. [Abstract] [PDF]  

Perspectives in Cancer Research:

Glutathione-associated Enzymes in Anticancer Drug Resistance

Kenneth D. Tew
Cancer Res 1994 54: 4313-4320. [Abstract] [PDF]  

Biochemistry and Biophysics:

Effect of Modulators on 5-Fluorouracil Metabolite Patterns in Murine Colon Carcinoma Determined by in Vitro ¹⁹F Nuclear Magnetic Resonance Spectroscopy

Yvonne J. L. Kamm, Ivonne M. C. M. Rietjens, Jacques Vervoort, Arend Heerschap, Gert Rosenbusch, Henny P. Hofs, and D. J. Theo Wagener
Cancer Res 1994 54: 4321-4326. [Abstract] [PDF]  

Carcinogenesis:

Structure-Activity Relationships of Isothiocyanates as Mechanism-based Inhibitors of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced Lung Tumorigenesis in A/J Mice

Ding Jiao, Karin I. Eklind, Chang-In Choi, Dhimant H. Desai, Shantu G. Amin, and Fung-Lung Chung
Cancer Res 1994 54: 4327-4333. [Abstract] [PDF]  

Inflammation Is Responsible for the Development of Wound-induced Tumors in Chickens Infected with Rous Sarcoma Virus

Manuela Martins-Green, Nancy Boudreau, and Mina J. Bissell
Cancer Res 1994 54: 4334-4341. [Abstract] [PDF]  

p53 Tumor Suppressor Gene Mutation in Early Esophageal Precancerous Lesions and Carcinoma among High-Risk Populations in Henan, China

Hongkun Gao, Li-Dong Wang, Qi Zhou, Jun-Yan Hong, Tong-Yuh Huang, and Chung S. Yang
Cancer Res 1994 54: 4342-4346. [Abstract] [PDF]  

Clinical Investigations:

Phase I and Pharmacokinetic Study of the Camptothecin Derivative Irinotecan, Administered on a Weekly Schedule in Cancer Patients

M. de Forni, R. Bugat, G. G. Chabot, S. Culine, J-M. Extra, A. Gouyette, I. Madelaine, M. E. Marty, and A. Mathieu-Boué
Cancer Res 1994 54: 4347-4354. [Abstract] [PDF]  

Experimental Therapeutics:

Paclitaxel Inhibits Progression of Mitotic Cells to G₁ Phase by Interference with Spindle Formation without Affecting Other Microtubule Functions during Anaphase and Telephase

Byron H. Long and Craig R. Fairchild
Cancer Res 1994 54: 4355-4361. [Abstract] [PDF]  

Radioimmunotherapy of Nude Mice Bearing a Human Interleukin 2 Receptor -expressing Lymphoma Utilizing the -emitting Radionuclide-conjugated Monoclonal Antibody ²¹²Bi-anti-Tac

Frank Hartmann, Eva M. Horak, Kayhan Garmestani, Chuanchu Wu, Martin W. Brechbiel, Robert W. Kozak, J. Tso, Sheri A. Kosteiny, Otto A. Gansow, David L. Nelson, and Thomas A. Waldmann
Cancer Res 1994 54: 4362-4370. [Abstract] [PDF]  

Extended Depletion of O⁶-Methylguanine-DNA Methyltransferase Activity following O⁶-Benzyl-2'-deoxyguanosine or O⁶-Benzylguanine Combined with Streptozotocin Treatment Enhances 1,3-Bis(2-chloroethyl)-1-nitrosourea Cytotoxicity

Upendra K. Marathi, M. Eileen Dolan, and Leonard C. Erickson
Cancer Res 1994 54: 4371-4375. [Abstract] [PDF]  

Monoclonal Antibody Delivery to Intraperitoneal Tumors in Rats: Effects of Route of Administration and Intraperitoneal Solution Osmolality

Michael F. Flessner and Robert L. Dedrick
Cancer Res 1994 54: 4376-4384. [Abstract] [PDF]  

Comparative Gompertzian Analysis of Alterations of Tumor Growth Patterns

Ioannis D. Bassukas
Cancer Res 1994 54: 4385-4392. [Abstract] [PDF]  

Efficacy and Toxicity of Ifosfamide Stereoisomers in an in Vivo Rat Mammary Carcinoma Model

I.W. Wainer, C.P. Granvil, T. Wang, and G. Batist
Cancer Res 1994 54: 4393-4397. [Abstract] [PDF]  

Efficient Transfer of Selectable and Membrane Reporter Genes in Hematopoietic Progenitor and Stem Cells Purified from Human Peripheral Blood

M. Valtieri, R. Schirò, C. Chelucci, B. Masella, U. Testa, I. Casella, E. Montesoro, G. Mariani, H. J. Hassan, and C. Peschle
Cancer Res 1994 54: 4398-4404. [Abstract] [PDF]  

Induction of M_r 78,000 Glucose-regulated Stress Protein in Poly(Adenosine Diphosphate-Ribose) Polymerase- and Nicotinamide Adenine Dinucleotide-deficient V79 Cell Lines and Its Relation to Resistance to the Topoisomerase II Inhibitor Etoposide

Satadal Chatterjee, Ming-Fang Cheng, Sosamma J. Berger, and Nathan A. Berger
Cancer Res 1994 54: 4405-4411. [Abstract] [PDF]  

Chemotherapy with [SP-4-3-(R)]-[1,1-Cyclobutanedicarboxylato(2-)](2-methyl-1,4-butanediamine-N,N')platinum (CI-973, NK121) in Combination with Standard Agents against Murine Tumors in Vivo

William L. Elliott, Billy J. Roberts, Curtis T. Howard, and Wilbur R. Leopold, III
Cancer Res 1994 54: 4412-4418. [Abstract] [PDF]  

Immunology:

Intrapleural Production of Interleukin 6 during Mesothelioma and Its Modulation by -Interferon Treatment

Gianpaola Monti, Marie-Claude Jaurand, Isabelle Monnet, Pascale Chretien, Laure Saint-Etienne, Lin Zeng, Alain Portier, Philippe Devillier, Pierre Galanaud, Jean Bignon, and Dominique Emilie
Cancer Res 1994 54: 4419-4423. [Abstract] [PDF]  

Characterization of Cloned Class I MHC-restricted, CD8⁺ Anti-Meth A Cytotoxic T-Lymphocytes: Recognition of an Epitope Derived from the Meth A gp110 Tumor Rejection Antigen

Maria Antonia Fassanito, Douglas Loftus, Rita M. De Leo, Lloyd W. Law, Ettore Appella, and Albert B. De Leo
Cancer Res 1994 54: 4424-4429. [Abstract] [PDF]  

Abnormal Cytokine Expression in Sézary and Adult T-Cell Leukemia Cells Correlates with the Functional Diversity between These T-Cell Malignancies

Craig L. Tendler, Jack D. Burton, Jonathan Jaffe, David Danielpour, Michael Charley, J. Philip McCoy, Mark R. Pittelkow, and Thomas A. Waldmann
Cancer Res 1994 54: 4430-4435. [Abstract] [PDF]  

Molecular Biology and Genetics:

In Vitro Mutational Spectrum of Aflatoxin B₁ in the Human Hypoxanthine Guanine Phosphoribosyltransferase Gene

Neal F. Cariello, Lisa Cui, and Thomas R. Skopek
Cancer Res 1994 54: 4436-4441. [Abstract] [PDF]  

Retrovirus-mediated Gene Transfer of Rat Glutathione S-Transferase Yc Confers Alkylating Drug Resistance in NIH 3T3 Mouse Fibroblasts

Mona Greenbaum, Sylvain Létourneau, Homa Assar, Robyn L. Schecter, Gerald Batist, and Denis Cournoyer
Cancer Res 1994 54: 4442-4447. [Abstract] [PDF]  

Hyperphosphorylation of p53 Induced by Okadaic Acid Attenuates Its Transcriptional Activation Function

Wei Zhang, Craig McClain, Jyh-pyng Gau, Xiang-Yang D. Guo, and Albert B. Deisseroth
Cancer Res 1994 54: 4448-4453. [Abstract] [PDF]  

Database and Software for the Analysis of Mutations in the Human p53 Gene

Neal F. Cariello, Lisa Cui, Christophe Beroud, and Thierry Soussi
Cancer Res 1994 54: 4454-4460. [Abstract] [PDF]  

Functional Analysis of the 5'-Flanking Region of the Human Gastrin-releasing Peptide Gene in Small Cell Lung Carcinoma Cell Lines

Srinivasa R. Nagalla and Eliot R. Spindel
Cancer Res 1994 54: 4461-4467. [Abstract] [PDF]  

Deficiency of Queuine, a Highly Modified Purine Base, in Transfer RNAs from Primary and Metastatic Ovarian Malignant Tumors in Women

Wlodzimierz Baranowski, Guy Dirheimer, Jerzy Andrezj Jakowicki, and Gérard Keith
Cancer Res 1994 54: 4468-4471. [Abstract] [PDF]  

Interphase Cytogenetic Analysis of Prostatic Carcinomas by Use of Nonisotopic in Situ Hybridization

Gustavo Bruno Baretton, Christian Valina, Thomas Vogt, Karin Schneiderbanger, Joachim Diebold, and Udo Löhrs
Cancer Res 1994 54: 4472-4480. [Abstract] [PDF]  

Allelotype Analysis of Cervical Carcinoma

A. B. Mitra, V. V. V. S. Murty, Rong G. Li, Mahendra Pratap, Usha K. Luthra, and R. S. K. Chaganti
Cancer Res 1994 54: 4481-4487. [Abstract] [PDF]  

Cloning and Sequence Analysis of the Promoter Region of the MRP Gene of HL60 Cells Isolated for Resistance to Adriamycin

Qichao Zhu and Melvin S. Center
Cancer Res 1994 54: 4488-4492. [Abstract] [PDF]  

Expression and Alternative Splicing of the Deleted in Colorectal Cancer (DCC) Gene in Normal and Malignant Tissues

Michael A. Reale, Gang Hu, Abrahim I. Zafar, Robert H. Getzenberg, Stuart M. Levine, and Eric R. Fearon
Cancer Res 1994 54: 4493-4501. [Abstract] [PDF]  

3-Methylcholanthrene Inactivates the p53 Gene in Syrian Hamster Embryo Fibroblasts by Inducing a Specific Intronic Point Mutation

Amador Albor, Denise M. Flessate, Thierry Soussi, and Vicente Notario
Cancer Res 1994 54: 4502-4507. [Abstract] [PDF]  

PML/RAR⁺ U937 Mutant and NB4 Cell Lines: Retinoic Acid Restores the Monocytic Differentiation Response to Vitamin D₃

Ugo Testa, Francesco Grignani, Tiziano Barberi, Marta Fagioli, Rosalba Masciulli, Pier Francesco Ferrucci, Davide Seripa, Antonio Camagna, Myriam Alcalay, Pier Giuseppe Pelicci, and Cesare Peschle
Cancer Res 1994 54: 4508-4515. [Abstract] [PDF]  

Tumor Biology:

Hyaluronan Receptors Are Expressed on Human Malignant Mesothelioma Cells but not on Normal Mesothelial Cells

Tomas Asplund and Paraskevi Heldin
Cancer Res 1994 54: 4516-4523. [Abstract] [PDF]  

Capacity of Individual Chronic Lymphatic Leukemia Lymphocytes and Leukemic Blast Cells for Repair of O⁶-Ethylguanine in DNA: Relation to Chemosensitivity in Vitro and Treatment Outcome

Mark R. Müller, Frank Seiler, Jürgen Thomale, Claudia Buschfort, Manfred F. Rajewsky, and Siegfried Seeber
Cancer Res 1994 54: 4524-4531. [Abstract] [PDF]  

Integrins and Laminins in Human Renal Carcinoma Cells and Tumors Grown in Nude Mice

Matti Korhonen, Hannu Sariola, Victor E. Gould, Lauri Kangas, and Ismo Virtanen
Cancer Res 1994 54: 4532-4538. [Abstract] [PDF]  

Normal Human Tissues, in Addition to Some Tumors, Express Multiple Different CD44 Isoforms

Stephen B. Fox, Jonathan Fawcett, David G. Jackson, Ian Collins, Kevin C. Gatter, Adrian L. Harris, Andrew Gearing, and David L. Simmons
Cancer Res 1994 54: 4539-4546. [Abstract] [PDF]  

Plasminogen Activation in Melanocytic Neoplasia

Catherine Delbaldo, Isabelle Masouye, Jean-Hilaire Saurat, Jean-Dominique Vassalli, and André-Pascal Sappino
Cancer Res 1994 54: 4547-4552. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 4553-4555. [PDF]  

Erratum

Cancer Res 1994 54: 4555 [PDF]  

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