Advances in Brief:

Expression of µ Class Glutathione S-Transferase Correlates with Event-free Survival in Childhood Acute Lymphoblastic Leukemia

Andrew G. Hall, Pernille Autzen, Alex R. Cattan, Archibald J. Malcolm, Michael Cole, Jennifer Kernahan, and Michael M. Reid
Cancer Res 1994 54: 5251-5254. [Abstract] [PDF]  

Modulation of Resistance to Anticancer Drugs by Inhibition of Metallothionein Synthesis

Masahiko Satoh, M. George Cherian, Nobumasa Imura, and Hidesuke Shimizu
Cancer Res 1994 54: 5255-5257. [Abstract] [PDF]  

Gene Therapy for Carcinoembryonic Antigen-producing Human Lung Cancer Cells by Cell Type-specific Expression of Herpes Simplex Virus Thymidine Kinase Gene

Tadashi Osaki, Yoshiro Tanio, Isao Tachibana, Shigeto Hosoe, Toru Kumagai, Ichiro Kawase, Shinzo Oikawa, and Tadamitsu Kishimoto
Cancer Res 1994 54: 5258-5261. [Abstract] [PDF]  

Mutational Analysis of CDKN2 (MTS1/p16^ink4) in Human Breast Carcinomas

Lin Xu, Dennis Sgroi, Christopher J. Sterner, Roberta L. Beauchamp, Denise M. Pinney, Suzanne Keel, Keisuke Ueki, Joni L. Rutter, Alan J. Buckler, David N. Louis, James F. Gusella, and Vijaya Ramesh
Cancer Res 1994 54: 5262-5264. [Abstract] [PDF]  

Identification of MART-1-specific T-Cell Receptors: T Cells Utilizing Distinct T-Cell Receptor Variable and Joining Regions Recognize the Same Tumor Epitope

David J. Cole, Daniel P. Weil, Peter Shamamian, Licia Rivoltini, Yutaka Kawakami, Suzanne Topalian, Christopher Jennings, Siona Eliyahu, Steven A. Rosenberg, and Michael I. Nishimura
Cancer Res 1994 54: 5265-5268. [Abstract] [PDF]  

Rarity of Somatic and Germline Mutations of the Cyclin-dependent Kinase 4 Inhibitor Gene, CDK4I, in Melanoma

Masataka Ohta, Hirokazu Nagai, Masayoshi Shimizu, Debora Rasio, David Berd, Michael Mastrangelo, Arun D. Singh, Jerry A. Shields, Carol L. Shields, Carlo M. Croce, and Kay Huebner
Cancer Res 1994 54: 5269-5272. [Abstract] [PDF]  

Hypoxic Activation of Nuclear Factor-B Is Mediated by a Ras and Raf Signaling Pathway and Does Not Involve MAP Kinase (ERK1 or ERK2)

Albert C. Koong, Eunice Y. Chen, Nahid F. Mivechi, Nicholas C. Denko, Peter Stambrook, and Amato J. Giaccia
Cancer Res 1994 54: 5273-5279. [Abstract] [PDF]  

Epidermal Growth Factor-mediated Apoptosis of MDA-MB-468 Human Breast Cancer Cells

Deborah K. Armstrong, Scott H. Kaufmann, Yvonne L. Ottaviano, Yuzo Furuya, Julie A. Buckley, John T. Isaacs, and Nancy E. Davidson
Cancer Res 1994 54: 5280-5283. [Abstract] [PDF]  

Public Issues:

Smoking and Lung Cancer: Scientific Challenges and Opportunities

Ernst L. Wynder and Dietrich Hoffmann
Cancer Res 1994 54: 5284-5295. [PDF]  

Perspectives in Cancer Research:

Cancers Beget Mutations versus Mutations Beget Cancers

Richmond T. Prehn
Cancer Res 1994 54: 5296-5300. [Abstract] [PDF]  

REVIEWS:

Monoclonal Antibodies as Agonists: An Expanded Role for Their Use in Cancer Therapy

Ellen S. Vitetta and Jonathan W. Uhr
Cancer Res 1994 54: 5301-5309. [PDF]  

Carcinogenesis:

Harvey ras (H-ras) Point Mutations Are Induced by 4-Nitroquinoline-1-oxide in Murine Oral Squamous Epithelia, while Squamous Cell Carcinomas and Loss of Heterozygosity Occur without Additional Exposure

Bo Yuan, Briana W. Heniford, Douglas M. Ackermann, Brian L. Hawkins, and Fred J. Hendler
Cancer Res 1994 54: 5310-5317. [Abstract] [PDF]  

A Role for Metallothionein and Zinc in Spontaneous Mutagenesis

Ekaterina I. Goncharova and Toby G. Rossman
Cancer Res 1994 54: 5318-5323. [Abstract] [PDF]  

Orotic Acid Enhancement of Preneoplastic and Neoplastic Lesions Induced in the Pancreas and Liver of Hamsters by N-Nitroso(2-hydroxypropyl) (2-oxopropyl)amine

Demetrius M. Kokkinakis and Jorge Albores-Saavedra
Cancer Res 1994 54: 5324-5332. [Abstract] [PDF]  

Isoprene, an Endogenous Hydrocarbon and Industrial Chemical, Induces Multiple Organ Neoplasia in Rodents after 26 Weeks of Inhalation Exposure

Ronald L. Melnick, Robert C. Sills, Joseph H. Roycroft, Billy J. Chou, Harvey A. Ragan, and Rodney A. Miller
Cancer Res 1994 54: 5333-5339. [Abstract] [PDF]  

Mutagenesis of ras Proto-Oncogenes in Rat Liver Tumors Induced by Vinyl Chloride

Olivier Froment, Sandra Boivin, Alain Barbin, Brigitte Bancel, Christian Trepo, and Marie-Jeanne Marion
Cancer Res 1994 54: 5340-5345. [Abstract] [PDF]  

Clinical investigations:

Ifosfamide and Carboplatin Combined with 41.8°C Whole-Body Hyperthermia in Patients with Refractory Sarcoma and Malignant Teratoma

Günter J. Wiedemann, Floriane d'Oleire, Erdmute Knop, Sawas Eleftheriadis, Peter Bucsky, Stephanie Feddersen, Miriam Klouche, Jürgen Geisler, Martin Mentzel, Peter Schmucker, Thomas Feyerabend, Christoph Weiss, and Thomas Wagner
Cancer Res 1994 54: 5346-5350. [Abstract] [PDF]  

Intratumor Variability in Prognostic Indicators May Be the Case of Conflicting Estimates of Patient Survival and Response to Therapy

Sam C. Barranco, Roger R. Perry, Mary E. Durm, Alice L. Werner, Sharon G. Gregorcyk, Wade E. Bolton, Paul Kolm, and Courtney M. Townsend, Jr.
Cancer Res 1994 54: 5351-5356. [Abstract] [PDF]  

Recruitment with High Physiological Doses of Estradiol Preceding Chemotherapy: Flow Cytometric and Therapeutic Results in Women with Locally Advanced Breast Cancer—A Southwest Oncology Group Study

Carol J. Fabian, Bruce F. Kimler, Richard McKittrick, Chan H. Park, Fritz Lin, Leela Krishnan, William R. Jewell, C. Kent Osborne, Silvana Martino, Laura F. Hutchins, Lucille A. Leong, and Stephanie Green
Cancer Res 1994 54: 5357-5362. [Abstract] [PDF]  

Endocrinology:

Reproducibility of Laboratory Assays for Steroid Hormones and Sex Hormone-binding Globulin

Nancy Potischman, Roni T. Falk, Virginia A. Laiming, Pentti K. Siiteri, and Robert N. Hoover
Cancer Res 1994 54: 5363-5367. [Abstract] [PDF]  

Experimental Therapeutics:

Effects of Amiodarone, Cyclosporin A, and PSC 833 on the Cytotoxicity of Mitoxantrone, Doxorubicin, and Vincristine in Non-P-glycoprotein Human Small Cell Lung Cancer Cell Lines

Winette T. A. van der Graaf, Elisabeth G. E. de Vries, Hetty Timmer-Bosscha, Gert Jan Meersma, Geert Mesander, Edo Vellenga, and Nanno H. Mulder
Cancer Res 1994 54: 5368-5373. [Abstract] [PDF]  

Effects of Photodynamic Therapy Using Mono-L-aspartyl Chlorin e₆ on Vessel Constriction, Vessel Leakage, and Tumor Response

Kimberly S. McMahon, T. Jeffery Wieman, Pamela H. Moore, and Victor H. Fingar
Cancer Res 1994 54: 5374-5379. [Abstract] [PDF]  

Potentiation by Interleukin 1 of Cisplatin and Carboplatin Antitumor Activity: Schedule-dependent and Pharmacokinetic Effects in the RIF-1 Tumor Model

Ming-Jei Chang, Wei-Dong Yu, Leonard M. Reyno, Ruth A. Modzelewski, Merrill J. Egorin, Kadir Erkmen, Daniel R. Vlock, Philip Furmanski, and Candace S. Johnson
Cancer Res 1994 54: 5380-5386. [Abstract] [PDF]  

6-Thioguanine-induced Growth Arrest in 6-Mercaptopurine-resistant Human Leukemia Cells

Claudia J. Morgan, Rehan N. Chawdry, Andrea R. Smith, Gina Siravo-Sagraves, and Ronald W. Trewyn
Cancer Res 1994 54: 5387-5393. [Abstract] [PDF]  

The Role of DNA Damage in the Resistance of Human Chronic Myeloid Leukemia Cells to Cyclophosphamide Analogues

Borje S. Andersson, Mohamad Mroue, Richard A. Britten, and David Murray
Cancer Res 1994 54: 5394-5400. [Abstract] [PDF]  

Human Cytidine Deaminase: Purification of Enzyme, Cloning, and Expression of Its Complementary DNA

Josée Laliberté and Richard L. Momparler
Cancer Res 1994 54: 5401-5407. [Abstract] [PDF]  

Enhancer Sequences of the DF3 Gene Regulate Expression of the Herpes Simplex Virus Thymidine Kinase Gene and Confer Sensitivity of Human Breast Cancer Cells to Ganciclovir

Yoshinobu Manome, Miyako Abe, Martin F. Hagen, Howard A. Fine, and Donald W. Kufe
Cancer Res 1994 54: 5408-5413. [Abstract] [PDF]  

Cytotoxicity of -Particle-emitting m-[²¹¹At]Astatobenzylguanidine on Human Neuroblastoma Cells

Donald K. Strickland, Ganesan Vaidyanathan, and Michael R. Zalutsky
Cancer Res 1994 54: 5414-5419. [Abstract] [PDF]  

Immunology:

B7-1/CD80-transduced Tumor Cells Elicit Better Systemic Immunity than Wild-Type Tumor Cells Admixed with Corynebacterium parvum

Lieping Chen, Patrick McGowan, Stephanie Ashe, Janet V. Johnston, Ingegerd Hellström, and Karl Erik Hellström
Cancer Res 1994 54: 5420-5423. [Abstract] [PDF]  

T Cells from Renal Cell Carcinoma Patients Exhibit an Abnormal Pattern of B-specific DNA-binding Activity: A Preliminary Report

Xiaoli Li, Jun Liu, Jeong-Kyu Park, Thomas A. Hamilton, Patricia Rayman, Eric Klein, Mark Edinger, Raymond Tubbs, Ronald Bukowski, and James Finke
Cancer Res 1994 54: 5424-5429. [Abstract] [PDF]  

Molecular Biology and Genetics:

State of the p53 Gene in Hepatocellular Carcinomas of Ground Squirrels and Woodchucks with Past and Ongoing Infection with Hepadnaviruses

Marianne B. Rivkina, John M. Cullen, William S. Robinson, and Patricia L. Marion
Cancer Res 1994 54: 5430-5437. [Abstract] [PDF]  

Structural Analysis of the Ras GTPase Activating Protein Catalytic Domain by Semirandom Mutagenesis: Implications for a Mechanism of Interaction with Ras-GTP

Lisa Hettich and Mark Marshall
Cancer Res 1994 54: 5438-5444. [Abstract] [PDF]  

Tumor Biology:

Tissue Distribution of Soluble and Receptor-Bound Urokinase in Human Breast Cancer Using a Panel of Monoclonal Antibodies

Maria V. Carriero, Paola Franco, Silvana Del Vecchio, Ornella Massa, Gerardo Botti, Giuseppe D'Aiuto, M. Patrizia Stoppelli, and Marco Salvatore
Cancer Res 1994 54: 5445-5454. [Abstract] [PDF]  

The Role of Platelet-derived Growth Factor Production by Tumor-associated Macrophages in Tumor Stroma Formation in Lung Cancer

Jean-Michel Vignaud, Béatrice Marie, Nathalie Klein, François Plénat, Michael Pech, Jacques Borrelly, Nadine Martinet, Adrien Duprez, and Yves Martinet
Cancer Res 1994 54: 5455-5463. [Abstract] [PDF]  

Immunophenotyping and Metastatic Localization of Breast Cancer

J. C. Gioanni, C. Mazeau, E. Zanghellini, F. Hecht, J. Gugenheim, F. Crafa, C. Granon, M. Namer, F. Ettore, and M. Schneider
Cancer Res 1994 54: 5464-5466. [Abstract] [PDF]  

Effect of Tissue Inhibitor of the Matrix Metalloproteinases-2 Expression on the Growth and Spontaneous Metastasis of a Human Melanoma Cell Line

Anthony M. P. Montgomery, Barbara M. Mueller, Ralph A. Reisfeld, Shirley M. Taylor, and Yves A. DeClerck
Cancer Res 1994 54: 5467-5473. [Abstract] [PDF]  

Androgen Receptor Activation in Prostatic Tumor Cell Lines by Insulin-like Growth Factor-I, Keratinocyte Growth Factor, and Epidermal Growth Factor

Zoran Culig, Alfred Hobisch, Marcus V. Cronauer, Christian Radmayr, Jan Trapman, Anton Hittmair, Georg Bartsch, and Helmut Klocker
Cancer Res 1994 54: 5474-5478. [Abstract] [PDF]  

Modulation by Retinoic Acid (RA) of Squamous Cell Differentiation, Cellular RA-binding Proteins, and Nuclear RA Receptors in Human Head and Neck Squamous Cell Carcinoma Cell Lines

Chang-Ping Zou, John L. Clifford, Xiao-Chun Xu, Peter G. Sacks, Pierre Chambon, Waun K. Hong, and Reuben Lotan
Cancer Res 1994 54: 5479-5487. [Abstract] [PDF]  

E-Cadherin Expression Determines the Mode of Replacement of Normal Urothelium by Human Bladder Carcinoma Cells

Johanna M. J. Rebel, Cornelia D. E. M. Thijssen, Marcel Vermey, Annie Delouvée, Ellen C. Zwarthoff, and Theodorus H. Van der Kwast
Cancer Res 1994 54: 5488-5492. [Abstract] [PDF]  

Meeting Report:

Risk Assessment in Environmental Carcinogenesis: An American Association for Cancer Research Special Conference in Cancer Research Cosponsored by the Environmental Mutagen Society

Bernard Strauss, Philip Hanawalt, and James Swenberg
Cancer Res 1994 54: 5493-5496. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 5497-5499. [PDF]  

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