Advances in Brief:

Long-Term Survival of Rats Harboring Brain Neoplasms Treated with Ganciclovir and a Herpes Simplex Virus Vector That Retains an Intact Thymidine Kinase Gene

Efstathios J. Boviatsis, John S. Park, Miguel Sena-Esteves, Christof M. Kramm, Maureen Chase, James T. Efird, Ming X. Wei, Xandra O. Breakefield, and E. Antonio Chiocca
Cancer Res 1994 54: 5745-5751. [Abstract] [PDF]  

Autocrine Motility Factor Induces Differential 12-Lipoxygenase Expression and Activity in High- and Low-Metastatic K1735 Melanoma Cell Variants

Steve Silletti, Jozsef Timar, Kenneth V. Honn, and Avraham Raz
Cancer Res 1994 54: 5752-5756. [Abstract] [PDF]  

Adoptive Immunotherapy with Murine Tumor-specific T Lymphocytes Engineered to Secrete Interleukin 2

Yoshiko Nakamura, Hiroaki Wakimoto, Junko Abe, Yumi Kanegae, Izumu Saito, Masaru Aoyagi, Kimiyoshi Hirakawa, and Hirofumi Hamada
Cancer Res 1994 54: 5757-5760. [Abstract] [PDF]  

Molecular Cloning of the B-CAM Cell Surface Glycoprotein of Epithelial Cancers: A Novel Member of the Immunoglobulin Superfamily

Ian G. Campbell, W. D. Foulkes, Gabriel Senger, John Trowsdale, Pilar Garin-Chesa, and Wolfgang J. Rettig
Cancer Res 1994 54: 5761-5765. [Abstract] [PDF]  

Prostatic Localization of Spontaneous Early Invasive Carcinoma in Lobund-Wistar Rats

Thomas D. Pugh, Chawnshang Chang, Hiroji Uemura, and Richard Weindruch
Cancer Res 1994 54: 5766-5770. [Abstract] [PDF]  

Abnormal Expression of Perlecan Proteoglycan in Metastatic Melanomas

Isabelle R. Cohen, Alan D. Murdoch, Michael F. Naso, Dario Marchetti, David Berd, and Renato V. Iozzo
Cancer Res 1994 54: 5771-5774. [Abstract] [PDF]  

Coexpression of the c-met Proto-oncogene and Hepatocyte Growth Factor in Human Pancreatic Cancer

Matthias Ebert, Munehiro Yokoyama, Helmut Friess, Markus W. Büchler, and Murray Korc
Cancer Res 1994 54: 5775-5778. [Abstract] [PDF]  

Relationship between the Structure of Taxol and Other Taxanes on Induction of Tumor Necrosis Factor- Gene Expression and Cytotoxicity

Catherine A. Burkhart, Joan W. Berman, Charles S. Swindell, and Susan Band Horwitz
Cancer Res 1994 54: 5779-5782. [Abstract] [PDF]  

Discovery of Short, 3'-Cholesterol-modified DNA Duplexes with Unique Antitumor Cell Activity

James H. Zhou, Balakrishna S. Pai, Michael W. Reed, Howard B. Gamper, Eugeny Lukhtanov, Mikhail Podyminogin, Rich B. Meyer, Jr., and Yung-chi Cheng
Cancer Res 1994 54: 5783-5787. [Abstract] [PDF]  

Detection of the M_r 190,000 Multidrug Resistance Protein, MRP, with Monoclonal Antibodies

David R. Hipfner, Stephan D. Gauldie, Roger G. Deeley, and Susan P. C. Cole
Cancer Res 1994 54: 5788-5792. [Abstract] [PDF]  

A Monoclonal Antibody against a Human B Lymphoblastoid Cell Line Induces Tumor Regression in Mice

Britta Hardy, Igal Yampolski, Riva Kovjazin, Michal Galli, and Abraham Novogrodsky
Cancer Res 1994 54: 5793-5796. [Abstract] [PDF]  

-Particle-induced p53 Protein Expression in a Rat Lung Epithelial Cell Strain

Albert W. Hickman, Richard J. Jaramillo, John F. Lechner, and Neil F. Johnson
Cancer Res 1994 54: 5797-5800. [Abstract] [PDF]  

Different Susceptibility to Smoking-induced DNA Damage among Male and Female Lung Cancer Patients

David Ryberg, Alan Hewer, David H. Phillips, and Aage Haugen
Cancer Res 1994 54: 5801-5803. [Abstract] [PDF]  

CDK4 Amplification Is an Alternative Mechanism to p16 Gene Homozygous Deletion in Glioma Cell Lines

Ju He, James R. Allen, V. Peter Collins, M. Joan Allalunis-Turner, Roseline Godbout, Rufus S. Day, III, and C. David James
Cancer Res 1994 54: 5804-5807. [Abstract] [PDF]  

Metallothionein IIA Is Up-Regulated by Hypoxia in Human A431 Squamous Carcinoma Cells

Brian J. Murphy, Keith R. Laderoute, Roxanne J. Chin, and Robert M. Sutherland
Cancer Res 1994 54: 5808-5810. [Abstract] [PDF]  

K-ras Mutations Are a Relatively Late Event in the Pathogenesis of Lung Carcinomas

Kenji Sugio, Yosuke Kishimoto, Arvind K. Virmani, Jaclyn Y. Hung, and Adi F. Gazdar
Cancer Res 1994 54: 5811-5815. [Abstract] [PDF]  

Differential Expression and Cell Cycle Regulation of the Cyclin-dependent Kinase 4 Inhibitor p16^Ink4

Sun W. Tam, Jerry W. Shay, and Michele Pagano
Cancer Res 1994 54: 5816-5820. [Abstract] [PDF]  

Highly Efficient Method for Obtaining a Subtracted Genomic DNA Library by the Modified In-Gel Competitive Reassociation Method

Hiroki Sasaki, Shintaro Nomura, Nobu Akiyama, Atsuhi Takahashi, Takashi Sugimura, Michio Oishi, and Masaaki Terada
Cancer Res 1994 54: 5821-5823. [Abstract] [PDF]  

p53 Gene Mutations Are Associated with Decreased Sensitivity of Human Lymphoma Cells to DNA Damaging Agents

Saijun Fan, Wafik S. El-Deiry, Insoo Bae, Jim Freeman, Daniel Jondle, Kishor Bhatia, Albert J. Fornace, Jr., Ian Magrath, Kurt W. Kohn, and Patrick M. O'Connor
Cancer Res 1994 54: 5824-5830. [Abstract] [PDF]  

Carcinogenesis:

Lack of Transforming Growth Factor-ß₁ Expression in Benign Skin Tumors of p53^null Mice Is Prognostic for a High Risk of Malignant Conversion

Wei Cui, Christopher J. Kemp, Elizabeth Duffie, Allan Balmain, and Rosemary J. Akhurst
Cancer Res 1994 54: 5831-5836. [Abstract] [PDF]  

Establishment of a Human System that Generates O₂^- and Induces 8-Hydroxydeoxyguanosine, Typical of Oxidative DNA Damage, by a Tumor Promotor

Toru Takeuchi, Madoka Nakajima, and Kanehisa Morimoto
Cancer Res 1994 54: 5837-5840. [Abstract] [PDF]  

Inhibitory Effects of Dietary Curcumin on Forestomach, Duodenal, and Colon Carcinogenesis in Mice

Mou-Tuan Huang, You-Rong Lou, Wei Ma, Harold L. Newmark, Kenneth R. Reuhl, and Allan H. Conney
Cancer Res 1994 54: 5841-5847. [Abstract] [PDF]  

Screening of Potential Chemopreventive Agents Using Biochemical Markers of Carcinogenesis

Sheela Sharma, Jill D. Stutzman, Gary J. Kelloff, and Vernon E. Steele
Cancer Res 1994 54: 5848-5855. [Abstract] [PDF]  

Regulation of Uridine Diphosphate Glucuronosyltransferase Expression by Phenolic Antioxidants

Khosrow Kashfi, Eun K. Yang, Jayanta Roy Chowdhury, Namita Roy Chowdhury, and Andrew J. Dannenberg
Cancer Res 1994 54: 5856-5859. [Abstract] [PDF]  

Endocrinology:

Hydroxytamoxifen Induces a Rapid and Irreversible Inactivation of an Estrogenic Response in an MCF-7-derived Cell Line

Eric Badia, Marie-Josephe Duchesne, Sylvie Fournier-Bidoz, Anne-Emmanuelle Simar-Blanchet, Beatrice Terouanne, Jean-Claude Nicolas, and Michel Pons
Cancer Res 1994 54: 5860-5866. [Abstract] [PDF]  

Alterations in Transforming Growth Factor- and -ß Production and Cell Responsiveness during the Progression of MCF-7 Human Breast Cancer Cells to Estrogen-Autonomous Growth

Mary E. Herman and Benita S. Katzenellenbogen
Cancer Res 1994 54: 5867-5874. [Abstract] [PDF]  

Clinical and Endocrine Effects of the Oral Aromatase Inhibitor Vorozole in Postmenopausal Patients with Advanced Breast Cancer

Stephen R. D. Johnston, Ian E. Smith, Deborah Doody, Stephen Jacobs, Hazel Robertshaw, and Mitchell Dowsett
Cancer Res 1994 54: 5875-5881. [Abstract] [PDF]  

Experimental Therapeutics:

In Vivo Modulation of Macrophage Tumoricidal Activity by Oral Administration of the Liposome-encapsulated Macrophage Activator CGP 19835A

Simon Tanguay, Corazon D. Bucana, Michael R. Wilson, Isaiah J. Fidler, Andrew C. von Eschenbach, and Jerald J. Killion
Cancer Res 1994 54: 5882-5888. [Abstract] [PDF]  

K252a, KT5720, KT5926, and U98017 Support Paclitaxel (Taxol)-dependent Cells and Synergize with Paclitaxel

Irene Abraham, Cindy L. Wolf, Kathleen E. Sampson, Alice L. Laborde, John A. Shelly, Paul A. Aristoff, and Harvey I. Skulnick
Cancer Res 1994 54: 5889-5894. [Abstract] [PDF]  

Somatostatin Analogues and Bombesin/Gastrin-releasing Peptide Antagonist RC-3095 Inhibit the Growth of Human Glioblastomas in Vitro and in Vivo

Jacek Pinski, Andrew V. Schally, Gabor Halmos, Karoly Szepeshazi, and Kate Groot
Cancer Res 1994 54: 5895-5901. [Abstract] [PDF]  

Pharmacological Characterization of Multidrug Resistant MRP-transfected Human Tumor Cells

Susan P. C. Cole, Kathryn E. Sparks, Karen Fraser, Douglas W. Loe, Caroline E. Grant, Gerald M. Wilson, and Roger G. Deeley
Cancer Res 1994 54: 5902-5910. [Abstract] [PDF]  

Relationship between Platinum-DNA Adduct Formation and Removal and Cisplatin Cytotoxicity in Cisplatin-sensitive and -resistant Human Ovarian Cancer Cells

Steven W. Johnson, Pamela A. Swiggard, Laura M. Handel, James M. Brennan, Andrew K. Godwin, Robert F. Ozols, and Thomas C. Hamilton
Cancer Res 1994 54: 5911-5916. [Abstract] [PDF]  

Collateral Sensitivity of Human Melanoma Multidrug-resistant Variants to the Polyamine Analogue, N¹,N¹¹-Diethylnorspermine

Carl W. Porter, Barbara Ganis, Youcef Rustum, Carol Wrzosek, Debora L. Kramer, and Raymond J. Bergeron
Cancer Res 1994 54: 5917-5924. [Abstract] [PDF]  

Inhibition of -Glutamyl Transpeptidase Activity by Acivicin in Vivo Protects the Kidney from Cisplatin-induced Toxicity

Marie H. Hanigan, Betty C. Gallagher, Peyton T. Taylor, Jr., and Mary K. Large
Cancer Res 1994 54: 5925-5929. [Abstract] [PDF]  

Immunology:

Early Stages of 1,2-Dimethylhydrazine-induced Colon Carcinogenesis Suppress Immune-regulated Ion Transport of Mouse Distal Colon

Russell R. Broaddus, Michael J. Wargovich, and Gilbert A. Castro
Cancer Res 1994 54: 5930-5936. [Abstract] [PDF]  

Pharmacokinetics of Pretargeted Monoclonal Antibody 2D12.5 and ⁸⁸Y-Janus-2-(p-Nitrobenzyl)-1,4,7,10-tetraazacyclododecanetetraacetic Acid (DOTA) in BALB/c Mice with KHJJ Mouse Adenocarcinoma: A Model for ⁹⁰Y Radioimmunotherapy

David A. Goodwin, Claude F. Meares, Naoto Watanabe, Maureen McTigue, Warak Chaovapong, Charles McK. Ransone, Oliver Renn, Douglas P. Greiner, David L. Kukis, and Sheila I. Kronenberger
Cancer Res 1994 54: 5937-5946. [Abstract] [PDF]  

Molecular Biology and Genetics:

Loss of Apc⁺ in Intestinal Adenomas from Min Mice

Cindy Luongo, Amy R. Moser, Sarah Gledhill, and William F. Dove
Cancer Res 1994 54: 5947-5952. [Abstract] [PDF]  

Inactivation of Both APC Alleles in Human and Mouse Tumors

Daniel B. Levy, Kelly J. Smith, Yasmin Beazer-Barclay, Stanley R. Hamilton, Bert Vogelstein, and Kenneth W. Kinzler
Cancer Res 1994 54: 5953-5958. [Abstract] [PDF]  

The Kinase Inhibitor Staurosporine Induces G₁ Arrest at Two Points: Effect on Retinoblastoma Protein Phosphorylation and Cyclin-dependent Kinase 2 in Normal and Transformed Cells

Joachim B. Schnier, Donna M. Gadbois, Kayoko Nishi, and E. Morton Bradbury
Cancer Res 1994 54: 5959-5963. [Abstract] [PDF]  

Autonomous Growth in Serum-free Medium and Production of Hepatocellular Carcinomas by Differentiated Hepatocyte Lines That Overexpress Transforming Growth Factor

Justina C. Wu, Glenn Merlino, Kveta Cveklova, Bedrich Mosinger, Jr., and Nelson Fausto
Cancer Res 1994 54: 5964-5973. [Abstract] [PDF]  

Tumor Biology:

Glutamine Modulates Phenotype and Stimulates Proliferation in Human Colon Cancer Cell Lines

Gregory A. Turowski, Zaihan Rashid, Fu Hong, Joseph A. Madri, and Marc D. Basson
Cancer Res 1994 54: 5974-5980. [Abstract] [PDF]  

Hox Genes in Normal and Neoplastic Mouse Mammary Gland

Yael Friedmann, Carla A. Daniel, Phyllis Strickland, and Charles W. Daniel
Cancer Res 1994 54: 5981-5985. [Abstract] [PDF]  

Malignant Melanoma in Ultraviolet Irradiated Laboratory Opossums: Initiation in Suckling Young, Metastasis in Adults, and Xenograft Behavior in Nude Mice

Edward S. Robinson, John L. VandeBerg, Gene B. Hubbard, and Thomas P. Dooley
Cancer Res 1994 54: 5986-5991. [Abstract] [PDF]  

Concomitant Increases in Galectin-1 and Its Glycoconjugate Ligands (Carcinoembryonic Antigen, Lamp-1, and Lamp-2) in Cultured Human Colon Carcinoma Cells by Sodium Butyrate

David W. Ohannesian, Dafna Lotan, and Reuben Lotan
Cancer Res 1994 54: 5992-6000. [Abstract] [PDF]  

Selective Release of Tumor Necrosis Factor Binding Protein II by Malignant Human Epidermal Cells Reveals Protection from Tumor Necrosis Factor -mediated Cytotoxicity

Peter Neuner, Gabriele Klosner, Mojgan Pourmojib, Franz Trautinger, and Robert Knobler
Cancer Res 1994 54: 6001-6005. [Abstract] [PDF]  

Letter to the Editor:

Correspondence re: G. Goldberg et al., Correspondence re: Z. Ram et al., In Situ Retroviral-mediated Gene Transfer for the Treatment of Brain Tumors in Rats. Cancer Res., 53: 83–88, 1993. Cancer Res., 54: 3947–3948, 1994.

Peter J. Stambrook, Linda Parysek, Wanli Bi, and Ronald Warnick
Cancer Res 1994 54: 6006 [PDF]  

Meeting Report:

Sixth International Workshop on Ataxia-Telangiectasia

Richard A. Gatti, Carmel M. McConville, A. Malcolm, and R. Taylor
Cancer Res 1994 54: 6007-6010. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 6011-6013. [PDF]  

Erratum

Cancer Res 1994 54: 6014 [PDF]  

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