Advances in Brief:

Complete Regression of Human Fibrosarcoma Xenografts after Local Newcastle Disease Virus Therapy

Robert M. Lorence, Burt B. Katubig, Kirk W. Reichard, Hernan M. Reyes, Anan Phuangsab, Mark D. Sassetti, Robert J. Walter, and Mark E. Peeples
Cancer Res 1994 54: 6017-6021. [Abstract] [PDF]  

Immunizing and Curative Potential of Replicating and Nonreplicating Murine Mammary Adenocarcinoma Cells Engineered with Interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, Tumor Necrosis Factor , Granulocyte-Macrophage Colony-stimulating Factor, and -Interferon Gene or Admixed with Conventional Adjuvants

Alessandra Allione, Manuela Consalvo, Patrizia Nanni, Pier Luigi Lollini, Federica Cavallo, Mirella Giovarelli, Marco Forni, Alberto Gulino, Mario P. Colombo, Paolo Dellabona, Hanno Hock, Thomas Blankenstein, Felicia M. Rosenthal, Bernd Gansbacher, Maria C. Bosco, Tiziana Musso, Luca Gusella, and Guido Forni
Cancer Res 1994 54: 6022-6026. [Abstract] [PDF]  

Cathepsin B Expression and Localization in Glioma Progression and Invasion

Sandra A. Rempel, Mark L. Rosenblum, Tom Mikkelsen, Pei-Sha Yan, Kristin D. Ellis, William A. Golembieski, Mansoureh Sameni, Jurij Rozhin, Grace Ziegler, and Bonnie F. Sloane
Cancer Res 1994 54: 6027-6031. [Abstract] [PDF]  

Spatial Heterogeneity in Tumor Perfusion Measured with Functional Computed Tomography at 0.05 µl Resolution

Leena M. Hamberg, Paul E. G. Kristjansen, George J. Hunter, Gerald L. Wolf, and Rakesh K. Jain
Cancer Res 1994 54: 6032-6036. [Abstract] [PDF]  

Ex Vivo Two-dimensional Proton Nuclear Magnetic Resonance Spectroscopy of Smooth Muscle Tumors: Advantages of Total Correlated Spectroscopy over Homonuclear J-correlated Spectroscopy

Mohanram Sivaraja, Christopher Turner, Kerry Souza, and Samuel Singer
Cancer Res 1994 54: 6037-6040. [Abstract] [PDF]  

Penetrance and Expressivity of the Chromosome 9p Melanoma Susceptibility Locus (MLM)

Lisa A. Cannon-Albright, Laurence J. Meyer, David E. Goldgar, Cathryn M. Lewis, William P. McWhorter, Marguerite Jost, Deborah Harrison, David E. Anderson, John J. Zone, and Mark H. Skolnick
Cancer Res 1994 54: 6041-6044. [Abstract] [PDF]  

Inhibition of the Growth of Human Pancreatic Cancer Cells by the Arginine Antimetabolite L-Canavanine

Diane Shomin Swaffar, Choo Yaw Ang, Pankaj B. Desai, and Gerald A. Rosenthal
Cancer Res 1994 54: 6045-6048. [Abstract] [PDF]  

CWR22: Androgen-dependent Xenograft Model Derived from a Primary Human Prostatic Carcinoma

Mark A. Wainstein, Feng He, Daniel Robinson, Hsing-Jien Kung, Stuart Schwartz, Joseph M. Giaconia, Nancy L. Edgehouse, Theresa P. Pretlow, Donald R. Bodner, Elroy D. Kursh, Martin I. Resnick, Allen Seftel, and Thomas G. Pretlow
Cancer Res 1994 54: 6049-6052. [Abstract] [PDF]  

Selective Enhancement by an Antiviral Agent of the Radiation-induced Cell Killing of Human Glioma Cells Transduced with HSV-tk Gene

Jae Ho Kim, Sang Hie Kim, Stephen L. Brown, and Svend O. Freytag
Cancer Res 1994 54: 6053-6056. [Abstract] [PDF]  

p53 Deletion as a Genetic Marker in Urothelial Tumor by Fluorescence in Situ Hybridization

Hideyasu Matsuyama, Yi Pan, Ensaf A. Mahdy, Per-Uno Malmström, Anders Hedrum, Matthias Uhlen, Christer Busch, Takashi Hirano, Gert Auer, Bernhard Tribukait, Katsusuke Naito, Peter Lichter, Peter Ekman, and Ulf S. R. Bergerheim
Cancer Res 1994 54: 6057-6060. [Abstract] [PDF]  

Loss of Heterozygosity of Chromosome 8 Microsatellite Loci Implicates a Candidate Tumor Suppressor Gene between the Loci D8S87 and D8S133 in Human Prostate Cancer

J. Trapman, H. F. B. M. Sleddens, M. M. van der Weiden, W. N. M. Dinjens, J. J. Konig, F. H. Schroder, P. W. Faber, and F. T. Bosman
Cancer Res 1994 54: 6061-6064. [Abstract] [PDF]  

Expression of Helix-Loop-Helix Factor Id-1 Is Dependent on the Hepatocyte Proliferation and Differentiation Status in Rat Liver and in Primary Culture

Catherine Le Jossic, Gennady P. Ilyin, Pascal Loyer, Denise Glaise, Sandrine Cariou, and Christiane Guguen-Guillouzo
Cancer Res 1994 54: 6065-6068. [Abstract] [PDF]  

Loss of Heterozygosity in Familial Tumors from Three BRCA1-linked Kindreds

Susan L. Neuhausen and C. Jay Marshall
Cancer Res 1994 54: 6069-6072. [Abstract] [PDF]  

c-fos Promoter Insensitivity to Phorbol Ester and Possible Role of Protein Kinase C in Androgen-independent Cancer Cells

Arnon Krongrad and Ge Bai
Cancer Res 1994 54: 6073-6077. [Abstract] [PDF]  

Transcriptional Repression of the D-Type Cyclin-dependent Kinase Inhibitor p16 by the Retinoblastoma Susceptibility Gene Product pRb

Yan Li, Michael A. Nichols, Jerry W. Shay, and Yue Xiong
Cancer Res 1994 54: 6078-6082. [Abstract] [PDF]  

Mammary Fibroblasts May Influence Breast Tumor Angiogenesis via Hypoxia-induced Vascular Endothelial Growth Factor Up-Regulation and Protein Expression

Lynn Hlatky, Christina Tsionou, Philip Hahnfeldt, and C. Norman Coleman
Cancer Res 1994 54: 6083-6086. [Abstract] [PDF]  

The E1A Oncogene Induces Resistance to the Effects of 1,25-Dihydroxyvitamin D₃ on Inhibition of Growth of Mouse Keratinocytes

Keunchil Park, Hyun Bae, Ahlke Heydemann, Anita B. Roberts, G. Paolo Dotto, Michael B. Sporn, and Seong-Jin Kim
Cancer Res 1994 54: 6087-6089. [Abstract] [PDF]  

Evidence for Multiple Pathways to Cellular Senescence

Masahiro Sasaki, Tsuyoshi Honda, Hideto Yamada, Norio Wake, J. Carl Barrett, and Mitsuo Oshimura
Cancer Res 1994 54: 6090-6093. [Abstract] [PDF]  

Frequent Loss of Heterozygosity on Chromosome 9 in Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus

Lila Tarmin, Jing Yin, Xiaoling Zhou, Hiroyuki Suzuki, Hai-Yan Jiang, Mun-Gan Rhyu, John M. Abraham, Mark J. Krasna, John Cottrell, and Stephen J. Meltzer
Cancer Res 1994 54: 6094-6096. [Abstract] [PDF]  

Susceptibility to Tumors Induced in Mice by Ethylnitrosourea Is Independent of Retinoblastoma Gene Dosage

Daniel J. Riley, Chen-Ching Lai, Chi-Yao Chang, Diane Jones, Eva Y-H. P. Lee, and Wen-Hwa Lee
Cancer Res 1994 54: 6097-6101. [Abstract] [PDF]  

Special Lecture:

Ultraviolet Radiation and Immunology: Something New under the Sun-Presidential Address

Margaret L. Kripke
Cancer Res 1994 54: 6102-6105. [Abstract] [PDF]  

Biochemistry and Biophysics:

Selective Platelet-derived Growth Factor Receptor Kinase Blockers Reverse sis-Transformation

Marina Kovalenko, Aviv Gazit, Annette Böhmer, Charlotte Rorsman, Lars Rönnstrand, Carl-Henrik Heldin, Johannes Waltenberger, Frank-D. Böhmer, and Alexander Levitzki
Cancer Res 1994 54: 6106-6114. [Abstract] [PDF]  

Antitumor Drug Fostriecin Inhibits the Mitotic Entry Checkpoint and Protein Phosphatases 1 and 2A

Michel Roberge, Christopher Tudan, Stewart M. F. Hung, Kenneth W. Harder, Frank R. Jirik, and Hilary Anderson
Cancer Res 1994 54: 6115-6121. [Abstract] [PDF]  

Carcinogenesis:

Transforming Growth Factor ß1 Promotes Spontaneous Transformation of Cultured Rat Liver Epithelial Cells

Xiaoyan Zhang, Taiqi Wang, Gerald Batist, and Ming-Sound Tsao
Cancer Res 1994 54: 6122-6128. [Abstract] [PDF]  

Promotional Effect of Two-Generation Exposure to a High-Fat Diet on Prostate Carcinogenesis in ACI/Seg Rats

Yasushi Kondo, Yukio Homma, Yoshio Aso, and Tadao Kakizoe
Cancer Res 1994 54: 6129-6132. [Abstract] [PDF]  

Clinical Investigations:

Cathepsin B Expression and Laminin Degradation as Factors Influencing Prognosis of Surgically Treated Patients with Lung Adenocarcinoma

Takashi Inoue, Teruyoshi Ishida, Kenji Sugio, and Keizo Sugimachi
Cancer Res 1994 54: 6133-6136. [Abstract] [PDF]  

Simultaneous Dose Escalation and Schedule Intensification of Carboplatin-based Chemotherapy Using Peripheral Blood Progenitor Cells and Filgrastim: A Phase I Trial

David Fennelly, Carolyn Wasserheit, Jeffrey Schneider, Thomas Hakes, Lillian Reich, John Curtin, T. J. Yao, Maurie Markman, Larry Norton, and John Crown
Cancer Res 1994 54: 6137-6142. [Abstract] [PDF]  

Endocrinology:

Lysophosphatidic Acid-depleted Serum, Hepatocyte Growth Factor and Stem Cell Growth Factor Stimulate Colony Growth of Small Cell Lung Cancer Cells through a Calcium-independent Pathway

Michael J. Seckl, Thomas Seufferlein, and Enrique Rozengurt
Cancer Res 1994 54: 6143-6147. [Abstract] [PDF]  

Epidemiology:

A Prospective Cohort Study on Allium Vegetable Consumption, Garlic Supplement Use, and the Risk of Lung Carcinoma in the Netherlands

Elisabeth Dorant, Piet A. van den Brandt, and R. Alexandra Goldbohm
Cancer Res 1994 54: 6148-6153. [Abstract] [PDF]  

Pan-Fried Meat Containing High Levels of Heterocyclic Aromatic Amines but Low Levels of Polycyclic Aromatic Hydrocarbons Induces Cytochrome P4501A2 Activity in Humans

Rashmi Sinha, Nathaniel Rothman, Ellen D. Brown, Steven D. Mark, Robert N. Hoover, Neil E. Caporaso, Orville A. Levander, Mark G. Knize, Nicholas P. Lang, and Fred F. Kadlubar
Cancer Res 1994 54: 6154-6159. [Abstract] [PDF]  

Experimental Therapeutics:

Chimeric (Mouse/Human) Anti-Colon Cancer Antibody c30.6 Inhibits the Growth of Human Colorectal Cancer Xenografts in scid/scid Mice

Peter F. Mount, Vivien R. Sutton, Wenjun Li, Jane Burgess, Ian F.C. McKenzie, Geoffrey A. Pietersz, and Joseph A. Trapani
Cancer Res 1994 54: 6160-6166. [Abstract] [PDF]  

The Role of Calcium, pH, and Cell Proliferation in the Programmed (Apoptotic) Death of Androgen-independent Prostatic Cancer Cells Induced by Thapsigargin

Yuzo Furuya, Per Lundmo, Alison D. Short, Donald L. Gill, and John T. Isaacs
Cancer Res 1994 54: 6167-6175. [Abstract] [PDF]  

Improved Tumor Targeting with Chemically Cross-Linked Recombinant Antibody Fragments

David J. King, Alison Turner, Andrew P. H. Farnsworth, John R. Adair, Raymond J. Owens, R. Barbara Pedley, Darren Baldock, Karen A. Proudfoot, Alastair D. G. Lawson, Nigel R. A. Beeley, Kenny Millar, T. Andrew Millican, Byron A. Boyce, Pari Antoniw, Andrew Mountain, Richard H. J. Begent, Dan Shochat, and Geoffrey T. Yarranton
Cancer Res 1994 54: 6176-6185. [Abstract] [PDF]  

Antidisialoganglioside Ricin A-Chain Immunotoxins Show Potent Antitumor Effects in Vitro and in a Disseminated Human Neuroblastoma Severe Combined Immunodeficiency Mouse Model

C. Gottstein, G. Schön, S. Tawadros, D. Kube, U. C. Wargalla-Plate, M. L. Hansmann, H. H. Wacker, F. Berthold, V. Diehl, and A. Engert
Cancer Res 1994 54: 6186-6193. [Abstract] [PDF]  

Mechanisms of Acquired Resistance to the Orally Active Platinum-based Anticancer drug Bis-acetato-ammine-dichloro-cyclohexylamine Platinum (IV) (JM216) in Two Human Ovarian Carcinoma Cell Lines

Kirste J. Mellish and Lloyd R. Kelland
Cancer Res 1994 54: 6194-6200. [Abstract] [PDF]  

The Role of Fludarabine-induced Apoptosis and Cell Cycle Synchronization in Enhanced Murine Tumor Radiation Response in Vivo

Vincent Grégoire, Nguyen T. Van, L. Clifton Stephens, William A. Brock, Luka Milas, William Plunkett, and Walter N. Hittelman
Cancer Res 1994 54: 6201-6209. [Abstract] [PDF]  

Design and Testing of Novel Cytotoxic Polyamine Analogues

Hirak S. Basu, Laurence J. Marton, Malgorzata Pellarin, Dennis F. Deen, James S. McManis, Charles Z. Liu, Raymond J. Bergeron, and Burt G. Feuerstein
Cancer Res 1994 54: 6210-6214. [Abstract] [PDF]  

Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione

Hubert A. A. M. Dirven, Ben van Ommen, and Peter J. van Bladeren
Cancer Res 1994 54: 6215-6220. [Abstract] [PDF]  

Mutations in Human O⁶-Alkylguanine-DNA Alkyltransferase Imparting Resistance to O⁶-Benzylguanine

Tina M. Crone, Karina Goodtzova, Suvarchala Edara, and Anthony E. Pegg
Cancer Res 1994 54: 6221-6227. [Abstract] [PDF]  

Systemic Gene Therapy of Murine Melanoma Using Tissue Specific Expression of the HSVtk Gene Involves an Immune Component

Richard G. Vile, J. Arly Nelson, Simon Castleden, Heung Chong, and Ian R. Hart
Cancer Res 1994 54: 6228-6234. [Abstract] [PDF]  

Vaginal Epithelial DNA Damage and Expression of Preneoplastic Markers in Mice during Chronic Dosing with Tumorigenic Levels of 3'-Azido-2',3'-dideoxythymidine

O. A. Olivero, F. A. Beland, N. F. Fullerton, and M. C. Poirier
Cancer Res 1994 54: 6235-6242. [Abstract] [PDF]  

Immunology:

Analysis of Interleukin 6 Gene Expression in Cervical Neoplasia Using a Quantitative Polymerase Chain Reaction Assay: Evidence for Enhanced Interleukin 6 Gene Expression in Invasive Carcinoma

E. Tartour, A. Gey, X. Sastre-Garau, C. Pannetier, V. Mosseri, P. Kourilsky, and W. H. Fridman
Cancer Res 1994 54: 6243-6248. [Abstract] [PDF]  

Molecular Biology and Genetics:

Differential Suppression of Mammary and Prostate Cancer Metastasis by Human Chromosomes 17 and 11

Carrie W. Rinker-Schaeffer, Anita L. Hawkins, Ning Ru, Jintans Dong, George Stoica, Constance A. Griffin, Tomohiko Ichikawa, J. Carl Barrett, and John T. Isaacs
Cancer Res 1994 54: 6249-6256. [Abstract] [PDF]  

Allelotype Analysis of Mouse Lung Carcinomas Reveals Frequent Allelic Losses on Chromosome 4 and an Association between Allelic Imbalances on Chromosome 6 and K-ras Activation

Monika E. Hegi, Theodora R. Devereux, William F. Dietrich, Charles J. Cochran, Eric S. Lander, Julie F. Foley, Robert R. Maronpot, Marshall W. Anderson, and Roger W. Wiseman
Cancer Res 1994 54: 6257-6264. [Abstract] [PDF]  

Loss of Heterozygosity Identifies Multiple Sites of Allelic Deletions on Chromosome 1 in Human Male Germ Cell Tumors

Susan Mathew, V. V. V. S. Murty, George J. Bosl, and R. S. K. Chaganti
Cancer Res 1994 54: 6265-6269. [Abstract] [PDF]  

Loss of Heterozygosity at 11q22–q23 in Breast Cancer

Stephen L. Carter, Massimo Negrini, Raffaele Baffa, Diane R. Gillum, Anne L. Rosenberg, Gordon F. Schwartz, and Carlo M. Croce
Cancer Res 1994 54: 6270-6274. [Abstract] [PDF]  

Tumor Biology:

H Blood Group Antigen Carried by CD44V Modulates Tumorigenicity of Rat Colon Carcinoma Cells

N. Labarrière, J. P. Piau, C. Otry, M. Denis, P. Lustenberger, K. Meflah, and J. Le Pendu
Cancer Res 1994 54: 6275-6281. [Abstract] [PDF]  

A Truncated ß-Catenin Disrupts the Interaction between E-Cadherin and -Catenin: A Cause of Loss of Intercellular Adhesiveness in Human Cancer Cell Lines

Tsukasa Oyama, Yae Kanai, Atsushi Ochiai, Shingo Akimoto, Tatsuya Oda, Kazuyoshi Yanagihara, Akira Nagafuchi, Shoichiro Tsukita, Sayumi Shibamoto, Fumiaki Ito, Masatoshi Takeichi, Hikaru Matsuda, and Setsuo Hirohashi
Cancer Res 1994 54: 6282-6287. [Abstract] [PDF]  

Letter to the Editor:

Correspondence re: M. Schiffman and A. Schatzkin, Test Reliability Is Critically Important to Molecular Epidemiology: An Example from Studies of Human Papillomavirus Infection and Cervical Neoplasia. Cancer Res. (Suppl.), 54: 1944s–1947s, 1994.

F. Xavier Bosch, Silvia de Sanjosé, and Nubia Muñoz
Cancer Res 1994 54: 6288-6289. [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 6290-6293. [PDF]  

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