Advances in Brief:

Loss of Heterozygosity on Chromosome 13 Is Common Only in the Biologically More Aggressive Subtypes of Ovarian Epithelial Tumors and Is Associated with Normal Retinoblastoma Gene Expression

Timothy M. Kim, William F. Benedict, Hong-Ji Xu, Shi-Xue Hu, Jim Gosewehr, Mihaela Velicescu, Eric Yin, Jianping Zheng, Gerrit D'Ablaing, and Louis Dubeau
Cancer Res 1994 54: 605-609. [Abstract] [PDF]  

Evidence of Functional RB Protein in Epithelial Ovarian Carcinomas despite Loss of Heterozygosity at the RB Locus

Mark K. Dodson, William A. Cliby, Hong-Ji Xu, Karen A. DeLacey, Shi-Xue Hu, Gary L. Keeney, Jian Li, Karl C. Podratz, Robert B. Jenkins, and William F. Benedict
Cancer Res 1994 54: 610-613. [Abstract] [PDF]  

The Role of p53 in Spontaneous and Radiation-induced Apoptosis in the Gastrointestinal Tract of Normal and p53-deficient Mice

Anita J. Merritt, Christopher S. Potten, Christopher J. Kemp, John A. Hickman, Allan Balmain, David P. Lane, and Peter A. Hall
Cancer Res 1994 54: 614-617. [Abstract] [PDF]  

P-Glycoprotein-associated Cl^- Currents Are Activated by Cell Swelling but Do Not Contribute to Cell Volume Regulation

Guillermo A. Altenberg, Joachim W. Deitmer, Dessa C. Glass, and Luis Reuss
Cancer Res 1994 54: 618-622. [Abstract] [PDF]  

Evaluation of the Potential Role of Class II Histocompatibility Antigen HLA-DR in Platelet/Tumor Cell Interaction

Patrizia Ferroni, Fiorella Guadagni, Antonella Spila, Francesca Martini, and Pier Paolo Gazzaniga
Cancer Res 1994 54: 623-625. [Abstract] [PDF]  

Gross and Microscopic Pathology of Induced Prostatic Complex Tumors Arising in Lobund-Wistar Rats

Michael B. Cohen, Paul M. Heidger, and David M. Lubaroff
Cancer Res 1994 54: 626-628. [Abstract] [PDF]  

Lack of Neurotoxicity of Oral Bisacetatoamminedichlorocyclohexylamine-platinum(IV) in Comparison to Cisplatin and Tetraplatin in the Rat

Mark J. McKeage, Frances E. Boxall, Mervyn Jones, and Kenneth R. Harrap
Cancer Res 1994 54: 629-631. [Abstract] [PDF]  

Specific Inhibition of Pre-Ribosomal RNA Processing in Extracts from the Lymphosarcoma Cells Treated with 5-Fluorouracil

Kalpana Ghoshal and Samson T. Jacob
Cancer Res 1994 54: 632-636. [Abstract] [PDF]  

ERBB2 (HER2/neu) Oncogene Is Frequently Amplified in Squamous Cell Carcinoma of the Uterine Cervix

A. B. Mitra, V. V. V. S. Murty, Mahendra Pratap, P. Sodhani, and R. S. K. Chaganti
Cancer Res 1994 54: 637-639. [Abstract] [PDF]  

Frequent Loss of Chromosome 9 in Human Primary Non-Small Cell Lung Cancer

Adrian Merlo, Edward Gabrielson, Frederic Askin, and David Sidransky
Cancer Res 1994 54: 640-642. [Abstract] [PDF]  

Prostacyclin as an Indicator of Preadipocyte Transformation: Studies in Vivo by Microdialysis and in Vitro

Christian Darimont, Gérard Ailhaud, and Raymond Negrel
Cancer Res 1994 54: 643-645. [Abstract] [PDF]  

Tumor-suppressive Activity of N03 Gene Product in v-src-transformed Rat 3Y1 Fibroblasts

Toshinori Ozaki and Shigeru Sakiyama
Cancer Res 1994 54: 646-648. [Abstract] [PDF]  

Analysis of the p53 Gene and Its Expression in Human Glioblastoma Cells

Erwin G. Van Meir, Tetsuro Kikuchi, Mitsuhiro Tada, Hong Li, Annie-Claire Diserens, Brian E. Wojcik, H-J. Su Huang, Theodore Friedmann, Nicolas de Tribolet, and Webster K. Cavenee
Cancer Res 1994 54: 649-652. [Abstract] [PDF]  

Public Issues:

New Directions in Molecular Medicine

Judith E. Karp and Samuel Broder
Cancer Res 1994 54: 653-665. [PDF]  

Special Lecture:

Drug Resistance: Genotype versus Phenotype—Thirty-second G. H. A. Clowes Memorial Award Lecture

June L. Biedler
Cancer Res 1994 54: 666-678. [PDF]  

Biochemistry and Biophysics:

Blocking of in Vitro DNA Replication by Deoxycytidine Adducts of the Mutagen and Clastogen 2-Bromoacrolein

Geertje J. M. van Beerendonk, Frank B. van Gog, Harry Vrieling, Paul G. Pearson, Sidney D. Nelson, and John H. N. Meerman
Cancer Res 1994 54: 679-684. [Abstract] [PDF]  

The Effect of the Iron(III) Chelator, Desferrioxamine, on Iron and Transferrin Uptake by the Human Malignant Melanoma Cell

Des Richardson, Prem Ponka, and Erica Baker
Cancer Res 1994 54: 685-689. [Abstract] [PDF]  

Cross-Competition between Vasoactive Intestinal Peptide and Somatostatin for Binding to Tumor Cell Membrane Receptors

Irene Virgolini, Qiong Yang, Shuren Li, Peter Angelberger, Nikolaus Neuhold, Bruno Niederle, Werner Scheithauer, and Peter Valent
Cancer Res 1994 54: 690-700. [Abstract] [PDF]  

Carcinogenesis:

Inhibition of Skin Tumorigenesis by Rosemary and Its Constituents Carnosol and Ursolic Acid

Mou-Tuan Huang, Chi-Tang Ho, Zhi Yuan Wang, Thomas Ferraro, You-Rong Lou, Kathe Stauber, Wei Ma, Constantino Georgiadis, Jeffrey D. Laskin, and Allan H. Conney
Cancer Res 1994 54: 701-708. [Abstract] [PDF]  

Clinical Investigations:

Phase I and Pharmacokinetic Study of Ormaplatin (Tetraplatin, NSC 363812) Administered on a Day 1 and Day 8 Schedule

Russell J. Schilder, Frank P. LaCreta, Raymond P. Perez, Steven W. Johnson, James M. Brennan, Andre Rogatko, Sherri Nash, Ceclia McAleer, Thomas C. Hamilton, David Roby, Robert C. Young, Robert F. Ozols, and Peter J. O'Dwyer
Cancer Res 1994 54: 709-717. [Abstract] [PDF]  

Epidemiology:

A Prospective Cohort Study on the Relation between Meat Consumption and the Risk of Colon Cancer

R. Alexandra Goldbohm, Piet A. van den Brandt, Pieter van 't Veer, Henny A. M. Brants, Elisabeth Dorant, Ferd Sturmans, and Rudolph J. J. Hermus
Cancer Res 1994 54: 718-723. [Abstract] [PDF]  

Experimental Therapeutics:

Antitumor Activity and Biochemical Effects of Aphidicolin Glycinate (NSC 303812) Alone and in Combination with Cisplatin in Vivo

Peter J. O'Dwyer, James D. Moyer, Matthew Suffness, Steadman D. Harrison, Jr., Richard Cysyk, Thomas C. Hamilton, and Jacqueline Plowman
Cancer Res 1994 54: 724-729. [Abstract] [PDF]  

Characteristics of P388/VMDRC.04, a Simple, Sensitive Model for Studying P-Glycoprotein Antagonists

Jin-Ming Yang, Sarah Goldenberg, Michael M. Gottesman, and William N. Hait
Cancer Res 1994 54: 730-737. [Abstract] [PDF]  

Preclinical Evaluation of WR-151327: An Orally Active Chemotherapy Protector

Dianna Green, Dennis Bensely, and Philip Schein
Cancer Res 1994 54: 738-741. [Abstract] [PDF]  

Cellular Pharmacology of N¹- and N⁸-Aziridinyl Analogues of Spermidine

Zhi-Min Yuan, Merrill J. Egorin, D. Marc Rosen, Marc A. Simon, and Patrick S. Callery
Cancer Res 1994 54: 742-748. [Abstract] [PDF]  

Quantitative and Qualitative Aspects of Topoisomerase I and II and ß in Untreated and Platinum/Cyclophosphamide Treated Malignant Ovarian Tumors

Ate G. J. van der Zee, Steven de Jong, W. Nicol Keith, Harrie Hollema, Henk Boonstra, and Elisabeth G. E. de Vries
Cancer Res 1994 54: 749-755. [Abstract] [PDF]  

Altered Subcellular Distribution of Topoisomerase II in a Drug-resistant Human Small Cell Lung Cancer Cell Line

Pamela W. Feldhoff, Shelagh E. L. Mirski, Susan P. C. Cole, and Daniel M. Sullivan
Cancer Res 1994 54: 756-762. [Abstract] [PDF]  

Effect of Human Natural Killer Cells on the Metastatic Growth of Human Melanoma Xenografts in Mice with Severe Combined Immunodeficiency

Laurie L. Hill, Bice Perussia, Peter A. McCue, and Robert Korngold
Cancer Res 1994 54: 763-770. [Abstract] [PDF]  

Cytotoxic Efficacy of 9-Nitrocamptothecin in the Treatment of Human Malignant Melanoma Cells in Vitro

Panayotis Pantazis, Janet A. Early, John T. Mendoza, Albert R. DeJesus, and Beppino C. Giovanella
Cancer Res 1994 54: 771-776. [Abstract] [PDF]  

Immunology:

Human Interleukin-3 Stimulates a Phosphatidylcholine Specific Phospholipase C and Protein Kinase C Translocation

Padmini Rao and R. Allan Mufson
Cancer Res 1994 54: 777-783. [Abstract] [PDF]  

Molecular Biology and Genetics:

Two Molecular Pathways to Transitional Cell Carcinoma of the Bladder

Charles H. Spruck, III, Petra F. Ohneseit, Mirella Gonzalez-Zulueta, David Esrig, Noriomi Miyao, Yvonne C. Tsai, Seth P. Lerner, Christoph Schmütte, Allen S. Yang, Richard Cote, Louis Dubeau, Peter W. Nichols, Gregers G. Hermann, Kenneth Steven, Thomas Horn, Donald G. Skinner, and Peter A. Jones
Cancer Res 1994 54: 784-788. [Abstract] [PDF]  

Inverse Correlation between Expression of Inducible Nitric Oxide Synthase Activity and Production of Metastasis in K-1735 Murine Melanoma Cells

Zhongyun Dong, Alexander H. Staroselsky, Xiaoxia Qi, Keping Xie, and Isaiah J. Fidler
Cancer Res 1994 54: 789-793. [Abstract] [PDF]  

Molecular Abnormalities of mdm2 and p53 Genes in Adult Soft Tissue Sarcomas

Carlos Cordon-Cardo, Esther Latres, Marija Drobnjak, Maria R. Oliva, Daphna Pollack, James M. Woodruff, Vincent Marechal, Jiandong Chen, Murray F. Brennan, and Arnold J. Levine
Cancer Res 1994 54: 794-799. [Abstract] [PDF]  

Tumor Biology:

Demonstration and Characterization of the Angiogenic Properties of Cervical Dysplasia

Karen K. Smith-McCune and Noel Weidner
Cancer Res 1994 54: 800-804. [Abstract] [PDF]  

Antiproliferative Effects of 1,25-Dihydroxyvitamin D₃ on Primary Cultures of Human Prostatic Cells

Donna M. Peehl, Roman J. Skowronski, Gordon K. Leung, Stephen T. Wong, Thomas A. Stamey, and David Feldman
Cancer Res 1994 54: 805-810. [Abstract] [PDF]  

Proliferation Kinetics of Recruited Cells in a Mouse Mammary Carcinoma

Alan Pollack, Nicholas H. A. Terry, R. Allen White, Shilong Cao, Marvin L. Meistrich, and Luka Milas
Cancer Res 1994 54: 811-817. [Abstract] [PDF]  

Bombesin Receptors in a Human Duodenal Tumor Cell Line: Binding Properties and Function

Barbara Y. Williams and Agnes Schonbrunn
Cancer Res 1994 54: 818-824. [Abstract] [PDF]  

Resistance to TNF- and Adriamycin in the Human Breast Cancer MCF-7 Cell Line: Relationship to MDR1, MnSOD, and TNF Gene Expression

Abdelmajid Zyad, Jean Bénard, Thomas Tursz, Robert Clarke, and Salem Chouaib
Cancer Res 1994 54: 825-831. [Abstract] [PDF]  

Reduced Malignancy of ras-transformed NIH 3T3 Cells Expressing Antisense Osteopontin RNA

Elke I. Behrend, Ann Marie Craig, Sylvia M. Wilson, David T. Denhardt, and Ann F. Chambers
Cancer Res 1994 54: 832-837. [Abstract] [PDF]  

Selective Down-Regulation of Integrin Receptors in Spheroids of Squamous Cell Carcinoma

Nahid S. Waleh, John Gallo, Tandora D. Grant, Brian J. Murphy, Randall H. Kramer, and Robert M. Sutherland
Cancer Res 1994 54: 838-843. [Abstract] [PDF]  

Inhibition of the Soluble and the Tumor Cell Receptor-bound Plasmin by Urinary Trypsin Inhibitor and Subsequent Effects on Tumor Cell Invasion and Metastasis

Hiroshi Kobayashi, Hiromitsu Shinohara, Kinya Takeuchi, Mariko Itoh, Michio Fujie, Motoo Saitoh, and Toshihiko Terao
Cancer Res 1994 54: 844-849. [Abstract] [PDF]  

Parathyroid Hormone-like Protein: Alternative Messenger RNA Splicing Pathways in Human Cancer Cell Lines

David W. Brandt, William Wachsman, and Leonard J. Deftos
Cancer Res 1994 54: 850-853. [Abstract] [PDF]  

Meeting Report:

Second International Cancer Chemoprevention Conference

Cancer Res 1994 54: 854-856. [PDF]  

Announcements:

Announcements

Cancer Res 1994 54: 857 [PDF]  

Calendar of Events

Cancer Res 1994 54: 858-859. [PDF]  

Articles:

Erratum

Cancer Res 1994 54: 859 [PDF]  

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