Advances in Brief:

Use of Recombinant Adenovirus to Transfer the Herpes Simplex Virus Thymidine Kinase (HSVtk) Gene to Thoracic Neoplasms: An Effective in Vitro Drug Sensitization System

W. Roy Smythe, Harry C. Hwang, Kunjlata M. Amin, Stephen L. Eck, Beverly L. Davidson, James M. Wilson, Larry R. Kaiser, and Steven M. Albelda
Cancer Res 1994 54: 2055-2059. [Abstract] [PDF]  

Homozygous Deletions within Chromosomal Bands 9p21–22 in Bladder Cancer

Walter M. Stadler, Jeniffer Sherman, Stefan K. Bohlander, Diane Roulston, Martin Dreyling, Daniel Rukstalis, and Olufunmilayo I. Olopade
Cancer Res 1994 54: 2060-2063. [Abstract] [PDF]  

Hepatocarcinoma-specific Mutant p53-249ser Induces Mitotic Activity but Has No Effect on Transforming Growth Factor ß1-mediated Apoptosis

Frédérique Ponchel, Alain Puisieux, Eric Tabone, Jean Philippe Michot, Gertraud Fröschl, Anne Pierre Morel, Thierry Frébourg, Bernard Fontanière, Franziska Oberhammer, and Mehmet Ozturk
Cancer Res 1994 54: 2064-2068. [Abstract] [PDF]  

Identification of a Common Clonal Human Immunodeficiency Virus Integration Site in Human Immunodeficiency Virus-associated Lymphomas

Bruce Shiramizu, Brian G. Herndier, and Michael S. McGrath
Cancer Res 1994 54: 2069-2072. [Abstract] [PDF]  

AGM-1470, a Potent Angiogenesis Inhibitor, Prevents the Entry of Normal but not Transformed Endothelial Cells into the G₁ Phase of the Cell Cycle

N. Antoine, R. Greimers, C. De Roanne, M. Kusaka, E. Heinen, L. J. Simar, and V. Castronovo
Cancer Res 1994 54: 2073-2076. [Abstract] [PDF]  

Mutations of the p53 Tumor Suppressor Gene Occur Infrequently in Wilms' Tumor

David Malkin, Elizabeth Sexsmith, Herman Yeger, Bryan R. G. Williams, and Max J. Coppes
Cancer Res 1994 54: 2077-2079. [Abstract] [PDF]  

Predictive Performance of a Pharmacodynamic Model for Oral Etoposide

Antonius A. Miller and Elizabeth A. Tolley
Cancer Res 1994 54: 2080-2083. [Abstract] [PDF]  

Genetic Instability of Microsatellite Sequences in Many Non-Small Cell Lung Carcinomas

Viji Shridhar, Jill Siegfried, Jay Hunt, Maria del Mar Alonso, and David I. Smith
Cancer Res 1994 54: 2084-2087. [Abstract] [PDF]  

Enhancement of X-Ray Cell Killing in Cultured Mammalian Cells by the Protein Phosphatase Inhibitor Calyculin A

Katsumasa Nakamura and Shigetoshi Antoku
Cancer Res 1994 54: 2088-2090. [Abstract] [PDF]  

Structure and Expression in Breast Tumors of Human TIMP-3, a New Member of the Metalloproteinase Inhibitor Family

José A. Uría, Adolfo A. Ferrando, Gloria Velasco, José M. P. Freije, and Carlos López-Otín
Cancer Res 1994 54: 2091-2094. [Abstract] [PDF]  

Down-Regulation of bcl-2 by p53 in Breast Cancer Cells

Subrata Haldar, Massimo Negrini, Maria Monne, Silvia Sabbioni, and Carlo M. Croce
Cancer Res 1994 54: 2095-2097. [Abstract] [PDF]  

Frequent Microsatellite Instability in Primary Small Cell Lung Cancer

Adrian Merlo, Mack Mabry, Edward Gabrielson, Robin Vollmer, Stephen B. Baylin, and David Sidransky
Cancer Res 1994 54: 2098-2101. [Abstract] [PDF]  

Biochemistry and Biophysics:

A Monoclonal Antibody Inhibits Adhesion to Fibronectin and Vitronectin of a Colon Carcinoma Cell Line and Recognizes the Integrins _vß₃, _vß₅, and _vß₆

Maxime Lehmann, Chantal Rabenandrasana, Richard Tamura, Jean-Claude Lissitzky, Vito Quaranta, Jacques Pichon, and Jacques Marvaldi
Cancer Res 1994 54: 2102-2107. [Abstract] [PDF]  

Carcinogenesis:

Interferon and Retinoic Acid Suppress the Growth of Human Papillomavirus Type 16 Immortalized Cervical Epithelial Cells, but Only Interferon Suppresses the Level of the Human Papillomavirus Transforming Oncogenes

Chapla Agarwal, Joan R. Hembree, Ellen A. Rorke, and Richard L. Eckert
Cancer Res 1994 54: 2108-2112. [Abstract] [PDF]  

Effects of Dietary Linoleic Acid on Pancreatic Carcinogenesis in Rats and Hamsters

Marko J. Appel, Annemarie van Garderen-Hoetmer, and Ruud A. Woutersen
Cancer Res 1994 54: 2113-2120. [Abstract] [PDF]  

Clinical Investigations:

Clinical Pharmacology of Hepatic Arterial Infusions of 5-Bromo-2'-deoxyuridine

William D. Ensminger, Suzette C. Walker, Philip L. Stetson, John G. Wagner, James A. Knol, Theodore S. Lawrence, and James C. Andrews
Cancer Res 1994 54: 2121-2124. [Abstract] [PDF]  

Elevated Plasma Lipid Peroxide Content Correlates with Rapid Plasma Clearance of All-trans-Retinoic Acid in Patients with Advanced Cancer

Josephia F. Muindi, Howard I. Scher, James R. Rigas, Raymond P. Warrell, Jr., and Charles W. Young
Cancer Res 1994 54: 2125-2128. [Abstract] [PDF]  

Endocrinology:

Effects of Gastrin on 3',5'-Cyclic Adenosine Monophosphate, Intracellular Calcium, and Phosphatidylinositol Hydrolysis in Human Colon Cancer Cells

Jin Ishizuka, Courtney M. Townsend, Jr., Richard J. Bold, Jean Martinez, Marc Rodriguez, and James C. Thompson
Cancer Res 1994 54: 2129-2135. [Abstract] [PDF]  

Pro-Gastrin-Releasing Peptide(31-98) Is a Specific Tumor Marker in Patients with Small Cell Lung Carcinoma

Yoshio Miyake, Tetsuro Kodama, and Ken Yamaguchi
Cancer Res 1994 54: 2136-2140. [Abstract] [PDF]  

Experimental Therapeutics:

Intrathecal Gene Therapy for Malignant Leptomeningeal Neoplasia

Zvi Ram, Stuart Walbridge, Eric M. Oshiro, John J. Viola, Yawen Chiang, Stephan N. Mueller, R. Michael Blaese, and Edward H. Oldfield
Cancer Res 1994 54: 2141-2145. [Abstract] [PDF]  

Targeted Therapy with Immunotoxins in a Nude Rat Model for Leptomeningeal Growth of Human Small Cell Lung Cancer

Arne Thormod Myklebust, Aslak Godal, and Øystein Fodstad
Cancer Res 1994 54: 2146-2150. [Abstract] [PDF]  

Tumor-selective Prodrug Activation by Fusion Protein-mediated Catalysis

Klaus Bosslet, Jörg Czech, and Dieter Hoffmann
Cancer Res 1994 54: 2151-2159. [Abstract] [PDF]  

Two-Step Targeting of Experimental Lung Metastases with Biotinylated Antibody and Radiolabeled Streptavidin

Tsuneo Saga, John N. Weinstein, Jae M. Jeong, Toshiro Heya, Jae T. Lee, Nhat Le, Chang H. Paik, Cynthia Sung, and Ronald D. Neumann
Cancer Res 1994 54: 2160-2165. [Abstract] [PDF]  

Streptavidin Distribution in Metastatic Tumors Pretargeted with a Biotinylated Monoclonal Antibody: Theoretical and Experimental Pharmacokinetics

Cynthia Sung, William W. van Osdol, Tsuneo Saga, Ronald D. Neumann, Robert L. Dedrick, and John N. Weinstein
Cancer Res 1994 54: 2166-2175. [Abstract] [PDF]  

Identification of a Methylcholanthrene-induced Aldehyde Dehydrogenase in a Human Breast Adenocarcinoma Cell Line Exhibiting Oxazaphosphorine-specific Acquired Resistance

Lakshmaiah Sreerama and Norman E. Sladek
Cancer Res 1994 54: 2176-2185. [Abstract] [PDF]  

Liposomes and Hyperthermia in Mice: Increased Tumor Uptake and Therapeutic Efficacy of Doxorubicin in Sterically Stabilized Liposomes

Shi Kun Huang, Paul R. Stauffer, Keelung Hong, John W. H. Guo, Theodore L. Phillips, Anthony Huang, and Demetrios Papahadjopoulos
Cancer Res 1994 54: 2186-2191. [Abstract] [PDF]  

Altered Queuine Modification of Transfer RNA Involved in the Differentiation of Human K562 Erythroleukemia Cells in the Presence of Distinct Differentiation Inducers

Ya-Lei Chen and Rong-Tsun Wu
Cancer Res 1994 54: 2192-2198. [Abstract] [PDF]  

(R,R)-2,2'-[1,2-Ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] Dimethanesulfonate (DMP 840), a Novel Bis-naphthalimide with Potent Nonselective Tumoricidal Activity in Vitro

M. R. Kirshenbaum, S-F. Chen, C. H. Behrens, L. M. Papp, M. M. Stafford, J-H. Sun, D. L. Behrens, J. R. Fredericks, S. T. Polkus, P. Sipple, A. D. Patten, D. Dexter, S. P. Seitz, and J. L. Gross
Cancer Res 1994 54: 2199-2206. [Abstract] [PDF]  

Interstitial Taxol Delivered from a Biodegradable Polymer Implant against Experimental Malignant Glioma

Kevin A. Walter, Mitchell A. Cahan, Aya Gur, Betty Tyler, John Hilton, O. Michael Colvin, Peter C. Burger, Abraham Domb, and Henry Brem
Cancer Res 1994 54: 2207-2212. [Abstract] [PDF]  

Liposomal N,N,N-Trimethylsphingosine (TMS) as an Inhibitor of B16 Melanoma Cell Growth and Metastasis with Reduced Toxicity and Enhanced Drug Efficacy Compared to Free TMS: Cell Membrane Signaling as a Target in Cancer Therapy III

Yong Serk Park, Sen-itiroh Hakomori, Shigeyuki Kawa, Fuqiang Ruan, and Yasuyuki Igarashi
Cancer Res 1994 54: 2213-2217. [Abstract] [PDF]  

Rat Glioblastoma Cells Expressing an Antisense RNA to the Insulin-like Growth Factor-1 (IGF-1) Receptor Are Nontumorigenic and Induce Regression of Wild-Type Tumors

Mariana Resnicoff, Christian Sell, Michele Rubini, Domenico Coppola, Diane Ambrose, Renato Baserga, and Raphael Rubin
Cancer Res 1994 54: 2218-2222. [Abstract] [PDF]  

Therapeutic Efficacy of Long Duration-Low Temperature Whole Body Hyperthermia When Combined with Tumor Necrosis Factor and Carboplatin in Rats

Yoshihisa Sakaguchi, Masato Makino, Tetsuya Kaneko, L. Clifton Stephens, Frederick R. Strebel, Lynn L. Danhauser, Gaye N. Jenkins, and Joan M. C. Bull
Cancer Res 1994 54: 2223-2227. [Abstract] [PDF]  

Molecular Biology and Genetics:

Antibody Response to Murine Anti-G_D2 Monoclonal Antibodies: Correlation with Patient Survival

Nai-Kong V. Cheung, Irene Y. Cheung, Adela Canete, Samuel J. Yeh, Brian Kushner, Mary Ann Bonilla, Glenn Heller, and Steven M. Larson
Cancer Res 1994 54: 2228-2233. [Abstract] [PDF]  

Involvement of Serum Response Element in Okadaic Acid-induced EGR-1 Transcription in Human T-Cells

Dharminder Chauhan, Surender M. Kharbanda, Hiroshi Uchiyama, Vikas P. Sukhatme, Donald W. Kufe, and Kenneth C. Anderson
Cancer Res 1994 54: 2234-2239. [Abstract] [PDF]  

Overexpression of Phospholipase C-1 in Familial Adenomatous Polyposis

Jae-Gahb Park, Young Han Lee, Sung Sook Kim, Kyu Joo Park, Dong-Young Noh, Sung Ho Ryu, and Pann-Ghill Suh
Cancer Res 1994 54: 2240-2244. [Abstract] [PDF]  

Retinoblastoma Protein is Rapidly Dephosphorylated by Elevated Cyclic Adenosine Monophosphate Levels in Human B-Lymphoid Cells

Jon Christoffersen, Erlend B. Smeland, Trond Stokke, Kjetil Taskén, Kristin Brevik Andersson, and Heidi Kiil Blomhoff
Cancer Res 1994 54: 2245-2250. [Abstract] [PDF]  

Lack of Correlation between N-myc and MAX Expression in Neuroblastoma Tumors and in Cell Lines: Implication for N-myc-MAX Complex Formation

Giuseppe Raschella, Antonino Romeo, Anna Negroni, Sabina Pucci, Carlo Dominici, Manuel A. Castello, Paola Bevilacqua, Armando Felsani, and Bruno Calabretta
Cancer Res 1994 54: 2251-2255. [Abstract] [PDF]  

Coactivation of the MDR1 and MYCN Genes in Human Neuroblastoma Cells during the Metastatic Process in the Nude Mouse

E. Ferrandis, J. Da Silva, G. Riou, and I. Bénard
Cancer Res 1994 54: 2256-2261. [Abstract] [PDF]  

Tumor Biology:

Activation of a Tumor-associated Protein Kinase (p40^TAK) and Casein Kinase 2 in Human Squamous Cell Carcinomas and Adenocarcinomas of the Lung

Maleki Daya-Makin, Jasbinder S. Sanghera, Tara L. Mogentale, Michelle Lipp, Julie Parchomchuk, James C. Hogg, and Steven L. Pelech
Cancer Res 1994 54: 2262-2268. [Abstract] [PDF]  

Compartmental Distribution of Tumor-specific Monoclonal Antibodies in Human Melanoma Xenografts

Ke Lin, Janice A. Nagy, Huanhuan Xu, Ty R. Shockley, Martin L. Yarmush, and Harold F. Dvorak
Cancer Res 1994 54: 2269-2277. [Abstract] [PDF]  

Virology:

Adeno-associated Virus Inhibits Human Papillomavirus Type 16: A Viral Interaction Implicated in Cervical Cancer

Paul L. Hermonat
Cancer Res 1994 54: 2278-2281. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1994 54: 2282-2283. [PDF]  

Erratum

Cancer Res 1994 54: 2284 [PDF]  

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