Program:

Introduction to the Fifth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer

David M. Goldenberg
Cancer Res 1995 55: 5708s-5709s. [PDF]  

Session I Radiochemistry of Antibodies:

Labeling of Polypeptides with Technetium-99m Using a Dextran Spacer

Anders Holmberg, Marcela Marquez, Jan-Erik Westlin, and Sten Nilsson
Cancer Res 1995 55: 5710s-5713s. [Abstract] [PDF]  

Identification of Metabolites of ¹¹¹In-Diethylenetriaminepentaacetic Acid-Monoclonal Antibodies and Antibody Fragments in Vivo

Buck E. Rogers, F. Nicholas Franano, James R. Duncan, W. Barry Edwards, Carolyn J. Anderson, Judith M. Connett, and Michael J. Welch
Cancer Res 1995 55: 5714s-5720s. [Abstract] [PDF]  

Site-specific Modifications of Light Chain Glycosylated Antilymphoma (LL2) and Anti-Carcinoembryonic Antigen (hImmu-14-N) Antibody Divalent Fragments

Serengulam V. Govindan, David M. Goldenberg, Gary L. Griffiths, Shui-on Leung, Michele J. Losman, and Hans J. Hansen
Cancer Res 1995 55: 5721s-5725s. [Abstract] [PDF]  

Prelabeling of Chimeric Monoclonal Antibody L6 with ⁹⁰Yttrium- and ¹¹¹Indium-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA) Chelates for Radioimmunodiagnosis and Therapy

Min Li, Claude F. Meares, Qansy Salako, David L. Kukis, Gao-Ren Zhong, Laird Miers, and Sally J. DeNardo
Cancer Res 1995 55: 5726s-5728s. [Abstract] [PDF]  

Session II Experimental Studies of Antibody Targeting:

Experimental Approaches to Increase Radiolabeled Antibody Localization in Tumors

Donald J. Buchsbaum
Cancer Res 1995 55: 5729s-5732s. [Abstract] [PDF]  

On the Validity of "Functional Affinity" Determination for Antibodies Binding to Cell Surface Antigens or Other Polyvalent Antigens

M. Jules Mattes
Cancer Res 1995 55: 5733s-5735s. [Abstract] [PDF]  

Preclinical Analysis of Intraperitoneal Administration of ¹¹¹In-labeled Human Tumor Reactive Monoclonal IgM AC6C3-2B12

Syed M. Quadri, Atif B. Malik, Xiu-Zhu Tang, Rebecca Patenia, Ralph S. Freedman, and Huibert M. Vriesendorp
Cancer Res 1995 55: 5736s-5742s. [Abstract] [PDF]  

Initial Studies of Monoclonal Antibody PAM4 Targeting to Xenografted Orthotopic Pancreatic Cancer

Rita Alisauskus, George Y. C. Wong, and David V. Gold
Cancer Res 1995 55: 5743s-5748s. [Abstract] [PDF]  

A Monoclonal Antibody-Cobra Venom Factor Conjugate Increases the Tumor-specific Uptake of a ^99mTc-labeled Anti-Carcinoembryonic Antigen Antibody by a Two-Step Approach

Hartmut Juhl, Maren Sievers, Katrin Baltzer, Frank Helmig, Heike Wolf, Winfried Brenner, and Holger Kalthoff
Cancer Res 1995 55: 5749s-5755s. [Abstract] [PDF]  

Session III Clinical Studies of Radiommunodetection:

Improving the Balance between Treatment and Diagnosis: A Role for Radioimmunodetection

Steven M. Larson
Cancer Res 1995 55: 5756s-5758s. [Abstract] [PDF]  

Fusion of Immunoscintigraphy Single Photon Emission Computed Tomography (SPECT) with CT of the Chest in Patients with Non-Small Cell Lung Cancer

Sanjeev Katyal, Elissa Lipcon Kramer, Marilyn E. Noz, Dorothy McCauley, Abraham Chachoua, and Alan Steinfeld
Cancer Res 1995 55: 5759s-5763s. [Abstract] [PDF]  

Improved Staging of B-Cell Non-Hodgkin's Lymphoma Patients with ^99mTc-labeled LL2 Monoclonal Antibody Fragment

Michael J. Blend, Hyewon Hyun, Mark Kozloff, Helene Levi, George Q. Mills, Massimo Gasparini, GianLuigi Buraggi, Lynne Hughes, Carl M. Pinsky, and David M. Goldenberg
Cancer Res 1995 55: 5764s-5770s. [Abstract] [PDF]  

⁶⁷Ga Citrate versus ^99mTc-labeled LL2-Fab' (Anti-CD22) Fragments in the Staging of B-Cell Non-Hodgkin's Lymphoma

Wolfgang S. Becker, Thomas M. Behr, Felix Cumme, Wolf Rössler, Jörg Wendler, Peter M. Kern, Martin Gramatzki, Jochen R. Kalden, David M. Goldenberg, and Friedrich G. Wolf
Cancer Res 1995 55: 5771s-5773s. [Abstract] [PDF]  

Radioimmunoscintigraphy of Colorectal Carcinoma Using Technetium-99m-labeled, Totally Human Monoclonal Antibody 88BV59H21-2

Seza A. Gulec, Aldo N. Serafini, Frederick L. Moffat, Ruben D. Vargas-Cuba, George N. Sfakianakis, Dido Franceschi, Virginia Z. Crichton, Ramaswamy Subramanian, Jerry L. Klein, and Robert L. De Jager
Cancer Res 1995 55: 5774s-5776s. [Abstract] [PDF]  

Targeting of Liver Metastases of Colorectal Cancer with IgG, F(ab')₂, and Fab' Anti-Carcinoembryonic Antigen Antibodies Labeled with ^99mTc: The Role of Metabolism and Kinetics

Thomas Behr, Wolfgang Becker, Ewald Hannappel, David M. Goldenberg, and Friedrich Wolf
Cancer Res 1995 55: 5777s-5785s. [Abstract] [PDF]  

Diagnostic Accuracy and Tumor-targeting Kinetics of Complete versus Fragmented ^99mTc-labeled Anti-Carcinoembryonic Antigen Antibodies: An Intraindividual Comparison

Thomas M. Behr, Wolfgang S. Becker, Michael W. Klein, Hans-J. Bair, Johannes R. Scheele, and Friedrich G. Wolf
Cancer Res 1995 55: 5786s-5793s. [Abstract] [PDF]  

Human Biodistribution of [¹¹¹In]Diethylenetriaminepentaacetic Acid-(DTPA)-D-[Phe¹]-octreotide and Peroperative Detection of Endocrine Tumors

Ulf Öhrvall, Jan-Erik Westlin, Sten Nilsson, Erik Wilander, Claes Juhlin, Jonas Rastad, and Göran Åkerström
Cancer Res 1995 55: 5794s-5800s. [Abstract] [PDF]  

Somatostatin Receptor Scintigraphy in Patients with Carcinoid Tumors: Comparison between Radioligand Uptake and Tumor Markers

Karl-Mikael Kälkner, Eva Tiensuu Janson, Sten Nilsson, Sten Carlsson, Kjell Öberg, and Jan-Erik Westlin
Cancer Res 1995 55: 5801s-5804s. [Abstract] [PDF]  

Metastatic Hormone-Refractory Prostatic Adenocarcinoma Expresses Somatostatin Receptors and Is Visualized in Vivo by [¹¹¹In]-labeled DTPA-D-[Phe¹]-Octreotide Scintigraphy

Sten Nilsson, Jean Claude Reubi, Karl-Mikael Kalkner, Jean Albert Laissue, Ursula Horisberger, Claes Olerud, and Jan-Erik Westlin
Cancer Res 1995 55: 5805s-5810s. [Abstract] [PDF]  

Session IV Radiation Physics, Biology, and Dosimetry:

Reconciliation of Tumor Dose Response to External Beam Radiotherapy versus Radioimmunotherapy with ¹³¹Iodine-labeled Antibody for a Colon Cancer Model

Peter L. Roberson and Donald J. Buchsbaum
Cancer Res 1995 55: 5811s-5816s. [Abstract] [PDF]  

Radiation-absorbed Dose Estimates to Normal Organs following Intraperitoneal ¹⁸⁶Re-labeled Monoclonal Antibody: Methods and Results

Hazel B. Breitz, James S. Durham, Darrell R. Fisher, and Paul L. Weiden
Cancer Res 1995 55: 5817s-5822s. [Abstract] [PDF]  

Threshold Estimation in Single Photon Emission Computed Tomography and Planar Imaging for Clinical Radioimmunotherapy

Yusuf E. Erdi, Barry W. Wessels, Murray H. Loew, and Alev K. Erdi
Cancer Res 1995 55: 5823s-5826s. [Abstract] [PDF]  

Estimates of Red Marrow Dose by Sacral Scintigraphy in Radioimmunotherapy Patients Having Non-Hodgkin's Lymphoma and Diffuse Bone Marrow Uptake

Malik Juweid, Robert M. Sharkey, Jeffry A. Siegel, Thomas Behr, and David M. Goldenberg
Cancer Res 1995 55: 5827s-5831s. [Abstract] [PDF]  

Session V Experimental Radioimmunotherapy, Including Pre-Targeting:

Overview of Studies on Experimental Radioimmunotherapy

Susan J. Knox
Cancer Res 1995 55: 5832s-5836s. [Abstract] [PDF]  

Yttrium-90 Chimeric L6 Therapy of Human Breast Cancer in Nude Mice and Apoptosis-related Messenger RNA Expression

Sally J. DeNardo, Paul H. Gumerlock, Michelle D. Winthrop, Philip C. Mack, Sung-Gil Chi, Kathleen R. Lamborn, Sui Shen, Laird A. Miers, Ralph W. deVere White, and Gerald L. DeNardo
Cancer Res 1995 55: 5837s-5841s. [Abstract] [PDF]  

Radioimmunotherapy of Breast Cancer Xenografts with Monoclonal Antibody ICR12 against c-erbB2 p185: Comparison of Iodogen and N-Succinimidyl 4-Methyl-3-(tri-n-butylstannyl)benzoate Radioiodination Methods

W. James B. Smellie, Christopher J. Dean, Nigel P. M. Sacks, Michael R. Zalutsky, Pradeep K. Garg, Paul Carnochan, and Suzanne A. Eccles
Cancer Res 1995 55: 5842s-5846s. [Abstract] [PDF]  

Selection of Tumor-specific Epitopes on Target Antigens for Radioimmunotherapy of Breast Cancer

Jerry A. Peterson, Joseph R. Couto, Michael R. Taylor, and Roberto L. Ceriani
Cancer Res 1995 55: 5847s-5851s. [Abstract] [PDF]  

Biological Activity of Two Humanized Antibodies against Two Different Breast Cancer Antigens and Comparison to Their Original Murine Forms

Roberto L. Ceriani, Edward W. Blank, Joseph R. Couto, and Jerry A. Peterson
Cancer Res 1995 55: 5852s-5856s. [Abstract] [PDF]  

In Vitro and in Vivo Reactivity of an Internalizing Antibody, RS7, with Human Breast Cancer

Lisa B. Shih, Hong Xuan, Rosarito Aninipot, Rhona Stein, and David M. Goldenberg
Cancer Res 1995 55: 5857s-5863s. [Abstract] [PDF]  

Development and Characterization of Anti-Renal Cell Carcinoma x Antichelate Bispecific Monoclonal Antibodies for Two-Phase Targeting of Renal Cell Carcinoma

Marion H. G. C. Kranenborg, Otto C. Boerman, Jeannette C. Oosterwijk-Wakka, Mirjam C. A. de Weijert, Frans H. M. Corstens, and Egbert Oosterwijk
Cancer Res 1995 55: 5864s-5867s. [Abstract] [PDF]  

Use of Anticytokeratin Monoclonal Anti-Idiotypic Antibodies to Improve Tumor:Nontumor Ratio in Experimental Radioimmunolocalization

Anders Ullén, Per Sandström, Katrine Riklund Åhlström, Birgitta Sundström, Berith Nilsson, Lisbeth Ärlestig, and Torgny Stigbrand
Cancer Res 1995 55: 5868s-5873s. [Abstract] [PDF]  

Enhanced Radioimmunotargeting of ¹²⁵I-labeled L6-Biotin Monoclonal Antibody (MAb) by Combining Preload of Cold L6 MAb and Subsequent Immunoadsorption in Rats

Michael Garkavij, Jan Tennvall, Sven-Erik Strand, Kristina Norrgren, Lars Lindgren, Rune Nilsson, and Hans-Olov Sjögren
Cancer Res 1995 55: 5874s-5880s. [Abstract] [PDF]  

Fractionated Radioimmunotherapy of Human Colon Carcinoma Xenografts with ¹³¹I-labeled Monoclonal Antibody CC49

Donald Buchsbaum, M. B. Khazaeli, Tiepu Liu, Sheila Bright, Kenneth Richardson, Margaret Jones, and Ruby Meredith
Cancer Res 1995 55: 5881s-5887s. [Abstract] [PDF]  

Session VI Clinical Radioimmunotherapy:

Review of Five Consecutive Studies of Radiolabeled Immunoglobulin Therapy in Hodgkin's Disease

Huibert M. Vriesendorp, Jeffery D. Morton, and Syed M. Quadri
Cancer Res 1995 55: 5888s-5892s. [Abstract] [PDF]  

Prognostic Factors for Radioimmunotherapy in Patients with B-Lymphocytic Malignancies

Gerald L. DeNardo, Kathleen R. Lamborn, Sally J. DeNardo, Desirée S. Goldstein, Edward G. Dolber-Smith, Linda A. Kroger, Edward C. Larkin, and Sui Shen
Cancer Res 1995 55: 5893s-5898s. [Abstract] [PDF]  

Treatment of Non-Hodgkin's Lymphoma with Radiolabeled Murine, Chimeric, or Humanized LL2, an Anti-CD22 Monoclonal Antibody

Malik Juweid, Robert M. Sharkey, Adeline Markowitz, Thomas Behr, Lawrence C. Swayne, Robert Dunn, Hans J. Hansen, Jerry Shevitz, Shui-On Leung, Arnold D. Rubin, Thomas Herskovic, Debra Hanley, and David M. Goldenberg
Cancer Res 1995 55: 5899s-5907s. [Abstract] [PDF]  

Radiolabeled Anti-CD33 Monoclonal Antibody M195 for Myeloid Leukemias

Joseph G. Juricic, Philip C. Caron, Tuomo K. Nikula, Esperanza B. Papadopoulos, Ronald D. Finn, Otto A. Gansow, Wilson H. Miller, Jr., Maurits W. Geerlings, Raymond P. Warrell, Jr., Steven M. Larson, and David A. Scheinberg
Cancer Res 1995 55: 5908s-5910s. [Abstract] [PDF]  

Initial Tumor Targeting, Biodistribution, and Pharmacokinetic Evaluation of the Monoclonal Antibody PAM4 in Patients with Pancreatic Cancer

Giuliano Mariani, Nicola Molea, Daniela Bacciardi, Ugo Boggi, Gino Fornaciari, Daniela Campani, Piero A. Salvadori, Pier Cristoforo Giulianotti, Franco Mosca, David V. Gold, Robert M. Sharkey, and David M. Goldenberg
Cancer Res 1995 55: 5911s-5915s. [Abstract] [PDF]  

Radioimmunotherapy for Breast Cancer Using Escalating Fractionated Doses of ¹³¹I-labeled Chimeric L6 Antibody with Peripheral Blood Progenitor Cell Transfusions

Carol M. Richman, Sally J. DeNardo, Lois F. O'Grady, and Gerald L. DeNardo
Cancer Res 1995 55: 5916s-5920s. [Abstract] [PDF]  

High-Dose ⁹⁰Y Mx-Diethylenetriaminepentaacetic Acid (DTPA)-BrE-3 and Autologous Hematopoietic Stem Cell Support (AHSCS) for the Treatment of Advanced Breast Cancer: A Phase I Trial

David M. Schrier, Salomon M. Stemmer, Timothy Johnson, Ravindra Kasliwal, James Lear, Steven Matthes, Sharon Taffs, Christopher Dufton, Stephan D. Glenn, Gregory Butchko, Robert L. Ceriani, Douglas Rovira, Paul Bunn, Elizabeth J. Shpall, Scott I. Bearman, Malcom Purdy, Pablo Cagnoni, and Roy B. Jones
Cancer Res 1995 55: 5921s-5924s. [Abstract] [PDF]  

Enhanced TAG-72 Expression and Tumor Uptake of Radiolabeled Monoclonal Antibody CC49 in Metastatic Breast Cancer Patients following -Interferon Treatment

James L. Murray, Daniel J. Macey, Edward J. Grant, Michael G. Rosenblum, Leela P. Kasi, Hua-Zhong Zhang, Ruth L. Katz, Paula T. Rieger, Donna LeBherz, Viju Bhadkamkar, John W. Greiner, Jeffrey Schlom, and Donald A. Podoloff
Cancer Res 1995 55: 5925s-5928s. [Abstract] [PDF]  

Initial Experience Evaluating ⁹⁰Yttrium-Radiolabeled Anti-Carcinoembryonic Antigen Chimeric T84.66 in a Phase I Radioimmunotherapy Trial

Jeffrey Y. C. Wong, Lawrence E. Williams, David M. Yamauchi, Tamara Odom-Maryon, Jose M. Esteban, Michael Neumaier, Anna M. Wu, David K. Johnson, F. James Primus, John E. Shively, and Andrew A. Raubitschek
Cancer Res 1995 55: 5929s-5934s. [Abstract] [PDF]  

Evaluation of a Complementarity-Determining Region-Grafted (Humanized) Anti-Carcinoembryonic Antigen Monoclonal Antibody in Preclinical and Clinical Studies

Robert M. Sharkey, Malik Juweid, Jerry Shevitz, Thomas Behr, Robert Dunn, Lawrence C. Swayne, George Y. Wong, Rosalyn D. Blumenthal, Gary L. Griffiths, Jeffry A. Siegel, Shui-on Leung, Hans J. Hansen, and David M. Goldenberg
Cancer Res 1995 55: 5935s-5945s. [Abstract] [PDF]  

Targeting and Initial Radioimmunotherapy of Medullary Thyroid Carcinoma with ¹³¹I-labeled Monoclonal Antibodies to Carcinoembryonic Antigen

Malik Juweid, Robert M. Sharkey, Thomas Behr, Lawrence C. Swayne, Arnold D. Rubin, Debra Hanley, Thomas Herskovic, Adeline Markowitz, Jeffry Siegel, and David M. Goldenberg
Cancer Res 1995 55: 5946s-5951s. [Abstract] [PDF]  

Local Treatment of Malignant Gliomas by Direct Infusion of Specific Monoclonal Antibodies Labeled with ¹³¹I: Comparison of the Results Obtained in Recurrent and Newly Diagnosed Tumors

Pietro Riva, Agostino Arista, Giancarlo Franceschi, Massimo Frattarelli, Carmelo Sturiale, Nada Riva, Michela Casi, and Rosetta Rossitti
Cancer Res 1995 55: 5952s-5956s. [Abstract] [PDF]  

Session VII Reengineered Antibodies:

Biological Properties of Chimeric Domain-deleted Anticarcinoma Immunoglobulins

Dale C. Slavin-Chiorini, Syed V. S. Kashmiri, Jeffrey Schlom, Benjamin Calvo, Lee Ming Shu, Margaret E. Schott, Diane E. Milenic, Philip Snoy, Jorge Carrasquillo, Kerr Anderson, and Patricia Horan Hand
Cancer Res 1995 55: 5957s-5967s. [Abstract] [PDF]  

Bacterial Expression of a Kemptide Fusion Protein Facilitates ³²P Labeling of a Humanized, Anti-Carcinoembryonic Antigen (hMN-14) Antibody Fragment

Shui-on Leung, Habibe Karacay, Michele J. Losman, Gary L. Griffiths, David M. Goldenberg, and Hans J. Hansen
Cancer Res 1995 55: 5968s-5972s. [Abstract] [PDF]  

Designing Human Consensus Antibodies with Minimal Positional Templates

Joseph R. Couto, Rosemarie B. Christian, Jerry A. Peterson, and Roberto L. Ceriani
Cancer Res 1995 55: 5973s-5977s. [Abstract] [PDF]  

Development and Evaluation of the Specificity of a Rat Monoclonal Anti-Idiotype Antibody, WN, to an Anti-B-Cell Lymphoma Monoclonal Antibody, LL2

Michele J. Losman, Shui-on Leung, Lisa B. Shih, Jerry Shevitz, Rajesh Shukla, Liana Haraga, David M. Goldenberg, and Hans J. Hansen
Cancer Res 1995 55: 5978s-5982s. [Abstract] [PDF]  

Targeting c-erbB-2 Expressing Tumors Using Single-Chain FV Monomers and Dimers

Mei-Sheng Tai, John E. McCartney, Gregory P. Adams, Donald Jin, Robert M. Hudziak, Hermann Oppermann, Axel A. Laminet, Michael A. Bookman, Ellen J. Wolf, Sen Liu, Walter F. Stafford, III, Irwin Fand, L. L. Houston, Louis M. Weiner, and James S. Huston
Cancer Res 1995 55: 5983s-5989s. [Abstract] [PDF]  

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