Advances in Brief:

Increased Frequency of Spontaneous Skin Tumors in Transgenic Mice Which Overexpress Ornithine Decarboxylase

Louis Megosh, Susan K. Gilmour, Dan Rosson, Aléjandro Peralta Soler, Manfred Blessing, Janet A. Sawicki, and Thomas G. O'Brien
Cancer Res 1995 55: 4205-4209. [Abstract] [PDF]  

Adenovirus-mediated Wild-Type p53 Expression Induces Apoptosis and Suppresses Tumorigenesis of Prostatic Tumor Cells

Chunlin Yang, Corrado Cirielli, Maurizio C. Capogrossi, and Antonino Passaniti
Cancer Res 1995 55: 4210-4213. [Abstract] [PDF]  

The LRP Gene Encoding a Major Vault Protein Associated with Drug Resistance Maps Proximal to MRP on Chromosome 16: Evidence That Chromosome Breakage Plays a Key Role in MRP or LRP Gene Amplification

Marilyn L. Slovak, Jennifer Pelkey Ho, Susan P. C. Cole, Roger G. Deeley, Lee Greenberger, Elisabeth G. E. de Vries, Henricus J. Broxterman, George L. Scheffer, and Rik J. Scheper
Cancer Res 1995 55: 4214-4219. [Abstract] [PDF]  

Breakpoint Heterogeneity in t(10;11) Translocation in AML-M4/M5 Resulting in Fusion of AF10 and MLL Is Resolved by Fluorescent in Situ Hybridization Analysis

H. Berna Beverloo, Maryvonne Le Coniat, Jacqueline Wijsman, Debra M. Lillington, Olivier Bernard, Annelies de Klein, Elisabeth van Wering, Jeanna Welborn, Bryan D. Young, Anne Hagemeijer, and Roland Berger
Cancer Res 1995 55: 4220-4224. [Abstract] [PDF]  

Rapid Incorporation of Carbon-11-labeled Diacylglycerol as a Probe of Signal Transduction in Glioma

Yoshio Imahori, Yoshio Ohmori, Ryou Fujii, Keigo Matsumoto, and Satoshi Ueda
Cancer Res 1995 55: 4225-4229. [Abstract] [PDF]  

A Strategy to Discover Circulating Angiogenesis Inhibitors Generated by Human Tumors

Catherine Chen, Sareh Parangi, Michael J. Tolentino, and Judah Folkman
Cancer Res 1995 55: 4230-4233. [Abstract] [PDF]  

Alteration of Glyceraldehyde-3-phosphate Dehydrogenase Activity and Messenger RNA Content by Androgen in Human Prostate Carcinoma Cells

Maureen O. Ripple and George Wilding
Cancer Res 1995 55: 4234-4236. [Abstract] [PDF]  

Susceptibility to Astrocytoma and Meningioma: Influence of Allelism at Glutathione S-Transferase (GSTT1 and GSTM1) and Cytochrome P-450 (CYP2D6) Loci

Jose Elexpuru-Camiruaga, Neil Buxton, Vishwapathi Kandula, Pilatha S. Dias, Donald Campbell, James McIntosh, John Broome, Peter Jones, Avis Inskip, Julie Alldersea, Anthony A. Fryer, and Richard C. Strange
Cancer Res 1995 55: 4237-4239. [Abstract] [PDF]  

Radiation-induced Apoptosis of Ewing's Sarcoma Cells: DNA Fragmentation and Proteolysis of Poly(ADP-ribose) Polymerase

Viatcheslav A. Soldatenkov, Sarada Prasad, Vicente Notario, and Anatoly Dritschilo
Cancer Res 1995 55: 4240-4242. [Abstract] [PDF]  

Ras CAAX Peptidomimetic FTI 276 Selectively Blocks Tumor Growth in Nude Mice of a Human Lung Carcinoma with K-Ras Mutation and p53 Deletion

Jiazhi Sun, Yimin Qian, Andrew D. Hamilton, and Saïd M. Sebti
Cancer Res 1995 55: 4243-4247. [Abstract] [PDF]  

HLA A2601-restricted CTLs Recognize a Peptide Antigen Expressed on Squamous Cell Carcinoma

Masanobu Nakao, Hideaki Yamana, Yasuhisa Imai, Yuji Toh, Uhi Toh, Akinori Kimura, Shunsuke Yanoma, Teruo Kakegawa, and Kyogo Itoh
Cancer Res 1995 55: 4248-4252. [Abstract] [PDF]  

Suppression of Saccharin-induced Mutagenicity by Interferon- in Human RSa Cells

Nobuo Suzuki and Hideko Suzuki
Cancer Res 1995 55: 4253-4256. [Abstract] [PDF]  

p53, through p21 (WAF1/CIP1), Induces Cyclin D1 Synthesis

Xinbin Chen, Jill Bargonetti, and Carol Prives
Cancer Res 1995 55: 4257-4263. [Abstract] [PDF]  

Microsatellite Instability and K-ras Mutations Associated with Pancreatic Adenocarcinoma and Pancreatitis

Teresa A. Brentnall, Ru Chen, John G. Lee, Michael B. Kimmey, Mary P. Bronner, Rodger C. Haggitt, Kris V. Kowdley, Lonny M. Hecker, and David R. Byrd
Cancer Res 1995 55: 4264-4267. [Abstract] [PDF]  

Loss of Heterozygosity Frequently Affects Chromosome 17q in Non-Small Cell Lung Cancer

Kwun M. Fong, Yoshiki Kida, Paul V. Zimmerman, Makoto Ikenaga, and Peter J. Smith
Cancer Res 1995 55: 4268-4272. [Abstract] [PDF]  

Abnormal Retention of Intron 9 in CD44 Gene Transcripts in Human Gastrointestinal Tumors

Kazuhiro Yoshida, John Bolodeoku, Takashi Sugino, Steven Goodison, Yasuhiro Matsumura, Bryan F. Warren, Tetsuya Toge, Eiichi Tahara, and David Tarin
Cancer Res 1995 55: 4273-4277. [Abstract] [PDF]  

Detection of p53 Mutations in Benign and Dysplastic Nevi

David B. Levin, Kenneth Wilson, Giovana Valadares de Amorim, Jane Webber, Patrick Kenny, and Wolfgang Kusser
Cancer Res 1995 55: 4278-4282. [Abstract] [PDF]  

Surfactant Protein Gene Expression in Metastatic and Micrometastatic Pulmonary Adenocarcinomas and Other Non-Small Cell Lung Carcinomas: Detection by Reverse Transcriptase-Polymerase Chain Reaction

Christoph Betz, Thomas Papadopoulos, Jürgen Buchwald, Jobst Dämmrich, and Hans Konrad Müller-Hermelink
Cancer Res 1995 55: 4283-4286. [Abstract] [PDF]  

Chromosome Band 11q23 Translocation Breakpoints Are DNA Topoisomerase II Cleavage Sites

Carolyn A. Felix, Beverly J. Lange, Matthew R. Hosler, Jolanta Fertala, and Mary-Ann Bjornsti
Cancer Res 1995 55: 4287-4292. [Abstract] [PDF]  

Cellular Levels of Thioredoxin Associated with Drug Sensitivity to Cisplatin, Mitomycin C, Doxorubicin, and Etoposide

Akira Yokomizo, Mayumi Ono, Hiroki Nanri, Yoshinari Makino, Takefumi Ohga, Morimasa Wada, Takashi Okamoto, Junji Yodoi, Michihiko Kuwano, and Kimitoshi Kohno
Cancer Res 1995 55: 4293-4296. [Abstract] [PDF]  

Biochemistry and Biophysics:

Augmentation of Transport for Cisplatin-Glutathione Adduct in Cisplatin-resistant Cancer Cells

Shinji Goto, Kazuhiro Yoshida, Tooru Morikawa, Yoshishige Urata, Keiichiro Suzuki, and Takahito Kondo
Cancer Res 1995 55: 4297-4301. [Abstract] [PDF]  

Carcinogenesis:

Transformation of Astrocytes in Transgenic Mice Expressing SV40 T Antigen under the Transcriptional Control of the Glial Fibrillary Acidic Protein Promoter

R. Andrew Danks, Jacqui M. Orian, Michael F. Gonzales, Seong-Seng Tan, Bruce Alexander, Katsuhiko Mikoshiba, and Andrew H. Kaye
Cancer Res 1995 55: 4302-4310. [Abstract] [PDF]  

Enhancement of Experimental Colon Carcinogenesis by Dietary 6-Phenylhexyl Isothiocyanate

Chinthalapally V. Rao, Abraham Rivenson, Barbara Simi, Edith Zang, Rachid Hamid, Gary J. Kelloff, Vernon Steele, and Bandaru S. Reddy
Cancer Res 1995 55: 4311-4318. [Abstract] [PDF]  

Intermittent Dosing with Oltipraz: Relationship between Chemoprevention of Aflatoxin-induced Tumorigenesis and Induction of Glutathione S-Transferases

Thomas Primiano, Patricia A. Egner, Thomas R. Sutter, Gary J. Kelloff, B. D. Roebuck, and Thomas W. Kensler
Cancer Res 1995 55: 4319-4324. [Abstract] [PDF]  

Different Removal of Ultraviolet Photoproducts in Genetically Related Xeroderma Pigmentosum and Trichothiodystrophy Diseases

Eric Eveno, François Bourre, Xavier Quilliet, Odile Chevallier-Lagente, Len Roza, André P. M. Eker, Wim J. Kleijer, Osamu Nikaido, Miria Stefanini, Jan H. J. Hoeijmakers, Dirk Bootsma, James E. Cleaver, Alain Sarasin, and Mauro Mezzina
Cancer Res 1995 55: 4325-4332. [Abstract] [PDF]  

Increased Risk of Mammary Carcinoma Development following Transplacental and Trans-Breast Milk Exposure to a Food-derived Carcinogen, 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley Rats

Ryohei Hasegawa, Juki Kimura, Makoto Yaono, Satoru Takahashi, Toshio Kato, Mitsuru Futakuchi, Masato Fukutake, Kazuo Fukutome, Keiji Wakabayashi, Takashi Sugimura, Nobuyuki Ito, and Tomoyuki Shirai
Cancer Res 1995 55: 4333-4338. [Abstract] [PDF]  

Clinical Investigations:

Phase II Trial of Murine Monoclonal Antibody D612 Combined with Recombinant Human Monocyte Colony-stimulating Factor (rhM-CSF) in Patients with Metastatic Gastrointestinal Cancer

Mansoor N. Saleh, M. B. Khazaeli, Richard H. Wheeler, R. Pat Bucy, Tiepu Liu, Michael P. Everson, David H. Munn, Jeff Schlom, and Albert F. LoBuglio
Cancer Res 1995 55: 4339-4346. [Abstract] [PDF]  

Endocrinology:

Carcinogenic Activities of Various Steroidal and Nonsteroidal Estrogens in the Hamster Kidney: Relation to Hormonal Activity and Cell Proliferation

Jonathan J. Li, Sara Antonia Li, Terry D. Oberley, and Jonathan A. Parsons
Cancer Res 1995 55: 4347-4351. [Abstract] [PDF]  

Experimental Therapeutics:

Increased Rate of Adenosine Triphosphate-dependent Etoposide (VP-16) Efflux in a Murine Leukemia Cell Line Overexpressing the Multidrug Resistance-associated Protein (MRP) Gene

Aurelio Lorico, Germana Rappa, Srinivasan Srimatkandada, Carlo V. Catapano, Daniel J. Fernandes, Joseph F. Germino, and Alan C. Sartorelli
Cancer Res 1995 55: 4352-4360. [Abstract] [PDF]  

Effect of Hydroxyurea on Cellular Iron Metabolism in Human Leukemic CCRF-CEM Cells: Changes in Iron Uptake and the Regulation of Transferrin Receptor and Ferritin Gene Expression following Inhibition of DNA Synthesis

Christopher R. Chitambar and Janine P. Wereley
Cancer Res 1995 55: 4361-4366. [Abstract] [PDF]  

Evidence for Altered Regulation of -Glutamylcysteine Synthetase Gene Expression among Cisplatin-sensitive and Cisplatin-resistant Human Ovarian Cancer Cell Lines

Kang-Shen Yao, Andrew K. Godwin, Steven W. Johnson, Robert F. Ozols, Peter J. O'Dwyer, and Thomas C. Hamilton
Cancer Res 1995 55: 4367-4374. [Abstract] [PDF]  

Tumor-specific Anti-Epidermal Growth Factor Receptor Variant III Monoclonal Antibodies: Use of the Tyramine-Cellobiose Radioiodination Method Enhances Cellular Retention and Uptake in Tumor Xenografts

Craig J. Reist, Gary E. Archer, Shekar N. Kurpad, Carol J. Wikstrand, Ganesan Vaidyanathan, Mark C. Willingham, David K. Moscatello, Albert J. Wong, Darell D. Bigner, and Michael R. Zalutsky
Cancer Res 1995 55: 4375-4382. [Abstract] [PDF]  

Immunology:

Bispecific Antibody-mediated Lysis of Placental and Germ Cell Alkaline Phosphatase Targeted Solid Tumors in Immunocompetent Mice

Karine A. Smans, Marc F. Hoylaerts, Sonoko Narisawa, José Luis Millán, and Marc E. De Broe
Cancer Res 1995 55: 4383-4390. [Abstract] [PDF]  

Nitric Oxide Production in Relation to Spontaneous B-Cell Lymphoma and Myositis in SJL Mice

Snait Tamir, Teresa deRojas-Walker, Aharon Gal, Ann H. Weller, Xiantang Li, James G. Fox, Gerald N. Wogan, and Steven R. Tannenbaum
Cancer Res 1995 55: 4391-4397. [Abstract] [PDF]  

Immunotherapy with Low and High Affinity Monoclonal Antibodies 17-1A and 323/A3 in a Nude Mouse Xenograft Carcinoma Model

Markwin P. Velders, Connie M. van Rhijn, Inge H. Briaire, Gert Jan Fleuren, Sven O. Warnaar, and Sergey V. Litvinov
Cancer Res 1995 55: 4398-4403. [Abstract] [PDF]  

Administration of Recombinant Interleukin 12 Prevents Outgrowth of Tumor Cells Metastasizing Spontaneously to Lung and Lymph Nodes

Jie Mu, Jian-Ping Zou, Norihiko Yamamoto, Tateki Tsutsui, Xu-Guang Tai, Michiko Kobayashi, Steven Herrmann, Hiromi Fujiwara, and Toshiyuki Hamaoka
Cancer Res 1995 55: 4404-4408. [Abstract] [PDF]  

Bispecific Antibody-mediated Target Cell-specific Costimulation of Resting T Cells via CD5 and CD28

Bart-Jan Kroesen, Annie Bakker, Rene A. W. van Lier, Hauw T. The, and Lou de Leij
Cancer Res 1995 55: 4409-4415. [Abstract] [PDF]  

Molecular Biology and Genetics:

Benign Breast Disease: Absence of Genetic Alterations at Several Loci Implicated in Breast Cancer Malignancy

Sarab Lizard-Nacol, Rosette Lidereau, Françoise Collin, Muriel Arnal, Lyse Hahnel, Patrick Roignot, Jean Cuisenier, and Jacques Guerrin
Cancer Res 1995 55: 4416-4419. [Abstract] [PDF]  

p53 Inactivation by HPV16 E6 Results in Increased Mutagenesis in Human Cells

Pamela A. Havre, Jianling Yuan, Lora Hedrick, Kathleen R. Cho, and Peter M. Glazer
Cancer Res 1995 55: 4420-4424. [Abstract] [PDF]  

Tumor Biology:

Differential Colon Cancer Cell Adhesion to E-, P-, and L-selectin: Role of Mucintype Glycoproteins

Gianna Mannori, Pascal Crottet, Oliviero Cecconi, Kohji Hanasaki, Alejandro Aruffo, Richard M. Nelson, Ajit Varki, and Michael P. Bevilacqua
Cancer Res 1995 55: 4425-4431. [Abstract] [PDF]  

Human c-myb Is Expressed in Cervical Carcinomas and Transactivates the HPV-16 Promoter

Wolf Nürnberg, Metin Artuc, Michael Nawrath, Josip Lovric, Sabine Stüting, Karin Moelling, Beate M. Czarnetzki, and Dirk Schadendorf
Cancer Res 1995 55: 4432-4437. [Abstract] [PDF]  

Overexpression of bcl-2 Protects Prostate Cancer Cells from Apoptosis in Vitro and Confers Resistance to Androgen Depletion in Vivo

Anthony J. Raffo, Harris Perlman, Min-Wei Chen, Mark L. Day, Jack S. Streitman, and Ralph Buttyan
Cancer Res 1995 55: 4438-4445. [Abstract] [PDF]  

Correlation of Retinoid Binding Affinity to Retinoic Acid Receptor with Retinoid Inhibition of Growth of Estrogen Receptor-positive MCF-7 Mammary Carcinoma Cells

Marcia I. Dawson, Wan-ru Chao, Polly Pine, Ling Jong, Peter D. Hobbs, Colette K. Rudd, Timothy C. Quick, Richard M. Niles, Xiao-kun Zhang, Angela Lombardo, Kathryn R. Ely, Braham Shroot, and Joseph A. Fontana
Cancer Res 1995 55: 4446-4451. [Abstract] [PDF]  

Aspirin Enhances Thermotolerance in Human Erythroleukemic Cells: An Effect Associated with the Modulation of the Heat Shock Response

Carla Amici, Antonio Rossi, and M. Gabriella Santoro
Cancer Res 1995 55: 4452-4457. [Abstract] [PDF]  

Purification and Identification of Mouse Lung Microvessel Endothelial Cell-derived Chemoattractant for Lung-metastasizing Murine RAW117 Large-Cell Lymphoma Cells: Identification as Mouse Monocyte Chemotactic Protein 1

Hironao Wakabayashi, Philip G. Cavanaugh, and Garth L. Nicolson
Cancer Res 1995 55: 4458-4464. [Abstract] [PDF]  

Enhanced Glutathione Peroxidase Expression Protects Cells from Hydroperoxides but not from Radiation or Doxorubicin

James Liebmann, Joyce Fisher, Claudia Lipschultz, Richard Kuno, and Dwight C. Kaufman
Cancer Res 1995 55: 4465-4470. [Abstract] [PDF]  

Reduced Expression of Proapoptotic Gene BAX Is Associated with Poor Response Rates to Combination Chemotherapy and Shorter Survival in Women with Metastatic Breast Adenocarcinoma

Stanislaw Krajewski, Carl Blomqvist, Kaarle Franssila, Maryla Krajewska, Veli-Matti Wasenius, Eero Niskanen, Stig Nordling, and John C. Reed
Cancer Res 1995 55: 4471-4478. [Abstract] [PDF]  

N-Ethyl-N-nitrosourea Treatment of Multiple Intestinal Neoplasia (Min) Mice: Age-related Effects on the Formation of Intestinal Adenomas, Cystic Crypts, and Epidermoid Cysts

Alex R. Shoemaker, Amy R. Moser, and William F. Dove
Cancer Res 1995 55: 4479-4485. [Abstract] [PDF]  

Letters to the Editor:

Correspondence re: D. S. Swaffar et al., Inhibition of the Growth of Human Pancreatic Cancer Cells by the Arginine Antimetabolite L-Canavanine. Cancer Res., 54: 6045–6048, 1994

Stephen A. Cann, Johannes P. van Netten, and Andrew S. Ross
Cancer Res 1995 55: 4486 [PDF]  

Correspondence re: D. S. Swaffar et al., Inhibition of the Growth of Human Pancreatic Cancer Cells by the Arginine Antimetabolite L-Canavanine. Cancer Res., 54: 6045–6048, 1994—Reply

Gerald A. Rosenthal, Diane S. Swaffar, and Choo Yaw Ang
Cancer Res 1995 55: 4486 [PDF]  

Meeting Report:

Targets for Specific Therapies in Leukemia

Bayard Clarkson, Bruce A. Chabner, and Robert A. Weinberg
Cancer Res 1995 55: 4488-4498. [PDF]  

Articles:

Announcements

Cancer Res 1995 55: 4499-4501. [PDF]  

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