Advances in Brief:

Nuclear Signaling Induced by Ionizing Radiation Involves Colocalization of the Activated p56/p53^lyn Tyrosine Kinase with p34^cdc2

Surender Kharbanda, Ahamed Saleem, Zhi-Min Yuan, Stine Kraeft, Ralph Weichselbaum, Lan Bo Chen, and Donald Kufe
Cancer Res 1996 56: 3617-3621. [Abstract] [PDF]  

Somatic and Germline Mutations of the BRCA2 Gene in Sporadic Ovarian Cancer

Karen A. Foster, Patricia Harrington, Judith Kerr, Paul Russell, Richard A. DiCioccio, Ian V. Scott, Ian Jacobs, Georgia Chenevix-Trench, Bruce A. J. Ponder, and Simon A. Gayther
Cancer Res 1996 56: 3622-3625. [Abstract] [PDF]  

Hypersensitizing Effect of Pluronic L61 on Cytotoxic Activity, Transport, and Subcellular Distribution of Doxorubicin in Multiple Drug-resistant Cells

Annie Venne, Shengmin Li, Rosemonde Mandeville, Alexander Kabanov, and Valery Alakhov
Cancer Res 1996 56: 3626-3629. [Abstract] [PDF]  

High Frequency of p16 (CDKN2/MTS-1/INK4A) Inactivation in Head and Neck Squamous Cell Carcinoma

Andre L. Reed, Joseph Califano, Paul Cairns, William H. Westra, Richard M. Jones, Wayne Koch, Steven Ahrendt, Yolanda Eby, Duane Sewell, Homaira Nawroz, Jiri Bartek, and David Sidransky
Cancer Res 1996 56: 3630-3633. [Abstract] [PDF]  

Two Differentially Expressed Genes in Normal Human Prostate Tissue and in Carcinoma

Fei-Lan Wang, Youbin Wang, Wai-Keung Wong, Yuan Liu, Frank John Addivinola, Peng Liang, Lan Bo Chen, Philip W. Kantoff, and Arthur B. Pardee
Cancer Res 1996 56: 3634-3637. [Abstract] [PDF]  

In Vitro Induction of Benzo(a)pyrene Diol Epoxide-DNA Adducts in Peripheral Lymphocytes as a Susceptibility Marker for Human Lung Cancer

Donghui Li, Mianying Wang, Lie Cheng, Margaret R. Spitz, Walter N. Hittelman, and Qingyi Wei
Cancer Res 1996 56: 3638-3641. [Abstract] [PDF]  

Frequent Coordinated Overexpression of the MRP/GS-X Pump and -Glutamylcysteine Synthetase Genes in Human Colorectal Cancers

M. Tien Kuo, Jia-Ju Bao, Steven A. Curley, Masahida Ikeguchi, Dennis A. Johnston, and Toshihisa Ishikawa
Cancer Res 1996 56: 3642-3644. [Abstract] [PDF]  

Transforming Growth Factor ß1 Suppresses Genomic Instability Independent of a G₁ Arrest, p53, and Rb

Adam B. Glick, Wendy C. Weinberg, I-Hui Wu, Wing Quan, and Stuart H. Yuspa
Cancer Res 1996 56: 3645-3650. [Abstract] [PDF]  

Pregnancy-dependent Growth of Mammary Tumors Is Associated with Overexpression of Insulin-like Growth Factor II

Hung Huynh, Lesley Alpert, and Michael Pollak
Cancer Res 1996 56: 3651-3654. [Abstract] [PDF]  

Methylation of the Estrogen Receptor CpG Island in Lung Tumors Is Related to the Specific Type of Carcinogen Exposure

Jean-Pierre J. Issa, Stephen B. Baylin, and Steven A. Belinsky
Cancer Res 1996 56: 3655-3658. [Abstract] [PDF]  

Separate Pathways for p53 Induction by Ionizing Radiation and N-(Phosphonoacetyl)-L-aspartate

Chaw-Yuan M. Chen, Ingrid Hall, Timothy J. Lansing, Tona M. Gilmer, Thea D. Tlsty, and Michael B. Kastan
Cancer Res 1996 56: 3659-3662. [Abstract] [PDF]  

High Prevalence of the 999del5 Mutation in Icelandic Breast and Ovarian Cancer Patients

Gudrun Johannesdottir, Julius Gudmundsson, Jon T. Bergthorsson, Adalgeir Arason, Bjarni A. Agnarsson, Gudny Eiriksdottir, Oskar T. Johannsson, Ake Borg, Sigurdur Ingvarsson, Douglas F. Easton, Valgardur Egilsson, and Rosa Björk Barkardottir
Cancer Res 1996 56: 3663-3665. [Abstract] [PDF]  

Anti-Epidermal Growth Factor Receptor Monoclonal Antibody 225 Up-Regulates p27^KIP1 and Induces G₁ Arrest in Prostatic Cancer Cell Line DU145

Ding Peng, Zhen Fan, Yang Lu, Tony DeBlasio, Howard Scher, and John Mendelsohn
Cancer Res 1996 56: 3666-3669. [Abstract] [PDF]  

Biochemistry and Biophysics:

Vitamin B₆ and Cancer: Synthesis and Occurrence of Adenosine-N⁶-diethylthioether-N-pyridoximine-5'-phosphate, a Circulating Human Tumor Marker

George P. Tryfiates, Peter M. Gannett, Ronald E. Bishop, Prem K. Shastri, Jason R. Ammons, and James G. Arbogast
Cancer Res 1996 56: 3670-3677. [Abstract] [PDF]  

Busulfan-Glutathione Conjugation Catalyzed by Human Liver Cytosolic Glutathione S-Transferases

John P. Gibbs, Maciej Czerwinski, and John T. Slattery
Cancer Res 1996 56: 3678-3681. [Abstract] [PDF]  

Chaotic Oscillations in Cultured Cells: Rat Prostate Cancer

Edwin M. Posadas, Stuart R. Criley, and Donald S. Coffey
Cancer Res 1996 56: 3682-3688. [Abstract] [PDF]  

Identification and Properties of a Major Plasma Metabolite of Irinotecan (CPT-11) Isolated from the Plasma of Patients

Laurent P. Rivory, Jean-François Riou, Marie-Christine Haaz, Serge Sable, Marc Vuilhorgne, Alain Commerçon, Susan M. Pond, and Jacques Robert
Cancer Res 1996 56: 3689-3694. [Abstract] [PDF]  

Carcinogenesis:

Dose-dependent Differences in the Mutational Profiles of (-)-(1R,2S,3S,4R)-3,4-Dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene and Its Less Carcinogenic Enantiomer

S-J. Caroline Wei, Richard L. Chang, Xiao X. Cui, Kathleen A. Merkler, Ching-Quo Wong, Haruhiko Yagi, Donald M. Jerina, and Allan H. Conney
Cancer Res 1996 56: 3695-3703. [Abstract] [PDF]  

Phase II Enzyme Expression in Rat Liver in Response to the Antiestrogen Tamoxifen

Emile F. Nuwaysir, Daniel A. Daggett, V. Craig Jordan, and Henry C. Pitot
Cancer Res 1996 56: 3704-3710. [Abstract] [PDF]  

A New Process of Cancer Prevention Mediated through Inhibition of Tumor Necrosis Factor Expression

Masami Suganuma, Sachiko Okabe, Eisaburo Sueoka, Naoyuki Iida, Atsumasa Komori, Seong-Jin Kim, and Hirota Fujiki
Cancer Res 1996 56: 3711-3715. [Abstract] [PDF]  

Two Dominant Host Resistance Genes to Pre-B Lymphoma in Wild-derived Inbred Mouse Strain MSM/Ms

Abujiang Pataer, Toshiyuki Kamoto, Ling-Min Lu, Yoshihiro Yamada, and Hiroshi Hiai
Cancer Res 1996 56: 3716-3720. [Abstract] [PDF]  

Increased Resistance to N,N',N''-Triethylenethiophosphoramide (Thiotepa) in Cells Expressing the Escherichia coli Formamidopyrimidine-DNA Glycosylase

R. D. Gill, C. Cussac, R. L. Souhami, and F. Laval
Cancer Res 1996 56: 3721-3724. [Abstract] [PDF]  

Clinical Investigations:

Prognostic Significance of Germ Line Polymorphisms of the CYP1A1 and Glutathione S-Transferase Genes in Patients with Non-Small Cell Lung Cancer

Isao Goto, Shuichi Yoneda, Mitsunobu Yamamoto, and Kaname Kawajiri
Cancer Res 1996 56: 3725-3730. [Abstract] [PDF]  

Experimental Therapeutics:

Augmentation of Antitumor Immunity with Bacterial Superantigen, Staphylococcal Enterotoxin B-bound Tumor Cells

Motomu Shimizu, Akira Yamamoto, Hideki Nakano, and Akio Matsuzawa
Cancer Res 1996 56: 3731-3736. [Abstract] [PDF]  

Brain-derived Neurotrophic Factor Protects Neuroblastoma Cells from Vinblastine Toxicity

Stefania Scala, Katja Wosikowski, Paraskevi Giannakakou, Paola Valle, June L. Biedler, Barbara A. Spengler, Enrico Lucarelli, Susan E. Bates, and Carol J. Thiele
Cancer Res 1996 56: 3737-3742. [Abstract] [PDF]  

Doxorubicin Encapsulated in Sterically Stabilized Liposomes Is Superior to Free Drug or Drug-containing Conventional Liposomes at Suppressing Growth and Metastases of Human Lung Tumor Xenografts

Takashi Sakakibara, Fang-An Chen, Hisashi Kida, Katsuyuki Kunieda, Rosa E. Cuenca, F. J. Martin, and Richard B. Bankert
Cancer Res 1996 56: 3743-3746. [Abstract] [PDF]  

Up-Regulation of Vascular Endothelial Growth Factor Production by Iron Chelators

Laurens V. Beerepoot, David T. Shima, Masatoshi Kuroki, Kiang-Teck Yeo, and Emile E. Voest
Cancer Res 1996 56: 3747-3751. [Abstract] [PDF]  

Involvement of ß-Glucuronidase in Intestinal Microflora in the Intestinal Toxicity of the Antitumor Camptothecin Derivative Irinotecan Hydrochloride (CPT-11) in Rats

Kiyoshi Takasuna, Takehiro Hagiwara, Masaaki Hirohashi, Michiyuki Kato, Mamoru Nomura, Eiichi Nagai, Tsuyoshi Yokoi, and Tetsuya Kamataki
Cancer Res 1996 56: 3752-3757. [Abstract] [PDF]  

Combination Suicide and Cytokine Gene Therapy for Hepatic Metastases of Colon Carcinoma: Sustained Antitumor Immunity Prolongs Animal Survival

Shu-Hsia Chen, Ken-ichiro Kosai, Bisong Xu, Khiem Pham-Nguyen, Charles Contant, Milton J. Finegold, and Savio L. C. Woo
Cancer Res 1996 56: 3758-3762. [Abstract] [PDF]  

Immunology:

Human Dendritic Cells Genetically Engineered to Express High Levels of the Human Epithelial Tumor Antigen Mucin (MUC-1)

Robert A. Henderson, Maya T. Nimgaonkar, Simon C. Watkins, Paul D. Robbins, Edward D. Ball, and Olivera J. Finn
Cancer Res 1996 56: 3763-3770. [Abstract] [PDF]  

Physiologically Based Kinetic Model of Effector Cell Biodistribution in Mammals: Implications for Adoptive Immunotherapy

Hui Zhu, Robert J. Melder, Laurence T. Baxter, and Rakesh K. Jain
Cancer Res 1996 56: 3771-3781. [Abstract] [PDF]  

Protective Antitumor Immunity Induced by Immunization with Completely Allogeneic Tumor Cells

René E. M. Toes, Ria J. J. Blom, Ellen van der Voort, Rienk Offringa, Cornelis J. M. Melief, and W. M. Kast
Cancer Res 1996 56: 3782-3787. [Abstract] [PDF]  

L-Lysine Effectively Blocks Renal Uptake of ¹²⁵I- or ^99mTc-labeled Anti-Tac Disulfide-stabilized Fv Fragment

Hisataka Kobayashi, Tae M. Yoo, In S. Kim, Meyoung-Kon Kim, Nhat Le, Keith O. Webber, Ira Pastan, Chang H. Paik, William C. Eckelman, and Jorge A. Carrasquillo
Cancer Res 1996 56: 3788-3795. [Abstract] [PDF]  

Selective Inhibition of Telomerase Activity during Terminal Differentiation of Immortal Cell Lines

Leslie J. Bestilny, Christopher B. Brown, Yutaka Miura, Laurie D. Robertson, and Karl T. Riabowol
Cancer Res 1996 56: 3796-3802. [Abstract] [PDF]  

Mapping of Chromosomal Imbalances in Pancreatic Carcinoma by Comparative Genomic Hybridization

Sabina Solinas-Toldo, Christine Wallrapp, Friedericke Müller-Pillasch, Martin Bentz, Thomas Gress, and Peter Lichter
Cancer Res 1996 56: 3803-3807. [Abstract] [PDF]  

Chromosome 7q Allelic Losses in Pancreatic Carcinoma

Alberto Achille, Maria O. Biasi, Giuseppe Zamboni, Giuseppe Bogina, Alba R. Magalini, Paolo Pederzoli, Manuel Perucho, and Aldo Scarpa
Cancer Res 1996 56: 3808-3813. [Abstract] [PDF]  

An Uncertain Role for p53 Gene Alterations in Human Prostate Cancers

James D. Brooks, G. Steven Bova, Charles M. Ewing, Steven Piantadosi, Bob S. Carter, John C. Robinson, Jonathan I. Epstein, and William B. Isaacs
Cancer Res 1996 56: 3814-3822. [Abstract] [PDF]  

Tumor Biology:

Quantitative Estimation of Epidermal Growth Factor Receptor and c-erbB-2 in Human Breast Cancer

Kevin W. Robertson, Jonathan R. Reeves, Gerard Smith, W. Nicol Keith, Bradford W. Ozanne, Timothy G. Cooke, and Peter D. Stanton
Cancer Res 1996 56: 3823-3830. [Abstract] [PDF]  

Increased Expression of the Insulin-like Growth Factor I (IGF-I) Receptor Gene in Hepatocellular Carcinoma Cell Lines: Implications of IGF-I Receptor Gene Activation by Hepatitis B Virus X Gene Product

Sun-Ok Kim, Jae-Gahb Park, and Young Ik Lee
Cancer Res 1996 56: 3831-3836. [Abstract] [PDF]  

Identification of Novel Regions of Deletion in Familial Wilms' Tumor by Comparative Genomic Hybridization

Rachel A. Altura, Marcus Valentine, Hao Li, James M. Boyett, Patricia Shearer, Paul Grundy, David N. Shapiro, and A. Thomas Look
Cancer Res 1996 56: 3837-3841. [Abstract] [PDF]  

Spontaneous Intestinal Carcinomas and Skin Neoplasms in Msh2-deficient Mice

Armin H. Reitmair, Mark Redston, Jian Chun Cai, Tony C.Y. Chuang, Matthew Bjerknes, Hazel Cheng, Kazy Hay, Steven Gallinger, Bharati Bapat, and Tak W. Mak
Cancer Res 1996 56: 3842-3849. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1996 56: 3850-3853. [PDF]  

Correction

Alphonse Taghian, Wilfried Budach, Anthony Zietman, Jill Freeman, Danielle Gioioso, Wlodzimierz Ruka, and Herman D. Suit
Cancer Res 1996 56: 3853 [PDF]  

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