Advances in Brief:

Double Knockout of the ALL-1 Gene Blocks Hematopoietic Differentiation in Vitro

Vincenzo Fidanza, Paola Melotti, Takahiro Yano, Tatsuya Nakamura, Alan Bradley, Eli Canaani, Bruno Calabretta, and Carlo M. Croce
Cancer Res 1996 56: 1179-1183. [Abstract] [PDF]  

Expression of c-erbB-3 and c-erbB-4 Proteins in Papillary Thyroid Carcinomas

Dagny R. Faksvåg Haugen, Lars A. Akslen, Jan Erik Varhaug, and Johan R. Lillehaug
Cancer Res 1996 56: 1184-1188. [Abstract] [PDF]  

Inhibition of Fatty Acid Synthesis Delays Disease Progression in a Xenograft Model of Ovarian Cancer

Ellen S. Pizer, Fawn D. Wood, Henry S. Heine, Fedor E. Romantsev, Gary R. Pasternack, and Francis P. Kuhajda
Cancer Res 1996 56: 1189-1193. [Abstract] [PDF]  

Cellular pH Gradient in Tumor versus Normal Tissue: Potential Exploitation for the Treatment of Cancer

Leo E. Gerweck and Kala Seetharaman
Cancer Res 1996 56: 1194-1198. [Abstract] [PDF]  

Potentiation of Enediyne-induced Apoptosis and Differentiation by Bcl-2

Megan Cortazzo and Nina Felice Schor
Cancer Res 1996 56: 1199-1203. [Abstract] [PDF]  

5-[²¹¹At]Astato-2'-deoxyuridine, an -Particle-emitting Endoradiotherapeutic Agent Undergoing DNA Incorporation

Ganesan Vaidyanathan, Roy H. Larsen, and Michael R. Zalutsky
Cancer Res 1996 56: 1204-1209. [Abstract] [PDF]  

Particulate Naturally Processed Peptides Prime a Cytotoxic Response against Human Melanoma in Vitro

Maria Pia Protti, Maria Adele Imro, Angelo A. Manfredi, Giuseppe Consogno, Silvia Heltai, Cinzia Arcelloni, Matteo Bellone, Paolo Dellabona, Giulia Casorati, and Claudio Rugarli
Cancer Res 1996 56: 1210-1213. [Abstract] [PDF]  

Genomic Organization of the Human p57^KIP2 Gene and Its Analysis in the G401 Wilms' Tumor Assay

Laura Hink Reid, Shyra J. Crider-Miller, Ande West, Mong-Hong Lee, Joan Massagué, and Bernard E. Weissman
Cancer Res 1996 56: 1214-1218. [Abstract] [PDF]  

Cyclin-dependent Kinase Inhibitor p57^KIP2 in Soft Tissue Sarcomas and Wilms' Tumors

Irene Orlow, Antonio Iavarone, Shyra J. Crider-Miller, Félix Bonilla, Esther Latres, Mong-Hong Lee, William L. Gerald, Joan Massagué, Bernard E. Weissman, and Carlos Cordón-Cardó
Cancer Res 1996 56: 1219-1221. [Abstract] [PDF]  

Suppression of MDA-MB-435 Breast Carcinoma Cell Metastasis following the Introduction of Human Chromosome 11

Karen K. Phillips, Danny R. Welch, Mary E. Miele, Jeong-Hyung Lee, Lisa L. Wei, and Bernard E. Weissman
Cancer Res 1996 56: 1222-1227. [Abstract] [PDF]  

Allelic Imbalance on Chromosome 3p in Oral Dysplastic Lesions: An Early Event in Oral Carcinogenesis

Luca Roz, Chu Lee Wu, Stephen Porter, Crispian Scully, Paul Speight, Andrew Read, Philip Sloan, and Nalin Thakker
Cancer Res 1996 56: 1228-1231. [Abstract] [PDF]  

Point Mutations of the Topoisomerase II Gene in Patients with Small Cell Lung Cancer Treated with Etoposide

Akihito Kubo, Atsuko Yoshikawa, Tomonori Hirashima, Noriyuki Masuda, Minoru Takada, Jiro Takahara, Masahiro Fukuoka, and Kazuhiko Nakagawa
Cancer Res 1996 56: 1232-1236. [Abstract] [PDF]  

Microsatellite Instability in Nonneoplastic Mucosa from Patients with Chronic Ulcerative Colitis

Teresa A. Brentnall, David A. Crispin, Mary P. Bronner, Sajeev P. Cherian, Molly Hueffed, Peter S. Rabinovitch, Cyrus E. Rubin, Rodger C. Haggitt, and C. Richard Boland
Cancer Res 1996 56: 1237-1240. [Abstract] [PDF]  

Germline and Somatic Mutations in an Oncogene: RET Mutations in Inherited Medullary Thyroid Carcinoma

Debbie J. Marsh, Scott D. Andrew, Charis Eng, Diana L. Learoyd, Amanda G. Capes, Ruth Pojer, Ann-Louise Richardson, Carol Houghton, Lois M. Mulligan, Bruce A. J. Ponder, and Bruce G. Robinson
Cancer Res 1996 56: 1241-1243. [Abstract] [PDF]  

Motility-related Protein-1 (MRP-1/CD9) Reduction as a Factor of Poor Prognosis in Breast Cancer

Masayuki Miyake, Keiji Nakano, Shin-ichi Itoi, Takashi Koh, and Toshihiko Taki
Cancer Res 1996 56: 1244-1249. [Abstract] [PDF]  

Frequency of the BRCA1 185delAG Mutation among Jewish Women with Ovarian Cancer and Matched Population Controls

Michael G. Muto, Daniel W. Cramer, Jacob Tangir, Ross Berkowitz, and Samuel Mok
Cancer Res 1996 56: 1250-1252. [Abstract] [PDF]  

Taxol Induces bcl-2 Phosphorylation and Death of Prostate Cancer Cells

Subrata Haldar, Janaki Chintapalli, and Carlo M. Croce
Cancer Res 1996 56: 1253-1255. [Abstract] [PDF]  

Biochemistry and Biophysics:

Induction of Muscle Protein Degradation and Weight Loss by a Tumor Product

Penio T. Todorov, Trudi M. McDevitt, Peter Cariuk, Brian Coles, Melanie Deacon, and Michael J. Tisdale
Cancer Res 1996 56: 1256-1261. [Abstract] [PDF]  

Defective Repair of Oxidative Damage in the Mitochondrial DNA of a Xeroderma Pigmentosum Group A Cell Line

Wesley J. Driggers, Valentina I. Grishko, Susan P. LeDoux, and Glenn L. Wilson
Cancer Res 1996 56: 1262-1266. [Abstract] [PDF]  

Carcinogenesis:

Copper-dependent Formation of Miscoding Etheno-DNA Adducts in the Liver of Long Evans Cinnamon (LEC) Rats Developing Hereditary Hepatitis and Hepatocellular Carcinoma

Jagadeesan Nair, Hideko Sone, Minako Nagao, Alain Barbin, and Helmut Bartsch
Cancer Res 1996 56: 1267-1271. [Abstract] [PDF]  

Influence of Liver Tumor Promoters on Apoptosis in Rat Hepatocytes Induced by 2-Acetylaminofluorene, Ultraviolet Light, or Transforming Growth Factor ß1

Wolfgang Wörner and Dieter Schrenk
Cancer Res 1996 56: 1272-1278. [Abstract] [PDF]  

Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa

Seung-Chul Baik, Hee-Shang Youn, Myung-Hee Chung, Woo-Kon Lee, Myung-Je Cho, Gyung-Hyuck Ko, Cheol-Keun Park, Hiroshi Kasai, and Kwang-Ho Rhee
Cancer Res 1996 56: 1279-1282. [Abstract] [PDF]  

Evidence That the Catechol 3,4-Dihydroxytamoxifen Is a Proximate Intermediate to the Reactive Species Binding Covalently to Proteins

Shangara S. Dehal and David Kupfer
Cancer Res 1996 56: 1283-1290. [Abstract] [PDF]  

Epidemiology:

Antioxidant Supplementation Decreases Oxidative DNA Damage in Human Lymphocytes

Susan J. Duthie, Aiguo Ma, Marion A. Ross, and Andrew R. Collins
Cancer Res 1996 56: 1291-1295. [Abstract] [PDF]  

Experimental Therapeutics:

Hepatic Biotransformation of Docetaxel (Taxotere®) in Vitro: Involvement of the CYP3A Subfamily in Humans

Françoise Marre, Ger-Jan Sanderink, Georges de Sousa, Claude Gaillard, Michel Martinet, and Roger Rahmani
Cancer Res 1996 56: 1296-1302. [Abstract] [PDF]  

Taxol-dependent Transcriptional Activation of IL-8 Expression in a Subset of Human Ovarian Cancer

Li-Fen Lee, C-C. Schuerer-Maly, Alan K. Lofquist, Caroline van Haaften-Day, Jenny P-Y. Ting, Charise M. White, Brian K. Martin, and J. Stephen Haskill
Cancer Res 1996 56: 1303-1308. [Abstract] [PDF]  

Pharmacokinetic Modulation of Irinotecan and Metabolites by Cyclosporin A

Elora Gupta, Ahmad R. Safa, Xiaolin Wang, and Mark J. Ratain
Cancer Res 1996 56: 1309-1314. [Abstract] [PDF]  

Comparison of the Effects of Three Different Toxin Genes and Their Levels of Expression on Cell Growth and Bystander Effect in Lung Adenocarcinoma

Diana K. Hoganson, Raj K. Batra, John C. Olsen, and Richard C. Boucher
Cancer Res 1996 56: 1315-1323. [Abstract] [PDF]  

Vascular Endothelial Growth Factor-Toxin Conjugate Specifically Inhibits KDR/flk-1-positive Endothelial Cell Proliferation in Vitro and Angiogenesis in Vivo

S. Ramakrishnan, T. A. Olson, V. L. Bautch, and D. Mohanraj
Cancer Res 1996 56: 1324-1330. [Abstract] [PDF]  

Sensitization of Human Breast Cancer Cells to Cyclophosphamide and Ifosfamide by Transfer of a Liver Cytochrome P450 Gene

Ling Chen, David J. Waxman, Dongshu Chen, and Donald W. Kufe
Cancer Res 1996 56: 1331-1340. [Abstract] [PDF]  

Adenovirus-mediated Prodrug Gene Therapy for Carcinoembryonic Antigen-producing Human Gastric Carcinoma Cells in Vitro

Torao Tanaka, Fumihiko Kanai, Satoshi Okabe, Yoko Yoshida, Hiroaki Wakimoto, Hirofumi Hamada, Yasushi Shiratori, Keng-Hsin Lan, Masako Ishitobi, and Masao Omata
Cancer Res 1996 56: 1341-1345. [Abstract] [PDF]  

Adenovirus-mediated Gene Transfer to Human Breast Tumor Cells: An Approach for Cancer Gene Therapy and Bone Marrow Purging

Prem Seth, Ulrich Brinkmann, Gretchen N. Schwartz, Dai Katayose, Ronald Gress, Ira Pastan, and Kenneth Cowan
Cancer Res 1996 56: 1346-1351. [Abstract] [PDF]  

Corticotropin-releasing Factor Decreases Vasogenic Brain Edema

Juri Tjuvajev, Hisao Uehara, Revathi Desai, Bradley Beattie, Cornelia Matei, Yan Zhou, Mary-Jeanne Kreek, Jason Koutcher, and Ronald Blasberg
Cancer Res 1996 56: 1352-1360. [Abstract] [PDF]  

Immunology:

Treatment of Microscopic Pulmonary Metastases with Recombinant Autologous Tumor Vaccine Expressing Interleukin 6 and Escherichia coli Cytosine Deaminase Suicide Genes

Craig A. Mullen, Demetrios Petropoulos, and Robert M. Lowe
Cancer Res 1996 56: 1361-1366. [Abstract] [PDF]  

Molecular Biology and Genetics:

Regulation of Insulin-like Growth Factor II P3 Promoter by p53: A Potential Mechanism for Tumorigenesis

Lijuan Zhang, Fatah Kashanchi, Qimin Zhan, Shili Zhan, John N. Brady, Albert J. Fornace, Prem Seth, and Lee J. Helman
Cancer Res 1996 56: 1367-1373. [Abstract] [PDF]  

Microsatellite Instability, Apoptosis, and Loss of p53 Function in Drug-resistant Tumor Cells

D. Alan Anthoney, Amanda J. McIlwrath, William M. Gallagher, Angela R. M. Edlin, and Robert Brown
Cancer Res 1996 56: 1374-1381. [Abstract] [PDF]  

Genetic Heterogeneity and Unmapped Genes for Colorectal Cancer

Cathryn M. Lewis, Susan L. Neuhausen, Denise Daley, F. Jeff Black, J. Swensen, Randall W. Burt, Lisa A. Cannon-Albright, and Mark H. Skolnick
Cancer Res 1996 56: 1382-1388. [Abstract] [PDF]  

Overexpression of Cyclin E in the HC11 Mouse Mammary Epithelial Cell Line Is Associated with Growth Inhibition and Increased Expression of p27^Kip1

Alessandro Sgambato, Edward Kyu-Ho Han, Ping Zhou, Ira Schieren, and I. Bernard Weinstein
Cancer Res 1996 56: 1389-1399. [Abstract] [PDF]  

Deregulated Apoptosis in Ataxia Telangiectasia: Association with Clinical Stigmata and Radiosensitivity

Eric Duchaud, Agnes Ridet, Dominique Stoppa-Lyonnet, Nicolas Janin, Ethel Moustacchi, and Filippo Rosselli
Cancer Res 1996 56: 1400-1404. [Abstract] [PDF]  

V(D)J Recombinase-mediated HPRT Mutations in Peripheral Blood Lymphocytes of Normal Children

Barry A. Finette, Tina Poseno, and Richard J. Albertini
Cancer Res 1996 56: 1405-1412. [Abstract] [PDF]  

Mutational Analysis of the Candidate Tumor Suppressor Genes TEL and KIP1 in Childhood Acute Lymphoblastic Leukemia

Kimberly Stegmaier, Seisho Takeuchi, Todd R. Golub, Stefan K. Bohlander, Claus R. Bartram, H. Phillip Koeffler, and D. Gary Gilliland
Cancer Res 1996 56: 1413-1417. [Abstract] [PDF]  

Partial Tandem Duplication of ALL1 as a Recurrent Molecular Defect in Acute Myeloid Leukemia with Trisomy 11

Michael A. Caligiuri, Matthew P. Strout, Steven A. Schichman, Krzysztof Mrózek, Diane C. Arthur, Geoffrey P. Herzig, Maria R. Baer, Charles A. Schiffer, Kristiina Heinonen, Sakari Knuutila, Tapio Nousiainen, Tapani Ruutu, AnneMarie W. Block, Philip Schulman, Jens Pedersen-Bjergaard, Carlo M. Croce, and Clara D. Bloomfield
Cancer Res 1996 56: 1418-1425. [Abstract] [PDF]  

Analysis of Replication Error (RER⁺) Phenotypes in Cervical Carcinoma

Amy A. Larson, Suzanne Kern, Robin L. Sommers, Jun Yokota, Webster K. Cavenee, and Garret M. Hampton
Cancer Res 1996 56: 1426-1431. [Abstract] [PDF]  

Tumor Biology:

Decreased Expression of Both the Low-Density Lipoprotein Receptor-related Protein/₂-Macroglobulin Receptor and Its Receptor-associated Protein in Late Stages of Cutaneous Melanocytic Tumor Progression

Teunis J. de Vries, Jan H. Verheijen, Anton C. W. de Bart, Ulrich H. Weidle, Dirk J. Ruiter, and Goos N. P. van Muijen
Cancer Res 1996 56: 1432-1439. [Abstract] [PDF]  

Gene Expression of Neural Cell Adhesion Molecule L1 in Malignant Gliomas and Biological Significance of L1 in Glioma Invasion

Shuichi Izumoto, Takanori Ohnishi, Norio Arita, Shoju Hiraga, Takuyu Taki, and Toru Hayakawa
Cancer Res 1996 56: 1440-1444. [Abstract] [PDF]  

Antisense RNA Inhibition of Phosphoprotein p18 Expression Abrogates the Transformed Phenotype of Leukemic Cells

Sima Jeha, Xiang-Nong Luo, Miloslav Beran, Hagop Kantarjian, and George F. Atweh
Cancer Res 1996 56: 1445-1450. [Abstract] [PDF]  

Role of bcl-X_L in the Control of Apoptosis in Murine Myeloma Cells

Eric R. Gauthier, Lyson Piché, Gérald Lemieux, and Réal Lemieux
Cancer Res 1996 56: 1451-1456. [Abstract] [PDF]  

Growth Regulation of Human Breast and Ovarian Tumor Cells by Heregulin: Evidence for the Requirement of ErbB2 as a Critical Component in Mediating Heregulin Responsiveness

Gail D. Lewis, Julie A. Lofgren, Amy E. McMurtrey, Andrew Nuijens, Brian M. Fendly, Kenneth D. Bauer, and Mark X. Sliwkowski
Cancer Res 1996 56: 1457-1465. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1996 56: 1466-1468. [PDF]  

Erratum

Cancer Res 1996 56: 1468 [PDF]  

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