Advances in Brief:

Barrett's Esophagus: Metaplastic Cells with Loss of Heterozygosity at the APC Gene Locus Are Clonal Precursors to Invasive Adenocarcinoma

Zhengping Zhuang, Alexander O. Vortmeyer, Eugene J. Mark, Robert Odze, Michael R. Emmert-Buck, Maria J. Merino, Hanlim Moon, Lance A. Liotta, and Paul H. Duray
Cancer Res 1996 56: 1961-1964. [Abstract] [PDF]  

bcl-x_s Gene Therapy Induces Apoptosis of Human Mammary Tumors in Nude Mice

Mark W. Ealovega, Patrick K. McGinnis, Venil N. Sumantran, Michael F. Clarke, and Max S. Wicha
Cancer Res 1996 56: 1965-1969. [Abstract] [PDF]  

Lack of Tumorigenicity of Cholesterol Epoxides and Estrone-3,4-quinone in the Rat Mammary Gland

Karam El-Bayoumy, Ben-Yi Ji, Pramod Upadhyaya, Young-Heum Chae, Christine Kurtzke, Abraham Rivenson, Bandaru S. Reddy, Shantu Amin, and Stephen S. Hecht
Cancer Res 1996 56: 1970-1973. [Abstract] [PDF]  

Polymorphism at the Glutathione S-Transferase Locus GSTM3: Interactions with Cytochrome P450 and Glutathione S-Transferase Genotypes as Risk Factors for Multiple Cutaneous Basal Cell Carcinoma

Lilian Yengi, Avis Inskip, Janice Gilford, Julie Alldersea, Lisa Bailey, Andrew Smith, John T. Lear, Adrian H. Heagerty, Bill Bowers, Philip Hand, John D. Hayes, Peter W. Jones, Richard C. Strange, and Anthony A. Fryer
Cancer Res 1996 56: 1974-1977. [Abstract] [PDF]  

5-Fluorouracil Suppresses Nitric Oxide Biosynthesis in Colon Carcinoma Cells

Yang Jin, Diane E. Heck, George DeGeorge, Yanan Tian, and Jeffrey D. Laskin
Cancer Res 1996 56: 1978-1982. [Abstract] [PDF]  

Uptake of Temozolomide in a Rat Glioma Model in the Presence and Absence of the Angiogenesis Inhibitor TNP-470

Damayanthi Devineni, Andres Klein-Szanto, and James M. Gallo
Cancer Res 1996 56: 1983-1987. [Abstract] [PDF]  

Allelic Imbalance on Chromosome 13q: Evidence for the Involvement of BRCA2 and RB1 in Sporadic Breast Cancer

Ute Hamann, Christian Herbold, Serban Costa, Erich-Franz Solomayer, Manfred Kaufmann, Gunther Bastert, Hans Ulrich Ulmer, Hans Frenzel, and Dymitr Komitowski
Cancer Res 1996 56: 1988-1990. [Abstract] [PDF]  

Apoptotic Response to Oncogenic Stimuli: Cooperative and Antagonistic Interactions between c-myb and the Growth Suppressor p53

Arturo Sala, Ida Casella, Luigi Grasso, Teresa Bellon, John C. Reed, Toshiyuki Miyashita, and Cesare Peschle
Cancer Res 1996 56: 1991-1996. [Abstract] [PDF]  

Identification of Two Candidate Tumor Suppressor Genes on Chromosome 17p13.3

David C. Schultz, Lisa Vanderveer, David B. Berman, Thomas C. Hamilton, Albert J. Wong, and Andrew K. Godwin
Cancer Res 1996 56: 1997-2002. [Abstract] [PDF]  

Functional Analysis of pRb2/p130 Interaction with Cyclins

Pier Paolo Claudio, Antonio De Luca, Candace M. Howard, Alfonso Baldi, Eduardo J. Firpo, Andrew Koff, Marco G. Paggi, and Antonio Giordano
Cancer Res 1996 56: 2003-2008. [Abstract] [PDF]  

In Vivo Oxygen Consumption Rate of DS Sarcoma Cells on Inhibition of DNA Synthesis

Oliver Thews, Debra K. Kelleher, and Peter Vaupel
Cancer Res 1996 56: 2009-2012. [Abstract] [PDF]  

Expression of Vascular Endothelial Growth Factor, Its Receptor, and Other Angiogenic Factors in Human Breast Cancer

Hitoshi Yoshiji, Daniel E. Gomez, Masabumi Shibuya, and Unnur P. Thorgeirsson
Cancer Res 1996 56: 2013-2016. [Abstract] [PDF]  

Hydroxylforms of p-Boronophenylalanine as Potential Boron Carriers on Boron Neutron Capture Therapy for Malignant Brain Tumors

Masao Takagaki, Koji Ono, Yoshifumi Oda, Haruhiko Kikuchi, Hisao Nemoto, Satoshi Iwamoto, Jianping Cai, and Yoshinori Yamamoto
Cancer Res 1996 56: 2017-2020. [Abstract] [PDF]  

Stable Transfection of the P-Glycoprotein Promoter Reproduces the Endogenous Overexpression Phenotype: The Role of MED-1

Tan A. Ince and Kathleen W. Scotto
Cancer Res 1996 56: 2021-2024. [Abstract] [PDF]  

Detection of DNA Adducts Formed by Aristolochic Acid in Renal Tissue from Patients with Chinese Herbs Nephropathy

Heinz H. Schmeiser, Christian A. Bieler, Manfred Wiessler, Charles van Ypersele de Strihou, and Jean-Pierre Cosyns
Cancer Res 1996 56: 2025-2028. [Abstract] [PDF]  

Wild-Type p53 Suppresses Transcription of the Human O⁶-Methylguanine-DNA Methyltransferase Gene

Linda C. Harris, Joanna S. Remack, Peter J. Houghton, and Thomas P. Brent
Cancer Res 1996 56: 2029-2032. [Abstract] [PDF]  

Biochemistry and Biophysics:

Apoptosis-associated Derangement of Mitochondrial Function in Cells Lacking Mitochondrial DNA

Philippe Marchetti, Santos A. Susin, Didier Decaudin, Susana Gamen, Maria Castedo, Tamara Hirsch, Naoufal Zamzami, Javier Naval, Anna Senik, and Guido Kroemer
Cancer Res 1996 56: 2033-2038. [Abstract] [PDF]  

Carcinogenesis:

Trisomy 7p and Malignant Transformation of Human Breast Epithelial Cells following Epidermal Growth Factor Withdrawal

Per Briand, Kirsten Vang Nielsen, Mogens Winkel Madsen, and Ole William Petersen
Cancer Res 1996 56: 2039-2044. [Abstract] [PDF]  

Chromium Induces a Persistent Activation of Mitogen-activated Protein Kinases by a Redox-sensitive Mechanism in H4 Rat Hepatoma Cells

Geumsoo Kim and Edward J. Yurkow
Cancer Res 1996 56: 2045-2051. [Abstract] [PDF]  

Metabolism and DNA Binding of the Environmental Colon Carcinogen 6-Nitrochrysene in Rats

Young-Heum Chae, K. Barry Delclos, Betty Blaydes, and Karam El-Bayoumy
Cancer Res 1996 56: 2052-2058. [Abstract] [PDF]  

Endocrinology:

The Expression of Gonadotropin-releasing Hormone and its Receptor in Endometrial Cancer, and its Relevance as an Autocrine Growth Factor

Ekaterini Chatzaki, Christopher M. R. Bax, Karin A. Eidne, Lorraine Anderson, J. Gedis Grudzinskas, and Christopher J. Gallagher
Cancer Res 1996 56: 2059-2065. [Abstract] [PDF]  

Experimental Therapeutics:

Fluorescence Imaging Studies for the Disposition of Daunorubicin Liposomes (DaunoXome) within Tumor Tissue

E. A. Forssen, R. Malé-Brune, J. P. Adler-Moore, M. J. A. Lee, P. G. Schmidt, T. B. Krasieva, S. Shimizu, and B. J. Tromberg
Cancer Res 1996 56: 2066-2075. [Abstract] [PDF]  

Treatment of Human Brain Tumor Xenografts with O⁶-Benzyl-2'-deoxyguanosine and BCNU

S. Clifford Schold, Jr., Demetrius M. Kokkinakis, Jack L. Rudy, Robert C. Moschel, and Anthony E. Pegg
Cancer Res 1996 56: 2076-2081. [Abstract] [PDF]  

Oral Administration of Anti-Doxorubicin Monoclonal Antibody Prevents Chemotherapy-induced Gastrointestinal Toxicity in Mice

Daniele Morelli, Sylvie Ménard, Maria I. Colnaghi, and Andrea Balsari
Cancer Res 1996 56: 2082-2085. [Abstract] [PDF]  

Pharmacodynamics of Taxol in Human Head and Neck Tumors

Yuebo Gan, M. Guillaume Wientjes, David E. Schuller, and Jessie L-S. Au
Cancer Res 1996 56: 2086-2093. [Abstract] [PDF]  

Pharmacological and Toxicological Aspects of New Imidazoacridinone Antitumor Agents

Birgit Berger, Hans Marquardt, and Johannes Westendorf
Cancer Res 1996 56: 2094-2104. [Abstract] [PDF]  

The Bryostatins Inhibit Growth of B16/F10 Melanoma Cells in Vitro through a Protein Kinase C-independent Mechanism: Dissociation of Activities Using 26-Epi-Bryostatin 1

Zoltan Szallasi, Linh Du, Rachel Levine, Nancy E. Lewin, Phi Nga Nguyen, Michael D. Williams, George R. Pettit, and Peter M. Blumberg
Cancer Res 1996 56: 2105-2111. [Abstract] [PDF]  

Nonlinear Pharmacokinetics of Paclitaxel in Mice Results from the Pharmaceutical Vehicle Cremophor EL

Alex Sparreboom, Olaf van Tellingen, Willem J. Nooijen, and Jos H. Beijnen
Cancer Res 1996 56: 2112-2115. [Abstract] [PDF]  

Gene Cloning and Characterization of Pseudomonas putida L-Methionine--deamino--mercaptomethane-lyase

Hiroki Hori, Kenji Takabayashi, Lisa Orvis, Dennis A. Carson, and Tsutomu Nobori
Cancer Res 1996 56: 2116-2122. [Abstract] [PDF]  

Immunology:

Comparative Metabolism and Retention of Iodine-125, Yttrium-90, and Indium-111 Radioimmunoconjugates by Cancer Cells

Oliver W. Press, Daming Shan, Janet Howell-Clark, Janet Eary, Frederick R. Appelbaum, Dana Matthews, David J. King, Adria M. R. Haines, Philip Hamann, Lois Hinman, Daniel Shochat, and Irwin D. Bernstein
Cancer Res 1996 56: 2123-2129. [Abstract] [PDF]  

Molecular Biology and Genetics:

Deletions and Insertions in the p53 Tumor Suppressor Gene in Human Cancers: Confirmation of the DNA Polymerase Slippage/Misalignment Model

Marc S. Greenblatt, Arthur P. Grollman, and Curtis C. Harris
Cancer Res 1996 56: 2130-2136. [Abstract] [PDF]  

Ploidy and Karyotypic Alterations Associated with Early Events in the Development of Hepatocarcinogenesis in Transgenic Mice Harboring c-myc and Transforming Growth Factor Transgenes

Linda M. Sargent, Nancy D. Sanderson, and Snorri S. Thorgeirsson
Cancer Res 1996 56: 2137-2142. [Abstract] [PDF]  

Allelic Loss on Chromosome 10 in Prostate Adenocarcinoma

Michael Ittmann
Cancer Res 1996 56: 2143-2147. [Abstract] [PDF]  

Cooperation between p53-dependent and p53-independent Apoptotic Pathways in Myeloid Cells

Amnon Peled, Dov Zipori, and Varda Rotter
Cancer Res 1996 56: 2148-2156. [Abstract] [PDF]  

Suppression of the Malignant Phenotype of Human Prostate Cancer Cell Line PPC-1 by Introduction of Normal Fragments of Human Chromosome 10

Yoshinori S. Murakami, Hans Albertsen, Arthur R. Brothman, Robin J. Leach, and Raymond L. White
Cancer Res 1996 56: 2157-2160. [Abstract] [PDF]  

Induction of Apoptosis as well as Necrosis by Hypoxia and Predominant Prevention of Apoptosis by Bcl-2 and Bcl-X_L

Shigeomi Shimizu, Yutaka Eguchi, Wataru Kamiike, Yuko Itoh, Jun-ichi Hasegawa, Kazuo Yamabe, Yoshinori Otsuki, Hikaru Matsuda, and Yoshihide Tsujimoto
Cancer Res 1996 56: 2161-2166. [Abstract] [PDF]  

Heterogeneous Mutation of the RET Proto-oncogene in Subpopulations of Medullary Thyroid Carcinoma

Charis Eng, Lois M. Mulligan, Catherine S. Healey, Carol Houghton, Andrea Frilling, Friedhelm Raue, Gerry A. Thomas, and Bruce A. J. Ponder
Cancer Res 1996 56: 2167-2170. [Abstract] [PDF]  

A Specific Deletion in the Breakpoint Cluster Region of the ALL-1 Gene Is Associated with Acute Lymphoblastic T-Cell Leukemias

Klaus Löchner, Gabi Siegler, Monika Führer, Johann Greil, Jörn D. Beck, George H. Fey, and Rolf Marschalek
Cancer Res 1996 56: 2171-2177. [Abstract] [PDF]  

Tumor Biology:

The Prognostic Significance of Bcl-2 and p53 Expression in Ovarian Carcinoma

J. Jonathan O. Herod, Aristides G. Eliopoulos, Jane Warwick, Gerald Niedobitek, Lawrence S. Young, and David J. Kerr
Cancer Res 1996 56: 2178-2184. [Abstract] [PDF]  

Concentration of Vascular Endothelial Growth Factor in the Serum and Tumor Tissue of Brain Tumor Patients

Shingo Takano, Yoshihiko Yoshii, Shinichi Kondo, Hideo Suzuki, Tooru Maruno, Shizuo Shirai, and Tadao Nose
Cancer Res 1996 56: 2185-2190. [Abstract] [PDF]  

Antitumor Effects of Granulocyte-Macrophage Colony-Stimulating Factor Production by Melanoma Cells

Cheryl A. Armstrong, Rafael Botella, Trephina H. Galloway, Nancy Murray, Jill M. Kramp, In Sung Song, and John C. Ansel
Cancer Res 1996 56: 2191-2198. [Abstract] [PDF]  

Immunohistochemical Staining for Markers of Future Neoplastic Progression in the Larynx

Dorothy L. Uhlman, George Adams, Dennis Knapp, Dorothee M. Aeppli, and Gloria Niehans
Cancer Res 1996 56: 2199-2205. [Abstract] [PDF]  

Regulation of the Adhesion of a Human Breast Carcinoma Cell Line to Type IV Collagen and Vitronectin: Roles for Lipoxygenase and Protein Kinase C

Rémi Palmantier, John D. Roberts, Wayne C. Glasgow, Thomas E. Eling, and Kenneth Olden
Cancer Res 1996 56: 2206-2212. [Abstract] [PDF]  

Alteration of ß-Catenin Expression in Colonic Epithelial Cells of Familial Adenomatous Polyposis Patients

Masafumi Inomata, Atsushi Ochiai, Shingo Akimoto, Seigo Kitano, and Setsuo Hirohashi
Cancer Res 1996 56: 2213-2217. [Abstract] [PDF]  

Phorbol Ester and Cyclic AMP-mediated Regulation of the Melanoma-associated Cell Adhesion Molecule MUC18/MCAM

Margaret M. Rummel, Christine Sers, and Judith P. Johnson
Cancer Res 1996 56: 2218-2223. [Abstract] [PDF]  

K-ras Oncogene Activation in Atypical Alveolar Hyperplasias of the Human Lung

William H. Westra, Inge O. Baas, Ralph H. Hruban, Fredric B. Askin, Kiersten Wilson, G. Johan A. Offerhaus, and Robbert J. C. Slebos
Cancer Res 1996 56: 2224-2228. [Abstract] [PDF]  

Expression of Tn and Sialyl-Tn Antigens in the Neoplastic Transformation of Uterine Cervical Epithelial Cells

Koji Terasawa, Hiroyuki Furumoto, Masaharu Kamada, and Toshihiro Aono
Cancer Res 1996 56: 2229-2232. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1996 56: 2233-2235. [PDF]  

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