Advances in Brief:

Induction of Cancer, Actinic Keratosis, and Specific p53 Mutations by UVB Light in Human Skin Maintained in Severe Combined Immunodeficient Mice

Taisei Nomura, Hiroo Nakajima, Tadashi Hongyo, Eiji Taniguchi, Kazuyasu Fukuda, Li Ya Li, Masayuki Kurooka, Kazuo Sutoh, Prakash M. Hande, Takanori Kawaguchi, Masato Ueda, and Hiroshi Takatera
Cancer Res 1997 57: 2081-2084. [Abstract] [PDF]  

Medulloblastomas of the Desmoplastic Variant Carry Mutations of the Human Homologue of Drosophila patched

Torsten Pietsch, Andreas Waha, Anke Koch, Jürgen Kraus, Steffen Albrecht, Jörg Tonn, Nils Sörensen, Frank Berthold, Bettina Henk, Nicole Schmandt, Helmut K. Wolf, Andreas von Deimling, Brandon Wainwright, Georgia Chenevix-Trench, Otmar D. Wiestler, and Carol Wicking
Cancer Res 1997 57: 2085-2088. [Abstract] [PDF]  

Constitutive Expression of Mature Transforming Growth Factor ß1 in the Liver Accelerates Hepatocarcinogenesis in Transgenic Mice

Valentina M. Factor, Chien-Yuan Kao, Eric Santoni-Rugiu, Joseph T. Woitach, Michael R. Jensen, and Snorri S. Thorgeirsson
Cancer Res 1997 57: 2089-2095. [Abstract] [PDF]  

Ionizing Radiation Mediates Expression of Cell Adhesion Molecules in Distinct Histological Patterns within the Lung

Dennis E. Hallahan and Subbulakshmi Virudachalam
Cancer Res 1997 57: 2096-2099. [Abstract] [PDF]  

Cytological Detection of Telomerase Activity Using an in Situ Telomeric Repeat Amplification Protocol Assay

Kazuma Ohyashiki, Junko H. Ohyashiki, Jiroh Nishimaki, Keisuke Toyama, Yoshiro Ebihara, Harubumi Kato, Woodring E. Wright, and Jerry W. Shay
Cancer Res 1997 57: 2100-2103. [Abstract] [PDF]  

Ornithine Decarboxylase Overexpression Leads to Increased Epithelial Tumor Invasiveness

Mary K. Smith, Mary A. Goral, Jane H. Wright, Lynn M. Matrisian, Rebecca J. Morris, Andres J. P. Klein-Szanto, and Susan K. Gilmour
Cancer Res 1997 57: 2104-2108. [Abstract] [PDF]  

Inhibition of Breast Cancer Tissue Aromatase Activity and Estrogen Concentrations by the Third-Generation Aromatase Inhibitor Vorozole

Paul C. de Jong, Joost van de Ven, Hans W. R. Nortier, Inge Maitimu-Smeele, Truus H. Donker, Jos H. H. Thijssen, Peter H. T. J. Slee, and Rien A. Blankenstein
Cancer Res 1997 57: 2109-2111. [Abstract] [PDF]  

FHIT Gene Expression in Human Ovarian, Endometrial, and Cervical Cancer Cell Lines

Denver T. Hendricks, Robert Taylor, Mark Reed, and Michael J. Birrer
Cancer Res 1997 57: 2112-2115. [Abstract] [PDF]  

Comparative Genomic Hybridization Analysis Detects Frequent, Often High-Level, Overrepresentation of DNA Sequences at 3q, 5p, 7p, and 8q in Human Non-Small Cell Lung Carcinomas

Binaifer R. Balsara, Gonosuke Sonoda, Stanislas du Manoir, Jill M. Siegfried, Edward Gabrielson, and Joseph R. Testa
Cancer Res 1997 57: 2116-2120. [Abstract] [PDF]  

Association between Cigarette Smoking and FHIT Gene Alterations in Lung Cancer

Gabriella Sozzi, Laura Sard, Laura De Gregorio, Antonio Marchetti, Katia Musso, Fiamma Buttitta, Silvana Tornielli, Silvia Pellegrini, Maria Luisa Veronese, Giacomo Manenti, Matteo Incarbone, Antonio Chella, Carlo A. Angeletti, Ugo Pastorino, Kay Huebner, Generoso Bevilaqua, Silvana Pilotti, Carlo M. Croce, and Marco A. Pierotti
Cancer Res 1997 57: 2121-2123. [Abstract] [PDF]  

TEP1, Encoded by a Candidate Tumor Suppressor Locus, Is a Novel Protein Tyrosine Phosphatase Regulated by Transforming Growth Factor ß

Da-Ming Li and Hong Sun
Cancer Res 1997 57: 2124-2129. [Abstract] [PDF]  

A Role for Perlecan in the Suppression of Growth and Invasion in Fibrosarcoma Cells

Micaela Mathiak, Cigdem Yenisey, Derrick S. Grant, Bela Sharma, and Renato V. Iozzo
Cancer Res 1997 57: 2130-2136. [Abstract] [PDF]  

Essential Role for Nuclear Phospholipase C ß₁ in Insulin-like Growth Factor I-induced Mitogenesis

Lucia Manzoli, Anna Maria Billi, Silvia Rubbini, Alberto Bavelloni, Irene Faenza, R. Stewart Gilmour, Sue-Goo Rhee, and Lucio Cocco
Cancer Res 1997 57: 2137-2139. [Abstract] [PDF]  

p16 and K-ras Gene Mutations in the Intraductal Precursors of Human Pancreatic Adenocarcinoma

Christopher A. Moskaluk, Ralph H. Hruban, and Scott E. Kern
Cancer Res 1997 57: 2140-2143. [Abstract] [PDF]  

Telomerase Activity: A Marker to Distinguish Follicular Thyroid Adenoma from Carcinoma

Christopher B. Umbricht, Motoyasu Saji, William H. Westra, Robert Udelsman, Martha A. Zeiger, and Saraswati Sukumar
Cancer Res 1997 57: 2144-2147. [Abstract] [PDF]  

Increased Genetic Stability of HeLa Cells after Connexin 43 Gene Transfection

Weibin Zhu, Nikolai Mironov, and Hiroshi Yamasaki
Cancer Res 1997 57: 2148-2150. [Abstract] [PDF]  

Cloning and Characterization of Mammalian 8-Hydroxyguanine-specific DNA Glycosylase/Apurinic, Apyrimidinic Lyase, a Functional mutM Homologue

Hiroyuki Aburatani, Yoshitaka Hippo, Toshimitsu Ishida, Rieko Takashima, Chikako Matsuba, Tatsuhiko Kodama, Masashi Takao, Akira Yasui, Kazuo Yamamoto, Midori Asano, Kazuhiro Fukasawa, Tomoko Yoshinari, Hideo Inoue, Eiko Ohtsuka, and Susumu Nishimura
Cancer Res 1997 57: 2151-2156. [Abstract] [PDF]  

Biochemistry and Biophysics:

Factors Affecting Topotecan-induced Programmed Cell Death: Adhesion Protects Cells from Apoptosis and Impairs Cleavage of Poly(ADP-Ribose)Polymerase

Cecilia M. Whitacre and Nathan A. Berger
Cancer Res 1997 57: 2157-2163. [Abstract] [PDF]  

Extracellular Factor(s) following Exposure to Particles Can Cause Sister Chromatid Exchanges in Normal Human Cells

Bruce E. Lehnert and Edwin H. Goodwin
Cancer Res 1997 57: 2164-2171. [Abstract] [PDF]  

Studies on the Metabolism of the Novel Antitumor Agent [N-methyl-¹¹C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in Rats and Humans prior to Phase I Clinical Trials

Safiye Osman, Sajinder K. Luthra, Frank Brady, Susan P. Hume, Gavin Brown, Robert J. A. Harte, Julian C. Matthews, William A. Denny, Bruce C. Baguley, Terry Jones, and Pat M. Price
Cancer Res 1997 57: 2172-2180. [Abstract] [PDF]  

Experimental Therapeutics:

Enhanced Antitumor Activity of Combination Radioimmunotherapy (¹³¹I-labeled Monoclonal Antibody A33) with Chemotherapy (Fluorouracil)

Jörg Tschmelitsch, Els Barendswaard, Clarence Williams, Jr., Tzy-Jyun Yao, Alfred M. Cohen, Lloyd J. Old, and Sydney Welt
Cancer Res 1997 57: 2181-2186. [Abstract] [PDF]  

Immunotherapy of BALB/c Mice Bearing Ehrlich Ascites Tumor with Vitamin D-binding Protein-derived Macrophage Activating Factor

Nobuto Yamamoto and Venkateswara R. Naraparaju
Cancer Res 1997 57: 2187-2192. [Abstract] [PDF]  

Overexpression of p21^waf1 Leads to Increased Inhibition of E2F-1 Phosphorylation and Sensitivity to Anticancer Drugs in Retinoblastoma-negative Human Sarcoma Cells

WeiWei Li, Jianguo Fan, Daniel Hochhauser, and Joseph R. Bertino
Cancer Res 1997 57: 2193-2199. [Abstract] [PDF]  

Efficacy of Hyperthermia and Polyunsaturated Fatty Acids on Experimental Carcinoma

Satoshi Kokura, Toshikazu Yoshikawa, Toshiro Kaneko, Shoji Iinuma, Shunichiro Nishimura, Kiichi Matsuyama, Yuji Naito, Norimasa Yoshida, and Motoharu Kondo
Cancer Res 1997 57: 2200-2202. [Abstract] [PDF]  

Induction of Apoptosis and Inhibition of Small Cell Lung Cancer Growth by the Quinoxaline Tyrphostins

Geoffrey W. Krystal, Patricia Carlson, and Julie Litz
Cancer Res 1997 57: 2203-2208. [Abstract] [PDF]  

Immunology:

Selective Up-Regulation of Protein Kinase C in Phorbol Ester-sensitive versus -resistant EL4 Mouse Thymoma Cells

Moira S. Resnick, Xuemei Luo, E. Griffith Vinton, and Julianne J. Sando
Cancer Res 1997 57: 2209-2215. [Abstract] [PDF]  

Enhanced Induction of Very Late Antigen 4/Lymphocyte Function-associated Antigen 1-dependent T-Cell Migration to Tumor Sites following Administration of Interleukin 12

Makoto Ogawa, Tateki Tsutsui, Jian-Ping Zou, Jie Mu, Rishani Wijesuriya, Wen-Gong Yu, Steven Herrmann, Takeshi Kubo, Hiromi Fujiwara, and Toshiyuki Hamaoka
Cancer Res 1997 57: 2216-2222. [Abstract] [PDF]  

Molecular Biology and Genetics:

Oncostatin M-mediated Transcriptional Suppression of the c-myc Gene in Breast Cancer Cells

Michael J. Spence, Robert E. Vestal, and Jingwen Liu
Cancer Res 1997 57: 2223-2228. [Abstract] [PDF]  

Extensive DNA Methylation Spanning the Rb Promoter in Retinoblastoma Tumors

Clare Stirzaker, Douglas S. Millar, Cheryl L. Paul, Peter M. Warnecke, Janet Harrison, Paul C. Vincent, Marianne Frommer, and Susan J. Clark
Cancer Res 1997 57: 2229-2237. [Abstract] [PDF]  

Allelic Deletions on Chromosome 11q13 in Multiple Endocrine Neoplasia Type 1-associated and Sporadic Gastrinomas and Pancreatic Endocrine Tumors

Larisa V. Debelenko, Zhengping Zhuang, Michael R. Emmert-Buck, Settara C. Chandrasekharappa, Pachiappan Manickam, Siradanahalli C. Guru, Stephen J. Marx, Monica C. Skarulis, Allen M. Spiegel, Francis S. Collins, Robert T. Jensen, Lance A. Liotta, and Irina A. Lubensky
Cancer Res 1997 57: 2238-2243. [Abstract] [PDF]  

Involvement of the Fanconi's Anemia Protein FAC in a Pathway That Signals to the Cyclin B/cdc2 Kinase

Frank A. E. Kruyt, Lonneke M. Dijkmans, Fré Arwert, and Hans Joenje
Cancer Res 1997 57: 2244-2251. [Abstract] [PDF]  

Effect of Mimosine on DNA Synthesis in Mammalian Cells

Lyuben M. Tsvetkov, George C. Russev, and Boyka B. Anachkova
Cancer Res 1997 57: 2252-2255. [Abstract] [PDF]  

FHIT and FRA3B 3p14.2 Allele Loss Are Common in Lung Cancer and Preneoplastic Bronchial Lesions and Are Associated with Cancer-related FHIT cDNA Splicing Aberrations

Kwun M. Fong, Eric J. Biesterveld, Arvind Virmani, Ignacio Wistuba, Yoshitaka Sekido, Scott A. Bader, Mohsen Ahmadian, S. Tiong Ong, Feyruz V. Rassool, Paul V. Zimmerman, Giuseppe Giaccone, Adi F. Gazdar, and John D. Minna
Cancer Res 1997 57: 2256-2267. [Abstract] [PDF]  

Activating Mutations in the N- and K-ras Oncogenes Differentially Affect the Growth Properties of the IL-6-dependent Myeloma Cell Line ANBL6

Daniel Billadeau, Pocheng Liu, Diane Jelinek, Nisha Shah, Tucker W. LeBien, and Brian Van Ness
Cancer Res 1997 57: 2268-2275. [Abstract] [PDF]  

Misexpression of Disrupted HMGI Architectural Factors Activates Alternative Pathways of Tumorigenesis

Alexei Tkachenko, Hena R. Ashar, Aurelia M. Meloni, Avery A. Sandberg, and Kiran K. Chada
Cancer Res 1997 57: 2276-2280. [Abstract] [PDF]  

Tumor Biology:

Regulation of CD44v6-containing Isoforms during Proliferation of Normal and Malignant Epithelial Cells

Tero Soukka, Marko Salmi, Heikki Joensuu, Lari Häkkinen, Petri Sointu, Leena Koulu, Kirsti Kalimo, Pekka Klemi, Reidar Grénman, and Sirpa Jalkanen
Cancer Res 1997 57: 2281-2289. [Abstract] [PDF]  

Amplification of the Genes BCHE and SLC2A2 in 40% of Squamous Cell Carcinoma of the Lung

Nicole Brass, Alexander Rácz, Dirk Heckel, Klaus Remberger, Gerhard W. Sybrecht, and Eckart U. Meese
Cancer Res 1997 57: 2290-2294. [Abstract] [PDF]  

Expression of MCAM/MUC18 by Human Melanoma Cells Leads to Increased Tumor Growth and Metastasis

Shanhai Xie, Mario Luca, Suyun Huang, Mordechai Gutman, Reuven Reich, Judith P. Johnson, and Menashe Bar-Eli
Cancer Res 1997 57: 2295-2303. [Abstract] [PDF]  

Reexpression of the Major Protein Kinase C Substrate, SSeCKS, Suppresses v-src-induced Morphological Transformation and Tumorigenesis

Xueying Lin and Irwin H. Gelman
Cancer Res 1997 57: 2304-2312. [Abstract] [PDF]  

Letters to the Editor:

Correspondence re: M. Stephen Meyn, Ataxia Telangiectasia and Cellular Responses to DNA Damage. Cancer Res., 55: 5991–6001, 1995

J. Martin Brown
Cancer Res 1997 57: 2313 [PDF]  

Correspondence re: M. Stephen Meyn, Ataxia Telangiectasia and Cellular Responses to DNA Damage. Cancer Res., 55: 5991–6001, 1995—Reply

M. Stephen Meyn
Cancer Res 1997 57: 2314-2315. [PDF]  

Articles:

Announcements

Cancer Res 1997 57: 2316-2318. [PDF]  

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