Advances in Brief:

Characterization of Prostatic Epithelial Cell Lines Derived from Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Model

Barbara A. Foster, Jeffrey R. Gingrich, Eugene D. Kwon, Christopher Madias, and Norman M. Greenberg
Cancer Res 1997 57: 3325-3330. [Abstract] [PDF]  

Drug-induced Apoptosis Is Associated with Enhanced Fas (Apo-1/CD95) Ligand Expression but Occurs Independently of Fas (Apo-1/CD95) Signaling in Human T-Acute Lymphatic Leukemia Cells

Andreas Villunger, Alexander Egle, Marion Kos, Bernd L. Hartmann, Stephan Geley, Reinhard Kofler, and Richard Greil
Cancer Res 1997 57: 3331-3334. [Abstract] [PDF]  

The DNA Repair Protein O⁶-Methylguanine-DNA Methyltransferase Protects against Skin Tumor Formation Induced by Antineoplastic Chloroethylnitrosourea

Klaus Becker, Cornelia M. Gregel, and Bernd Kaina
Cancer Res 1997 57: 3335-3338. [Abstract] [PDF]  

Development of an Adenovirus Vector with Tetracycline-regulatable Human Tumor Necrosis Factor Gene Expression

Shi-Xue Hu, Wan Ji, Yunli Zhou, Christopher Logothetis, and Hong-Ji Xu
Cancer Res 1997 57: 3339-3343. [Abstract] [PDF]  

Epothilone B Stabilizes Microtubuli of Macrophages Like Taxol without Showing Taxol-like Endotoxin Activity

Peter F. Mühlradt and Florenz Sasse
Cancer Res 1997 57: 3344-3346. [Abstract] [PDF]  

Methylation of the BRCA1 Gene in Sporadic Breast Cancer

Alexander Dobrovic and David Simpfendorfer
Cancer Res 1997 57: 3347-3350. [Abstract] [PDF]  

A BRCA1 Mutant Alters G₂-M Cell Cycle Control in Human Mammary Epithelial Cells

Jeffrey S. Larson, John L. Tonkinson, and Mei T. Lai
Cancer Res 1997 57: 3351-3355. [Abstract] [PDF]  

Loss of Heterozygosity at 16q24.1–q24.2 Is Significantly Associated with Metastatic and Aggressive Behavior of Prostate Cancer

Jussi P. Elo, Päivi Härkönen, Atte P. Kyllönen, Olavi Lukkarinen, Matti Poutanen, Reijo Vihko, and Pirkko Vihko
Cancer Res 1997 57: 3356-3359. [Abstract] [PDF]  

Two- and Three-dimensional Cell Structures Govern Epidermal Growth Factor Survival Function in Human Bladder Carcinoma Cell Lines

Virginie Dangles, Françoise Féménia, Véronique Lainé, Madeleine Berthelemy, Danielle Le Rhun, Marie-France Poupon, Daniel Levy, and Isabelle Schwartz-Cornil
Cancer Res 1997 57: 3360-3364. [Abstract] [PDF]  

Nitric Oxide Induces Conformational and Functional Modifications of Wild-Type p53 Tumor Suppressor Protein

Sylvie Calmels, Pierre Hainaut, and Hiroshi Ohshima
Cancer Res 1997 57: 3365-3369. [Abstract] [PDF]  

Association between CpG Island Methylation and Microsatellite Instability in Colorectal Cancer

Nita Ahuja, Avinash L. Mohan, Qing Li, Joshua M. Stolker, James G. Herman, Stanley R. Hamilton, Stephen B. Baylin, and Jean-Pierre J. Issa
Cancer Res 1997 57: 3370-3374. [Abstract] [PDF]  

Cytotoxic Synergy between Flavopiridol (NSC 649890, L86-8275) and Various Antineoplastic Agents: The Importance of Sequence of Administration

Keith C. Bible and Scott H. Kaufmann
Cancer Res 1997 57: 3375-3380. [Abstract] [PDF]  

Prognostic Role of the Cyclin-dependent Kinase Inhibitor p27 in Non-Small Cell Lung Cancer

Vincenzo Esposito, Alfonso Baldi, Antonio De Luca, Angela M. Groger, Massimo Loda, Giovan Giacomo Giordano, Mario Caputi, Feliciano Baldi, Michele Pagano, and Antonio Giordano
Cancer Res 1997 57: 3381-3385. [Abstract] [PDF]  

Dissociation of Radiation-induced Phosphorylation of Replication Protein A from the S-Phase Checkpoint

Susan E. Morgan and Michael B. Kastan
Cancer Res 1997 57: 3386-3389. [Abstract] [PDF]  

A p53-independent Pathway for Induction of p21^waf1cip1 and Concomitant G₁ Arrest in UV-irradiated Human Skin Fibroblasts

Martin Loignon, Raouf Fetni, Alasdair J. E. Gordon, and Elliot A. Drobetsky
Cancer Res 1997 57: 3390-3394. [Abstract] [PDF]  

Biochemistry and Biophysics:

Effect of the Chimeric Soluble Granulocyte Colony-stimulating Factor Receptor on the Proliferation of Leukemic Blast Cells from Patients with Acute Myeloblastic Leukemia

Yoshinobu Asano, Toshihiro Yokoyama, Shoichiro Shibata, Shinji Kobayashi, Kazuya Shimoda, Hitoshi Nakashima, Seiichi Okamura, and Yoshiyuki Niho
Cancer Res 1997 57: 3395-3397. [Abstract] [PDF]  

The Classification of Benign and Malignant Human Prostate Tissue by Multivariate Analysis of ¹H Magnetic Resonance Spectra

Per Hahn, Ian C. P. Smith, Leonard Leboldus, Charles Littman, Ray L. Somorjai, and Tedros Bezabeh
Cancer Res 1997 57: 3398-3401. [Abstract] [PDF]  

CYP2D6 Catalyzes Tamoxifen 4-Hydroxylation in Human Liver

Shangara S. Dehal and David Kupfer
Cancer Res 1997 57: 3402-3406. [Abstract] [PDF]  

Biochemical Characterization of the Protein Activity Responsible for High Molecular Weight DNA Fragmentation during Drug-induced Apoptosis

Peng Huang, Kalpana Ballal, and William Plunkett
Cancer Res 1997 57: 3407-3414. [Abstract] [PDF]  

Pharmacokinetic Analysis of 5-[¹⁸F]Fluorouracil Tissue Concentrations Measured with Positron Emission Tomography in Patients with Liver Metastases from Colorectal Adenocarcinoma

Jutta Kissel, Gunnar Brix, Matthias E. Bellemann, Ludwig G. Strauss, Antonia Dimitrakopoulou-Strauss, Rüdiger Port, Uwe Haberkorn, and Walter J. Lorenz
Cancer Res 1997 57: 3415-3423. [Abstract] [PDF]  

Carcinogenesis:

Cancer Chemopreventive Activity Mediated by Deguelin, a Naturally Occurring Rotenoid

George O. Udeani, Clarissa Gerhäuser, Cathy F. Thomas, Richard C. Moon, Jerrome W. Kosmeder, A. Douglas Kinghorn, Robert M. Moriarty, and John M. Pezzuto
Cancer Res 1997 57: 3424-3428. [Abstract] [PDF]  

Regulation of Ornithine Decarboxylase Induction by Deguelin, a Natural Product Cancer Chemopreventive Agent

Clarissa Gerhäuser, Sang Kook Lee, Jerry W. Kosmeder, Robert M. Moriarty, Ernest Hamel, Rajendra G. Mehta, Richard C. Moon, and John M. Pezzuto
Cancer Res 1997 57: 3429-3435. [Abstract] [PDF]  

Evidence That Cutaneous Carcinogen-initiated Epithelial Cells from Mice Are Quiescent Rather Than Actively Cycling

Rebecca J. Morris, Kathleen Coulter, Kimberly Tryson, and Sharon R. Steinberg
Cancer Res 1997 57: 3436-3443. [Abstract] [PDF]  

Retinyl Methyl Ether Down-Regulates Activator Protein 1 Transcriptional Activation in Breast Cancer Cells

Anissa Agadir, Y. Fulmer Shealy, Donald L. Hill, and Xiao-kun Zhang
Cancer Res 1997 57: 3444-3450. [Abstract] [PDF]  

Specific Chromosomal Changes in Albumin Simian Virus 40 T Antigen Transgenic Rat Liver Neoplasms

Linda M. Sargent, Yvonne P. Dragan, Gerald Sattler, Yi-Hua Xu, John Wiley, and Henry C. Pitot
Cancer Res 1997 57: 3451-3456. [Abstract] [PDF]  

Urinary Excretion of Unmetabolized and Phase II Conjugates of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline in Humans: Relationship to Cytochrome P4501A2 and N-Acetyltransferase Activity

W. G. Stillwell, La Creis R. Kidd, John S. Wishnok, Steven R. Tannenbaum, and Rashmi Sinha
Cancer Res 1997 57: 3457-3464. [Abstract] [PDF]  

Dietary Fat and Colon Cancer: Modulation of Cyclooxygenase-2 by Types and Amount of Dietary Fat during the Postinitiation Stage of Colon Carcinogenesis

Jagveer Singh, Rachid Hamid, and Bandaru S. Reddy
Cancer Res 1997 57: 3465-3470. [PDF]  

p53 Mutations, Chronic Hepatitis B Virus Infection, and Alfatoxin Exposure in Hepatocellular Carcinoma in Taiwan

Ruth M. Lunn, Yu-Jing Zhang, Li-Yu Wang, Chien-Jen Chen, Po-Huang Lee, Chue-Shue Lee, Wei-Yann Tsai, and Regina M. Santella
Cancer Res 1997 57: 3471-3477. [Abstract] [PDF]  

Endocrinology:

A Functional Assay in Yeast for the Human Estrogen Receptor Displays Wild-Type and Variant Estrogen Receptor Messenger RNAs Present in Breast Carcinoma

Mariska A. J. van Dijk, Arno N. Floore, Kim I. M. Kloppenborg, and Laura J. van't Veer
Cancer Res 1997 57: 3478-3485. [Abstract] [PDF]  

MCF7/LCC9: An Antiestrogen-resistant MCF-7 Variant in Which Acquired Resistance to the Steroidal Antiestrogen ICI 182,780 Confers an Early Cross-Resistance to the Nonsteroidal Antiestrogen Tamoxifen

Nils Brünner, Birgitte Boysen, Stana Jirus, Todd C. Skaar, Claus Holst-Hansen, Jeremy Lippman, Thomas Frandsen, Mogens Spang-Thomsen, Suzanne A. W. Fuqua, and Robert Clarke
Cancer Res 1997 57: 3486-3493. [Abstract] [PDF]  

Blockade of the Stimulatory Effect of Estrogens, OH-Tamoxifen, OH-Toremifene, Droloxifene, and Raloxifene on Alkaline Phosphatase Activity by the Antiestrogen EM-800 in Human Endometrial Adenocarcinoma Ishikawa Cells

Jacques Simard, Rocio Sanchez, Donald Poirier, Sylvain Gauthier, Shankar M. Singh, Yves Merand, Alain Belanger, Claude Labrie, and Fernand Labrie
Cancer Res 1997 57: 3494-3497. [Abstract] [PDF]  

Experimental therapeutics:

Regulation of Proliferation and Ras Localization in Transformed Cells by Products of Mevalonate Metabolism

Jennifer A. Cuthbert and Peter E. Lipsky
Cancer Res 1997 57: 3498-3505. [Abstract] [PDF]  

Methotrexate Is Excreted into the Bile by Canalicular Multispecific Organic Anion Transporter in Rats

Masayuki Masuda, Yuji I'izuka, Masayo Yamazaki, Ryuichiro Nishigaki, Yukio Kato, Kayoko Ni'inuma, Hiroshi Suzuki, and Yuichi Sugiyama
Cancer Res 1997 57: 3506-3510. [Abstract] [PDF]  

Antitumor Activity and Immunotherapeutic Properties of Flt3-Ligand in a Murine Breast Cancer Model

Keyue Chen, Stephen Braun, Stewart Lyman, Yi Fan, Christie M. Traycoff, Eric A. Wiebke, Jay Gaddy, George Sledge, Hal E. Broxmeyer, and Kenneth Cornetta
Cancer Res 1997 57: 3511-3516. [Abstract] [PDF]  

Immunology:

T-Cell Receptor -Chain Expression on Tumor-infiltrating Lymphocytes from Renal Cell Carcinoma

Gaetano Cardi, John A. Heaney, Alan R. Schned, Dorothy M. Phillips, Mark T. Branda, and Marc S. Ernstoff
Cancer Res 1997 57: 3517-3519. [Abstract] [PDF]  

Molecular Biology and Genetics:

Loss of Heterozygosity Analysis in Primary Mammary Tumors and Lung Metastases of MMTV-MTAg and MMTV-neu Transgenic Mice

Steve R. Ritland, Gerald J. Rowse, Yue Chang, and Sandra J. Gendler
Cancer Res 1997 57: 3520-3525. [Abstract] [PDF]  

Expression of Neurogenic Basic Helix-Loop-Helix Genes in Primitive Neuroectodermal Tumors

Robert C. Rostomily, Olivia Bermingham-McDonogh, Mitchel S. Berger, Stephen J. Tapscott, Thomas A. Reh, and James M. Olson
Cancer Res 1997 57: 3526-3531. [Abstract] [PDF]  

Neurofilament Heavy Chain-like Messenger RNA and Protein Are Present in Benign Prostate and Down-Regulated in Prostatic Carcinoma

Rosemary L. Schleicher, Stephen B. Hunter, Ming Zhang, Ming Zheng, Wenxiao Tan, Claudiu I. Bandea, Michael T. Fallon, David G. Bostwick, and Vijay A. Varma
Cancer Res 1997 57: 3532-3536. [Abstract] [PDF]  

Analysis of Expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, Homologues of the Multidrug Resistance-associated Protein Gene (MRP1), in Human Cancer Cell Lines

Marcel Kool, Marcel de Haas, George L. Scheffer, Rik J. Scheper, Michiel J.T. van Eijk, Jenneke A. Juijn, Frank Baas, and Piet Borst
Cancer Res 1997 57: 3537-3547. [Abstract] [PDF]  

Isolation of a Candidate Gene, CAB1, for Cholesterol Transport to Mitochondria from the c-ERBB-2 Amplicon by a Modified cDNA Selection Method

Nobu Akiyama, Hiroki Sasaki, Tomoki Ishizuka, Tatsuya Kishi, Hiromi Sakamoto, Masahiko Onda, Hisamaru Hirai, Yoshio Yazaki, Takashi Sugimura, and Masaaki Terada
Cancer Res 1997 57: 3548-3553. [Abstract] [PDF]  

RNA Fingerprinting Displays UVB-specific Disruption of Transcriptional Control in Human Melanocytes

Thomas M. M. Vogt, John Welsh, Wilhelm Stolz, Frank Kullmann, Barbara Jung, Michael Landthaler, and Michael McClelland
Cancer Res 1997 57: 3554-3561. [Abstract] [PDF]  

Translational Enhancement of mdm2 Oncogene Expression in Human Tumor Cells Containing a Stabilized Wild-Type p53 Protein

John E. Landers, Suzanne L. Cassel, and Donna L. George
Cancer Res 1997 57: 3562-3568. [Abstract] [PDF]  

Inhibitors of Both Nuclear Factor-B and Activator Protein-1 Activation Block the Neoplastic Transformation Response

Jian-Jian Li, Chandra Westergaard, Paritosh Ghosh, and Nancy H. Colburn
Cancer Res 1997 57: 3569-3576. [Abstract] [PDF]  

Tumor Biology:

Purification and Characterization of Human Lung Fibroblast Motility-stimulating Factor for Human Soft Tissue Sarcoma Cells: Identification as an NH₂-terminal Fragment of Human Fibronectin

Mei Hu, Raphael E. Pollock, and Garth L. Nicolson
Cancer Res 1997 57: 3577-3584. [Abstract] [PDF]  

Prevention of Breast Cancer Growth, Invasion, and Metastasis by Antiestrogen Tamoxifen Alone or in Combination with Urokinase Inhibitor B-428

Rosie Hongmei Xing, Andrew Mazar, Jack Henkin, and Shafaat Ahmed Rabbani
Cancer Res 1997 57: 3585-3593. [Abstract] [PDF]  

Inhibition of Prostate Cancer Neovascularization and Growth by Urokinase-Plasminogen Activator Receptor Blockade

Christopher P. Evans, Fred Elfman, Sareh Parangi, Marion Conn, Gerald Cunha, and Marc A. Shuman
Cancer Res 1997 57: 3594-3599. [Abstract] [PDF]  

Resistance to Radiation-induced Apoptosis in Burkitt's Lymphoma Cells Is Associated with Defective Ceramide Signaling

Julie M. Michael, Martin F. Lavin, and Dianne J. Watters
Cancer Res 1997 57: 3600-3605. [Abstract] [PDF]  

Synergy between Transforming Growth Factor and Hepatitis B Virus Surface Antigen in Hepatocellular Proliferation and Carcinogenesis

John L. Jakubczak, Francis V. Chisari, and Glenn Merlino
Cancer Res 1997 57: 3606-3611. [Abstract] [PDF]  

Tumor Cells with Organ-specific Metastatic Ability Show Distinctive Trafficking in Vivo: Analyses by Positron Emission Tomography and Bioimaging

Chieko Koike, Manabu Watanabe, Naoto Oku, Hideo Tsukada, Tatsuro Irimura, and Shoji Okada
Cancer Res 1997 57: 3612-3619. [Abstract] [PDF]  

Meeting Report:

Molecular Mechanisms for Inflammation-promoted Pathogenesis of Cancer—The Sixteenth International Symposium of the Sapporo Cancer Seminar

Julie Parsonnet
Cancer Res 1997 57: 3620-3624. [PDF]  

Articles:

Announcements

Cancer Res 1997 57: 3625-3627. [PDF]  

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