Advances in Brief:

Characterization of a 4-Mb Region at Chromosome 6q21 Harboring a Replicative Senescence Gene

Cristina Morelli, Tim Sherratt, Cecilia Trabanelli, Paola Rimessi, Francesca Gualandi, Martin J. Greaves, Massimo Negrini, John M. Boyle, and Giuseppe Barbanti-Brodano
Cancer Res 1997 57: 4153-4157. [Abstract] [PDF]  

Loss of Retinoic Acid Receptor ß Expression in Breast Cancer and Morphologically Normal Adjacent Tissue but not in the Normal Breast Tissue Distant from the Cancer

Martin Widschwendter, Jennifer Berger, Günter Daxenbichler, Elisabeth Müller-Holzner, Andreas Widschwendter, Adelcy Mayr, Christian Marth, and Alain G. Zeimet
Cancer Res 1997 57: 4158-4161. [Abstract] [PDF]  

Multigenerational Effects of Dietary Fat Carcinogenesis in Mice

Bruce E. Walker and Lori A. Kurth
Cancer Res 1997 57: 4162-4163. [Abstract] [PDF]  

Genetic Mapping of Lung Cancer Modifier Loci Specifically Affecting Tumor Initiation and Progression

Giacomo Manenti, Manuela Gariboldi, Antonio Fiorino, Nicola Zanesi, Marco A. Pierotti, and Tommaso A. Dragani
Cancer Res 1997 57: 4164-4166. [Abstract] [PDF]  

Detection of Prostate Cancer Cells Circulating in Peripheral Blood by Reverse Transcription-PCR for hKLK2

Masako Kawakami, Toshikazu Okaneya, Kenichi Furihata, Osamu Nishizawa, and Tsutomu Katsuyama
Cancer Res 1997 57: 4167-4170. [Abstract] [PDF]  

Genetic Alterations Accumulate during Cervical Tumorigenesis and Indicate a Common Origin for Multifocal Lesions

Amy A. Larson, Shu-Yuan Liao, Eric J. Stanbridge, Webster K. Cavenee, and Garret M. Hampton
Cancer Res 1997 57: 4171-4176. [Abstract] [PDF]  

Human Mitogen-activated Protein Kinase Kinase 4 as a Candidate Tumor Suppressor

David H-F. Teng, William L. Perry, III, James K. Hogan, Michelle Baumgard, Russell Bell, Simin Berry, Thaylon Davis, David Frank, Cheryl Frye, Thomas Hattier, Rong Hu, Srikanth Jammulapati, Teresa Janecki, Amber Leavitt, Jeffrey T. Mitchell, Ralph Pero, David Sexton, Marianne Schroeder, Pi-Hsia Su, Brad Swedlund, John M. Kyriakis, Joseph Avruch, Paul Bartel, Alexander K. C. Wong, Arnold Oliphant, Alun Thomas, Mark H. Skolnick, and Sean V. Tavtigian
Cancer Res 1997 57: 4177-4182. [Abstract] [PDF]  

Somatic Mutations of PTEN in Glioblastoma Multiforme

Steven I. Wang, Janusz Puc, Jing Li, Jeffrey N. Bruce, Paul Cairns, David Sidransky, and Ramon Parsons
Cancer Res 1997 57: 4183-4186. [Abstract] [PDF]  

PTEN Gene Mutations Are Seen in High-Grade but not in Low-Grade Gliomas

B. K. Ahmed Rasheed, Timothy T. Stenzel, Roger E. McLendon, Ramon Parsons, Allan H. Friedman, Henry S. Friedman, Darell D. Bigner, and Sandra H. Bigner
Cancer Res 1997 57: 4187-4190. [Abstract] [PDF]  

Genomic Structure and Genetic Mapping of the Human Neutral Cysteine Protease Bleomycin Hydrolase

Susana E. Montoya, Robert E. Ferrell, and John S. Lazo
Cancer Res 1997 57: 4191-4195. [Abstract] [PDF]  

Pretreatment Prediction of the Chemotherapeutic Response of Human Glioma Cell Cultures Using Nuclear Magnetic Resonance Spectroscopy and Artificial Neural Networks

Wael El-Deredy, Sally M. Ashmore, Neil M. Branston, John L. Darling, Steven R. Williams, and David G. T. Thomas
Cancer Res 1997 57: 4196-4199. [Abstract] [PDF]  

Selection of Human Cervical Epithelial Cells That Possess Reduced Apoptotic Potential to Low-Oxygen Conditions

Charlotte Y. Kim, Mitchell H. Tsai, Cynthia Osmanian, Thomas G. Graeber, Jong Eun Lee, Rona G. Giffard, Joseph A. DiPaolo, Donna M. Peehl, and Amato J. Giaccia
Cancer Res 1997 57: 4200-4204. [Abstract] [PDF]  

Virally Directed Cytosine Deaminase/5-Fluorocytosine Gene Therapy Enhances Radiation Response in Human Cancer Xenografts

Nader N. Hanna, Helena J. Mauceri, Jeffery D. Wayne, Dennis E. Hallahan, Donald W. Kufe, and Ralph R. Weichselbaum
Cancer Res 1997 57: 4205-4209. [Abstract] [PDF]  

Basal Cell Tetrasomy in Low-Grade Cervical Squamous Intraepithelial Lesions Infected with High-Risk Human Papillomaviruses

Shirley A. Southern, Mark F. Evans, and C. Simon Herrington
Cancer Res 1997 57: 4210-4213. [Abstract] [PDF]  

Skin Autografts in Epidermodysplasia Verruciformis: Human Papillomavirus-associated Cutaneous Changes Need Over 20 Years for Malignant Conversion

Slawomir Majewski and Stefania Jablonska
Cancer Res 1997 57: 4214-4216. [Abstract] [PDF]  

A Region of Allelic Imbalance in 1q31–32 in Primary Breast Cancer Coincides with a Recombination Hot Spot

Javier Benítez, Ana Osorio, Alicia Barroso, Eva Arranz, Miguel A. Díaz-Guillén, Mercedes Robledo, Santiago Rodríguez de Córdoba, and Damián Heine-Suñer
Cancer Res 1997 57: 4217-4220. [Abstract] [PDF]  

Inactivation of Smad4 in Gastric Carcinomas

Steven M. Powell, Jeffrey C. Harper, Stanley R. Hamilton, C. Rahj Robinson, and Oscar W. Cummings
Cancer Res 1997 57: 4221-4224. [Abstract] [PDF]  

Identification of Cellular TSG101 Protein in Multiple Human Breast Cancer Cell Lines

Qing Zhong, Chi-Fen Chen, Yumay Chen, Phang-Lang Chen, and Wen-Hwa Lee
Cancer Res 1997 57: 4225-4228. [Abstract] [PDF]  

Biochemistry and Biophysics:

Oxidation of Cyclophosphamide to 4-Hydroxycyclophosphamide and Deschloroethylcyclophosphamide in Human Liver Microsomes

Song Ren, Ji-Sun Yang, Thomas F. Kalhorn, and John T. Slattery
Cancer Res 1997 57: 4229-4235. [Abstract] [PDF]  

Nucleocytoplasmic Functionality of Metallothionein

Elizabeth S. Woo and John S. Lazo
Cancer Res 1997 57: 4236-4241. [Abstract] [PDF]  

Oxythiamine and Dehydroepiandrosterone Inhibit the Nonoxidative Synthesis of Ribose and Tumor Cell Proliferation

Laszlo G. Boros, Joaquim Puigjaner, Marta Cascante, Wai-Nang Paul Lee, James L. Brandes, Sara Bassilian, Fouza I. Yusuf, Robert D. Williams, Pete Muscarella, W. Scott Melvin, and William J. Schirmer
Cancer Res 1997 57: 4242-4248. [Abstract] [PDF]  

Increased 2,6 Sialylation of N-Glycans in a Transgenic Mouse Model of Hepatocellular Carcinoma

Dominique Pousset, Véronique Piller, Nicole Bureaud, Michel Monsigny, and Friedrich Piller
Cancer Res 1997 57: 4249-4256. [Abstract] [PDF]  

Carcinogenesis:

Protection Conferred by Selenium Deficiency against Aflatoxin B₁ in the Rat Is Associated with the Hepatic Expression of an Aldo-Keto Reductase and a Glutathione S-Transferase Subunit That Metabolize the Mycotoxin

Ronald McLeod, Elizabeth M. Ellis, John R. Arthur, Gordon E. Neal, David J. Judah, Margaret M. Manson, and John D. Hayes
Cancer Res 1997 57: 4257-4266. [Abstract] [PDF]  

Sulindac Causes Rapid Regression of Preexisting Tumors in Min/+ Mice Independent of Prostaglandin Biosynthesis

Chun-Hung Chiu, Michael F. McEntee, and Jay Whelan
Cancer Res 1997 57: 4267-4273. [Abstract] [PDF]  

Earlier Onset of Melanotroph Carcinogenesis in Mice with Inherited Mutant Paternal Allele of the Retinoblastoma Gene

Alexander Yu. Nikitin, Daniel J. Riley, and Wen-Hwa Lee
Cancer Res 1997 57: 4274-4278. [Abstract] [PDF]  

Experimental Therapeutics:

In Vivo Selective Gene Expression and Therapy Mediated by Adenoviral Vectors for Human Carcinoembryonic Antigen-producing Gastric Carcinoma

Keng-Hsin Lan, Fumihiko Kanai, Yasushi Shiratori, Makoto Ohashi, Torao Tanaka, Takehito Okudaira, Yoko Yoshida, Hirofumi Hamada, and Masao Omata
Cancer Res 1997 57: 4279-4284. [Abstract] [PDF]  

Characterization of the p53 Tumor Suppressor Pathway in Cell Lines of the National Cancer Institute Anticancer Drug Screen and Correlations with the Growth-Inhibitory Potency of 123 Anticancer Agents

Patrick M. O'Connor, Joany Jackman, Insoo Bae, Timothy G. Myers, Saijun Fan, Masato Mutoh, Dominic A. Scudiero, Ann Monks, Edward A. Sausville, John N. Weinstein, Stephen Friend, Albert J. Fornace, Jr., and Kurt W. Kohn
Cancer Res 1997 57: 4285-4300. [Abstract] [PDF]  

Role of Topoisomerase IIß in the Resistance of 9-OH-ellipticine-resistant Chinese Hamster Fibroblasts to Topoisomerase II Inhibitors

Sophie Dereuddre, Charlotte Delaporte, and Alain Jacquemin-Sablon
Cancer Res 1997 57: 4301-4308. [Abstract] [PDF]  

Growth Inhibitory Effects of Sodium Phenylacetate (NSC 3039) on Ovarian Carcinoma Cells in Vitro

Gabriella Ferrandina, Bohuslav Melichar, Amy Loercher, Claire F. Verschraegen, Andrzej P. Kudelka, Creighton L. Edwards, Giovanni Scambia, John J. Kavanagh, James L. Abbruzzese, and Ralph S. Freedman
Cancer Res 1997 57: 4309-4315. [Abstract] [PDF]  

R-Flurbiprofen Chemoprevention and Treatment of Intestinal Adenomas in the APC^Min/+ Mouse Model: Implications for Prophylaxis and Treatment of Colon Cancer

William J. Wechter, Darko Kantoci, E. David Murray, Jr., David D. Quiggle, Douglas D. Leipold, Karina M. Gibson, and John D. McCracken
Cancer Res 1997 57: 4316-4324. [Abstract] [PDF]  

Molecular Chemotherapy Combined with Radiation Therapy Enhances Killing of Cholangiocarcinoma Cells in Vitro and in Vivo

Lee C. Pederson, Donald J. Buchsbaum, Selwyn M. Vickers, Sreekanth R. Kancharla, Matthew S. Mayo, David T. Curiel, and Murray A. Stackhouse
Cancer Res 1997 57: 4325-4332. [Abstract] [PDF]  

Intratumoral Delivery of Boronated Epidermal Growth Factor for Neutron Capture Therapy of Brain Tumors

Weilian Yang, Rolf F. Barth, Dianne M. Adams, and Albert H. Soloway
Cancer Res 1997 57: 4333-4339. [Abstract] [PDF]  

Decreasing the Apoptotic Threshold of Tumor Cells through Protein Kinase C Inhibition and Sphingomyelinase Activation Increases Tumor Killing by Ionizing Radiation

Steven J. Chmura, Helena J. Mauceri, Sunil Advani, Ruth Heimann, Michael A. Beckett, Edwardine Nodzenski, Jose Quintans, Donald W. Kufe, and Ralph R. Weichselbaum
Cancer Res 1997 57: 4340-4347. [Abstract] [PDF]  

Immunology:

Synthetic Peptides Derived from the Melanocyte-stimulating Hormone Receptor MC1R Can Stimulate HLA-A2-restricted Cytotoxic T Lymphocytes That Recognize Naturally Processed Peptides on Human Melanoma Cells

Flavio Salazar-Onfray, Tsutomu Nakazawa, Vijay Chhajlani, Max Petersson, Klas Kärre, Giuseppe Masucci, Esteban Celis, Alessandro Sette, Scott Southwood, Ettore Appella, and Rolf Kiessling
Cancer Res 1997 57: 4348-4355. [Abstract] [PDF]  

Molecular Biology and Genetics:

Developmental Exposure to Diethylstilbestrol Elicits Demethylation of Estrogen-responsive Lactoferrin Gene in Mouse Uterus

Shuanfang Li, Kimberly A. Washburn, Rick Moore, Tomohide Uno, Christina Teng, Retha R. Newbold, John A. McLachlan, and Masahiko Negishi
Cancer Res 1997 57: 4356-4359. [Abstract] [PDF]  

Mapping of DNA Amplifications at 15 Chromosomal Localizations in 1875 Breast Tumors: Definition of Phenotypic Groups

Frank Courjal, Marguerite Cuny, Joelle Simony-Lafontaine, Geneviève Louason, Paul Speiser, Robert Zeillinger, Carmen Rodriguez, and Charles Theillet
Cancer Res 1997 57: 4360-4367. [Abstract] [PDF]  

Comparative Genomic Hybridization Analysis of Breast Tumors with Predetermined Profiles of DNA Amplification

Frank Courjal and Charles Theillet
Cancer Res 1997 57: 4368-4377. [Abstract] [PDF]  

Polychlorinated Biphenyls and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Induce Intrachromosomal Recombination in Vitro and in Vivo

Robert H. Schiestl, Jiri Aubrecht, Wendy Y. Yap, Sridevi Kandikonda, and Samy Sidhom
Cancer Res 1997 57: 4378-4383. [Abstract] [PDF]  

A Lack of Radiation-induced Ornithine Decarboxylase Activity Prevents Enhanced Reactivation of Herpes Simplex Virus and Is Linked to Non-Cancer Proneness in Xeroderma Pigmentosum Patients

Carrol Terleth, Theo van Laar, Ron Schouten, Harry van Steeg, Hennie Hodemaekers, Thera Wormhoudt, Paulien D. M. Cornelissen-Steijger, Peter J. Abrahams, and Alex J. van der Eb
Cancer Res 1997 57: 4384-4392. [Abstract] [PDF]  

Mutation Frequency and Spectrum in Lymphocytes of Small Cell Lung Cancer Patients Receiving Etoposide Chemotherapy

Larissa Karnaoukhova, Joyce Moffat, Heidi Martins, and Barry Glickman
Cancer Res 1997 57: 4393-4407. [Abstract] [PDF]  

The Absolute Number of Trans-Rearrangements between the TCRG and TCRB Loci Is Predictive of Lymphoma Risk: A Severe Combined Immune Deficiency (SCID) Murine Model

Florigio Lista, Virginia Bertness, Cynthia J. Guidos, Jayne S. Danska, and Ilan R. Kirsch
Cancer Res 1997 57: 4408-4413. [Abstract] [PDF]  

Inhibition of Tumor Promoter-induced Activator Protein 1 Activation and Cell Transformation by Tea Polyphenols, (-)-Epigallocatechin Gallate, and Theaflavins

Zigang Dong, Wei-ya Ma, Chuanshu Huang, and Chung S. Yang
Cancer Res 1997 57: 4414-4419. [Abstract] [PDF]  

Frameshift Somatic Mutations in Gastrointestinal Cancer of the Microsatellite Mutator Phenotype

Hiroyuki Yamamoto, Hisako Sawai, and Manuel Perucho
Cancer Res 1997 57: 4420-4426. [Abstract] [PDF]  

Tumor Biology:

Immunolocalization and Messenger RNA Expression of Bone Morphogenetic Protein-6 in Human Benign and Malignant Prostatic Tissue

Freddie C. Hamdy, Pernillle Autzen, Mary C. Robinson, C. H. Wilson Horne, David E. Neal, and Craig N. Robson
Cancer Res 1997 57: 4427-4431. [Abstract] [PDF]  

In Vivo Induction of Murine Cytokine Production by Carcinoembryonic Antigen

Kirsten H. Edmiston, Aniruddha Gangopadhyay, Yutaka Shoji, Alex P. Nachman, Peter Thomas, and J. Milburn Jessup
Cancer Res 1997 57: 4432-4436. [Abstract] [PDF]  

Meeting Report:

Eighth Annual Pezcoller Symposium: Genomic Instability and Immortality in Cancer

Enrico Mihich and Leland Hartwell
Cancer Res 1997 57: 4437-4441. [PDF]  

Articles:

Announcements

Cancer Res 1997 57: 4442-4444. [PDF]  

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