Advances in Brief:

Dietary Restriction Reduces Insulin-like Growth Factor I Levels, Which Modulates Apoptosis, Cell Proliferation, and Tumor Progression in p53-deficient Mice

Sandra E. Dunn, Frank W. Kari, John French, Joel R. Leininger, Greg Travlos, Ralph Wilson, and J. Carl Barrett
Cancer Res 1997 57: 4667-4672. [Abstract] [PDF]  

Hyperlipidemia Enhancement of Renal Preneoplasia but not Tumor Formation Is Due to Elevated Apoptosis in the Eker Rat

Shunji Miki, Yoshitsugu Miki, Hiroaki Mitani, Bunzo Sato, Masahiro Yamamoto, and Okio Hino
Cancer Res 1997 57: 4673-4676. [Abstract] [PDF]  

Trichoepitheliomas Contain Somatic Mutations in the Overexpressed PTCH Gene: Support for a Gatekeeper Mechanism in Skin Tumorigenesis

Igor Vorechovsky, Anne Birgitte Undén, Bengt Sandstedt, Rune Toftgård, and Mona Ståhle-Bäckdahl
Cancer Res 1997 57: 4677-4681. [Abstract] [PDF]  

Somatic Mutations of the MEN1 Tumor Suppressor Gene in Sporadic Gastrinomas and Insulinomas

Zhengping Zhuang, Alexander O. Vortmeyer, Svetlana Pack, Steve Huang, Thu A. Pham, Chaoyu Wang, Won-Sang Park, Sunita K. Agarwal, Larisa V. Debelenko, MaryBeth Kester, Siradanahalli C. Guru, Pachiappan Manickam, Shodimu-Emmanuel Olufemi, Fang Yu, Christina Heppner, Judy S. Crabtree, Monica C. Skarulis, David J. Venzon, Michael R. Emmert-Buck, Allen M. Spiegel, Settara C. Chandrasekharappa, Francis S. Collins, A. Lee Burns, Stephen J. Marx, Robert T. Jensen, Lance A. Liotta, and Irina A. Lubensky
Cancer Res 1997 57: 4682-4686. [Abstract] [PDF]  

Androgen-independent Prostate Cancer Progression in the TRAMP Model

Jeffrey R. Gingrich, Roberto J. Barrios, Michael W. Kattan, Hyun S. Nahm, Milton J. Finegold, and Norman M. Greenberg
Cancer Res 1997 57: 4687-4691. [Abstract] [PDF]  

Loss of FHIT Expression in Cervical Carcinoma Cell Lines and Primary Tumors

David L. Greenspan, Denise C. Connolly, Rong Wu, Rachel Y. Lei, Joshua T. C. Vogelstein, Young-Tak Kim, Jung Eun Mok, Nubia Muñoz, F. Xavier Bosch, Keerti Shah, and Kathleen R. Cho
Cancer Res 1997 57: 4692-4698. [Abstract] [PDF]  

A Precise Interchromosomal Reciprocal Exchange between Hot Spots for Cleavable Complex Formation by Topoisomerase II in Amsacrine-treated Chinese Hamster Ovary Cells

Rui-Hua Zhou, Peng Wang, Ying Zou, Colleen K. Jackson-Cook, and Lawrence F. Povirk
Cancer Res 1997 57: 4699-4702. [Abstract] [PDF]  

Loss of p21^Waf1/Cip1 Sensitizes Tumors to Radiation by an Apoptosis-independent Mechanism

Bradly G. Wouters, Amato J. Giaccia, Nicholas C. Denko, and J. Martin Brown
Cancer Res 1997 57: 4703-4706. [Abstract] [PDF]  

Early Age at Diagnosis in Families Providing Evidence of Linkage to the Hereditary Prostate Cancer Locus (HPC1) on Chromosome 1

Henrik Grönberg, Jianfeng Xu, Jeffrey R. Smith, John D. Carpten, Sarah D. Isaacs, Diha Freije, G. Steven Bova, Patrick C. Walsh, Francis S. Collins, Jeffrey M. Trent, Deborah A. Meyers, and William B. Isaacs
Cancer Res 1997 57: 4707-4709. [Abstract] [PDF]  

Somatic Deletions and Mutations in the Cowden Disease Gene, PTEN, in Sporadic Thyroid Tumors

Patricia L. M. Dahia, Debbie J. Marsh, Zimu Zheng, Jan Zedenius, Paul Komminoth, Tony Frisk, Goran Wallin, Ramon Parsons, Michel Longy, Catharina Larsson, and Charis Eng
Cancer Res 1997 57: 4710-4713. [Abstract] [PDF]  

Activated Ki-ras Enhances Sensitivity of Ceramide-induced Apoptosis without c-Jun NH₂-Terminal Kinase/Stress-activated Protein Kinase or Extracellular Signal-regulated Kinase Activation in Human Colon Cancer Cells

Mariko Ohmori, Senji Shirasawa, Masanori Furuse, Koji Okumura, and Takehiko Sasazuki
Cancer Res 1997 57: 4714-4717. [Abstract] [PDF]  

Association of Human T-Cell Leukemia Virus and Myelodysplastic Syndrome in a Central European Population

Heidrun Karlic, Michaela Möstl, Hermann Mucke, Borislava Pavlova, Michael Pfeilstöcker, and Renate Heinz
Cancer Res 1997 57: 4718-4721. [Abstract] [PDF]  

Adenovirus-Mediated Overexpression of the Transcription Factor E2F-1 Induces Apoptosis in Human Breast and Ovarian Carcinoma Cell Lines and Does Not Require p53

Kelly K. Hunt, Jiong Deng, Ta-Jen Liu, Marcia Wilson-Heiner, Stephen G. Swisher, Gary Clayman, and Mien-Chie Hung
Cancer Res 1997 57: 4722-4726. [Abstract] [PDF]  

Sunlight Induces Pyrimidine Dimers Preferentially at 5-Methylcytosine Bases

Stella Tommasi, Mikhail F. Denissenko, and Gerd P. Pfeifer
Cancer Res 1997 57: 4727-4730. [Abstract] [PDF]  

Patched (ptch)-associated Preferential Expression of Smoothened (smoh) in Human Basal Cell Carcinoma of the Skin

Mireille Kallassy, Rune Toftgård, Masato Ueda, Keiko Nakazawa, Igor Vorechovsky, Hiroshi Yamasaki, and Hisayoshi Nakazawa
Cancer Res 1997 57: 4731-4735. [Abstract] [PDF]  

PTEN/MMAC1 Mutations in Endometrial Cancers

John I. Risinger, A. Kate Hayes, Andrew Berchuck, and J. Carl Barrett
Cancer Res 1997 57: 4736-4738. [Abstract] [PDF]  

Microsatellite Instability Analysis: A Multicenter Study for Reliability and Quality Control

Tina Bocker, Johannes Diermann, Waltraut Friedl, Johannes Gebert, Elke Holinski-Feder, Judith Karner-Hanusch, Magnus von Knebel-Doeberitz, Konrad Koelble, Gabriela Moeslein, Hans-Konrad Schackert, Hans-Christian Wirtz, Richard Fishel, and Josef Rüschoff
Cancer Res 1997 57: 4739-4743. [Abstract] [PDF]  

Biochemistry and Biophysics:

Expression of Three UDP-N-acetyl--D-galactosamine:Polypeptide GalNAc N-Acetylagalactosaminyltransferases in Adenocarcinoma Cell Lines

Marie E. Sutherlin, Isao Nishimori, Thomas Caffrey, Eric P. Bennett, Helle Hassan, Ulla Mandel, David Mack, Takeshi Iwamura, Henrik Clausen, and Michael A. Hollingsworth
Cancer Res 1997 57: 4744-4748. [Abstract] [PDF]  

Carcinogenesis:

Diagnostic Microsatellite Instability: Definition and Correlation with Mismatch Repair Protein Expression

Wolfgang Dietmaier, Sabine Wallinger, Tina Bocker, Frank Kullmann, Richard Fishel, and Josef Rüschoff
Cancer Res 1997 57: 4749-4756. [Abstract] [PDF]  

Inhibition of Human Cytochrome P450-catalyzed Oxidations of Xenobiotics and Procarcinogens by Synthetic Organoselenium Compounds

Tsutomu Shimada, Karam El-Bayoumy, Pramod Upadhyaya, Thomas R. Sutter, F. Peter Guengerich, and Hiroshi Yamazaki
Cancer Res 1997 57: 4757-4764. [Abstract] [PDF]  

Cyclin D1 Overexpression in Rat Two-Stage Bladder Carcinogenesis and Its Relationship with Oncogenes, Tumor Suppressor Genes, and Cell Proliferation

Chyi Chia R. Lee, Shinji Yamamoto, Hideki Wanibuchi, Seiji Wada, Kazunobu Sugimura, Taketoshi Kishimoto, and Soji Fukushima
Cancer Res 1997 57: 4765-4776. [Abstract] [PDF]  

Clinical Investigations:

Angiogenesis of Uterine Cervical Carcinoma: Characterization by Pharmacokinetic Magnetic Resonance Parameters and Histological Microvessel Density with Correlation to Lymphatic Involvement

Hans Hawighorst, Paul G. Knapstein, Wolfgang Weikel, Michael V. Knopp, Ivan Zuna, Almuth Knof, Gunnar Brix, Uwe Schaeffer, Claudia Wilkens, Stefan O. Schoenberg, Marco Essig, Peter Vaupel, and Gerhard van Kaick
Cancer Res 1997 57: 4777-4786. [Abstract] [PDF]  

Epidemiology and Prevention:

Associations of Sedentary Lifestyle, Obesity, Smoking, Alcohol Use, and Diabetes with the Risk of Colorectal Cancer

Loïc Le Marchand, Lynne R. Wilkens, Laurence N. Kolonel, Jean H. Hankin, and Li-Ching Lyu
Cancer Res 1997 57: 4787-4794. [Abstract] [PDF]  

Experimental Therapeutics:

Selective Tumor Apoptosis by MF13, L-Prolyl-L-m-[bis(chloroethyl)amino]-phenylalanyl-L-norvaline Ethyl Ester, a New Sarcolysin Containing Tripeptide

John Roboz, Jiandong Jiang, James F. Holland, and J. George Bekesi
Cancer Res 1997 57: 4795-4802. [Abstract] [PDF]  

Potent Antitumor Activity of a Novel Nucleoside Analogue, BCH-4556 (ß-L-Dioxolane-cytidine), in Human Renal Cell Carcinoma Xenograft Tumor Models

Salam A. Kadhim, Terry L. Bowlin, William R. Waud, Elyzabeth G. Angers, Lucie Bibeau, Jean-Marc DeMuys, Krzysztof Bednarski, Alex Cimpoia, and Giorgio Attardo
Cancer Res 1997 57: 4803-4810. [Abstract] [PDF]  

Cellular Pharmacokinetics and Cytotoxicity of Camptothecin and Topotecan at Normal and Acidic pH

Attia Gabr, Annemieke Kuin, Marjanka Aalders, Hoda El-Gawly, and Lou A. Smets
Cancer Res 1997 57: 4811-4816. [Abstract] [PDF]  

O⁶-Methylguanine-DNA Methyltransferase (MGMT) Transfectants of a 1,3-Bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive Colon Cancer Cell Line Selectively Repopulate Heterogeneous MGMT⁺/MGMT^- Xenografts after BCNU and O⁶-Benzylguanine plus BCNU

Weldon P. Phillips, Jr., James K. V. Willson, Sanford D. Markowitz, Elizabeth Zborowska, Nasir H. Zaidi, Lili Liu, Nahida H. Gordon, and Stanton L. Gerson
Cancer Res 1997 57: 4817-4823. [Abstract] [PDF]  

Systemic Therapy with 3BIT, a Triple Combination Cocktail of Anti-CD19, -CD22, and -CD38-Saporin Immunotoxins, Is Curative of Human B-Cell Lymphoma in Severe Combined Immunodeficient Mice

David J. Flavell, Armorel Noss, Karen A. F. Pulford, Noel Ling, and Sopsamorn U. Flavell
Cancer Res 1997 57: 4824-4829. [Abstract] [PDF]  

Potentiation of Cytochrome P450/Cyclophosphamide-based Cancer Gene Therapy by Coexpression of the P450 Reductase Gene

Ling Chen, Li J. Yu, and David J. Waxm
Cancer Res 1997 57: 4830-4837. [Abstract] [PDF]  

Induction of Apoptosis and Cell Cycle Arrest by CP-358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase

James D. Moyer, Elsa G. Barbacci, Kenneth K. Iwata, Lee Arnold, Bruce Boman, Ann Cunningham, Catherine DiOrio, Jonathan Doty, Michael J. Morin, Mikel P. Moyer, Mark Neveu, Vincent A. Pollack, Leslie R. Pustilnik, Margaret M. Reynolds, Don Sloan, April Theleman, and Penny Miller
Cancer Res 1997 57: 4838-4848. [Abstract] [PDF]  

Immunology:

Monocyte Chemoattractant Protein Inhibits the Generation of Tumor-reactive T Cells

Liaomin Peng, Suyu Shu, and John C. Krauss
Cancer Res 1997 57: 4849-4854. [Abstract] [PDF]  

Human Papillomavirus-specific Cytotoxic T Lymphocytes in Patients with Cervical Intraepithelial Neoplasia Grade III

Mercy Nimako, Alison N. Fiander, Gavin W. G. Wilkinson, Leszek K. Borysiewicz, and Stephen Man
Cancer Res 1997 57: 4855-4861. [Abstract] [PDF]  

Molecular Biology and Genetics:

Persistent Clonal Proliferation of Human T-lymphotropic Virus Type I-infected Cells in Vivo

Ken-ichiro Etoh, Sadahiro Tamiya, Kazunari Yamaguchi, Akihiko Okayama, Hirohito Tsubouchi, Toru Ideta, Nancy Mueller, Kiyoshi Takatsuki, and Masao Matsuoka
Cancer Res 1997 57: 4862-4867. [Abstract] [PDF]  

CDKN2A/p16 Is Inactivated in Most Melanoma Cell Lines

Marina Castellano, Pamela M. Pollock, Marilyn K. Walters, Louise E. Sparrow, Louise M. Down, Brian G. Gabrielli, Peter G. Parsons, and Nicholas K. Hayward
Cancer Res 1997 57: 4868-4875. [Abstract] [PDF]  

Ribonucleotide Reductase R2 Gene Expression and Changes in Drug Sensitivity and Genome Stability

Aiping Huang, Huizhou Fan, William R. Taylor, and Jim A. Wright
Cancer Res 1997 57: 4876-4881. [Abstract] [PDF]  

Regulation of Collagenase-3 Expression in Human Breast Carcinomas Is Mediated by Stromal-Epithelial Cell Interactions

José A. Uría, Mona Stahle-Bäckdahl, Motoharu Seiki, Antonio Fueyo, and Carlos López-Otín
Cancer Res 1997 57: 4882-4888. [Abstract] [PDF]  

Tumor Biology:

CD44 Expression Is Aberrant in Benign Schwann Cell Tumors Possessing Mutations in the Neurofibromatosis Type 2, but not Type 1, Gene

Larry Sherman, Lee B. Jacoby, Johannes Lampe, Patricia Pelton, Adriano Aguzzi, Peter Herrlich, and Helmut Ponta
Cancer Res 1997 57: 4889-4897. [Abstract] [PDF]  

Establishment of Human Peripheral Lung Epithelial Cell Lines (HPL1) Retaining Differentiated Characteristics and Responsiveness to Epidermal Growth Factor, Hepatocyte Growth Factor, and Transforming Growth Factor ß1

Akira Masuda, Masashi Kondo, Toshiko Saito, Yasushi Yatabe, Tomoko Kobayashi, Mitsumasa Okamoto, Motokazu Suyama, Toshitada Takahashi, and Takashi Takahashi
Cancer Res 1997 57: 4898-4904. [Abstract] [PDF]  

MXI1, a Putative Tumor Suppressor Gene, Suppresses Growth of Human Glioblastoma Cells

Daniel S. Wechsler, Candace A. Shelly, Christy A. Petroff, and Chi V. Dang
Cancer Res 1997 57: 4905-4912. [Abstract] [PDF]  

DNA Hypermethylation at the D17S5 Locus in Non-Small Cell Lung Cancers: Its Association with Smoking History

Keisuke Eguchi, Yae Kanai, Koichi Kobayashi, and Setsuo Hirohashi
Cancer Res 1997 57: 4913-4915. [Abstract] [PDF]  

Role of Intracellular Redox Status in Apoptosis Induction of Human T-Cell Leukemia Virus Type I-infected Lymphocytes by 13-cis-Retinoic Acid

Keizo Furuke, Tetsuro Sasada, Yasuyo Ueda-Taniguchi, Akira Yamauchi, Takashi Inamoto, Yoshio Yamaoka, Hiroshi Masutani, and Junji Yodoi
Cancer Res 1997 57: 4916-4923. [Abstract] [PDF]  

Specific and Efficient Peptide Substrates for Assaying the Proteolytic Activity of Prostate-specific Antigen

Samuel R. Denmeade, Wei Lou, Janita Lövgren, Johan Malm, Hans Lilja, and John T. Isaacs
Cancer Res 1997 57: 4924-4930. [Abstract] [PDF]  

Differential Effects of Synthetic Nuclear Retinoid Receptor-selective Retinoids on the Growth of Human Non-Small Cell Lung Carcinoma Cells

Shi-Yong Sun, Ping Yue, Marcia I. Dawson, Braham Shroot, Serge Michel, William W. Lamph, Richard A. Heyman, Min Teng, Roshantha A. S. Chandraratna, Koichi Shudo, Waun K. Hong, and Reuben Lotan
Cancer Res 1997 57: 4931-4939. [Abstract] [PDF]  

B Lymphocytes from Patients with Chronic Lymphoproliferative Disorders Are Equipped with Different Costimulatory Molecules

Livio Trentin, Renato Zambello, Rosaria Sancetta, Monica Facco, Andrea Cerutti, Alessandra Perin, Marta Siviero, Umberto Basso, Michela Bortolin, Fausto Adami, Carlo Agostini, and Gianpietro Semenzato
Cancer Res 1997 57: 4940-4947. [Abstract] [PDF]  

Elimination of Established Murine Colon Carcinoma Metastases by Antibody- Interleukin 2 Fusion Protein Therapy

Rong Xiang, Holger N. Lode, Carrie S. Dolman, Torsten Dreier, Nissi M. Varki, Xiuqi Qian, Kin-Ming Lo, Yan Lan, Michael Super, Stephen D. Gillies, and Ralph A. Reisfeld
Cancer Res 1997 57: 4948-4955. [Abstract] [PDF]  

Betulinic Acid Triggers CD95 (APO-1/Fas)- and p53-independent Apoptosis via Activation of Caspases in Neuroectodermal Tumors

Simone Fulda, Claudia Friesen, Marek Los, Carsten Scaffidi, Walter Mier, Mary Benedict, Gabriel Nuñez, Peter H. Krammer, Marcus E. Peter, and Klaus-Michael Debatin
Cancer Res 1997 57: 4956-4964. [Abstract] [PDF]  

Mechanisms of the Regulation of Thioredoxin Reductase Activity in Cancer Cells by the Chemopreventive Agent Selenium

Alfred Gallegos, Margareta Berggren, John R. Gasdaska, and Garth Powis
Cancer Res 1997 57: 4965-4970. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1997 57: 4971-4973. [PDF]  

Errata

Cancer Res 1997 57: 4973 [PDF]  

Employment Register of the American for Cancer Research

Cancer Res 1997 57: 4974-4984. [PDF]  

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