Advances in Brief:

High Frequency of Fibroblast Growth Factor (FGF) 8 Expression in Clinical Prostate Cancers and Breast Tissues, Immunohistochemically Demonstrated by a Newly Established Neutralizing Monoclonal Antibody against FGF 8

Akira Tanaka, Akiko Furuya, Motoo Yamasaki, Nobuo Hanai, Ken Kuriki, Tomoko Kamiakito, Yutaka Kobayashi, Hiroki Yoshida, Morio Koike, and Masashi Fukayama
Cancer Res 1998 58: 2053-2056. [Abstract] [PDF]  

Up-Regulation of Fas (APO-1/CD95) Ligand and Down-Regulation of Fas Expression in Human Esophageal Cancer

Catherine Gratas, Yasuo Tohma, Christoph Barnas, Philippe Taniere, Pierre Hainaut, and Hiroko Ohgaki
Cancer Res 1998 58: 2057-2062. [Abstract] [PDF]  

Distinct Patterns of E-Cadherin CpG Island Methylation in Papillary, Follicular, Hurthle's Cell, and Poorly Differentiated Human Thyroid Carcinoma

Jeremy R. Graff, Victoria E. Greenberg, James G. Herman, William H. Westra, Erwin R. Boghaert, Kenneth B. Ain, Motoyasu Saji, Martha A. Zeiger, Stephen G. Zimmer, and Stephen B. Baylin
Cancer Res 1998 58: 2063-2066. [Abstract] [PDF]  

Helicobacter pylori Infection Enhances N-Methyl-N-nitrosourea-induced Stomach Carcinogenesis in the Mongolian Gerbil

Atsushi Sugiyama, Fukuto Maruta, Tatsuo Ikeno, Kimitaka Ishida, Seiji Kawasaki, Tsutomu Katsuyama, Nobuyuki Shimizu, and Masae Tatematsu
Cancer Res 1998 58: 2067-2069. [Abstract] [PDF]  

Carcinogens Preferentially Bind at Methylated CpG in the p53 Mutational Hot Spots

James X. Chen, Yi Zheng, Melissa West, and Moon-shong Tang
Cancer Res 1998 58: 2070-2075. [Abstract] [PDF]  

Mutation, Allelotyping, and Transcription Analyses of the p73 Gene in Prostatic Carcinoma

Hiroyuki Takahashi, Shingo Ichimiya, Yoshinori Nimura, Masatoshi Watanabe, Masakuni Furusato, Shin Wakui, Ryuichi Yatani, Shigeo Aizawa, and Akira Nakagawara
Cancer Res 1998 58: 2076-2077. [Abstract] [PDF]  

Expression of Fas(APO-1/CD95) in Tumor-infiltrating and Peripheral Blood Lymphocytes in Patients with Renal Cell Carcinoma

Gaetano Cardi, John A. Heaney, Alan R. Schned, and Marc S. Ernstoff
Cancer Res 1998 58: 2078-2080. [Abstract] [PDF]  

Location of Several Putative Genes Possibly Involved in Human Breast Cancer Progression

Keltouma Driouch, Marianne Briffod, Ivan Bièche, Marie-Hélène Champème, and Rosette Lidereau
Cancer Res 1998 58: 2081-2086. [Abstract] [PDF]  

Somatic Mutations in LKB1 Are Rare in Sporadic Colorectal and Testicular Tumors

Egle Avizienyte, Stina Roth, Anu Loukola, Akseli Hemminki, Ragnhild A. Lothe, Anna E. Stenwig, Sophie D. Fosså, Reijo Salovaara, and Lauri A. Aaltonen
Cancer Res 1998 58: 2087-2090. [Abstract] [PDF]  

Wild-Type and Mutant Forms of p53 Activate Human Topoisomerase I: A Possible Mechanism for Gain of Function in Mutants

Amador Albor, Shinsuke Kaku, and Molly Kulesz-Martin
Cancer Res 1998 58: 2091-2094. [Abstract] [PDF]  

Frequent PTEN/MMAC Mutations in Endometrioid but not Serous or Mucinous Epithelial Ovarian Tumors

Koshiro Obata, Sarah J. Morland, Richard H. Watson, Andrew Hitchcock, Georgia Chenevix-Trench, Eric J. Thomas, and Ian G. Campbell
Cancer Res 1998 58: 2095-2097. [Abstract] [PDF]  

Tirapazamine Is Metabolized to Its DNA-damaging Radical by Intranuclear Enzymes

James W. Evans, Kazuo Yudoh, Yvette M. Delahoussaye, and J. Martin Brown
Cancer Res 1998 58: 2098-2101. [Abstract] [PDF]  

Biochemistry and Biophysics:

Induction of Apoptosis and Activation of Interleukin 1ß-Converting Enzyme/Ced-3 Protease (Caspase-3) and c-Jun NH₂-Terminal Kinase 1 by Benzo(a)pyrene

Wei Lei, Rong Yu, Sandhya Mandlekar, and A-N. Tony Kong
Cancer Res 1998 58: 2102-2106. [Abstract] [PDF]  

Carcinogenesis:

Genetic Polymorphisms in Catechol-O-Methyltransferase, Menopausal Status, and Breast Cancer Risk

Patricia A. Thompson, Peter G. Shields, Jo L. Freudenheim, Angie Stone, John E. Vena, James R. Marshall, Saxon Graham, Rosemary Laughlin, Takuma Nemoto, Fred F. Kadlubar, and Christine B. Ambrosone
Cancer Res 1998 58: 2107-2110. [Abstract] [PDF]  

A Bcl-x_L Transgene Promotes Malignant Conversion of Chemically Initiated Skin Papillomas

John C. Pena, Charles M. Rudin, and Craig B. Thompson
Cancer Res 1998 58: 2111-2116. [Abstract] [PDF]  

Clinical Investigations:

Telomerase Activity and Alterations in Telomere Length in Human Brain Tumors

Shoju Hiraga, Takanori Ohnishi, Shuichi Izumoto, Eiji Miyahara, Yonehiro Kanemura, Hirotaka Matsumura, and Norio Arita
Cancer Res 1998 58: 2117-2125. [Abstract] [PDF]  

Experimental Therapeutics:

Inhibition of Microtubule Assembly in Tumor Cells by 3-Bromoacetylamino Benzoylurea, a New Cancericidal Compound

Jian-Dong Jiang, Yue Wang, John Roboz, James Strauchen, James F. Holland, and J. George Bekesi
Cancer Res 1998 58: 2126-2133. [Abstract] [PDF]  

Modulation of Bcl-2 Protein Levels by an Intracellular Anti-Bcl-2 Single-Chain Antibody Increases Drug-induced Cytotoxicity in the Breast Cancer Cell Line MCF-7

Alain Piché, Jon Grim, Claudine Rancourt, Jesùs Gómez-Navarro, John C. Reed, and David T. Curiel
Cancer Res 1998 58: 2134-2140. [Abstract] [PDF]  

Pharmacodynamics of Immediate and Delayed Effects of Paclitaxel: Role of Slow Apoptosis and Intracellular Drug Retention

Jessie L-S. Au, Dong Li, Yuebo Gan, Xiang Gao, Andrew L. Johnson, Jeffrey Johnston, Nancy J. Millenbaugh, Seong H. Jang, Hyo-Jeong Kuh, Chiung-Tong Chen, and M. Guillaume Wientjes
Cancer Res 1998 58: 2141-2148. [Abstract] [PDF]  

Immunology:

Molecular Analysis of the HLA-A2 Antigen Loss by Melanoma Cells SK-MEL-29.1.22 and SK-MEL-29.1.29

Zhigang Wang, Barbara Seliger, Norio Mike, Frank Momburg, Alex Knuth, and Soldano Ferrone
Cancer Res 1998 58: 2149-2157. [Abstract] [PDF]  

Molecular Biology and Genetics:

Glial Cell Line-derived Neurotrophic Factor/Neurturin-induced Differentiation and Its Enhancement by Retinoic Acid in Primary Human Neuroblastomas Expressing c-Ret, GFR-1, and GFR-2

Tomoro Hishiki, Yoshinori Nimura, Eriko Isogai, Kazuhiro Kondo, Shingo Ichimiya, Yohko Nakamura, Toshinori Ozaki, Shigeru Sakiyama, Masayoshi Hirose, Naohiko Seki, Hideyo Takahashi, Naomi Ohnuma, Masahiro Tanabe, and Akira Nakagawara
Cancer Res 1998 58: 2158-2165. [Abstract] [PDF]  

Allelic Loss of 16q23.2–24.2 Is an Independent Marker of Good Prognosis in Primary Breast Cancer

Lise Lotte Hansen, Mette Yilmaz, Jens Overgaard, Jørn Andersen, and Torben A. Kruse
Cancer Res 1998 58: 2166-2169. [Abstract] [PDF]  

Chromosomal Gains and Losses in Primary Cutaneous Melanomas Detected by Comparative Genomic Hybridization

Boris C. Bastian, Philip E. LeBoit, Henning Hamm, Eva-Bettina Bröcker, and Dan Pinkel
Cancer Res 1998 58: 2170-2175. [Abstract] [PDF]  

Increased Translocations and Aneusomy in Chromosomes 8 and 21 Among Workers Exposed to Benzene

Martyn T. Smith, Luoping Zhang, Yunxia Wang, Richard B. Hayes, Guilan Li, Joseph Wiemels, Mustafa Dosemeci, Nina Titenko-Holland, Liqiang Xi, Prema Kolachana, Songnian Yin, and Nathaniel Rothman
Cancer Res 1998 58: 2176-2181. [Abstract] [PDF]  

Cap43, a Novel Gene Specifically Induced by Ni²⁺ Compounds

Daoji Zhou, Konstantin Salnikow, and Max Costa
Cancer Res 1998 58: 2182-2189. [Abstract] [PDF]  

Germ-Line-derived Hinge Domain p53 Mutants Have Lost Apoptotic but not Cell Cycle Arrest Functions

Oscar N. Aurelio, Jean-Francois Cajot, Mai L-H. Hua, Zeenat Khwaja, and Eric J. Stanbridge
Cancer Res 1998 58: 2190-2195. [Abstract] [PDF]  

Cloning, Characterization, and Chromosomal Localization of a Gene Frequently Deleted in Human Liver Cancer (DLC-1) Homologous to Rat RhoGAP

Bao-Zhu Yuan, Mark J. Miller, Catherine L. Keck, Drazen B. Zimonjic, Snorri S. Thorgeirsson, and Nicholas C. Popescu
Cancer Res 1998 58: 2196-2199. [Abstract] [PDF]  

Tumor Biology:

Normal Keratinocytes Suppress Early Stages of Neoplastic Progression in Stratified Epithelium

Ashkan Javaherian, Michael Vaccariello, Norbert E. Fusenig, and Jonathan A. Garlick
Cancer Res 1998 58: 2200-2208. [Abstract] [PDF]  

Matrix Metalloproteinases-2 and -9 Are Expressed in Human Neuroblastoma: Contribution of Stromal Cells to Their Production and Correlation with Metastasis

Yasuo Sugiura, Hiroyuki Shimada, Robert C. Seeger, Walter E. Laug, and Yves A. DeClerck
Cancer Res 1998 58: 2209-2216. [Abstract] [PDF]  

The Role of Type I and Type II Tumor Necrosis Factor (TNF) Receptors in the Ability of TNF- to Transduce a Proliferative Signal in the Human Megakaryoblastic Leukemic Cell Line Mo7e

Richard Y. Liu, Chun Fan, Steven Mitchell, Q. Chen, Jerry Wu, and Kenneth S. Zuckerman
Cancer Res 1998 58: 2217-2223. [Abstract] [PDF]  

Downstream Events in Mammary Gland Morphogenesis Mediated by Reexpression of the ₂ß₁ Integrin: The Role of the ₆ and ß₄ Integrin Subunits

Hong Sun, Samuel A. Santoro, and Mary M. Zutter
Cancer Res 1998 58: 2224-2233. [Abstract] [PDF]  

Expression of Urokinase-Type Plasminogen Activator (u-PA), u-PA Receptor, and Tissue-Type PA Messenger RNAs in Human Hepatocellular Carcinoma

Giuseppina De Petro, Daniela Tavian, Alessandro Copeta, Nazario Portolani, Stefano Maria Giulini, and Sergio Barlati
Cancer Res 1998 58: 2234-2239. [Abstract] [PDF]  

Transformation of Epithelial Madin-Darby Canine Kidney Cells with p60^v-src Induces Expression of Membrane-Type 1 Matrix Metalloproteinase and Invasiveness

Yoshifumi Kadono, Yasunori Okada, Mikio Namiki, Motoharu Seiki, and Hiroshi Sato
Cancer Res 1998 58: 2240-2244. [Abstract] [PDF]  

Expression of Ribonucleotide Reductase after Ionizing Radiation in Human Cervical Carcinoma Cells

Mei-Ling Kuo and Timothy J. Kinsella
Cancer Res 1998 58: 2245-2252. [Abstract] [PDF]  

Activation of the ras-Mitogen-activated Protein Kinase Pathway and Phosphorylation of ets-2 at Position Threonine 72 in Human Ovarian Cancer Cell Lines

Suzanne E. Patton, Michele L. Martin, Lori L. Nelsen, Xianjun Fang, Gordon B. Mills, Robert C. Bast, Jr., and Michael C. Ostrowski
Cancer Res 1998 58: 2253-2259. [Abstract] [PDF]  

12-O-Tetradecanoylphorbol-13-acetate-induced Apoptosis in LNCaP Cells Is Mediated through Ceramide Synthase

Mark Garzotto, Margaret White-Jones, Youwei Jiang, Desiree Ehleiter, Wen-Chieh Liao, Adriana Haimovitz-Friedman, Zvi Fuks, and Richard Kolesnick
Cancer Res 1998 58: 2260-2264. [Abstract] [PDF]  

Articles:

Announcements

Cancer Res 1998 58: 2265-2267. [PDF]  

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